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MA32889B1 - Composes de pyrazine comme inhibiteurs de phosphodiesterase 10 - Google Patents

Composes de pyrazine comme inhibiteurs de phosphodiesterase 10

Info

Publication number
MA32889B1
MA32889B1 MA33928A MA33928A MA32889B1 MA 32889 B1 MA32889 B1 MA 32889B1 MA 33928 A MA33928 A MA 33928A MA 33928 A MA33928 A MA 33928A MA 32889 B1 MA32889 B1 MA 32889B1
Authority
MA
Morocco
Prior art keywords
phosphodiesterase
inhibitors
pyrazine compounds
compounds act
methods
Prior art date
Application number
MA33928A
Other languages
Arabic (ar)
English (en)
Inventor
Jennifer R Allen
Matthew P Bourbeau
Ning Chen
Essa Hu
Roxanne Kunz
Shannon Rumfelt
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA32889B1 publication Critical patent/MA32889B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés de pyrazine et des compositions les contenant, ainsi que des procédés de préparation de ces composés. L'invention concerne également des procédés permettant de traiter des troubles et des maladies pouvant être traitées par inhibition de PDE 10, par exemple l'obésité, les diabètes non-insulino-dépendants, la schizophrénie, le trouble bipolaire, le trouble obsessionnel compulsif, etc.
MA33928A 2008-11-14 2011-06-10 Composes de pyrazine comme inhibiteurs de phosphodiesterase 10 MA32889B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11456708P 2008-11-14 2008-11-14
US16621209P 2009-04-02 2009-04-02
PCT/US2009/064637 WO2010057121A1 (fr) 2008-11-14 2009-11-16 Composes de pyrazine comme inhibiteurs de phosphodiesterase 10

Publications (1)

Publication Number Publication Date
MA32889B1 true MA32889B1 (fr) 2011-12-01

Family

ID=41478512

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33928A MA32889B1 (fr) 2008-11-14 2011-06-10 Composes de pyrazine comme inhibiteurs de phosphodiesterase 10

Country Status (31)

Country Link
US (4) US8053438B2 (fr)
EP (1) EP2364308B1 (fr)
JP (1) JP5746972B2 (fr)
KR (1) KR20110083746A (fr)
CN (1) CN102300860B (fr)
AR (1) AR074358A1 (fr)
AU (1) AU2009313768B2 (fr)
BR (1) BRPI0922095A2 (fr)
CA (1) CA2742993C (fr)
CL (1) CL2011001094A1 (fr)
CO (1) CO6382157A2 (fr)
CR (1) CR20110326A (fr)
CY (1) CY1113680T1 (fr)
DK (1) DK2364308T3 (fr)
EA (1) EA019206B1 (fr)
ES (1) ES2397218T3 (fr)
HK (1) HK1161251A1 (fr)
HR (1) HRP20130054T1 (fr)
IL (1) IL212687A0 (fr)
MA (1) MA32889B1 (fr)
MX (1) MX2011005100A (fr)
NZ (1) NZ592508A (fr)
PE (1) PE20110581A1 (fr)
PL (1) PL2364308T3 (fr)
PT (1) PT2364308E (fr)
RS (1) RS52598B (fr)
SI (1) SI2364308T1 (fr)
SM (1) SMT201200061B (fr)
TN (1) TN2011000221A1 (fr)
TW (1) TWI396689B (fr)
WO (1) WO2010057121A1 (fr)

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WO2010077992A1 (fr) * 2008-12-17 2010-07-08 Amgen Inc. Composés aminopyridines et carboxypyridines en tant que inhibiteurs de phosphodiestérase 10
GEP20146004B (en) 2009-02-05 2014-01-10 Takeda Pharmaceuticals Co Pyridazinone compounds
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
MX2011011907A (es) * 2009-05-12 2012-01-20 Albany Molecular Res Inc 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
MA34007B1 (fr) 2010-02-19 2013-02-01 Boehringer Ingelheim Int Derives de pyridine tricycliques medicaments contenant ces composes leur utilisation et leur procede de preparation
BR112012032087A2 (pt) 2010-06-24 2016-11-16 Takeda Pharmaceuticals Co composto, medicamento, e, uso de um composto
WO2012018909A1 (fr) 2010-08-04 2012-02-09 Takeda Pharmaceutical Company Limited Composés hétérocycliques condensés
US8883788B2 (en) 2010-08-04 2014-11-11 Takeda Pharmaceutical Company Limited Fused heterocyclic ring compound
EP2604597B1 (fr) 2010-08-10 2017-01-04 Takeda Pharmaceutical Company Limited Composé hétérocyclique et utilisation de celui-ci comme inhibiteur de phosphodiesterase 10a
HUE037860T2 (hu) 2010-11-19 2018-09-28 Ligand Pharm Inc Heterociklusos aminok és alkalmazásuk
EP2663565B1 (fr) 2011-01-11 2017-03-15 Sunovion Pharmaceuticals Inc. Composés hétéroaryles et leurs procédés d'utilisation
EP2687529B1 (fr) 2011-03-16 2016-07-13 Takeda Pharmaceutical Company Limited Composé hétérocyclique condensé
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WO2015048281A1 (fr) 2013-09-27 2015-04-02 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisation
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CN104649882A (zh) * 2015-02-11 2015-05-27 南通恒盛精细化工有限公司 一种磷酸二酯酶抑制剂的中间体制备工艺
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WO2017047602A1 (fr) * 2015-09-18 2017-03-23 科研製薬株式会社 Dérivé biaryle et médicament le contenant
CN111615515B (zh) * 2018-01-19 2023-11-24 苏州信诺维医药科技股份有限公司 杂环化合物、制备方法及其在医药上的应用
CN109020977B (zh) * 2018-10-26 2020-11-13 安庆奇创药业有限公司 一种Acalabrutinib的制备方法
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Also Published As

Publication number Publication date
TWI396689B (zh) 2013-05-21
JP2012508776A (ja) 2012-04-12
HK1161251A1 (en) 2012-08-24
IL212687A0 (en) 2011-07-31
CA2742993A1 (fr) 2010-05-20
CL2011001094A1 (es) 2011-11-11
EA019206B1 (ru) 2014-01-30
NZ592508A (en) 2013-04-26
KR20110083746A (ko) 2011-07-20
PL2364308T3 (pl) 2013-03-29
US8247418B2 (en) 2012-08-21
TW201030006A (en) 2010-08-16
US20110160182A1 (en) 2011-06-30
EA201100748A1 (ru) 2011-10-31
ES2397218T3 (es) 2013-03-05
CR20110326A (es) 2011-07-28
AU2009313768B2 (en) 2013-01-10
DK2364308T3 (da) 2013-02-04
MX2011005100A (es) 2011-05-30
US20100137278A1 (en) 2010-06-03
SI2364308T1 (sl) 2013-01-31
US20120277209A1 (en) 2012-11-01
RS52598B (en) 2013-04-30
WO2010057121A1 (fr) 2010-05-20
PE20110581A1 (es) 2011-09-03
HRP20130054T1 (hr) 2013-02-28
TN2011000221A1 (en) 2012-12-17
AU2009313768A1 (en) 2010-05-20
BRPI0922095A2 (pt) 2019-09-24
EP2364308B1 (fr) 2012-10-24
SMT201200061B (it) 2013-01-14
CA2742993C (fr) 2015-01-20
AR074358A1 (es) 2011-01-12
US8053438B2 (en) 2011-11-08
CN102300860B (zh) 2014-08-27
US20110160202A1 (en) 2011-06-30
PT2364308E (pt) 2013-01-08
CN102300860A (zh) 2011-12-28
CO6382157A2 (es) 2012-02-15
CY1113680T1 (el) 2016-06-22
EP2364308A1 (fr) 2011-09-14
US8329700B2 (en) 2012-12-11
JP5746972B2 (ja) 2015-07-08

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