MA45600A - Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées - Google Patents
Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associéesInfo
- Publication number
- MA45600A MA45600A MA045600A MA45600A MA45600A MA 45600 A MA45600 A MA 45600A MA 045600 A MA045600 A MA 045600A MA 45600 A MA45600 A MA 45600A MA 45600 A MA45600 A MA 45600A
- Authority
- MA
- Morocco
- Prior art keywords
- associated methods
- neuroactive steroids
- steroids substituted
- substituted
- neuroactive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0029—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
- C07J7/003—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/006—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662360887P | 2016-07-11 | 2016-07-11 | |
| US201662360884P | 2016-07-11 | 2016-07-11 | |
| US201662360876P | 2016-07-11 | 2016-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45600A true MA45600A (fr) | 2019-05-15 |
Family
ID=59388162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045600A MA45600A (fr) | 2016-07-11 | 2017-07-11 | Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20190233465A1 (fr) |
| EP (2) | EP4406602A2 (fr) |
| JP (2) | JP7065825B2 (fr) |
| AU (3) | AU2017296295B2 (fr) |
| CA (1) | CA3030420A1 (fr) |
| DK (1) | DK3481844T3 (fr) |
| ES (1) | ES2992037T3 (fr) |
| MA (1) | MA45600A (fr) |
| WO (1) | WO2018013615A1 (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2753632T (lt) | 2011-09-08 | 2023-07-10 | Sage Therapeutics, Inc. | Neuroaktyvieji steroidai, jų kompozicijos ir naudojimas |
| CN104136452A (zh) | 2011-10-14 | 2014-11-05 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| US20140057885A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| SMT202100475T1 (it) | 2013-03-13 | 2021-09-14 | Sage Therapeutics Inc | Steroidi neuroattivi |
| AU2014256228C1 (en) | 2013-04-17 | 2017-09-14 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| CA2909545A1 (fr) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor-c21-n-pyrazolyl-steroides c3,3-disubstitues et procedes d'utilisation de ceux-ci |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| RS61733B1 (sr) | 2013-07-19 | 2021-05-31 | Sage Therapeutics Inc | Neuroaktivni steroidi, njihove kompozicije i upotrebe |
| CA2921512C (fr) | 2013-08-23 | 2024-05-28 | Sage Therapeutics, Inc. | Steroides neuroactifs, compositions et utilisations |
| WO2015195962A1 (fr) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs, leurs compositions et utilisations |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| EP3206493B1 (fr) | 2014-10-16 | 2020-05-06 | Sage Therapeutics, Inc. | Compositions et méthodes pour traiter des troubles du snc |
| CN117024502A (zh) | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| SI3224269T1 (sl) | 2014-11-27 | 2020-10-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
| ES2857082T3 (es) | 2015-01-26 | 2021-09-28 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| EP3258939B1 (fr) | 2015-02-20 | 2022-09-07 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs, compositions, et leurs utilisations |
| HUE055199T2 (hu) | 2015-07-06 | 2021-11-29 | Sage Therapeutics Inc | Oxiszterolok és alkalmazási eljárásaik |
| HRP20220716T1 (hr) | 2016-04-01 | 2022-09-02 | Sage Therapeutics, Inc. | Oksisteroli i postupci za njihovu uporabu |
| WO2017193046A1 (fr) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxystérols et méthodes d'utilisation associées |
| MA45600A (fr) | 2016-07-11 | 2019-05-15 | Sage Therapeutics Inc | Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées |
| IL309259A (en) | 2016-07-11 | 2024-02-01 | Sage Therapeutics Inc | C17, c20, and c21 substituted neuroactive steroids and their methods of use |
| IL302480A (en) | 2016-08-23 | 2023-06-01 | Sage Therapeutics Inc | A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid |
| US11149056B2 (en) | 2016-09-30 | 2021-10-19 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods of use thereof |
| KR20230051723A (ko) | 2016-10-18 | 2023-04-18 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
| DK3529257T3 (da) | 2016-10-18 | 2023-08-07 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| JP2021505608A (ja) | 2017-12-08 | 2021-02-18 | セージ セラピューティクス， インコーポレイテッド | ＣＮＳ障害を処置するためのジュウテリウム化された２１−［４−シアノ−ピラゾール−１−イル］−１９−ノル−プレガン−３．α−オール−２０−オン誘導体 |
| MX2020008422A (es) * | 2018-02-11 | 2020-09-21 | Jiangsu Hansoh Pharmaceutical Group Co Ltd | Regulador derivado de esteroides, metodo para prepararlos y usos de los mismos. |
| CN111040015B (zh) * | 2018-10-15 | 2022-03-18 | 南京诺瑞特医药科技有限公司 | 19-去甲-c21取代类固醇衍生物 |
| CN113272315B (zh) * | 2018-12-26 | 2023-08-08 | 张家口华健致远生物科技有限公司 | 一类类固醇化合物及其用途 |
| US20220089636A1 (en) * | 2019-01-14 | 2022-03-24 | Beijing Xuanyi Pharmasciences Co., Ltd. | Tetrazolone substituted steroids and use thereof |
| PE20230244A1 (es) | 2019-05-31 | 2023-02-07 | Sage Therapeutics Inc | Esteroides neuroactivos y composiciones de estos |
| US20220275020A1 (en) * | 2019-08-07 | 2022-09-01 | Shanghai Hansoh Biomedical Co., Ltd. | Salt and crystal form of steroid derivative regulator |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| US20230346801A1 (en) | 2020-03-25 | 2023-11-02 | Sage Therapeutics, Inc. | Use of agents for treatment of respiratory conditions |
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-
2017
- 2017-07-11 MA MA045600A patent/MA45600A/fr unknown
- 2017-07-11 CA CA3030420A patent/CA3030420A1/fr active Pending
- 2017-07-11 ES ES17743137T patent/ES2992037T3/es active Active
- 2017-07-11 AU AU2017296295A patent/AU2017296295B2/en active Active
- 2017-07-11 JP JP2019500826A patent/JP7065825B2/ja active Active
- 2017-07-11 US US16/316,851 patent/US20190233465A1/en not_active Abandoned
- 2017-07-11 EP EP24170063.2A patent/EP4406602A2/fr active Pending
- 2017-07-11 EP EP17743137.6A patent/EP3481844B1/fr active Active
- 2017-07-11 WO PCT/US2017/041605 patent/WO2018013615A1/fr unknown
- 2017-07-11 DK DK17743137.6T patent/DK3481844T3/da active
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2021
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2022
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| US20230021308A9 (en) | 2023-01-19 |
| AU2022200247A1 (en) | 2022-02-10 |
| AU2022200247B2 (en) | 2024-03-07 |
| EP3481844B1 (fr) | 2024-04-17 |
| EP3481844A1 (fr) | 2019-05-15 |
| JP7065825B2 (ja) | 2022-05-12 |
| EP4406602A2 (fr) | 2024-07-31 |
| AU2017296295B2 (en) | 2022-02-24 |
| CA3030420A1 (fr) | 2018-01-18 |
| DK3481844T3 (da) | 2024-07-22 |
| ES2992037T3 (es) | 2024-12-05 |
| JP2022105088A (ja) | 2022-07-12 |
| US20250092084A1 (en) | 2025-03-20 |
| AU2024200851A1 (en) | 2024-02-29 |
| WO2018013615A1 (fr) | 2018-01-18 |
| US11993628B2 (en) | 2024-05-28 |
| US20220002340A1 (en) | 2022-01-06 |
| JP2019520417A (ja) | 2019-07-18 |
| JP7611186B2 (ja) | 2025-01-09 |
| AU2017296295A1 (en) | 2019-01-24 |
| US20190233465A1 (en) | 2019-08-01 |
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