KR850006451A - 항생제 LL-D42067α 및 LL-D42067β의 제조방법 - Google Patents
항생제 LL-D42067α 및 LL-D42067β의 제조방법 Download PDFInfo
- Publication number
- KR850006451A KR850006451A KR1019850001752A KR850001752A KR850006451A KR 850006451 A KR850006451 A KR 850006451A KR 1019850001752 A KR1019850001752 A KR 1019850001752A KR 850001752 A KR850001752 A KR 850001752A KR 850006451 A KR850006451 A KR 850006451A
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- South Korea
- Prior art keywords
- antibiotics
- microbial
- madure
- microorganism
- nitrogen
- Prior art date
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- DQPBSXMRMTWOAQ-UHFFFAOYSA-N antibiotic d 42067a Chemical compound OC1CCC(O)C(C2=O)=C1OC1=C2C(O)=C2C3=C(O)C(C(N(C)C(C)=C4)=O)=C4C(OCO4)=C3C4CC2=C1OC DQPBSXMRMTWOAQ-UHFFFAOYSA-N 0.000 title claims description 11
- 239000003242 anti bacterial agent Substances 0.000 title claims 8
- 229940088710 antibiotic agent Drugs 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 230000000813 microbial effect Effects 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 150000001449 anionic compounds Chemical class 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 3
- 229910001412 inorganic anion Inorganic materials 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 241000187362 Actinomadura Species 0.000 claims 2
- 238000010564 aerobic fermentation Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 241001269524 Dura Species 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/03—Actinomadura
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Husbandry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 LL-D42067α, NRRL 15734로 표시되는 화합물의 자외선 흡수스펙트럼이다.
제2도는 LL-D42067α, NRRL 15734로 표시되는 화합물의 적외선 흡수스펙트럼이다.
제3도는 LL-D42067α, NRRL 15734로 표시되는 화합물의 CDCl3용액중 양성자 핵자기 공명스펙트럼이다.
Claims (4)
- 미생물 기탁번호가 NRRL 15734 미생물 악티노마두라 마두레 변종 시마오엔시스(Actinomaduramadurae Subspecies Simaoensis)나 또는 항생제 LL-D42067α 또는 항생 LL-D42067β를 생성해내는 그의 돌연변이주를 탄소, 질소및 무기음이온과 양이온염으로 된 동화원을 함유하는 멸균액체배지내에서 상기 배지중에 상당량의 LL-D42067α 또는 LL-D42067β가 생성될 때까지 호기 발효시킨 다음 그로부터 항생제를 회수하는 것으로 구성된 항생제 LL-D42067α 및 LL-D42067β의 제조방법.
- 기탁번호 NRRL 15734인 미생물 악티노마두라 마두레 변종 시마오엔시스 또는 항생제 LL-D42067α나 LL-D42067β를 생성해내는 그의 돌연변이 주로 된 생균배앙물로 접종된 탄소, 질소 및 무기음이온과 양이옥염의 동화원을 함유하는 멸균액체배지를 호기 발효시키고 이때 상기 발효배양액은 pH 7,0-7.6 온도 24-32℃에서 90-200시간동안 멸균공기를 주입해주면서 진탕하에 유지시키며, 그런다음 매시(mash)를 수확하고 항생제를 추출하는 것으로 구성된 항생제 LL-D42067α 및 LL-D42067β의 제조방법.
- 탄소, 질소, 및 무기음이온과 양이온 염으로 된 동화원을 함유하는 수성 배지내에서 발효시켰을 때회수 가능한 양의 항생제 LL-D42067α 및 LL-D42067β를 산출해 낼수 있는 기탁번호 NRRL-15734인 미생물 악티노마두라 마두레 변종 시마오엔시스의 생물학적으로 순수한 배양물.
- 제3항에 있어서, 상기 미생물이 돌연변이 유발을 받아 미생물이 유전적으로 변형되었으나 항생제 LL-D42067α 또는 LL-D42067β를 합성하는 능력은 그대로 보유하고 있는 미생물 악티노마두라 마두레 변종 시마오엔시스의 생물학적으로 순수한 배양물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/593,159 US4578468A (en) | 1984-03-26 | 1984-03-26 | Antibiotic LL-D42067β |
| US593,152 | 1990-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850006451A true KR850006451A (ko) | 1985-10-05 |
Family
ID=24373630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850001752A KR850006451A (ko) | 1984-03-19 | 1985-03-18 | 항생제 LL-D42067α 및 LL-D42067β의 제조방법 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4578468A (ko) |
| JP (1) | JPH0613520B2 (ko) |
| KR (1) | KR850006451A (ko) |
| CA (1) | CA1236785A (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087567A (en) * | 1990-01-12 | 1992-02-11 | Bristol-Myers Squibb Company | Antitumor antibiotic BMY-42428 |
| US5304373A (en) * | 1991-10-22 | 1994-04-19 | Bristol-Myers Squibb Co. | Antitumor antibiotic |
| JPH1145149A (ja) * | 1997-07-28 | 1999-02-16 | Sony Corp | データ表示装置及び方法並びに記録媒体、データ送信装置及び方法 |
| CA2411966C (en) * | 2000-04-26 | 2008-11-18 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Compositions for treating or preventing malaria and method of treating malaria |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551533A (en) * | 1984-03-26 | 1985-11-05 | American Cyanamid Company | Antibiotic LL-D42067α |
-
1984
- 1984-03-26 US US06/593,159 patent/US4578468A/en not_active Expired - Lifetime
-
1985
- 1985-03-18 KR KR1019850001752A patent/KR850006451A/ko not_active Application Discontinuation
- 1985-03-18 JP JP60052573A patent/JPH0613520B2/ja not_active Expired - Lifetime
- 1985-03-22 CA CA000477223A patent/CA1236785A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60209522A (ja) | 1985-10-22 |
| US4578468A (en) | 1986-03-25 |
| JPH0613520B2 (ja) | 1994-02-23 |
| CA1236785A (en) | 1988-05-17 |
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| Date | Code | Title | Description |
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Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19850318 |
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Patent event code: PA02012R01D Patent event date: 19870928 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19850318 Comment text: Patent Application |
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| PE0601 | Decision on rejection of patent |
Patent event date: 19901228 Comment text: Decision to Refuse Application Patent event code: PE06012S01D |