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KR850005414A - 치환된 5,11-디하이드로-6H-디벤즈 [b.e]아제핀-6-온의 제조방법 - Google Patents

치환된 5,11-디하이드로-6H-디벤즈 [b.e]아제핀-6-온의 제조방법 Download PDF

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Publication number
KR850005414A
KR850005414A KR1019850000318A KR850000318A KR850005414A KR 850005414 A KR850005414 A KR 850005414A KR 1019850000318 A KR1019850000318 A KR 1019850000318A KR 850000318 A KR850000318 A KR 850000318A KR 850005414 A KR850005414 A KR 850005414A
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South Korea
Prior art keywords
methyl
dibenz
dihydro
piperidinyl
acid addition
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KR1019850000318A
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English (en)
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KR910006986B1 (ko
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에버라인 볼프강 (외 5)
Original Assignee
베쩰, 좀머
닥터 칼토매 게젤샤프트 미트 베슈랭크터하프퉁
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Publication of KR850005414A publication Critical patent/KR850005414A/ko
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Publication of KR910006986B1 publication Critical patent/KR910006986B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

치환된 5,11-디하이드로-6H-디벤즈 [b.e]아제핀-6-온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 구조식(Ⅲ)의 5,11-디하이드로-6H-디벤즈-[b.e]아제핀-6-온을 그의 디리튬염으로 전환시킨 다음 이 디리튬염을 하기 일반식(Ⅲ)의 에스테르와 반응시키고, 필요하다면, 생성화된 화합물을, 무기산 또는 유기산과의 산부가염으로 전환시킴을 특징으로 하여, 하기 일반식(Ⅰ)의 치환된 5,11-디하이드로-6H-디벤즈 [b.e]아제핀-온 및 이의 산부가염을 제조하는 방법.
    상기식에서, A는 (1-메틸-4-피페리디닐)아세틸 또는 (4-메틸-1-피페라지닐)아세틸이고, A'는(1-메틸-4-피페리디닐)메틸 또는 (4-메틸-1-피페라지닐)-메틸기이고, R은 탄소수 1내지 10의 알킬기 또는 탄소수 7내지 13의 아르알킬기이다.
  2. 하기 구조식(Ⅳ)의 카복실산의 반응성 유도체를 1-메틸-4-아미노-피페리딘과 반응시키고, 필요하다면, 그 생성물을 무기산 또는 유기산과의 산부가염으로 전환시킴을 특징으로 하여, 하기 일반식(Ⅰb)의 5,11-디하이드로-11-[[(1-메틸-4-피페리디닐)아미노]카보닐]-6H-디벤즈 [b.e]아제핀-6-온 및 이의 산부가염을 제조하는 방법.
    상기식에서, A는 [(1-메틸-4-피페리디닐)]아미노카보닐기이다.
  3. 제1항에 있어서, 구조식(Ⅲ)의 화합물을, -60℃ 내지 0℃의 온도에서 유기 불활성용매 존재하에 N-부틸리튬(경우에 따라, 테트라메틸에틸렌디아민의 존재하), 3급 부틸리, 튬리 튬디이소프로필아미드, 리튬 디시클로헥실아미드 또는 리튬페닐을 사용하여 그의 디리튬염으로 전환시키고, 일반식(Ⅲ)의 에스테르와의 후속반응을, 주위온도 이하의 온도로 동일한 반응혼합물중에서 수행함을 특징으로 하는 방법.
  4. 제2항에 있어서, 사용된 구조식(Ⅳ)의 카복실산의 반응유도체가 산 할로겐화물, 혼합 무수물, N,N'-카보닐디아미다졸 또는 N,N'-디시클로헥실카보디이미드와의 반응생성물, 또는 탄소수 1내지 8의 지방족 알코올 또는 탄소수 7내지 13의 아르지방족 알코올과의 이의 에스테르이고, 반응성 유도체를, 주위온도내지 반응혼합물의 비점에서, 불활성 유기용매의 존재하 또는 과량의 1-메틸-4-아미노-피페리딘 존재하에 1-메틸-4-아미노-피페리딘과 반응시킴을 특징으로 하는 방법.
  5. 제1항에 있어서, 5,11-디하이드로-11-[(1-메틸-4-피페리디닐)아세틸]-6H-디벤즈[b,e]아제핀-6-온 및 이의 약학적으로 허용되는 산부가염을 제조하는 방법.
  6. 제1항에 있어서, 5,11-디하이드로-11-[(1-메틸-4-피페리디닐)아세틸]-6H-디벤즈[b,e]아제핀-6-온 및 이의 약학적으로 허용되는 산부가염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000318A 1984-01-21 1985-01-19 치환된 5,11-디하이드로-6H-디벤즈[b,e]아제핀-6-온의 제조방법 KR910006986B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843402060 DE3402060A1 (de) 1984-01-21 1984-01-21 Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DEP3402060.8 1984-01-21
DE????P3402060,8? 1984-01-21

Publications (2)

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KR850005414A true KR850005414A (ko) 1985-08-26
KR910006986B1 KR910006986B1 (ko) 1991-09-14

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KR1019850000318A KR910006986B1 (ko) 1984-01-21 1985-01-19 치환된 5,11-디하이드로-6H-디벤즈[b,e]아제핀-6-온의 제조방법

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US (1) US4567178A (ko)
EP (1) EP0149840B1 (ko)
JP (1) JPH0662575B2 (ko)
KR (1) KR910006986B1 (ko)
AT (1) ATE42553T1 (ko)
AU (1) AU570761B2 (ko)
CA (1) CA1241651A (ko)
CS (1) CS247094B2 (ko)
DD (1) DD235259A5 (ko)
DE (2) DE3402060A1 (ko)
DK (1) DK159441C (ko)
ES (2) ES8601908A1 (ko)
FI (1) FI79534C (ko)
GR (1) GR850131B (ko)
HU (1) HU193250B (ko)
IE (1) IE57754B1 (ko)
IL (1) IL74101A (ko)
NO (1) NO161619C (ko)
NZ (1) NZ210875A (ko)
PH (1) PH23209A (ko)
PL (2) PL142866B1 (ko)
PT (1) PT79837B (ko)
SU (1) SU1308196A3 (ko)
ZA (1) ZA85414B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531682A1 (de) * 1985-09-05 1987-03-12 Thomae Gmbh Dr K (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel
IT8819192A0 (it) * 1988-01-25 1988-01-25 Angeli Inst Spa Amminochetoni di dibenzo e piridobenzo azepinoni sostituiti e composizioni farmaceutiche.
US5256699A (en) * 1988-10-18 1993-10-26 Ciba-Geify Corporation Dispersible tablet formulation of diclofenac acid free base
DE3838912A1 (de) * 1988-11-17 1990-05-23 Thomae Gmbh Dr K Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
EP1047675A1 (en) * 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
SG80041A1 (en) * 1998-06-08 2001-04-17 Advanced Medicine Inc Muscarinic receptor antagonists
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
UA73543C2 (uk) * 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
EP1235802B1 (en) 1999-12-07 2005-07-13 Theravance, Inc. Carbamate derivatives having muscarinic receptor antagonist activity
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor

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DE1795176C3 (de) * 1968-08-20 1974-10-24 Dr. Karl Thomae Gmbh, 7950 Biberach hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung
CH624682A5 (ko) * 1976-11-10 1981-08-14 Sandoz Ag
DE2918832A1 (de) * 1979-05-10 1980-11-20 Basf Ag 5,6-dihydro-11-alkylen-morphantridin- 6-one
DE3204157A1 (de) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

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IE850117L (en) 1985-07-21
PH23209A (en) 1989-06-06
ZA85414B (en) 1986-09-24
NO161619B (no) 1989-05-29
CS247094B2 (en) 1986-11-13
GR850131B (ko) 1985-05-17
JPS60161970A (ja) 1985-08-23
IE57754B1 (en) 1993-03-24
ES8604524A1 (es) 1986-02-01
AU3779285A (en) 1985-08-01
PL255144A1 (en) 1986-08-12
FI79534C (fi) 1990-01-10
DK159441C (da) 1991-03-18
DK21585D0 (da) 1985-01-17
ES539668A0 (es) 1985-11-16
HU193250B (en) 1987-08-28
CA1241651A (en) 1988-09-06
DK21585A (da) 1985-07-22
NZ210875A (en) 1987-07-31
PL142903B1 (en) 1987-12-31
DD235259A5 (de) 1986-04-30
NO850216L (no) 1985-07-22
DE3402060A1 (de) 1985-08-01
SU1308196A3 (ru) 1987-04-30
PL251603A1 (en) 1985-12-17
IL74101A (en) 1988-09-30
DK159441B (da) 1990-10-15
PT79837A (en) 1985-02-01
ATE42553T1 (de) 1989-05-15
PL142866B1 (en) 1987-12-31
AU570761B2 (en) 1988-03-24
FI850228L (fi) 1985-07-22
ES545025A0 (es) 1986-02-01
FI79534B (fi) 1989-09-29
JPH0662575B2 (ja) 1994-08-17
PT79837B (en) 1986-12-18
FI850228A0 (fi) 1985-01-18
DE3477927D1 (en) 1989-06-01
NO161619C (no) 1989-09-06
KR910006986B1 (ko) 1991-09-14
ES8601908A1 (es) 1985-11-16
HUT37141A (en) 1985-11-28
EP0149840B1 (de) 1989-04-26
US4567178A (en) 1986-01-28
EP0149840A1 (de) 1985-07-31
IL74101A0 (en) 1985-04-30

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