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KR890700033A - 외상치료 및 뼈 재생 - Google Patents

외상치료 및 뼈 재생

Info

Publication number
KR890700033A
KR890700033A KR1019880700829A KR880700829A KR890700033A KR 890700033 A KR890700033 A KR 890700033A KR 1019880700829 A KR1019880700829 A KR 1019880700829A KR 880700829 A KR880700829 A KR 880700829A KR 890700033 A KR890700033 A KR 890700033A
Authority
KR
South Korea
Prior art keywords
growth factor
purified
composition
trauma
ratio
Prior art date
Application number
KR1019880700829A
Other languages
English (en)
Other versions
KR960005708B1 (ko
Inventor
엔.안토니아즈 해리
시.윌리암스 레이
이.린치 사무엘
Original Assignee
원본미기재
인스티튜트 오브 몰레큘러 바이올로지, 인코오포레이티드
프레지던트 앤드 펠로우즈 오브 하바드 콜리지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 인스티튜트 오브 몰레큘러 바이올로지, 인코오포레이티드, 프레지던트 앤드 펠로우즈 오브 하바드 콜리지 filed Critical 원본미기재
Publication of KR890700033A publication Critical patent/KR890700033A/ko
Application granted granted Critical
Publication of KR960005708B1 publication Critical patent/KR960005708B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

외상치료 및 뼈 재생
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 정제된 혈소판-유도된 성장인자와 정제된 인슐린-형 성장 인자로 구성된 조성물의 상처-치료적양을 포유류의 상처에 적용하는 것으로 구성된 포유류의 외상을 치료하는 방법.
  2. 정제된 혈소판-유도된 성장 인자와 정제된 인슐린-형 성장인자로 구성된 조성물의 상처-치료적양을 포유류에 투여하는 것으로 구성된 포유류의 뼈의 재생방법.
  3. 제1항 또는 제2항에 있어서, 상기 조성물내의 상기 혈소판-유도된 성장인자와 상기 인슐린-형 성장인자의 중량대 중량비율이 1：4 내지 25：1인 방법.
  4. 제3항에 있어서, 상기 비율이 1：2와 10：1 사이인 방법.
  5. 제4항에 있어서, 상기 비율이 1：1 또는 2：1 방법.
  6. 정제된 혈소판유도된 성장인자와 정제된 인슐린형 성장인자가 중량비 1：4 내지 25：1 구성된 외상치료 및 뼈 재생용 조성물.
  7. 제6항에 있어서, 상기 비율이 1：2와 10：1인 사이인 조성물.
  8. 제7항에 있어서, 상기 비율이 1：1 또는 2：1 인 조성물.
  9. 정제된 혈소판-유도된 성장인자와 정제된 인슐린-형 성장인자가 중량비로 1:4 내지 25:1로 혼합하는 것으로 구성된 외상치료용 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700829A 1986-11-14 1987-11-13 외상 치료 및 뼈 재생용 조성물 KR960005708B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93076286A 1986-11-14 1986-11-14
US930762 1986-11-14
US930,762 1986-11-14
PCT/US1987/002975 WO1988003409A1 (en) 1986-11-14 1987-11-13 Wound healing and bone regeneration

Publications (2)

Publication Number Publication Date
KR890700033A true KR890700033A (ko) 1989-03-02
KR960005708B1 KR960005708B1 (ko) 1996-05-01

Family

ID=25459724

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880700829A KR960005708B1 (ko) 1986-11-14 1987-11-13 외상 치료 및 뼈 재생용 조성물

Country Status (15)

Country Link
EP (1) EP0289584B1 (ko)
JP (1) JPH01500199A (ko)
KR (1) KR960005708B1 (ko)
CN (1) CN1027346C (ko)
AT (1) ATE88899T1 (ko)
AU (1) AU600069B2 (ko)
DE (1) DE3785758T2 (ko)
DK (1) DK175889B1 (ko)
IE (1) IE60517B1 (ko)
MX (1) MX170454B (ko)
NO (1) NO883127L (ko)
NZ (1) NZ222551A (ko)
OA (1) OA09159A (ko)
WO (1) WO1988003409A1 (ko)
ZA (1) ZA878566B (ko)

Families Citing this family (38)

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US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
IL95641A0 (en) * 1989-09-15 1991-06-30 Curative Tech Inc Preparation of a platelet releasate product
ZA9010332B (en) * 1989-12-22 1991-08-28 Ciba Geigy Method of reducing or preventing adverse effect of steroid therapy and compositions therefor
ES2106031T3 (es) * 1990-04-10 1997-11-01 Inst Molecular Biology Inc Una composicion comprendiendo un factor de crecimiento, su metodo de obtencion y uso.
CA2082420C (en) * 1990-05-30 2004-07-20 Harry N. Antoniades Wound healing composition comprising purified igf-i or igf-ii and a purified tgf-.beta.
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7189410B1 (en) 1990-11-27 2007-03-13 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
WO1993008825A1 (en) * 1991-11-04 1993-05-13 Zymogenetics, Inc. Pdgf gel formulation
FR2691911B1 (fr) * 1992-06-05 1994-11-25 Delmas Olivier Dispositif permettant l'obtention d'un surnageant de thrombocytes activés, procédé mettant en Óoeuvre le dispositif et surnageant obtenu.
WO1993025226A1 (en) * 1992-06-08 1993-12-23 Kabi Pharmacia Ab Use of growth factor igf-i and/or igf-ii
FR2696095B1 (fr) * 1992-09-30 1994-11-25 Inoteb Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application.
CN1055023C (zh) * 1993-01-03 2000-08-02 周至譓 伤口护理剂
EP0804562B1 (en) 1994-07-12 2002-10-09 Human Genome Sciences, Inc. Connective tissue growth factor-2
US7026299B2 (en) 1994-07-12 2006-04-11 Human Genome Sciences, Inc. Connective tissue growth factor-2
US5712249A (en) * 1994-09-08 1998-01-27 Ciba-Geigy Corporation Use of insulin-like growth factors I and II for inhibition of inflammatory response
EP0871730B1 (en) * 1995-10-11 2004-08-18 Chiron Corporation Combination pdgf, kgf, igf and igfbp for wound healing
ATE253120T1 (de) 1996-12-13 2003-11-15 Chiron Corp Verfahren zur expression von heterologen proteinen in hefe
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
GB2369572A (en) 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7241874B2 (en) 2002-06-26 2007-07-10 Zimmer Ortho Biologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
JP5368102B2 (ja) 2005-11-17 2013-12-18 バイオミメティック セラピューティクス， インコーポレイテッド ｒｈＰＤＧＦ−ＢＢ及び生体適合性マトリックスを用いた顎顔面骨強化
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2668189C (en) 2006-11-03 2016-01-26 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures comprising a solution of platelet derived growth factor (pdgf) incorporated in a biocompatible matrix
WO2009100454A1 (en) 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
WO2010030714A2 (en) 2008-09-09 2010-03-18 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
CN102397534B (zh) * 2010-09-07 2013-10-23 中国人民解放军总医院 胰岛素在制备促进颌骨组织愈合的药物中的用途
KR101965592B1 (ko) * 2011-11-22 2019-08-13 (주)아모레퍼시픽 성장 인자를 포함하는 피부 재생 촉진제
EP3206670A4 (en) 2014-10-14 2018-06-20 Samuel Lynch Compositions for treating wounds

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Also Published As

Publication number Publication date
DE3785758T2 (de) 1993-08-05
NZ222551A (en) 1989-11-28
AU8328987A (en) 1988-06-01
EP0289584B1 (en) 1993-05-05
JPH01500199A (ja) 1989-01-26
CN1027346C (zh) 1995-01-11
ATE88899T1 (de) 1993-05-15
DE3785758D1 (de) 1993-06-09
EP0289584A1 (en) 1988-11-09
NO883127L (no) 1988-09-12
OA09159A (en) 1992-03-31
ZA878566B (en) 1989-07-26
IE873075L (en) 1988-05-14
DK393288A (da) 1988-09-13
KR960005708B1 (ko) 1996-05-01
MX170454B (es) 1993-08-24
NO883127D0 (no) 1988-07-13
DK393288D0 (da) 1988-07-14
EP0289584A4 (en) 1990-01-08
CN87101250A (zh) 1988-06-08
JPH0581569B2 (ko) 1993-11-15
DK175889B1 (da) 2005-05-30
IE60517B1 (en) 1994-07-27
WO1988003409A1 (en) 1988-05-19
AU600069B2 (en) 1990-08-02

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