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KR910014113A - 활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템 - Google Patents

활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템 Download PDF

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Publication number
KR910014113A
KR910014113A KR1019910001241A KR910001241A KR910014113A KR 910014113 A KR910014113 A KR 910014113A KR 1019910001241 A KR1019910001241 A KR 1019910001241A KR 910001241 A KR910001241 A KR 910001241A KR 910014113 A KR910014113 A KR 910014113A
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KR
South Korea
Prior art keywords
therapeutic system
matrix layer
layer
matrix
transdermal therapeutic
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KR1019910001241A
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English (en)
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KR960005142B1 (ko
Inventor
호프만 한스-라이너
미첼-홀스트만
Original Assignee
원본미기재
엘테에스, 로만 테라피-시스테메게엠베하 운트 콤파니 카게
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Publication of KR910014113A publication Critical patent/KR910014113A/ko
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Publication of KR960005142B1 publication Critical patent/KR960005142B1/ko
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 활성물질로서 툴로부테롤 또는 그것의 약학적허용염을 함유하고, 활성물질에 대해 거의 불침투성인 이장층과 활성물질을 함유하는 적어도 하나의 매트릭스층으로 구성되며, 상기 매트릭스층이 적어도 하나의 스티렌-1,3-디엔-스티렌 블록공중합체를 포함하는 경피성 치료 시스템.
  2. 제1항에 있어서, 상기 스티렌-1,3-디엔-스티렌 블록공중합체가 스티렌-부타디엔-스티렌-또는 스티렌-이소프렌-스티렌 블록공중합체인 경피성 치료시스템.
  3. 제1항에 있어서, 상기 매트릭스층이 자가-접착식인 경피성 치료 시스템.
  4. 제1항에 있어서, 상기 활성물질을 함유하는 매트릭스 층이 자가-접착식이 아니고 활성물질을 함유하지 않은 분리 접착층이 존재하는 경피성치료 시스템.
  5. 제1항 내지 제4항중 어느한항에 있어서, 다수의 활성물질을 함유하는 매트릭스층이 존재하는경피성 치료 시스템.
  6. 제5항에 있어서, 다수의 활성물질을 함유하는 매트릭스층인 경우에, 그 활성물질의 농도가 피부쪽층으로 갈수록 점점 낮아지는 경피성 치료 시스템.
  7. 제1항 내지 제3항중 어느 한항에 있어서, 활성물질을 함유하지 않는 적어도 하나의 매트릭스층이 활성물질을 함유하는 적어도 하나의 매트릭스층과 함께 존재하느 경피성 치료 시스템.
  8. 제1항 내지 제4항중 어느한항에 있어서, 상기 활성물질이 완전 용해에 의해 매트릭스 내에 균질하게 분산되어 있는 경피성 치료시스템.
  9. 제1항 내지 제4항중 어느한항에 있어서, 상기 활성물질이 미세캡슐 또는 미분 현탁액 상태로 매트릭스 내에 존재하는 경피성 치료 시스템.
  10. 제1항에 있어서, 매트릭스층이 중합체, 수지, 및 임의의 연화제를 포함하는 경피성 치료 시스템.
  11. 활성물질을 포함한 패트릭스층의 성분들을 필요하다면 적당한 용매중에 용해시킴으로써 균질히게하고, 이 혼합물을 활성물질에 불투과성인 이장층에 부착시킨후 용매를 제거하는 것을 구성되는 제1항 내지 제10항중 어느한항에 의한 경피성 치료 시스템의 제조방법.
  12. 제11항에 있어서, 임의로 용매를 포함하는 매트릭스층의 성분들의 균질한 혼합물을 접착-방지 보호층 또는 중간층에 부착시키는 제조방법.
  13. 제11항 또는 제12항에 있어서, 상기 자가접착 매트릭스층 또는 매트릭스 층들을 바람직하게는 적층 코팅 방법에의해 초기에는 이장층으로 사용된 접착방지 포일로부터 최종 이장층으로 옮기는 제조방법.
  14. 제11항에 있어서, 매트릭스층(들)의 성분들 및 활성물질을 가열에 의해 용매없이 서로 균질하게 혼합시키는 제조방법.
  15. 제11항 내지 제14항중 어느한항에 있어서, 매트릭스층(들)의 균질한 혼합물을 펴거나 압출시켜서 이장층에 부착시키는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910001241A 1990-01-26 1991-01-25 활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템 Expired - Fee Related KR960005142B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4002281A DE4002281A1 (de) 1990-01-26 1990-01-26 Transdermales therapeutisches system mit dem wirkstoff tulobuterol
DEP40022811 1990-01-26
DEP4002281 1990-01-26

Publications (2)

Publication Number Publication Date
KR910014113A true KR910014113A (ko) 1991-08-31
KR960005142B1 KR960005142B1 (ko) 1996-04-22

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ID=6398833

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Application Number Title Priority Date Filing Date
KR1019910001241A Expired - Fee Related KR960005142B1 (ko) 1990-01-26 1991-01-25 활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템

Country Status (25)

Country Link
US (1) US5254348A (ko)
EP (1) EP0439180B1 (ko)
JP (1) JP2633089B2 (ko)
KR (1) KR960005142B1 (ko)
AT (1) ATE121302T1 (ko)
AU (1) AU624546B2 (ko)
CA (1) CA2034934C (ko)
CZ (1) CZ281991B6 (ko)
DE (2) DE4002281A1 (ko)
DK (1) DK0439180T3 (ko)
ES (1) ES2076383T3 (ko)
FI (1) FI100693B (ko)
HR (1) HRP930871B1 (ko)
HU (1) HU206972B (ko)
IE (1) IE67642B1 (ko)
IL (1) IL97006A (ko)
MY (1) MY105279A (ko)
NO (1) NO180108C (ko)
NZ (1) NZ236885A (ko)
PL (1) PL166248B1 (ko)
PT (1) PT96579B (ko)
SI (1) SI9110125A (ko)
SK (1) SK279112B6 (ko)
YU (1) YU48549B (ko)
ZA (1) ZA91560B (ko)

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CA2034934A1 (en) 1991-07-27
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NO910296L (no) 1991-07-29
ES2076383T3 (es) 1995-11-01
IL97006A (en) 1994-06-24
NO180108C (no) 1997-02-26
SK279112B6 (sk) 1998-06-03
IE67642B1 (en) 1996-04-17
YU48549B (sh) 1998-11-05
SI9110125A (sl) 1998-06-30
CA2034934C (en) 1996-06-25
DE4002281C2 (ko) 1992-09-10
US5254348A (en) 1993-10-19
PT96579A (pt) 1991-10-15
HU206972B (en) 1993-03-01
JP2633089B2 (ja) 1997-07-23
FI910389A0 (fi) 1991-01-25
IE910267A1 (en) 1991-07-31
MY105279A (en) 1994-09-30
AU6940191A (en) 1991-08-01
FI910389L (fi) 1991-07-27
NO180108B (no) 1996-11-11
JPH05194202A (ja) 1993-08-03
HRP930871B1 (en) 1997-12-31
EP0439180A2 (de) 1991-07-31
EP0439180B1 (de) 1995-04-19
NO910296D0 (no) 1991-01-25
DE4002281A1 (de) 1991-08-01
IL97006A0 (en) 1992-03-29
PT96579B (pt) 1998-07-31
ZA91560B (en) 1991-10-30
KR960005142B1 (ko) 1996-04-22
YU12591A (sh) 1994-05-10
CZ16291A3 (en) 1997-04-16
CZ281991B6 (cs) 1997-04-16
ATE121302T1 (de) 1995-05-15
DE59105209D1 (de) 1995-05-24
EP0439180A3 (en) 1991-10-30
AU624546B2 (en) 1992-06-11
HRP930871A2 (en) 1995-02-28
PL288852A1 (en) 1991-12-02
HU910274D0 (en) 1991-08-28

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