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LU79294A1 - Procede pour la preparation de nouveaux derives de la morphine et application a titre de medicament - Google Patents

Procede pour la preparation de nouveaux derives de la morphine et application a titre de medicament

Info

Publication number
LU79294A1
LU79294A1 LU79294A LU79294A LU79294A1 LU 79294 A1 LU79294 A1 LU 79294A1 LU 79294 A LU79294 A LU 79294A LU 79294 A LU79294 A LU 79294A LU 79294 A1 LU79294 A1 LU 79294A1
Authority
LU
Luxembourg
Prior art keywords
procedure
preparation
application
medicinal product
morphine derivatives
Prior art date
Application number
LU79294A
Other languages
English (en)
French (fr)
Inventor
R Kobylecki
J Lewis
I Guest
G Kirby
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of LU79294A1 publication Critical patent/LU79294A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU79294A 1977-03-23 1978-03-22 Procede pour la preparation de nouveaux derives de la morphine et application a titre de medicament LU79294A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (1)

Publication Number Publication Date
LU79294A1 true LU79294A1 (fr) 1979-10-29

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79294A LU79294A1 (fr) 1977-03-23 1978-03-22 Procede pour la preparation de nouveaux derives de la morphine et application a titre de medicament

Country Status (24)

Country Link
US (1) US4241066A (xx)
JP (1) JPS53119899A (xx)
AT (1) AT361139B (xx)
AU (1) AU519643B2 (xx)
BE (1) BE865183A (xx)
CA (1) CA1089456A (xx)
CH (1) CH629809A5 (xx)
CS (1) CS200542B2 (xx)
DD (1) DD133950A5 (xx)
DE (1) DE2812580A1 (xx)
DK (1) DK149858C (xx)
ES (1) ES468173A1 (xx)
FI (1) FI68236C (xx)
FR (1) FR2384774A1 (xx)
GB (1) GB1593191A (xx)
IE (1) IE46443B1 (xx)
IT (1) IT1105176B (xx)
LU (1) LU79294A1 (xx)
NL (1) NL7803083A (xx)
NZ (1) NZ186692A (xx)
PL (1) PL114723B1 (xx)
SE (1) SE436131B (xx)
SU (1) SU921467A3 (xx)
ZA (1) ZA781527B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
CA2105072C (en) * 1992-01-23 1998-07-28 Hiroshi Nagase Morphinan derivative and its pharmaceutical applications
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
CN104383542B (zh) 2003-04-08 2017-09-26 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
JP2008546688A (ja) 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路
CA2646313C (en) * 2006-04-21 2014-05-20 Nektar Therapeutics Al, Corporation Stereoselective reduction of a morphinone
EP2565195B1 (en) 2007-03-29 2015-05-06 Wyeth LLC Peripheral opioid receptor and antagonists and uses thereof
CA2865661C (en) 2007-03-29 2016-05-17 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2344509B1 (en) 2008-09-30 2015-11-11 Mallinckrodt LLC Processes for the production of buprenorphine with reduced impurity formation
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
PL114723B1 (en) 1981-02-28
PL205498A1 (pl) 1979-04-09
IT1105176B (it) 1985-10-28
GB1593191A (en) 1981-07-15
IE46443B1 (en) 1983-06-15
AT361139B (de) 1981-02-25
JPS53119899A (en) 1978-10-19
IE780515L (en) 1978-09-23
FI68236B (fi) 1985-04-30
FI68236C (fi) 1985-08-12
CA1089456A (en) 1980-11-11
SE436131B (sv) 1984-11-12
CH629809A5 (fr) 1982-05-14
ES468173A1 (es) 1979-09-16
DD133950A5 (de) 1979-01-31
NZ186692A (en) 1980-02-21
DK149858C (da) 1987-06-29
SE7803328L (sv) 1978-09-24
SU921467A3 (ru) 1982-04-15
FR2384774A1 (fr) 1978-10-20
AU519643B2 (en) 1981-12-17
CS200542B2 (en) 1980-09-15
FR2384774B1 (xx) 1981-10-16
NL7803083A (nl) 1978-09-26
DK149858B (da) 1986-10-13
IT7848544A0 (it) 1978-03-22
DK130078A (da) 1978-09-24
FI780882A (fi) 1978-09-24
ATA204278A (de) 1980-07-15
BE865183A (fr) 1978-09-22
ZA781527B (en) 1979-04-25
JPH0112755B2 (xx) 1989-03-02
US4241066A (en) 1980-12-23
AU3435778A (en) 1979-09-27
DE2812580A1 (de) 1978-10-05

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