LU84632A1 - Stabilisierte insulinloesungen und verfahren zu ihrer herstellung - Google Patents

Stabilisierte insulinloesungen und verfahren zu ihrer herstellung Download PDF

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Publication number: LU84632A1
Authority: LU; Luxembourg
Prior art keywords: insulin; zinc; solution according; solution; hexamer
Prior art date: 1982-02-05

Application number

LU84632A

Other languages

German (de)

English (en)

French (fr)

Inventor

Svend Havelund

Joergen Vejlgaard Brange Jens

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-05

Filing date

1983-02-04

Publication date

1983-09-08

1983-02-04 Application filed by Novo Industri As filed Critical Novo Industri As

1983-09-08 Publication of LU84632A1 publication Critical patent/LU84632A1/de

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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 316
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HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 65
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PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 37
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PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 20
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 19
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OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
230000009918 complex formation Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
229930003836 cresol Natural products 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000000835 fiber Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
239000000203 mixture Substances 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000006174 pH buffer Substances 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000011282 treatment Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000004474 valine Substances 0.000 description 1

Classifications

- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Microelectronics & Electronic Packaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Manufacturing & Machinery (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

LU84632A 1982-02-05 1983-02-04 Stabilisierte insulinloesungen und verfahren zu ihrer herstellung LU84632A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK49182		1982-02-05
DK49182		1982-02-05

Publications (1)

Publication Number	Publication Date
LU84632A1 true LU84632A1 (fr)	1983-09-08

Family

ID=8094159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU84632A LU84632A1 (fr)	1982-02-05	1983-02-04	Stabilisierte insulinloesungen und verfahren zu ihrer herstellung

Country Status (22)

Country	Link
US (1)	US4476118A (no)
JP (1)	JPS58192818A (no)
AT (1)	AT382780B (no)
AU (1)	AU549981B2 (no)
BE (1)	BE895832A (no)
CA (1)	CA1203476A (no)
CH (1)	CH657530A5 (no)
DE (1)	DE3303860A1 (no)
ES (1)	ES519533A0 (no)
FI (1)	FI78616C (no)
FR (1)	FR2521009B1 (no)
GB (1)	GB2114573B (no)
GR (1)	GR77388B (no)
IE (1)	IE54548B1 (no)
IT (1)	IT1178455B (no)
LU (1)	LU84632A1 (no)
NL (1)	NL187269C (no)
NO (1)	NO161204C (no)
NZ (1)	NZ203189A (no)
PT (1)	PT76195B (no)
SE (1)	SE460948B (no)
ZA (1)	ZA83742B (no)

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US20050065066A1 (en) *	2002-12-20	2005-03-24	Kaarsholm Niels Christian	Stabilised insulin compositions
DE60317565T2 (de) *	2002-12-20	2008-09-11	Novo Nordisk A/S	Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
WO2004096266A1 (en) *	2003-05-02	2004-11-11	Novo Nordisk A/S	Improved physical stability of insulin formulations
BRPI0413276B8 (pt) *	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
KR101276754B1 (ko) *	2004-07-19	2013-06-19	바이오콘 리미티드	인슐린―올리고머 접합체，제형 및 이들의 용도
ATE519780T1 (de) *	2005-12-28	2011-08-15	Novo Nordisk As	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
US20090136538A1 (en) *	2006-05-22	2009-05-28	Jan Jezek	Stable vaccine formulation
GB0700523D0 (en) *	2007-01-11	2007-02-21	Insense Ltd	The Stabilisation Of Proteins
CA2681158C (en)	2007-03-13	2018-09-18	Nutrition 21, Inc.	Methods and compositions for the sustained release of chromium
JP5552046B2 (ja) *	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
PT2597103T (pt) *	2007-11-16	2017-02-08	Novo Nordisk As	Composições farmacêuticas contendo insulina e um péptido insulinotrófico
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RU2540922C2 (ru) *	2008-10-30	2015-02-10	Ново Нордиск А/С	Лечение сахарного диабета с использованием инъекций инсулина с частотой менее одного раза в день
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
ES2927800T3 (es)	2011-03-01	2022-11-11	Nutrition 21 Llc	Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
JP6322642B2 (ja)	2012-11-13	2018-05-09	アドシア	置換されたアニオン性化合物を含有する速効型インスリン製剤
RU2015129087A (ru) *	2012-12-19	2017-02-02	Вокхардт Лимитед	Стабильная водная композиция, содержащая инсулин человека или его аналог или производное
AU2013368990B2 (en)	2012-12-26	2017-05-18	Wockhardt Limited	Pharmaceutical composition
TWI641381B (zh) *	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
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WO2015084694A2 (en) *	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
TW201630622A (zh)	2014-12-16	2016-09-01	美國禮來大藥廠	速效胰島素組合物
JO3749B1 (ar)	2015-08-27	2021-01-31	Lilly Co Eli	تركيبات إنسولين سريعة المفعول
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US2787575A (en) *	1950-11-22	1957-04-02	Organon	Zinc-glycine-insulin composition and production thereof
US2882203A (en) *	1951-06-26	1959-04-14	Novo Terapeutisk Labor As	Injectable insulin preparation with protracted effect
DE1044360B (de) *	1953-08-19	1958-11-20	Roskilde Medical Company Ltd R	Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) *	1954-02-18	1957-01-10	Dr Dr Guenther Weitzel	Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) *	1957-06-08	1962-10-16	Novo Terapeutisk Labor As	Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) *	1957-08-10	1961-12-26	Novo Terapeutish Lab A S	Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) *	1958-05-12	1963-05-28	Novo Terapeutisk Labor As	Quick acting insulin preparation
FR1263220A (fr) *	1958-08-01	1961-06-09	Novo Terapeutisk Labor As	Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) *	1967-03-01	1970-01-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) *	1968-08-09	1972-08-09	Novo Terapeutisk Labor As	Improvements in or relating to injectable insulin preparations
US3657425A (en) *	1969-03-12	1972-04-18	Burroughs Wellcome Co	Beef insulin preparations
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ES8403723A1 (es) *	1982-03-03	1984-04-16	Nordisk Insulinlab	Procedimiento de producir preparaciones de insulina.

1983
- 1983-02-03 FI FI830375A patent/FI78616C/fi not_active IP Right Cessation
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 ES ES519533A patent/ES519533A0/es active Granted
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AT382780B (de)	1987-04-10
DE3303860C2 (no)	1989-12-28
FI830375L (fi)	1983-08-06
IE54548B1 (en)	1989-11-08
AU1113683A (en)	1983-08-11
PT76195A (en)	1983-03-01
CH657530A5 (de)	1986-09-15
NZ203189A (en)	1985-07-31
ES8500060A1 (es)	1984-10-16
ATA38983A (de)	1986-09-15
PT76195B (en)	1986-01-27
NO161204B (no)	1989-04-10
FI830375A0 (fi)	1983-02-03
BE895832A (fr)	1983-08-04
NL187269C (nl)	1991-08-01
IT1178455B (it)	1987-09-09
FR2521009B1 (fr)	1987-07-17
GB2114573A (en)	1983-08-24
GB2114573B (en)	1985-05-01
SE8300598L (sv)	1983-08-06
AU549981B2 (en)	1986-02-20
ES519533A0 (es)	1984-10-16
ZA83742B (en)	1983-11-30
NL187269B (nl)	1991-03-01
JPH0367056B2 (no)	1991-10-21
GB8303133D0 (en)	1983-03-09
DE3303860A1 (de)	1983-08-18
IT8319420A0 (it)	1983-02-04
NO161204C (no)	1989-07-19
CA1203476A (en)	1986-04-22
NO830385L (no)	1983-08-08
SE8300598D0 (sv)	1983-02-04
SE460948B (sv)	1989-12-11
FI78616B (fi)	1989-05-31
JPS58192818A (ja)	1983-11-10
NL8300440A (nl)	1983-09-01
FR2521009A1 (fr)	1983-08-12
US4476118A (en)	1984-10-09
GR77388B (no)	1984-09-11
IE830220L (en)	1983-08-05
FI78616C (fi)	1989-09-11

Publication	Publication Date	Title
DE3303860C2 (no)	1989-12-28
AT408611B (de)	2002-01-25	Insulinanalogon-protamin-komplex
AT408720B (de)	2002-02-25	Parenterale pharmazeutische formulierung eines humaninsulinanalogon-komplexes
EP0357978B1 (de)	1992-05-13	Pharmazeutische Zubereitung zur Behandlung des Diabetes mellitus
DE69428860T2 (de)	2002-05-02	Insulin Formulierung
DE69708121T2 (de)	2002-08-01	Halogenid-enthaltende insulinzubereitungen
DE69834956T2 (de)	2007-05-24	Stabile Insulinformulierungen
DE3240177C2 (no)	1993-07-22
DE69434963T2 (de)	2008-01-17	Selektiv auf die leber wirkende pharmazeutisch aktive substanz
DE68905203T2 (de)	1993-07-22	Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten.
DE10114178A1 (de)	2002-10-10	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE69115590T2 (de)	1996-08-01	4-Chinolonderivate mit einem zweiwertigen Metallion komplexiert enthaltende Zusammensetzung
DE3837825A1 (de)	1990-05-10	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
EP3202394A1 (de)	2017-08-09	Wässrige insulinzubereitungen enthaltend methionin
DE69827357T2 (de)	2005-11-24	Menschliches Wachstumshormon enthaltende pharmazeutische Zusammensetzung
EP2451471A1 (de)	2012-05-16	Langsamwirkende insulinzubereitungen
CH652031A5 (de)	1985-10-31	Stabilisierte insulinpraeparate und verfahren zu deren herstellung.
EP0291863B1 (de)	1992-01-22	Mischkristalle aus Insulin und Insulinderivaten, Verfahren zur Herstellung dieser Mischkristalle und diese Mischkristalle enthaltende pharmazeutische Mittel
EP0166971B1 (de)	1990-02-28	Insulinzubereitungen, Verfahren zu deren Herstellung und deren Verwendung
DE1212679B (de)	1966-03-17	Verfahren zur Herstellung von Insulinloesungen
EP0187361A2 (de)	1986-07-16	Präparate mit verzögerter Wirkung, Verfahren zu deren Herstellung sowie entprechende Mittel zur Human- bzw. veterinärmedizinischen Anwendung
DE60001489T2 (de)	2003-12-04	Pharmazeutische zubereitung für die intravenöse oder intramuskuläre verabreichung von octreotid
AT401469B (de)	1996-09-25	Pharmazeutische wässrige lösung zur parenteralen anwendung enthaltend einen in situ gebildeten komplex von einem alkaloid mit bis-indol-gerüst, sowie verfahren zu deren herstellung
DE2427732A1 (de)	1975-02-27	Mittel zum anaesthesieren von saeugetieren
EP0013962B1 (de)	1982-01-27	Aminosäuren und Mineralsalze enthaltende Infusionslösung