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KR880003605A - 헤파린-함유 유착방지 장벽 및 사용방법 - Google Patents

헤파린-함유 유착방지 장벽 및 사용방법 Download PDF

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Publication number
KR880003605A
KR880003605A KR870010809A KR870010809A KR880003605A KR 880003605 A KR880003605 A KR 880003605A KR 870010809 A KR870010809 A KR 870010809A KR 870010809 A KR870010809 A KR 870010809A KR 880003605 A KR880003605 A KR 880003605A
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South Korea
Prior art keywords
heparin
fabric
adhesion
absorbed
organs
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KR870010809A
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English (en)
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KR950013460B1 (ko
Inventor
린스키 캐리
커닝햄 티모씨
파인스 엘리
Original Assignee
웨인 알. 에버하트
죤슨 앤드 죤슨 프로덕츠, 인코포레이티드
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Publication of KR880003605A publication Critical patent/KR880003605A/ko
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Publication of KR950013460B1 publication Critical patent/KR950013460B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424—Anti-adhesion agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

내용 없음

Description

헤파린-함유 유착방지 장벽 및 사용방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 신체기관을 감쌀 수 있고 이에 적합하며 부착성이 있고, 신체내에서 30일 이내에 거의 흡수될 수 있으며, 무독성의 유착방지 유효량 및 역가로 존재하는 헤파린을 갖는 산화된 재생성 셀룰로오즈 직물을 함유하는 개선된 유착방지 장벽 직물.
  2. 제1항에 있어서, 직물에 흡수된 헤파린을 외과수술 동안 신체 기관상에 실용시 액체 형태로 직물에 적용시키는 개선된 유착방지 장벽 직물.
  3. 제1항에 있어서, 헤파린을 언급한 직물상에 흡수시킨 후, 건조시킨, 개선된 유착방지 장벽 직물.
  4. 제1항에 있어서, 헤파린을 직물상에 흡수시키고 헤파힌 함유 직물을 건조시킨 후 무균 상태로 밀봉한 개선된 유착방지 장벽 직물.
  5. 제1항에 있어서, 사용된 헤파린의 양이 직물을 포화시키기에 충분하면서 헤파린이 방울져 떨어지지 않을 정도인 개선된 유착방지 장벽 직물.
  6. 제1항에 있어서, 사용된 헤파린이 100 내지 2000 미국 약전(usp)헤파린 단위의 역가를 갖는 주사용 헤파린 나트륨 형태인 개선된 유착방지 장벽 직물.
  7. 제1항에 있어서, 산화된 재생성 셀룰로오즈 직물이 편직물인 개선된 유착방지 장벽 직물.
  8. 외과수술 부위와 인접 조직간에 제1 내지 제 7항중 어느 한 항의 헤파린 함유 산화된 재생성 셀룰로오즈 유착방지 장벽 직물을 물리적으로 장벽으로서 장치함을 특징으로 하여, 외과적 유착을 방지하는 방법.
  9. 신체기관을 감쌀 수 있고, 이에 적합하며 부착성이 있고 신체내에서 30일 이내에 거의 흡수될 수 있는, 직물상에 흡수된 헤파린을 함유하는 산화된 재생성 셀룰로즈 직물을 신체 내부 기관의 외면에 적용시킴을 특징으로 하여, 외과수술 중 외과적 유착을 방지하기 위해 헤파린을 신체 내부 기관에 국소적으로 투여하는 방법.
  10. 제9항에 있어서, 직물을 언급한 체내 기관에 적용시킨 후, 헤파린을 산화된 재생성 셀룰로즈 직물상에 흡수시키는 방법.
  11. 제9항에 있어서, 직물을 신체 기관에 적용시키기 전에 헤파린을 산화된 재생성 셀룰로즈 직물상에 흡수시키는 방법.
  12. 제9,10 또는 11항에 있어서, 산화된 재생성 셀룰로오즈 직물상의 헤파린 양이 직물상에 또는 직물내에 모두 잔존하여 과량의 헤파린이 다른 기관 또는 체강내로 유입되지 않고 헤파린 부재시 일어나는 정도 이상의 유착을 방지하기에 충분하나 직물을 포화시키는 양 이하이며 헤파린의 역가가 100 내지 2000usp헤파린 단위인 방법.
  13. 외과수술에 사용하기에 안전하며 신체기관을 감쌀 수 있고, 이에 적합하며 부착성이 있고, 신체 내에서 30일 이내에 거의 흡수될 수 있으며, 매트릭스 상에 무독성의 유착 방지 유효량 및 역가로 존재하는 헤파린을 함유하는 매트릭스로 구성된 개선된 유착방지용 장벽 물질.
  14. 외과수술 부위와 인접 조직간에 제13항의 헤파린 함유 유착 방지용 장벽 물질을 물리적 장벽으로서 장치함을 특징으로 하는 외과적 유착을 방지하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870010809A 1986-09-29 1987-09-29 헤파린-함유 유착 방지용 차단물 KR950013460B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/912,450 US4840626A (en) 1986-09-29 1986-09-29 Heparin-containing adhesion prevention barrier and process
US912450 1986-09-29

Publications (2)

Publication Number Publication Date
KR880003605A true KR880003605A (ko) 1988-05-28
KR950013460B1 KR950013460B1 (ko) 1995-11-08

Family

ID=25431943

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870010809A KR950013460B1 (ko) 1986-09-29 1987-09-29 헤파린-함유 유착 방지용 차단물

Country Status (17)

Country Link
US (1) US4840626A (ko)
EP (1) EP0262890B1 (ko)
JP (1) JP2563110B2 (ko)
KR (1) KR950013460B1 (ko)
AT (1) ATE98132T1 (ko)
AU (1) AU602726B2 (ko)
CA (1) CA1300022C (ko)
DE (1) DE3788404T2 (ko)
DK (1) DK510687A (ko)
ES (1) ES2047493T3 (ko)
GR (1) GR871484B (ko)
IE (1) IE63282B1 (ko)
MX (1) MX165863B (ko)
MY (1) MY100808A (ko)
NZ (1) NZ221806A (ko)
PH (1) PH24128A (ko)
ZA (1) ZA877284B (ko)

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ES2047493T3 (es) 1994-03-01
DE3788404D1 (de) 1994-01-20
CA1300022C (en) 1992-05-05
DK510687A (da) 1988-03-30
AU602726B2 (en) 1990-10-25
KR950013460B1 (ko) 1995-11-08
ZA877284B (en) 1989-04-26
EP0262890B1 (en) 1993-12-08
DK510687D0 (da) 1987-09-28
PH24128A (en) 1990-03-05
EP0262890A2 (en) 1988-04-06
EP0262890A3 (en) 1989-08-16
GR871484B (en) 1988-02-03
MX165863B (es) 1992-12-08
NZ221806A (en) 1989-07-27
ATE98132T1 (de) 1993-12-15
JPS63102752A (ja) 1988-05-07
IE872604L (en) 1988-03-29
DE3788404T2 (de) 1994-05-05
MY100808A (en) 1991-02-28
JP2563110B2 (ja) 1996-12-11
AU7902687A (en) 1988-03-31
IE63282B1 (en) 1995-04-05
US4840626A (en) 1989-06-20

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