KR860003269A - 항균 조성물 및 그 유효성분의 제조방법 - Google Patents
항균 조성물 및 그 유효성분의 제조방법 Download PDFInfo
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- KR860003269A KR860003269A KR1019850007829A KR850007829A KR860003269A KR 860003269 A KR860003269 A KR 860003269A KR 1019850007829 A KR1019850007829 A KR 1019850007829A KR 850007829 A KR850007829 A KR 850007829A KR 860003269 A KR860003269 A KR 860003269A
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- South Korea
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- residues
- same
- 4g1cnacβ1
- represent
- hydrogen atom
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- 239000000203 mixture Substances 0.000 title claims 7
- 239000004480 active ingredient Substances 0.000 title claims 3
- 230000000845 anti-microbial effect Effects 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 102000002068 Glycopeptides Human genes 0.000 claims 7
- 108010015899 Glycopeptides Proteins 0.000 claims 7
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 5
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 229920001184 polypeptide Chemical group 0.000 claims 4
- 108090000765 processed proteins & peptides Chemical group 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 108010055851 Acetylglucosaminidase Proteins 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 244000046052 Phaseolus vulgaris Species 0.000 claims 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
Abstract
Description
Claims (8)
- 하기 일반식(Ⅰ)의 당펩티드 및/또는 올리고 당류를 유효성분으로 함유함을 특징으로 하는, Ⅰ형 섭모(fimbriae)를 갖는 병원성균에 대한 항균 조성물.식중 R1은 수소원자, 4G1cNAcβ1→ASN 잔기 또는 4G1cNACβ1→잔기(R' 및 R"는 같거나, 서로 다르며 아미노산잔기 또는 폴리펩티드 잔기를 나타낸다.)이고; R2, R3및 R4는 같거나 서로 다르며 수소원자, 만노스잔기 또는 올리고만노시드 사슬을 나타낸다.
- 제1항에 있어서, R1이 4G1cNAβ1→ASN잔기 또는 4G1cNAcβ1→잔기(R' 및 R″는 같거나 서로 다르며 아미노산잔기 또는 폴리펩티드 사슬을 나타낸다)이고; R3및 R4가 수소원자를 나타내고 R2가 수소원자 또는 만노스 잔기인 일반식(Ⅰ)의 화합물을 유효 성분으로 함유함을 특징으로 하는 조성물.
- 제1항에 있어서, R1,R3및 R4가 수소원자이고, R2가 수소원자 또는 만노스 잔기인 일반식(Ⅰ)의 화합물을 유효성분으로 함유함을 특징으로 하는 조성물.
- 제1항에 있어서, 바람직하게는 공유 결합에 의해 고분자 지지체에 결합된 일반식(Ⅰ) 〔식중 R1은 4G1cNAcβ1→ASN 잔기 또는 4G1cNAcβ1→잔기(R',R″는 상지 제1항의 정의와 같다.)이고 R1,R2,R3및 R4가 상기 제1항의 정의와 동일하다.〕의 당펩티드를 함유함을 특징으로 하는 조성물.
- 제1항 내지 3항중 어느 하나에 있어서, 식품의 형태, 바람직하게는 분유의 형태인 조성물.
- 단백질 분해효소를 이용하여 식물성 유래당단백질을 분해하고, 생성된 당텝티드를 엔도-β--아세틸글루코사미니다아제 H를 이용하여 올리고당류로 전환시키고, 당펩티드 또는 소득한 올리고 당류를 두만노스 잔기 사이의 α1→2결합을 우선적으로 절단하는 엑소-α-만노시다아제를 이용한 조절분해시킴을 특징으로 하는 일반식(Ⅰ)에 해당하는 당펩티드의 제조방법.식중 R1은 수소원자, 4G1cNAcβ1→ASN 잔기 또는 4G1cNAcβ1→잔기(R' 및 R″는 같거나 서로 다르며 아미노산 잔기 또는 폴리펩티드 사슬을 나타낸다)를 나타내고; R2,R3및 R4는 같거나 서로 다르며 수소원자, 만노스 잔기 또는 올리고만노시드 사슬을 나타낸다.
- 제6항에 있어서, 원료인 당펩티드가 탈지 식물성분말에서 분리한 것이고, 바람직하게는 콩(soya-bean) 당단백질 7 S 또는 콩(bean) 당단백질 Ⅱ가 풍부한 분리물의 형태임을 특징으로 하는 방법.
- 활성 고분자 지지체를 당펩티드 용액과 반응시킴을 특징으로 하는 공유결합에 의해 고분자 지지체에 결합된 하기 일반식(Ⅰ)의 당펩티드를 함유하는 조성물의 제조방법.식중 R1은 AG1NAcβ1→ASN 잔기 또는 4G1cNAcβ1→잔기(R' 및 R″는 같거나 서로 다르며 아미노산잔기 또는 폴리펩티드 사슬을 나타낸다.)이고, R2,R3및 R4는 같거나 서로 다르며 수소원자, 만노스 잔기 또는 올리고만노시드 사슬을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH5136/84-6 | 1984-10-26 | ||
CH5136/84A CH660557A5 (fr) | 1984-10-26 | 1984-10-26 | Composition anti-bacterienne et procede de preparation de ses constituants actifs. |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860003269A true KR860003269A (ko) | 1986-05-21 |
KR910008798B1 KR910008798B1 (ko) | 1991-10-21 |
Family
ID=4288552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850007829A KR910008798B1 (ko) | 1984-10-26 | 1985-10-23 | 항균 조성물과 그 유효성분의 제조방법 |
Country Status (15)
Country | Link |
---|---|
US (1) | US4939123A (ko) |
EP (1) | EP0179324B1 (ko) |
JP (1) | JP2566913B2 (ko) |
KR (1) | KR910008798B1 (ko) |
AT (1) | ATE68501T1 (ko) |
AU (1) | AU577411B2 (ko) |
CA (1) | CA1280987C (ko) |
CH (1) | CH660557A5 (ko) |
DE (1) | DE3584414D1 (ko) |
ES (2) | ES8800360A1 (ko) |
FI (1) | FI86081C (ko) |
IL (1) | IL76628A (ko) |
NO (1) | NO164719C (ko) |
PT (1) | PT81372B (ko) |
ZA (1) | ZA857842B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2605185B1 (fr) * | 1986-10-17 | 1993-08-20 | Meiji Seika Kaisha | Procede de culture des plantes |
DE68910212T2 (de) * | 1988-07-12 | 1994-03-03 | Aquaspersions Ltd | Bekämpfung unerwünschter Schädlinge. |
US5041236A (en) * | 1989-10-27 | 1991-08-20 | The Procter & Gamble Company | Antimicrobial methods and compositions employing certain lysozymes and endoglycosidases |
EP0425016B1 (en) * | 1989-10-27 | 1995-12-20 | The Procter & Gamble Company | Antimicrobial method and formulation employing type II endoglycosidase and antimicrobial agent |
US5238843A (en) * | 1989-10-27 | 1993-08-24 | Genencor International, Inc. | Method for cleaning a surface on which is bound a glycoside-containing substance |
US5258304A (en) * | 1989-10-27 | 1993-11-02 | Genencor International, Inc. | Method of removing microorganisms from surfaces with Type II endoglycosidase |
US5141925A (en) * | 1990-04-23 | 1992-08-25 | Trustees Of Tufts College | Vivo methods for treating coccidiosis |
US5718909A (en) * | 1991-02-18 | 1998-02-17 | Medscand Ab | Sheet containing carbohydrate derivative for removal of E. coli |
US5500206A (en) * | 1994-04-29 | 1996-03-19 | The Procter & Gamble Company | Oral compositions comprising actinomyces viscosus fimbriae |
JP3576720B2 (ja) | 1996-10-15 | 2004-10-13 | 株式会社東海理化電機製作所 | ダイアル操作装置 |
JP3061616B1 (ja) * | 1999-04-09 | 2000-07-10 | 株式会社セラリカ野田 | 低カロリ―調製ロ―ヤルゼリ― |
FR2802536B1 (fr) * | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
ITMI20030391A1 (it) * | 2003-03-04 | 2004-09-05 | S I I T S R L Servizio Internaz Ionale Imballa | Formulazioni anticarie a base di faseolamina. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH14773A (en) * | 1976-01-01 | 1981-12-09 | Kureha Chemical Ind Co Ltd | Protein-bound polysaccharides |
JPS5576818A (en) * | 1978-12-06 | 1980-06-10 | Hitoshi Ito | Agent for improving hepatic function |
AU6770981A (en) * | 1980-01-28 | 1981-08-17 | Svensson, S. E. | Isolation of carbohydrates from cell tissue |
AU561066B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Antibacterial composition containing an oligosaccharide |
AU561067B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Anti-bacterial composition containing an oligosaccharide |
EP0089940A1 (en) * | 1982-03-23 | 1983-09-28 | BioCarp AB | Compositions for therapeutic or diagnostic use containing oligosaccharides |
IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
US4613589A (en) * | 1985-08-19 | 1986-09-23 | Abbott Laboratories | D-manno-2-octulosonic acid derivatives, pharmaceutical compositions and method of use |
US4613590A (en) * | 1985-08-19 | 1986-09-23 | Abbott Laboratories | Amino D-manno-2-octulopyranosidonate containing compounds, pharmaceutical compositions and method of use |
-
1984
- 1984-10-26 CH CH5136/84A patent/CH660557A5/fr not_active IP Right Cessation
-
1985
- 1985-10-03 DE DE8585112511T patent/DE3584414D1/de not_active Expired - Fee Related
- 1985-10-03 AT AT85112511T patent/ATE68501T1/de not_active IP Right Cessation
- 1985-10-03 EP EP85112511A patent/EP0179324B1/fr not_active Expired - Lifetime
- 1985-10-09 IL IL76628A patent/IL76628A/xx not_active IP Right Cessation
- 1985-10-09 US US06/785,914 patent/US4939123A/en not_active Expired - Lifetime
- 1985-10-10 CA CA000492707A patent/CA1280987C/en not_active Expired - Fee Related
- 1985-10-11 AU AU48514/85A patent/AU577411B2/en not_active Ceased
- 1985-10-11 ZA ZA857842A patent/ZA857842B/xx unknown
- 1985-10-23 KR KR1019850007829A patent/KR910008798B1/ko not_active IP Right Cessation
- 1985-10-24 JP JP60238555A patent/JP2566913B2/ja not_active Expired - Fee Related
- 1985-10-25 FI FI854179A patent/FI86081C/fi not_active IP Right Cessation
- 1985-10-25 ES ES548242A patent/ES8800360A1/es not_active Expired
- 1985-10-25 NO NO854273A patent/NO164719C/no unknown
- 1985-10-25 PT PT81372A patent/PT81372B/pt not_active IP Right Cessation
-
1987
- 1987-01-12 ES ES557292A patent/ES8802458A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI86081C (fi) | 1992-07-10 |
ES8802458A1 (es) | 1988-06-16 |
ATE68501T1 (de) | 1991-11-15 |
EP0179324A2 (fr) | 1986-04-30 |
US4939123A (en) | 1990-07-03 |
CA1280987C (en) | 1991-03-05 |
IL76628A (en) | 1991-06-10 |
ES557292A0 (es) | 1988-06-16 |
NO854273L (no) | 1986-04-28 |
DE3584414D1 (de) | 1991-11-21 |
JPS61103829A (ja) | 1986-05-22 |
ZA857842B (en) | 1986-05-28 |
PT81372A (fr) | 1985-11-01 |
CH660557A5 (fr) | 1987-05-15 |
AU577411B2 (en) | 1988-09-22 |
IL76628A0 (en) | 1986-02-28 |
ES8800360A1 (es) | 1987-11-01 |
JP2566913B2 (ja) | 1996-12-25 |
NO164719B (no) | 1990-07-30 |
EP0179324A3 (en) | 1988-05-18 |
KR910008798B1 (ko) | 1991-10-21 |
PT81372B (pt) | 1987-11-30 |
FI854179A0 (fi) | 1985-10-25 |
FI86081B (fi) | 1992-03-31 |
ES548242A0 (es) | 1987-11-01 |
AU4851485A (en) | 1986-05-01 |
EP0179324B1 (fr) | 1991-10-16 |
FI854179L (fi) | 1986-04-27 |
NO164719C (no) | 1990-11-07 |
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