[go: up one dir, main page]

KR890701753A - 아미노산 아미드의 라세미화 방법 - Google Patents

아미노산 아미드의 라세미화 방법

Info

Publication number
KR890701753A
KR890701753A KR1019890700689A KR890700689A KR890701753A KR 890701753 A KR890701753 A KR 890701753A KR 1019890700689 A KR1019890700689 A KR 1019890700689A KR 890700689 A KR890700689 A KR 890700689A KR 890701753 A KR890701753 A KR 890701753A
Authority
KR
South Korea
Prior art keywords
strain
ncib
amino acid
amidase
enzyme
Prior art date
Application number
KR1019890700689A
Other languages
English (en)
Inventor
고드트프레드센 소벤에릭
킴클라우센
인그보르센 크젤드
프란시스커스 마리아 헤르메스 후베르투스
Original Assignee
원본미기재
노보 인더스트리 에이/에스
스태미카본 베. 뷔.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK426887A external-priority patent/DK426887D0/da
Priority claimed from DK586187A external-priority patent/DK586187D0/da
Priority claimed from NL8802014A external-priority patent/NL8802014A/nl
Application filed by 원본미기재, 노보 인더스트리 에이/에스, 스태미카본 베. 뷔. filed Critical 원본미기재
Publication of KR890701753A publication Critical patent/KR890701753A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

내용 없음

Description

아미노산 아미드의 라세미화 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 일반식(I)으로 표시되는 화합물의 완전한 또는 부분적인 라세미화 방법에 있어서, 이 화합물을 문제의 아미드에 대한 아미노산 아미드 라세마제 활성이 있는 효소에 노출시키는 것을 특징으로 하는 방법.
    R-CH(NH2)-CONH2
    여기에서 R은 인돌일, 벤질옥시, 때에따라 하이드록시, 머캅토, 아미노, 할로겐, 페닐, 페녹시, 벤질 또는 저급 알킬티오로 치환된 저급알킬 또는 때에따라 하이드록시, 아미노, 할로겐, 카르복시 또는 저급알콕시 중의 하나 또는 그 이상으로 치환된 페닐을 나타낸다.
  2. 제1항에 있어서, 상기 효소가 로도코커스 균주, 바람직하기로는 NCIB 12569 균주 또는 슈도모나스, 바람직하기로는 슈도모나스 푸티다, 가장 바람직하기로는 NCIB 40042 균주인 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 상기 효소가 NCIB 12569 균주 또는 NCIB 40042 균주로부터 얻어질 수 있는 것을 특징으로 하는 방법.
  4. 제1항 내지 3항중 어느 한항에 있어서, 문제의 아미드에 대한 입체 선택성 아미노산 아미드 아미다제 활성이 있는 효소의 존재하에서 라세미화가 이루어지는 것을 특징으로 하는 방법.
  5. 제4항에 있어서, 상기 입체 선택성 아미다제가 L-특이성인 것을 특징으로 하는 방법.
  6. 제5항에 있어서, 상기 L-특이성 아미다제가 슈도모나스, 바람직하기로는 슈도모나스 푸티다, 가장 바람직하기로는 ATCC 12633 균주 또는 NCIB 40042 균주로부터 유도되는 것임을 특징으로 하는 방법.
  7. 제4항에 있어서, 상기 입체 선택성 아미다제가 D-특이성인 것을 특징으로 하는 방법.
  8. 제7항에 있어서, D-특이성 아미다제가 로도코커스 균주, 바람직하기로는 NCIB 40041 균주, 또는 슈도모나스 균주, 바람직하기로는 슈도모나스 푸티다, 가장 바람직하기로는 NCIB 40042 균주인 것을 특징으로 하는 방법.
  9. 제4항에 있어서, 아미드 라세마제와 입체 선택성 아미다제 활성이 모두 하나의 미생물에서 발현되는 것을 특징으로 하는 방법.
  10. 제1항 내지 9항중 어느 한항에 있어서, 유기용매의 존재하에서 반응이 진행되는 것을 특징으로 하는 방법.
  11. 본 명세서에서 기술된 것을 특징으로 하는 새로운 특징 또는 이런 특징들이 결합된 것.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890700689A 1987-08-17 1988-08-17 아미노산 아미드의 라세미화 방법 KR890701753A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DK426887A DK426887D0 (da) 1987-08-17 1987-08-17 Fremgangsmaade til fremstilling af kemiske forbindelser
DK4268/87 1987-08-17
DK5861/87 1987-11-10
DK586187A DK586187D0 (ko) 1987-11-10 1987-11-10
NL8802014A NL8802014A (nl) 1988-08-03 1988-08-03 Werkwijze voor de enzymatische bereiding van optisch aktieve aminozuren.
NL88-02014 1988-08-03
PCT/DK1988/000134 WO1989001525A1 (en) 1987-08-17 1988-08-17 Process for preparation of organic chemicals

Publications (1)

Publication Number Publication Date
KR890701753A true KR890701753A (ko) 1989-12-21

Family

ID=27221962

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890700689A KR890701753A (ko) 1987-08-17 1988-08-17 아미노산 아미드의 라세미화 방법

Country Status (11)

Country Link
EP (2) EP0307023A1 (ko)
JP (1) JPH02501531A (ko)
KR (1) KR890701753A (ko)
AT (1) ATE82326T1 (ko)
AU (1) AU613963B2 (ko)
DE (1) DE3875953T2 (ko)
DK (1) DK170672B1 (ko)
ES (1) ES2051892T3 (ko)
FI (1) FI891822A (ko)
NO (1) NO891547L (ko)
WO (1) WO1989001525A1 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383403A1 (en) * 1989-02-16 1990-08-22 Stamicarbon B.V. Process for preparation of organic chemicals
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.
DK161690D0 (da) * 1990-07-05 1990-07-05 Novo Nordisk As Fremgangsmaade til fremstilling af enantiomere forbindelser
EP0537921A3 (en) * 1991-10-04 1993-06-16 Schering Corporation Enzymatic synthesis of chiral alpha-hydroxyketones and derivatives
DE59509369D1 (de) * 1994-05-09 2001-08-02 Degussa Verfahren zur gewinnung von peptidamidase enthaltenden mikroorganismen, damit gewonnene mikroorganismen, darin enthaltene peptidamidasen und deren verwendung
CA2150526C (en) * 1994-06-09 2005-11-15 Andreas Kiener Biotechnological process for the preparation of cyclic s-.alpha.-amino carboxylic acids and r-.alpha.-amino carboxamides
US6133002A (en) * 1997-09-25 2000-10-17 Dsm N.V. Process for preparing optically active 2-amino-ω-oxoalkanoic acid derivatives
NL1007113C2 (nl) * 1997-09-25 1999-03-26 Dsm Nv Werkwijze voor de bereiding van optisch actieve 2-amino-omega- oxoalkaanzuurderivaten.
JP4492765B2 (ja) * 1998-07-15 2010-06-30 三菱瓦斯化学株式会社 Ｌ−アリシンアセタールの製造法
IL140861A (en) * 1998-07-15 2004-06-01 Bristol Myers Squibb Co Dioxolane pentanoic acid and processes for the preparation thereof
WO2003106691A1 (en) * 2002-06-14 2003-12-24 Dsm Ip Assets B.V. POLYPEPTIDES HAVING α- H-α-AMINO ACID AMIDE RACEMASE ACTIVITY AND NUCLEIC ACIDS ENCODING THE SAME
WO2004005517A2 (en) * 2002-07-09 2004-01-15 Degussa Ag L-amidase from rhizobium huautlense
JP4122416B2 (ja) * 2004-02-24 2008-07-23 関西ティー・エル・オー株式会社 α−アミノ−ε−カプロラクタムラセマーゼを用いた、Ｄ及びＬ−アミノ酸アミドの混合物の製造方法、Ｄ又はＬ−アミノ酸の製造方法、Ｄ又はＬ−アミノ酸アミドの製造方法
DE102004013842A1 (de) 2004-03-20 2005-10-13 Degussa Ag Nitrilhydratasen aus Metagenombibliotheken

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3683512D1 (de) * 1985-02-25 1992-03-05 Mitsubishi Gas Chemical Co Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure.
NL8501093A (nl) * 1985-04-12 1986-11-03 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide.
JPS6255097A (ja) * 1985-09-04 1987-03-10 Nitto Chem Ind Co Ltd Ｌ−アミノ酸の製造法

Also Published As

Publication number Publication date
ATE82326T1 (de) 1992-11-15
NO891547D0 (no) 1989-04-14
EP0330695A1 (en) 1989-09-06
EP0307023A1 (en) 1989-03-15
WO1989001525A1 (en) 1989-02-23
JPH02501531A (ja) 1990-05-31
DE3875953D1 (de) 1992-12-17
DK183489A (da) 1989-04-17
NO891547L (no) 1989-06-15
DE3875953T2 (de) 1993-06-03
ES2051892T3 (es) 1994-07-01
AU613963B2 (en) 1991-08-15
DK183489D0 (da) 1989-04-17
EP0330695B1 (en) 1992-11-11
AU2316188A (en) 1989-03-09
DK170672B1 (da) 1995-11-27
FI891822A0 (fi) 1989-04-17
FI891822A (fi) 1989-04-17

Similar Documents

Publication Publication Date Title
KR890701753A (ko) 아미노산 아미드의 라세미화 방법
KR920012454A (ko) 7-아미노세팔로스포란 산 및 이의 유도체를 제조하는 효소적방법
EP0228392A1 (en) Process for preparing optically active, organic compounds
US4211840A (en) Method for producing D-α-amino acid
Nagasawa et al. 3-Chloro-D-alanine chloride-lyase (deaminating) of Pseudomonas putida CR 1.1. Purification and characterization of a novel enzyme occurring in 3-chloro-D-alanine-resistant pseudomonads.
KR890003948A (ko) 아실아미노산 라세마제, 그의 제조방법 및 용도
KR890012002A (ko) 광학적으로 활성인 2-아릴알칸산 제조 방법
KR920000942A (ko) 에난티오머 선택적 생체 촉매화 아실화 방법
KR860003996A (ko) 혼합 효소계를 사용하여 n-아실아미노산 에스테르를 입체선택적으로 가수분해하는 방법
DE50109138D1 (de) Verfahren zur Herstellung von Aminosäuren
US5215897A (en) Process for producing L-amino acids
ES2085487T3 (es) Un procedimiento para la preparacion de acidos 2-alcanoicos enantiomericos.
GB9321325D0 (en) Microorganism and its use
ATE77412T1 (de) Verfahren zur enzymatischen auftrennung von racemischen 2-amino-1-alkanolen.
KR880003009A (ko) 카르니틴의 제조방법
NL8800224A (nl) Werkwijze ter bereiding van zwavelhoudende l-alpha-aminozuren.
US5902736A (en) Process for the production of D-α-amino acids by hydrolysis of the corresponding N-carbamyl derivative
JP2674078B2 (ja) Ｄ−α−アミノ酸の製造法
NL8702449A (nl) Werkwijze voor de bereiding van een d-alfa-aminozuur uit het overeenkomstige alfa-ketozuur.
JPH07106149B2 (ja) アミノペプチダーゼ及びその使用
Asano et al. Recent Developments in Aminopeptidases, Racemases, and Oxidases
Soda et al. Enantiomer synthesis of amino acids with pyridoxal enzymes
Sano BCR/LS 2
EP0352846A1 (en) Process for the preparation of biocatalysts with previously absent stereoselective enzyme activity
JPH0455674B2 (ko)

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19890417

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid