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KR850007270A - 항암제 LL-D49194α₁,LL-D49194β1,LL-D49194β2,LL-D49194β3,LL-D49194γ,LL-D49194δ,LL-D49194ε,LL-D49194ζ,LL-D49194n,LL-D49194ω1,LL-D49194ω2 및 LL-D49194ω3의 제조방법 - Google Patents

항암제 LL-D49194α₁,LL-D49194β1,LL-D49194β2,LL-D49194β3,LL-D49194γ,LL-D49194δ,LL-D49194ε,LL-D49194ζ,LL-D49194n,LL-D49194ω1,LL-D49194ω2 및 LL-D49194ω3의 제조방법 Download PDF

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KR850007270A
KR850007270A KR1019850002228A KR850002228A KR850007270A KR 850007270 A KR850007270 A KR 850007270A KR 1019850002228 A KR1019850002228 A KR 1019850002228A KR 850002228 A KR850002228 A KR 850002228A KR 850007270 A KR850007270 A KR 850007270A
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vinaisus
antibiotics
streptomyces
drapus
culture
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리이(외 5) 메이딘-밍
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죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
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Abstract

내용 없음

Description

항암제 LL-D49194α1, LL-D49194β1, LL-D49194β2, LL-D49194β3, LL-D49194, LL-D49194ζ, LL-D49194n, LL-D49194ω1LL-D49194ω2,및 LL-D49194ω3의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 LL-D49194α1의 자외선 흡수 스펙트럼들; 제2도는 LL-D49194α1의 적외선 흡수 스펙트럼; 제3도는 LL-D49194α1의 양성자 자기공명 스펙트럼;

Claims (6)

  1. 동화가능한 탄소원, 질소원 및 무기염 함유 액상 배지내에서 미생물 스트렙토마이세스 비네시우스-드라푸스 HRHL 15735 또는 그의 변이주를, 상기 배지에 실질적 항생 활성이 부여될 때까지 호기적 발효시킨 후 그로부터 항생물질을 회수하는 것으로 구성되는, 항생물질 LL-D49194α1; LL-D49194β1; LL-D49194β2; LL-D49194β3; LL-D49194; LL-D49194; LL-D49194; LL-D49194ζ; LL-D49194η; LL-D49194ω1; LL-D49194ω2및 LL-D49194ω3의 제조방법.
  2. 동화가능한 탄소원, 질소원 및 무기염을 함유하며 미생물 스트렙토마이세스 비네시우스-드라푸스 NRRI 15735 또는 그 변이주의 생육성 배양균으로 접종시킨 액상 배지를 호기적 발효시키고, 상기 발효 배양물을 90-200시간동안 24-32℃의 온도로 유지시킨 후 매시(mash)를 수확하고 항생물질을 추출하는 것으로 구성되는, 항생물질 LL-D49194α1; LL-D49194β1; LL-D49194β2; LL-D49194β3; LL-D49194; LL-D49194; LL-D49194; LL-D49194ζ; LL-D49194η; LL-D49194ω1; LL-D49194ω2,및 LL-D49194ω3의 제조방법.
  3. 동화가능한 탄소원, 질소원 및 무기질을 함유하는, 수성 영양 배지내에서의 발효시, 회수량의 항생물질 LL-D49194α1; LL-D49194β1; LL-D49194β2; LL-D49194β3; LL-D49194;LL-D49194;LL-D49194;LL-D49194ζ;LL-D49194η; LL-D49194ω1LL-D49194ω2및 LL-D49194ω3를 생산할 수 있는, 미생물 스트렙토마이세스비네시우스-드라푸스 NRRL15735의 생물학적 순수배양균.
  4. 제3항에 있어서, 미생물이 자연 변이되어 유전적으로는 변화되었으나 항생물질 LL-D49194α1; LL-D49194β1; LL-D49194β2; LL-D49194β3; LL-D49194; LL-D49194; LL-D49194; LL-D49194ζ; LL-D49194η; LL-D49194ω1LL-D49194ω2및 LL-D49194ω3의 합성능력은 여전히 보유하고 있는, 미생물 스트렙토마이세스 비네시우스-드라푸스의 생물학적 순수 배양균.
  5. 제3항에 있어서, 미생물이 변이유발체의 작용을 받아 유전적으로 변화되었으나 항생물질 LL-D49194α1; LL-D49194β1; LL-D49194β2; LL-D49194β3; LL-D49194; LL-D49194; LL-D49194; LL-D49194ζ; LL-D49194η; LL-D49194ω1LL-D49194ω2,및 LL-D49194ω3의 합성능력은 여전히 보유하고 있는, 미생물 스트랩토마이세스 비네시우스-드라푸스의 생물학적 순수 배양균.
  6. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850002228A 1984-04-04 1985-04-03 항암제 LL-D49194α₁,LL-D49194β1,LL-D49194β2,LL-D49194β3,LL-D49194γ,LL-D49194δ,LL-D49194ε,LL-D49194ζ,LL-D49194n,LL-D49194ω1,LL-D49194ω2 및 LL-D49194ω3의 제조방법 Ceased KR850007270A (ko)

Applications Claiming Priority (2)

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US59649984A 1984-04-04 1984-04-04
US596499 1984-04-04

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KR850007270A true KR850007270A (ko) 1985-12-02

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KR1019850002228A Ceased KR850007270A (ko) 1984-04-04 1985-04-03 항암제 LL-D49194α₁,LL-D49194β1,LL-D49194β2,LL-D49194β3,LL-D49194γ,LL-D49194δ,LL-D49194ε,LL-D49194ζ,LL-D49194n,LL-D49194ω1,LL-D49194ω2 및 LL-D49194ω3의 제조방법

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EP (1) EP0157203A3 (ko)
JP (1) JPS60226892A (ko)
KR (1) KR850007270A (ko)
AU (1) AU586419B2 (ko)
CA (1) CA1235081A (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978748A (en) * 1988-02-29 1990-12-18 American Cyanamid Company Intermediate and process for producing the antibacterial and antitumor agents LL-E33288ε-I and LL-E33288Epsilon-Br
DE102004017793A1 (de) * 2004-02-21 2005-09-08 Biofrontera Discovery Gmbh Trioxacarcine und deren Verwendung
MA41216A (fr) 2014-12-19 2017-10-24 Univ Rice William M Synthèse totale de trioxacarcine dc-45-a2 et préparation d'analogues de trioxacarcine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5661398A (en) * 1979-10-26 1981-05-26 Kyowa Hakko Kogyo Co Ltd Substance dc-45 and its preparation
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
EP0071428B1 (en) * 1981-07-22 1985-04-10 Kyowa Hakko Kogyo Kabushiki Kaisha Compounds, having antibiotic activity, obtainable by cultivating streptomyces bottropensis

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CA1235081A (en) 1988-04-12
EP0157203A2 (en) 1985-10-09
AU586419B2 (en) 1989-07-13
EP0157203A3 (en) 1986-10-01
AU4077585A (en) 1985-10-10
JPS60226892A (ja) 1985-11-12

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