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MX2011012136A - Anticuerpo anti-axl. - Google Patents

Anticuerpo anti-axl.

Info

Publication number
MX2011012136A
MX2011012136A MX2011012136A MX2011012136A MX2011012136A MX 2011012136 A MX2011012136 A MX 2011012136A MX 2011012136 A MX2011012136 A MX 2011012136A MX 2011012136 A MX2011012136 A MX 2011012136A MX 2011012136 A MX2011012136 A MX 2011012136A
Authority
MX
Mexico
Prior art keywords
antibody
axl
axl antibody
anexelekto
humanizing
Prior art date
Application number
MX2011012136A
Other languages
English (en)
Inventor
Hiroyuki Tsunoda
Tomoyuki Igawa
Atsuhiko Maeda
Tatsuhiko Tachibana
Taichi Kuramochi
Hajime Miyamoto
Atsushi Matsuo
Hiratoke Shiraiwa
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2011012136A publication Critical patent/MX2011012136A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe que al humanizar un anticuerpo anti-AXL que se origina de ratón, se puede reducir la inmunogenicidad del mismo en humanos. Se proporciona un anticuerpo capaz de unir a una región específica en Anexelekto (AXL); y un anticuerpo humanizado construido basado en este anticuerpo. El anticuerpo anti-AXL mencionado anteriormente tiene una alta actividad antitumoral y, por lo tanto, es útil como un agente para reducir la cantidad de expresión de AXL, un fármaco anticáncer y como un diagnóstico de cáncer.
MX2011012136A 2009-05-15 2010-05-14 Anticuerpo anti-axl. MX2011012136A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009118725 2009-05-15
PCT/JP2010/058166 WO2010131733A1 (ja) 2009-05-15 2010-05-14 抗axl抗体

Publications (1)

Publication Number Publication Date
MX2011012136A true MX2011012136A (es) 2012-04-10

Family

ID=43085106

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012136A MX2011012136A (es) 2009-05-15 2010-05-14 Anticuerpo anti-axl.

Country Status (22)

Country Link
US (1) US9340615B2 (es)
EP (1) EP2431393B1 (es)
JP (1) JP5669732B2 (es)
KR (1) KR20120024763A (es)
CN (1) CN102459344A (es)
AR (1) AR076875A1 (es)
AU (1) AU2010248365A1 (es)
BR (1) BRPI1011145A2 (es)
CA (1) CA2761891A1 (es)
CL (1) CL2011002877A1 (es)
CO (1) CO6460749A2 (es)
CR (1) CR20110646A (es)
EC (1) ECSP11011538A (es)
IL (1) IL216097A0 (es)
MA (1) MA33405B1 (es)
MX (1) MX2011012136A (es)
PE (1) PE20120562A1 (es)
RU (1) RU2011151069A (es)
SG (1) SG176074A1 (es)
TW (1) TW201041595A (es)
WO (1) WO2010131733A1 (es)
ZA (1) ZA201108526B (es)

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WO2010131733A1 (ja) 2010-11-18
AU2010248365A1 (en) 2011-12-22
CL2011002877A1 (es) 2012-05-25
AR076875A1 (es) 2011-07-13
CO6460749A2 (es) 2012-06-15
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CA2761891A1 (en) 2010-11-18
MA33405B1 (fr) 2012-07-03
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US20120121587A1 (en) 2012-05-17

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