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ES2053619T3 - Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia. - Google Patents

Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia.

Info

Publication number
ES2053619T3
ES2053619T3 ES88108458T ES88108458T ES2053619T3 ES 2053619 T3 ES2053619 T3 ES 2053619T3 ES 88108458 T ES88108458 T ES 88108458T ES 88108458 T ES88108458 T ES 88108458T ES 2053619 T3 ES2053619 T3 ES 2053619T3
Authority
ES
Spain
Prior art keywords
viruses
free
cryoprecipitate
chromatography
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88108458T
Other languages
English (en)
Inventor
Andrew Smith
Myriana Centre Regiona Burnouf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE REGIONAL DE TRANSFUSION
Centre Regional de Transfusion Sanguine de Lille
Original Assignee
CENTRE REGIONAL DE TRANSFUSION
Centre Regional de Transfusion Sanguine de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8199005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2053619(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CENTRE REGIONAL DE TRANSFUSION, Centre Regional de Transfusion Sanguine de Lille filed Critical CENTRE REGIONAL DE TRANSFUSION
Application granted granted Critical
Publication of ES2053619T3 publication Critical patent/ES2053619T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA FABRICACION DE UN FACTOR ANTIHEMOFILICO (AHF O FACTOR VIII) LIBRE DE VIRUS POR TRATAMIENTO CON DETERGENTES/MEDIOS DE DISOLUCION ORGANICOS BIOCOMPATIBLES POR LIMPIEZA DE UN QUIROPRECIPITADO, QUE SE CARACTERIZA PORQUE ANTES DE LA LIBERACION DEL QUIROPRECIPITADO DE VIRUS EL QUIROPRECIPITADO DERRETIDO SE EXTRAE EN PH 6,5 A 7,5 CON AGUA CONTENIENDO 1 A 3 U/ML DE HEPARINA Y SE MEZCLA CON UNA SUSPENSION DE HIDROXIDO DE ALUMINIO Y TRAS ENFRIAMIENTO A 10 A 18 C Y AJUSTE DEL VALOR PH EN 6 A 7 SE CENTRIFUGA O FILTRA Y SEGUIDAMENTE SE REELABORA DE LA MANERA CONOCIDA. VENTAJOSAMENTE SE SOMETE TRAS ELIMINACION DE LOS VIRUS LA PRUEBA A UNA CROMATOGRAFIA DE GUELPERMEACION EN MATERIALES DE IONES INTERCAMBIABLES.
ES88108458T 1988-05-27 1988-05-27 Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia. Expired - Lifetime ES2053619T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88108458A EP0343275B1 (de) 1988-05-27 1988-05-27 Verfahren zur Herstellung eines hochreinen, virusfreien Antihämophiliefaktors mittels Chromatographie

Publications (1)

Publication Number Publication Date
ES2053619T3 true ES2053619T3 (es) 1994-08-01

Family

ID=8199005

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88108458T Expired - Lifetime ES2053619T3 (es) 1988-05-27 1988-05-27 Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia.

Country Status (5)

Country Link
EP (1) EP0343275B1 (es)
AT (1) ATE85220T1 (es)
DE (1) DE3878227D1 (es)
ES (1) ES2053619T3 (es)
GR (1) GR3007446T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367840B1 (de) 1988-11-05 1993-02-03 Octapharma AG Verfahren zur Herstellung eines hochreinen, nicht infektiösen Antihämophiliefaktors mittels Chromatographie
FR2665364A2 (fr) * 1990-03-15 1992-02-07 Fondation Nale Transfusion San Procede de preparation d'une solution concentree de facteur viii.
FR2659557A1 (fr) * 1990-03-15 1991-09-20 Fondation Nale Transfusion San Procede de preparation d'une solution concentree de facteur viii.
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
FR2681867B1 (fr) 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
DE4204694C3 (de) * 1992-02-01 1995-10-12 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
EP0674531A1 (de) * 1992-12-16 1995-10-04 IMMUNO Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
ES2099678B1 (es) * 1995-11-03 1998-02-16 Grifols Grupo Sa Procedimiento para la inactivacion de virus en proteinas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4478825A (en) * 1983-10-14 1984-10-23 Armour Pharmaceutical Company Warm ethanol method for preparation of low fibrinogen antihemophilic factor
DE3432083A1 (de) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
EP0238701B1 (de) * 1986-03-27 1992-03-18 Octapharma AG Verfahren zur Herstellung eines hochgereinigten Antihämophilie-Faktors
US4789545A (en) * 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof

Also Published As

Publication number Publication date
GR3007446T3 (es) 1993-07-30
EP0343275A1 (de) 1989-11-29
DE3878227D1 (de) 1993-03-18
EP0343275B1 (de) 1993-02-03
ATE85220T1 (de) 1993-02-15

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