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LT3411411T - 1h-indazol-3-karboksamidų dariniai ir susiję junginiai, kaip d faktoriaus inhibitoriai, skirti gydyti ligas, kurioms būdingas aberantinės komplemento sistemos aktyvumas, tokias kaip imunologiniai sutrikimai - Google Patents

1h-indazol-3-karboksamidų dariniai ir susiję junginiai, kaip d faktoriaus inhibitoriai, skirti gydyti ligas, kurioms būdingas aberantinės komplemento sistemos aktyvumas, tokias kaip imunologiniai sutrikimai

Info

Publication number
LT3411411T
LT3411411T LTEP17748044.9T LT17748044T LT3411411T LT 3411411 T LT3411411 T LT 3411411T LT 17748044 T LT17748044 T LT 17748044T LT 3411411 T LT3411411 T LT 3411411T
Authority
LT
Lithuania
Prior art keywords
indazole
inhibitors
factor
related compounds
treating diseases
Prior art date
Application number
LTEP17748044.9T
Other languages
English (en)
Inventor
Pravin Kotian
Yarlagadda Babu
Weihe Zhang
Lakshminarayana Vogeti
Minwan Wu
Venkat CHINTAREDDY
Krishnan RAMAN
Original Assignee
Biocryst Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharmaceuticals, Inc. filed Critical Biocryst Pharmaceuticals, Inc.
Publication of LT3411411T publication Critical patent/LT3411411T/lt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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LTEP17748044.9T 2016-02-01 2017-02-01 1h-indazol-3-karboksamidų dariniai ir susiję junginiai, kaip d faktoriaus inhibitoriai, skirti gydyti ligas, kurioms būdingas aberantinės komplemento sistemos aktyvumas, tokias kaip imunologiniai sutrikimai LT3411411T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662289653P 2016-02-01 2016-02-01
PCT/US2017/015953 WO2017136395A1 (en) 2016-02-01 2017-02-01 Benzopyrazole compounds and analogues thereof

Publications (1)

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LT3411411T true LT3411411T (lt) 2021-06-25

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LTEP17748044.9T LT3411411T (lt) 2016-02-01 2017-02-01 1h-indazol-3-karboksamidų dariniai ir susiję junginiai, kaip d faktoriaus inhibitoriai, skirti gydyti ligas, kurioms būdingas aberantinės komplemento sistemos aktyvumas, tokias kaip imunologiniai sutrikimai

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US (3) US10849883B2 (lt)
EP (2) EP3411411B3 (lt)
JP (2) JP6924766B2 (lt)
KR (1) KR20180117624A (lt)
CN (2) CN115490751A (lt)
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HU (1) HUE055258T2 (lt)
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MA (1) MA43979B1 (lt)
MD (1) MD3411411T2 (lt)
MX (2) MX2018008869A (lt)
MY (1) MY201629A (lt)
PH (1) PH12018501537B1 (lt)
PL (1) PL3411411T6 (lt)
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