KR950700925A - 음이온 교환 크로마토그래피법을 이용한 고순도의 바이러스 불활성화된 인자 viii회수방법(process for recovering a high-purity virusinactivated factor viii by anion ex-changer chromatography) - Google Patents
음이온 교환 크로마토그래피법을 이용한 고순도의 바이러스 불활성화된 인자 viii회수방법(process for recovering a high-purity virusinactivated factor viii by anion ex-changer chromatography)Info
- Publication number
- KR950700925A KR950700925A KR1019940702645A KR19940702645A KR950700925A KR 950700925 A KR950700925 A KR 950700925A KR 1019940702645 A KR1019940702645 A KR 1019940702645A KR 19940702645 A KR19940702645 A KR 19940702645A KR 950700925 A KR950700925 A KR 950700925A
- Authority
- KR
- South Korea
- Prior art keywords
- pct
- factor viii
- chromatography
- anion
- virusinactivated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229960000301 factor viii Drugs 0.000 title abstract 2
- 150000001450 anions Chemical class 0.000 title 1
- 238000004587 chromatography analysis Methods 0.000 title 1
- 239000000969 carrier Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 102000001690 Factor VIII Human genes 0.000 abstract 1
- 108010054218 Factor VIII Proteins 0.000 abstract 1
- 238000005571 anion exchange chromatography Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4204694.7 | 1992-02-01 | ||
DE4204694A DE4204694C3 (de) | 1992-02-01 | 1992-02-01 | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
PCT/EP1993/000114 WO1993015105A1 (en) | 1992-02-01 | 1993-01-20 | Process for recovering a high-purity virus-inactivated factor viii by anion exchanger chromatography |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950700925A true KR950700925A (ko) | 1995-02-20 |
KR100240310B1 KR100240310B1 (ko) | 2000-01-15 |
Family
ID=6451895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940702645A Expired - Lifetime KR100240310B1 (ko) | 1992-02-01 | 1993-01-20 | 음이온교환크로마토그래피법을이용한고순도의바이러스불활성화된인자8회수방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5714590A (ko) |
EP (1) | EP0625161B9 (ko) |
JP (1) | JP3556947B2 (ko) |
KR (1) | KR100240310B1 (ko) |
AT (1) | ATE203249T1 (ko) |
AU (1) | AU670776B2 (ko) |
DE (2) | DE4204694C3 (ko) |
DK (1) | DK0625161T4 (ko) |
ES (1) | ES2157920T5 (ko) |
FI (1) | FI109908B (ko) |
GR (1) | GR3036849T3 (ko) |
NO (1) | NO315426B1 (ko) |
PT (1) | PT625161E (ko) |
RU (1) | RU2096414C1 (ko) |
TW (1) | TW362099B (ko) |
WO (1) | WO1993015105A1 (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69229272T2 (de) * | 1991-09-05 | 2000-02-03 | Baxter International Inc., Deerfield | Topischer fibrinogenkomplex |
DE4342132C1 (de) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
DE4407837C1 (de) * | 1994-03-09 | 1995-08-17 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie |
AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
FR2874216B1 (fr) * | 2004-08-16 | 2006-11-03 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
HUE029454T2 (en) * | 2009-11-13 | 2017-03-28 | Grifols Therapeutics Inc | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
RU2445974C2 (ru) * | 2010-04-26 | 2012-03-27 | Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН | Способ получения концентрата фактора viii из плазмы крови человека |
AU2011343813B2 (en) | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
DE3811042A1 (de) * | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
ES2053619T3 (es) * | 1988-05-27 | 1994-08-01 | Centre Regional De Transfusion | Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia. |
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
ES2053684T3 (es) * | 1988-11-05 | 1994-08-01 | Octapharma Ag | Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia. |
GB8913183D0 (en) * | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
-
1992
- 1992-02-01 DE DE4204694A patent/DE4204694C3/de not_active Expired - Lifetime
-
1993
- 1993-01-20 AU AU33517/93A patent/AU670776B2/en not_active Expired
- 1993-01-20 PT PT93902233T patent/PT625161E/pt unknown
- 1993-01-20 US US08/284,403 patent/US5714590A/en not_active Expired - Lifetime
- 1993-01-20 EP EP93902233A patent/EP0625161B9/en not_active Expired - Lifetime
- 1993-01-20 WO PCT/EP1993/000114 patent/WO1993015105A1/en active IP Right Grant
- 1993-01-20 JP JP51290293A patent/JP3556947B2/ja not_active Expired - Lifetime
- 1993-01-20 ES ES93902233T patent/ES2157920T5/es not_active Expired - Lifetime
- 1993-01-20 DK DK93902233T patent/DK0625161T4/da active
- 1993-01-20 KR KR1019940702645A patent/KR100240310B1/ko not_active Expired - Lifetime
- 1993-01-20 DE DE69330458T patent/DE69330458T3/de not_active Expired - Lifetime
- 1993-01-20 AT AT93902233T patent/ATE203249T1/de active
- 1993-01-20 RU RU9394035758A patent/RU2096414C1/ru not_active IP Right Cessation
- 1993-01-28 TW TW082100487A patent/TW362099B/zh not_active IP Right Cessation
-
1994
- 1994-07-28 FI FI943545A patent/FI109908B/fi not_active IP Right Cessation
- 1994-07-29 NO NO19942832A patent/NO315426B1/no not_active IP Right Cessation
-
2001
- 2001-10-09 GR GR20010401713T patent/GR3036849T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5714590A (en) | 1998-02-03 |
FI109908B (fi) | 2002-10-31 |
NO942832L (no) | 1994-07-29 |
PT625161E (pt) | 2001-10-31 |
DE69330458D1 (de) | 2001-08-23 |
TW362099B (en) | 1999-06-21 |
EP0625161A1 (en) | 1994-11-23 |
EP0625161B9 (en) | 2007-09-19 |
JP3556947B2 (ja) | 2004-08-25 |
GR3036849T3 (en) | 2002-01-31 |
FI943545A0 (fi) | 1994-07-28 |
RU2096414C1 (ru) | 1997-11-20 |
DE69330458T3 (de) | 2008-01-17 |
EP0625161B2 (en) | 2007-05-16 |
DE69330458T2 (de) | 2002-05-29 |
AU670776B2 (en) | 1996-08-01 |
DE4204694A1 (de) | 1993-08-12 |
ATE203249T1 (de) | 2001-08-15 |
DK0625161T3 (da) | 2001-09-24 |
KR100240310B1 (ko) | 2000-01-15 |
NO315426B1 (no) | 2003-09-01 |
DE4204694C3 (de) | 1995-10-12 |
WO1993015105A1 (en) | 1993-08-05 |
DE4204694C2 (de) | 1994-02-10 |
JPH07503241A (ja) | 1995-04-06 |
ES2157920T3 (es) | 2001-09-01 |
EP0625161B1 (en) | 2001-07-18 |
NO942832D0 (no) | 1994-07-29 |
FI943545L (fi) | 1994-07-28 |
AU3351793A (en) | 1993-09-01 |
ES2157920T5 (es) | 2007-12-16 |
DK0625161T4 (da) | 2007-09-03 |
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