[go: up one dir, main page]

DK3548135T3 - Kerne-skal-mikronålsindretninger og anvendelser deraf - Google Patents

Kerne-skal-mikronålsindretninger og anvendelser deraf Download PDF

Info

Publication number
DK3548135T3
DK3548135T3 DK17879565.4T DK17879565T DK3548135T3 DK 3548135 T3 DK3548135 T3 DK 3548135T3 DK 17879565 T DK17879565 T DK 17879565T DK 3548135 T3 DK3548135 T3 DK 3548135T3
Authority
DK
Denmark
Prior art keywords
core
needle devices
shell micro
micro
shell
Prior art date
Application number
DK17879565.4T
Other languages
English (en)
Inventor
Zhen Gu
Yanqi Ye
Jinqiang Wang
Original Assignee
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State filed Critical Univ North Carolina State
Application granted granted Critical
Publication of DK3548135T3 publication Critical patent/DK3548135T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6955Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004Glucose oxidase (1.1.3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y111/00Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01Peroxidases (1.11.1)
    • C12Y111/01006Catalase (1.11.1.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DK17879565.4T 2016-12-05 2017-12-05 Kerne-skal-mikronålsindretninger og anvendelser deraf DK3548135T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662430260P 2016-12-05 2016-12-05
PCT/US2017/064723 WO2018106696A1 (en) 2016-12-05 2017-12-05 Core-shell microneedle devices and uses thereof

Publications (1)

Publication Number Publication Date
DK3548135T3 true DK3548135T3 (da) 2021-11-22

Family

ID=62491316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17879565.4T DK3548135T3 (da) 2016-12-05 2017-12-05 Kerne-skal-mikronålsindretninger og anvendelser deraf

Country Status (7)

Country Link
US (2) US11697007B2 (da)
EP (2) EP3799865B1 (da)
JP (1) JP7232526B2 (da)
CN (1) CN110167624B (da)
CA (1) CA3045882A1 (da)
DK (1) DK3548135T3 (da)
WO (1) WO2018106696A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019143293A1 (en) * 2018-01-16 2019-07-25 Nanyang Technological University Self-implantable micro-drug-reservoirs for localized and controlled ocular drug delivery
US11724941B2 (en) 2018-02-15 2023-08-15 North Carolina State University Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization
EP3765029A4 (en) * 2018-04-13 2021-12-08 North Carolina State University ERO SENSITIVE MICRO-NEEDLE PATCH FOR TREATMENT OF VULGAR ACNE
CA3110487A1 (en) * 2018-08-24 2020-02-27 North Carolina State University Microneedle-array patches with glucose-responsive matrix for closed-loop insulin delivery
US20210213266A1 (en) * 2018-08-24 2021-07-15 North Carolina State University Cardiac Cell Microneedle Patch for Treating Heart Diseases
EP3852721A4 (en) * 2018-09-20 2022-06-29 Singapore Health Services Pte Ltd Conductive microneedle patch for active agent delivery
CN109675185A (zh) * 2019-01-02 2019-04-26 浙江大学 一种苯硼酸水凝胶基糖敏微针贴及其制备方法
JP2021153914A (ja) * 2020-03-27 2021-10-07 国立大学法人 東京医科歯科大学 薬剤送達デバイスおよびその製造方法
CN115734798A (zh) 2020-04-28 2023-03-03 提克纳有限责任公司 微针组件
KR102740788B1 (ko) * 2020-07-02 2024-12-09 연세대학교 산학협력단 멀티 레이어 마이크로니들 구조체 및 이의 제조 방법
DK4048152T3 (da) 2020-07-29 2024-03-11 Biolinq Incorporated System til kontinuerlig analytovervågning med mikronålsindretning
CN115998850A (zh) * 2022-12-26 2023-04-25 中山大学 一种尿酸响应性水凝胶微针及其制备方法
US12336816B2 (en) 2023-02-02 2025-06-24 Biolinq Incorporated Method for improved sensor sensitivity of a microneedle-based continuous analyte monitoring system
WO2024167986A2 (en) * 2023-02-10 2024-08-15 Alj Creative Works, Llc Programmable drug-device microneedle system for the treament of diabetes, obesity, and associated conditions
CN117159443B (zh) * 2023-10-19 2024-04-19 暨南大学 原位超分子凝胶微针贴片及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002349295A1 (en) 2001-12-02 2003-06-17 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
JP5559054B2 (ja) 2007-09-28 2014-07-23 ザ クイーンズ ユニヴァーシティ オブ ベルファスト 送達装置および方法
US20090175840A1 (en) 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
ES2547654T3 (es) 2008-10-31 2015-10-07 Tremrx, Inc. Vacunación con vectores poxvirales mediante alteración mecánica epidérmica
US9339529B2 (en) * 2012-02-17 2016-05-17 Massachusetts Institute Of Technology Glucose-responsive microgels for closed loop insulin delivery
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
EP2991673A4 (en) 2013-04-30 2016-12-21 Massachusetts Inst Technology INJECTABLE NANON NETWORKS FOR DIABETES TREATMENT
US10987039B2 (en) * 2014-12-03 2021-04-27 Stmicroelectronics S.R.L. Microneedle array device and method of making
CN107530296B (zh) 2015-04-21 2021-06-22 北卡罗来纳州立大学 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统
US10894151B2 (en) 2015-04-23 2021-01-19 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring
CN110167537A (zh) 2016-11-07 2019-08-23 北卡罗来纳州立大学 用于增强葡萄糖反应性胰岛素的递送的装有双敏感囊泡的贴剂
WO2018106697A1 (en) 2016-12-05 2018-06-14 North Carolina State University H 2o 2-responsive nanoparticles and uses thereof

Also Published As

Publication number Publication date
EP3548135A1 (en) 2019-10-09
CN110167624B (zh) 2021-11-19
JP2020512283A (ja) 2020-04-23
EP3548135B1 (en) 2021-10-13
JP7232526B2 (ja) 2023-03-03
US20230364402A1 (en) 2023-11-16
EP3548135A4 (en) 2020-07-29
CA3045882A1 (en) 2018-06-14
EP3799865B1 (en) 2022-06-15
US20190351206A1 (en) 2019-11-21
EP3799865A1 (en) 2021-04-07
US11697007B2 (en) 2023-07-11
WO2018106696A1 (en) 2018-06-14
CN110167624A (zh) 2019-08-23

Similar Documents

Publication Publication Date Title
DK3548135T3 (da) Kerne-skal-mikronålsindretninger og anvendelser deraf
DK3625263T3 (da) Anti-galectin- 9-antistoffer og anvendelser deraf
IL293377A (en) Hsd17b13 variants and uses thereof
DK3448386T3 (da) Isoquinolin-3-ylcarboxamider og fremstilling og anvendelse deraf
DK3383916T3 (da) Anti-CD73-antistoffer og anvendelser deraf
DK3485010T3 (da) Bacillus cibi-dnase-varianter og anvendelser deraf
DK3610005T3 (da) Peptidligase og anvendelse deraf
DK3365368T3 (da) Tgfbeta1-bindende immunoglobuliner og anvendelse deraf
DK3283106T3 (da) Terapeutiske antistoffer og anvendelser deraf
DK3668512T3 (da) Pyruvatkinasemodulatorer og anvendelse deraf
DK3322804T3 (da) Nuklease-uafhængigt målrettet genredigeringsplatform og anvendelser deraf
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3368534T3 (da) Valbenazin-ditosylat og polymorfer deraf
DK3354282T3 (da) Glycan-terapeutiske midler og relaterede fremgangsmåder deraf
DK3484865T3 (da) Somatostatinmodulatorer og anvendelser deraf
DK3516160T3 (da) Brøndanordning og tilhørende fremgangsmåder
DK3532499T3 (da) ANTI-IL-33-antistoffer og anvendelser deraf
EP3597500A4 (en) DRIVING ASSISTANCE DEVICE AND PROCEDURE
EP3499437A4 (en) COMMERCIAL IMPROVEMENT ASSISTANCE DEVICE AND COMMERCIAL IMPROVEMENT ASSISTANCE METHOD
DK3402821T3 (da) Psma-bindende antistof og anvendelser deraf
DK3209773T3 (da) Prolintolerante tripeptidylpeptidaser og anvendelser deraf
EP3481952A4 (en) METHYLATION MARKERS IN THE TREATMENT OF LEUKEMIA AND USES THEREOF
DK3256598T3 (da) Svampestammer og anvendelsesfremgangsmåder
DK3128005T3 (da) Sirp-alfa-variantkonstruktioner og anvendelser deraf
DK3423076T3 (da) Topisk cyclosporinholdige formuleringer og anvendelser deraf