[go: up one dir, main page]

MA49959B1 - Formulation liposomale pour lubrification d'articulation - Google Patents

Formulation liposomale pour lubrification d'articulation

Info

Publication number
MA49959B1
MA49959B1 MA49959A MA49959A MA49959B1 MA 49959 B1 MA49959 B1 MA 49959B1 MA 49959 A MA49959 A MA 49959A MA 49959 A MA49959 A MA 49959A MA 49959 B1 MA49959 B1 MA 49959B1
Authority
MA
Morocco
Prior art keywords
pharmaceutical composition
joint
liposomal formulation
gpl
membrane
Prior art date
Application number
MA49959A
Other languages
English (en)
Other versions
MA49959A (fr
Inventor
Yechezkel Barenholz
Yaniv Dolev
Keren Turjeman
Gadi Sarfati
Maty Ayal-Hershkovitz
Original Assignee
Moebius Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moebius Medical Ltd filed Critical Moebius Medical Ltd
Publication of MA49959A publication Critical patent/MA49959A/fr
Publication of MA49959B1 publication Critical patent/MA49959B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition pharmaceutique pour la lubrification des articulations, la composition pharmaceutique comprenant un agent de tonicité non ionique comprenant un polyol, et des liposomes comprenant au moins une membrane comprenant au moins un phospholipide (pl) choisi parmi un glycérophospholipide (gpl), ledit gpl comportant deux chaînes hydrocarbonées en c12 à c18, identiques ou différentes, et d'une sphingomyéline (sm) comportant une chaîne hydrocarbonée en c12 à c18, la composition pharmaceutique étant essentiellement exempte d'un agent pharmaceutiquement actif supplémentaire, l'au moins une membrane présentant une température de transition de phase dans la plage d'environ 20 °c à environ 39 °c et l'articulation présentant une température d'articulation qui est au-dessus de la température de transition de phase.
MA49959A 2017-08-22 2018-08-21 Formulation liposomale pour lubrification d'articulation MA49959B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (fr) 2017-08-22 2018-08-21 Formulation liposomale pour lubrification d'articulation

Publications (2)

Publication Number Publication Date
MA49959A MA49959A (fr) 2020-07-01
MA49959B1 true MA49959B1 (fr) 2023-07-31

Family

ID=65439381

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49959A MA49959B1 (fr) 2017-08-22 2018-08-21 Formulation liposomale pour lubrification d'articulation

Country Status (25)

Country Link
US (2) US11123293B2 (fr)
EP (2) EP3672653B1 (fr)
JP (2) JP7082336B2 (fr)
KR (2) KR102607729B1 (fr)
CN (2) CN114601799B (fr)
AU (3) AU2018319594B2 (fr)
BR (1) BR112020003767B1 (fr)
CA (2) CA3073368C (fr)
DK (1) DK3672653T3 (fr)
EA (1) EA202090476A1 (fr)
ES (1) ES2948715T3 (fr)
FI (1) FI3672653T3 (fr)
HR (1) HRP20230566T1 (fr)
HU (1) HUE062030T2 (fr)
IL (3) IL312816A (fr)
LT (1) LT3672653T (fr)
MA (1) MA49959B1 (fr)
MX (2) MX2020002041A (fr)
MY (1) MY197149A (fr)
PH (1) PH12020500331A1 (fr)
PL (1) PL3672653T3 (fr)
PT (1) PT3672653T (fr)
SG (1) SG11202000773QA (fr)
SI (1) SI3672653T1 (fr)
WO (1) WO2019038763A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
AU2024209031A1 (en) 2023-01-19 2025-01-02 Moebius Medical Ltd. A long-acting liposomal composition for treatment of pain in articular disorders

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403592A (en) 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
EP0319638A1 (fr) * 1987-12-08 1989-06-14 Estee Lauder Inc. Compositions cosmétiques et pharmaceutiques contenant des liposomes et procédés pour l'utilisation de telles compositions
US5941909A (en) * 1995-02-14 1999-08-24 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
AUPN723395A0 (en) 1995-12-19 1996-01-18 Macnaught Medical Pty Limited Lubrication methods
US6379648B1 (en) * 1999-02-01 2002-04-30 The Curators Of The University Of Missouri Biodegradable glass compositions and methods for radiation therapy
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
JP2004521112A (ja) * 2001-01-24 2004-07-15 メステックス アクチエンゲゼルシャフト 関節痛治療薬を製造することへの神経毒性物質の使用
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
DE60231385D1 (de) * 2001-03-29 2009-04-16 Scripps Research Inst Formulierungen, die eingeschlossene wirkstoffe enthalten, und ihre verwendung
EP1423081A4 (fr) 2001-06-25 2005-05-25 Depuy Int Ltd Composition comprenant des glycosaminoglycanes et des inhibiteurs d'hyaluronidase destinee au traitement d'articulations arthritiques
JP2004535434A (ja) * 2001-06-25 2004-11-25 デピユイ 関節炎にかかった関節の処置のためのグリコサミノグリカン類のリポソームカプセル化
US20060029655A1 (en) * 2001-06-25 2006-02-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method for preparation of vesicles loaded with biological material and different uses thereof
DE10255106A1 (de) * 2002-11-24 2004-06-09 Novosom Ag Liposomale Glucocorticoide
US7205006B2 (en) 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
EP1750671B1 (fr) 2004-06-03 2008-10-15 Bracco Research S.A. Assemblage liposomale pour son utilisation therapeutique et/ou diagnostique
CN101027065A (zh) * 2004-06-15 2007-08-29 陈献 磷脂组合物及其制备和使用方法
US20070071840A1 (en) 2005-09-27 2007-03-29 Sridevi Dhanaraj Method for treatment of cartilage disorders with centella extract
ITPD20060202A1 (it) 2006-05-22 2007-11-23 Univ Degli Studi Trieste Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc
CN101541308B (zh) * 2006-09-28 2012-02-01 哈达斯特医疗研究服务和开发有限公司 甘油磷脂用于关节润滑的用途
WO2008079982A2 (fr) 2006-12-21 2008-07-03 Centocor, Inc. Composition de liposome utilisée pour cibler le récepteur egf
FR2918276B1 (fr) * 2007-07-02 2010-01-22 Anteis Sa "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires"
US20110171288A1 (en) 2008-02-20 2011-07-14 Fatemeh Mohammadi Topical compositions and methods for whitening skin
WO2011158237A1 (fr) 2010-06-17 2011-12-22 Yeda Research And Development Co. Ltd., Liposomes lipidiques de phosphatidylcholine comme lubrifiants pour lubrification frontière dans des milieux aqueux
IL206739A (en) 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
US20140038917A1 (en) 2011-04-19 2014-02-06 Anteis S.A. Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
GB201206486D0 (en) * 2012-04-12 2012-05-30 Sequessome Technology Holdings Ltd Vesicular formulations and uses thereof
PL2854769T3 (pl) 2012-07-05 2023-08-07 Taiwan Liposome Company, Ltd. Sposoby leczenia zapalenia stawów
CN104688721A (zh) 2014-10-11 2015-06-10 黄萍 一种含紫杉醇脂质体的抗类风湿性关节炎药物凝胶剂及其制备方法

Also Published As

Publication number Publication date
AU2023203309A1 (en) 2023-06-22
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
CA3073368A1 (fr) 2019-02-28
BR112020003767A2 (pt) 2020-09-01
PH12020500331A1 (en) 2020-10-05
EP3672653B1 (fr) 2023-03-29
FI3672653T3 (fi) 2023-06-07
HUE062030T2 (hu) 2023-09-28
US11123293B2 (en) 2021-09-21
AU2023203309B2 (en) 2024-10-10
JP7383759B2 (ja) 2023-11-20
DK3672653T3 (da) 2023-06-12
AU2025200077A1 (en) 2025-01-23
US20200170948A1 (en) 2020-06-04
IL301801B1 (en) 2024-06-01
JP2020531538A (ja) 2020-11-05
KR20230166148A (ko) 2023-12-06
IL272630B2 (en) 2023-09-01
EA202090476A1 (ru) 2020-06-29
PL3672653T3 (pl) 2023-08-14
JP2022110090A (ja) 2022-07-28
AU2018319594B2 (en) 2023-06-15
IL272630B1 (en) 2023-05-01
SG11202000773QA (en) 2020-03-30
BR112020003767B1 (pt) 2023-10-10
EP4223284A1 (fr) 2023-08-09
MY197149A (en) 2023-05-26
CN111065423A (zh) 2020-04-24
US12214077B2 (en) 2025-02-04
CN111065423B (zh) 2022-04-12
ES2948715T3 (es) 2023-09-18
SI3672653T1 (sl) 2023-08-31
CN114601799A (zh) 2022-06-10
IL312816A (en) 2024-07-01
PT3672653T (pt) 2023-06-29
IL301801B2 (en) 2024-10-01
LT3672653T (lt) 2023-07-10
HRP20230566T1 (hr) 2023-08-18
IL272630A (en) 2020-03-31
MX2023009082A (es) 2023-08-08
KR102607729B1 (ko) 2023-11-29
NZ761298A (en) 2024-03-22
KR20200044006A (ko) 2020-04-28
EP3672653A4 (fr) 2021-01-13
EP3672653A1 (fr) 2020-07-01
US20210369613A1 (en) 2021-12-02
WO2019038763A1 (fr) 2019-02-28
CN114601799B (zh) 2023-09-26
CA3073368C (fr) 2024-01-02
CA3219776A1 (fr) 2019-02-28
JP7082336B2 (ja) 2022-06-08
AU2018319594A1 (en) 2020-02-20
IL301801A (en) 2023-05-01

Similar Documents

Publication Publication Date Title
MA49959B1 (fr) Formulation liposomale pour lubrification d'articulation
MA29606B1 (fr) Combinaison pharmaceutique comprenant un antibacterien et une substance active choisie parmi le carveol, le thymol, l'eugenol, le borneol et le carvacrol
MA29573B1 (fr) Composition pharmaceutique comprenant un antiviral , un antitumoral ou un antiparasitaire, et un actif choisi parmi le carveol , le thymol, l' eugenol, le borneol et le carvacrol
MA53076B1 (fr) Compositions solides comportant un agoniste glp-1, du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate et un lubrifiant
CA2176840A1 (fr) Association d'un compose a activite anti-microbienne et d'un monoalkylether de glycerol
AR125412A2 (es) Composiciones herbicidas
HK1112411A1 (en) Ophthalmic emulsions containing an immunosuppressive agent
BR0015095A (pt) Concentrados não aquosos ou pobres em água de misturas de substâncias-ativas para a proteção de plantas
TNSN07425A1 (fr) Combinaison pharmaceutique comprenant un agent antifongique et un actif choisi parmi le carveol,l'eugenol, le thymol, le borneol, le carvacrol, et les ionones alpha-et-beta-.
WO2003016466A3 (fr) Anticorps anti-$g(a)$g(b)
FR3063893B1 (fr) Emulsions doubles huile-dans-huile-dans-eau
US6004909A (en) Non-toxic antimicrobial lubricant
FR3092968B1 (fr) Complement alimentaire
MX2022000713A (es) Derivados de bencenosulfonamida y usos de las mismas.
MA39421A (fr) Peptides dérivés de l'ezrine et compositions pharmaceutiques correspondantes
MA37672A1 (fr) Formulation d'agoniste des récepteurs à la somatostatine
EP4048288A4 (fr) Agent anti-c5 pour le traitement de la dégénérescence maculaire liée à l'âge (dmla) sèche ou d'une atrophie géographique secondaire à la dmla sèche
MA31541B1 (fr) Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine
TH2001000930A (th) สูตรผสมไลโพโซมสำหรับการหล่อลื่นข้อต่อ
FR3047488B1 (fr) Compositions detergentes pour le nettoyage dans l'industrie cosmetique et pharmaceutique.
FR3030864B1 (fr) Utilisation d'une composition elastomerique chargee pour la fabrication d'un joint pour emballage de matiere radioactive, joint et emballage associes
Furman Mineralocorticoid Antagonists
FR3115682B1 (fr) Compositions à base de méthyl-cyclodextrines pour le traitement et/ou la prévention de la stéatose hépatique
US20200330370A1 (en) Method for topical solvent-free aromatic drug delivery system
PL442757A1 (pl) Kompozycja farmaceutyczna zawierająca auranofinę, jej zastosowanie oraz produkt leczniczy zawierający tą kompozycję