KR870003122A - 3-비닐 세팔로스포린 유도체의 제조방법 - Google Patents
3-비닐 세팔로스포린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR870003122A KR870003122A KR1019850006544A KR850006544A KR870003122A KR 870003122 A KR870003122 A KR 870003122A KR 1019850006544 A KR1019850006544 A KR 1019850006544A KR 850006544 A KR850006544 A KR 850006544A KR 870003122 A KR870003122 A KR 870003122A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- preparing
- syn
- xii
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims 10
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims 1
- 108700023418 Amidases Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000005922 amidase Human genes 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000020176 deacylation Effects 0.000 claims 1
- 238000005947 deacylation reaction Methods 0.000 claims 1
- 238000007257 deesterification reaction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- -1 nitrile salt Chemical class 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000006000 trichloroethyl group Chemical group 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (3)
- 구조식(X)의 활성화된 카르복실산 유도체(Syn-이성체)와 구조식(XI) 또는 구조식(XII)의 3-비닐 세펨 유도체를 반응시켜 구조식(XIII)의 화합물을 만들고, 아연으로 보호기를 동시에 제거하여 구조식(Ⅰ)(Syn-이성체)의 화합물을 제조하는 방법.(상기구조식에서 R2는 수소 혹은 트리클로로 에틸기이다)
- 제1항에 있어서, 구조식(XI)의 화합물은 구조식(XIV)의 화합물을 1,8-디아자비사이클로[5,4,0]운덱-7-엔과 같은 염기존재하에 구조식(XV)의 이미니움 염과 반응시킨후 생성된 구조식(XVI)의 화합물을 분리하지 않고 바로 탈리반응시킨후 탈아실화하여 제조하는 방법.
- 제1항에 있어서, 구조식(XII)의 화합물은 구조식(XVII)의 화합물을 아연으로 탈에스테르화하여 구조식 (XVIII)의 화합물을 만든후 아미다아제(Amisdae)로 탈아실화하여 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019850006544A KR870001807B1 (ko) | 1985-09-07 | 1985-09-07 | 3-비닐 세팔로 스포린 유도체의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019850006544A KR870001807B1 (ko) | 1985-09-07 | 1985-09-07 | 3-비닐 세팔로 스포린 유도체의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR870003122A true KR870003122A (ko) | 1987-04-15 |
| KR870001807B1 KR870001807B1 (ko) | 1987-10-13 |
Family
ID=19242618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850006544A KR870001807B1 (ko) | 1985-09-07 | 1985-09-07 | 3-비닐 세팔로 스포린 유도체의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR870001807B1 (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100392409B1 (ko) | 2000-03-20 | 2003-07-22 | 한미정밀화학주식회사 | 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법 |
-
1985
- 1985-09-07 KR KR1019850006544A patent/KR870001807B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR870001807B1 (ko) | 1987-10-13 |
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