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MA51039A - Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose - Google Patents

Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose

Info

Publication number
MA51039A
MA51039A MA051039A MA51039A MA51039A MA 51039 A MA51039 A MA 51039A MA 051039 A MA051039 A MA 051039A MA 51039 A MA51039 A MA 51039A MA 51039 A MA51039 A MA 51039A
Authority
MA
Morocco
Prior art keywords
transmembranary
mucoviscidosis
processes
conductance regulator
modulators
Prior art date
Application number
MA051039A
Other languages
English (en)
Inventor
Paul T Angell
Cristian Harrison
Robert M Hughes
Berenice Lewandowski
Benjamin J Littler
Vito Melillo
William A Nugent
David Andrew Siesel
David Smith
John Studley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MA51039A publication Critical patent/MA51039A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Amplifiers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
MA051039A 2017-12-08 2018-12-07 Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose MA51039A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762596452P 2017-12-08 2017-12-08
US201862623725P 2018-01-30 2018-01-30
US201862649970P 2018-03-29 2018-03-29

Publications (1)

Publication Number Publication Date
MA51039A true MA51039A (fr) 2020-10-14

Family

ID=64902470

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051039A MA51039A (fr) 2017-12-08 2018-12-07 Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose

Country Status (13)

Country Link
US (2) US11465985B2 (fr)
EP (1) EP3720849A2 (fr)
JP (1) JP7245834B2 (fr)
KR (1) KR102716244B1 (fr)
CN (1) CN111757874B (fr)
AU (1) AU2018380426B2 (fr)
CA (1) CA3085006A1 (fr)
IL (1) IL275049B2 (fr)
MA (1) MA51039A (fr)
MX (1) MX2020005753A (fr)
NZ (1) NZ765171A (fr)
TW (1) TWI801465B (fr)
WO (1) WO2019113476A2 (fr)

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TWI774712B (zh) 2016-12-09 2022-08-21 美商維泰克斯製藥公司 囊性纖維化跨膜傳導調控劑之調節劑、醫藥組合物、治療方法及製備該調節劑之方法
CA3066084A1 (fr) 2017-06-08 2018-12-13 Vertex Pharmaceuticals Incorporated Methodes de traitement de la fibrose kystique
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
KR102606188B1 (ko) 2017-08-02 2023-11-23 버텍스 파마슈티칼스 인코포레이티드 피롤리딘 화합물을 제조하기 위한 공정
IL273831B2 (en) 2017-10-19 2024-10-01 Vertex Pharma Crystalline forms and compositions of cftr modulators
CN111757874B (zh) 2017-12-08 2024-03-08 弗特克斯药品有限公司 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
FI3752510T3 (fi) 2018-02-15 2023-03-14 Vertex Pharma Makrosyklit kystisen fibroosin transmembraanisen konduktanssinsäätäjän modulaattoreina, niiden farmaseuttisia koostumuksia, niiden käyttö kystisen fibroosin hoidossa ja menetelmä niiden valmistamiseksi
US11414439B2 (en) 2018-04-13 2022-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
TW202120517A (zh) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
CN114599657B (zh) 2019-08-14 2024-10-11 弗特克斯药品有限公司 Cftr调节剂的结晶形式
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
CN111943848B (zh) * 2020-08-19 2023-05-05 苏州旺山旺水生物医药有限公司 一种elexacaftor中间体的制备方法及其应用
US12186306B2 (en) 2020-12-10 2025-01-07 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
IL314449A (en) 2022-02-03 2024-09-01 Vertex Pharma Methods of treatment for cystic fibrosis
EP4472983A1 (fr) 2022-02-03 2024-12-11 Vertex Pharmaceuticals Incorporated Procédés de préparation et formes cristallines de (6a,12a)-17-amino-12-méthyl-6,15-bis(trifluorométhyl)-13,19-dioxa-3,4,18-triazatricyclo[ 12.3.1.12,5]nonadéca-1(18),2,4,14,16-pentaén-6-ol
WO2023154291A1 (fr) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique
WO2023224931A1 (fr) 2022-05-16 2023-11-23 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique
AU2023272562A1 (en) 2022-05-16 2024-11-07 Vertex Pharmaceuticals Incorporated Solid forms of a macrocyclic compounds as cftr modulators and their preparation
CN115536493A (zh) * 2022-10-20 2022-12-30 海门瑞一医药科技有限公司 一种制取3,3,3-三氟甲基-2,2-二甲基丙烷醇的简单方法

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WO2019113476A3 (fr) 2019-07-25
EP3720849A2 (fr) 2020-10-14
CN111757874B (zh) 2024-03-08
KR102716244B1 (ko) 2024-10-14
AU2018380426A1 (en) 2020-06-25
CN111757874A (zh) 2020-10-09
IL275049B2 (en) 2023-02-01
JP7245834B2 (ja) 2023-03-24
TWI801465B (zh) 2023-05-11
AU2018380426B2 (en) 2023-05-18
IL275049B (en) 2022-10-01
NZ765171A (en) 2024-12-20
KR20200097293A (ko) 2020-08-18
US20210246117A1 (en) 2021-08-12
JP2021505579A (ja) 2021-02-18
US20240025877A1 (en) 2024-01-25

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