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KR850001536A - Grf유사체의 제법 - Google Patents

Grf유사체의 제법 Download PDF

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Publication number
KR850001536A
KR850001536A KR1019840005252A KR840005252A KR850001536A KR 850001536 A KR850001536 A KR 850001536A KR 1019840005252 A KR1019840005252 A KR 1019840005252A KR 840005252 A KR840005252 A KR 840005252A KR 850001536 A KR850001536 A KR 850001536A
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South Korea
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gln
arg
leu
ala
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KR1019840005252A
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KR900006560B1 (ko
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보렌 피터 (외 5)
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원본미기재
더 솔크 인스티튜트 훠 바이오로지칼 스터디이즈
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Priority claimed from US06/527,292 external-priority patent/US4610976A/en
Priority claimed from US06/541,167 external-priority patent/US4585756A/en
Priority claimed from US06/585,814 external-priority patent/US4605643A/en
Application filed by 원본미기재, 더 솔크 인스티튜트 훠 바이오로지칼 스터디이즈 filed Critical 원본미기재
Publication of KR850001536A publication Critical patent/KR850001536A/ko
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Publication of KR900006560B1 publication Critical patent/KR900006560B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

GRF유사체의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. (a) 적어도 하나의 보호기를 가지고 있는 하기 구조식(Ⅱ)의 화합물을 생성한 후 ; (b)구조식(Ⅱ)의 화합물로부터 보호기(들) 분리제거하여 구조식(Ⅰ)의 펩티드 또는 생물학적으로 활성인 그의 분절을 얻은 다음 소망에 따라 (c) 결과 생성된 펩티드를 그의 무독성 부가염으로 전환시키는 것으로 구성된, 하기 구조식(Ⅰ)의 화합물의 제조방법.
  2. (Ⅰ) : H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-R13-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-R28-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gln-Gly-Ala-R41-Val-Arg-Leu-Y.
  3. (여기서 R13은 Val 또는 Ile이며; R28은 Ser 또는 Asn이며; R41은 Arg 또는 Lys이며; Y는 OH또는 NH2이다).
  4. (Ⅱ) : X1-Tyr(X2)-Ala-Asp(X3)-Ala-Ile-Phe-Thr(X4)-Asn-Ser(X5)-Tyr(X2)-Arg(X6)-Lys(X7)-R13-Leu-Gln-Gly-Gln-Leu-Ser(X5)-Ala-Arg(X6)-Lys(X7)-Leu-Gln-Gln-Asp(X3)-Ile-Met-R28(X5)-Arg(X6)-Gln-Gln-Gly-Glu(X3)-Arg(X6)-Asn-Gln-Glu(X3)-Gln-Gly-Ala-R41(X6또는 X7)-Val-Arg(X6)-Leu-X8.
  5. (여기서 R28부터 C-말단에 이르는 잔기중 어떤 것 또는 모두는 제거될 수 있으며, (X1), (X2), (X3), (X4), (X5), (X6) 및 (X7)은 각기 수소이거나 보호기이며, (X8)은 아미드 또는 하이드록실이거나 보호기이다.)
  6. 제1항에 있어서, R28이 Asn이며, B41이 Lys인 방법.
  7. 제2항에 있어서, R13이 Ile인 방법.
  8. 제2항에 있어서, R13이 Val인 방법.
  9. 제2항에 있어서, R13이 Val, R28이 Ser, R41이 Arg인 방법.
  10. 제1항 내지 5항중 어느 하나에서, Y가 NH2인 방법.
  11. 제1항 내지 5항중 어느 하나에서, Y가 OH인 방법.
  12. 제1항 내지 7항중 어느 하나에서, X1이 수소 또는 α-아미노보호기이며; X2가 수소 또는 Tyr의 페놀성 하이드록실기의 보호기이며; X3가 수소 또는 Asp 또는 Glu카복실기의 보호기이며; X4가 수소 또는 Thr의 알콜성 하이드록실기의 보호기이며; X5가 수소 또는 Ser의 알콜성 하이드록실기의 보호기이며; X6가 수소 또는 Arg이 구아니디노기의 보호기이며; X8이 OH, OCH3에스테르, 아미드, 하이드라지드, -O-CH2-수지지체 및 -NH-수지지지체로 구성된 군으로부터 선택되는 방법.
  13. 제8항에 있어서, X1이 BOC, X2가 2,6-디클로로벤질, X3가 Bzl, X4가 Bzl, X5가 Bzl, X6가 Tos, X7이 2-클로로벤질옥시카보닐이며 X8가 -O-CH2-수지지지체인 방법.
  14. 제8항에 있어서, X1이 BOC, X2가 2,6-디클로로벤질, X3가 Bzl, X4가 Bzl, X5가 Bzl, X6가 Tos, X7이 2-클로로벤질옥시카보닐, X8이 -NH-수지지지체인 방법.
  15. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840005252A 1983-08-29 1984-08-28 Grf 유사체의 제법 Expired KR900006560B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US06/527,292 US4610976A (en) 1983-08-29 1983-08-29 Porcine GRF
US06/541,167 US4585756A (en) 1983-10-12 1983-10-12 Bovine GRF
US585814 1984-03-02
US06/585,814 US4605643A (en) 1984-03-02 1984-03-02 Ovine GRF
US527292 1984-03-02
US541167 2000-04-03

Publications (2)

Publication Number Publication Date
KR850001536A true KR850001536A (ko) 1985-03-30
KR900006560B1 KR900006560B1 (ko) 1990-09-13

Family

ID=27414960

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005252A Expired KR900006560B1 (ko) 1983-08-29 1984-08-28 Grf 유사체의 제법

Country Status (20)

Country Link
EP (1) EP0137689B1 (ko)
JP (1) JPH0676437B2 (ko)
KR (1) KR900006560B1 (ko)
AR (1) AR248284A1 (ko)
AU (1) AU577542B2 (ko)
CS (1) CS251085B2 (ko)
DD (1) DD228266A5 (ko)
DE (1) DE3461641D1 (ko)
DK (1) DK161835C (ko)
EG (1) EG17263A (ko)
ES (1) ES8606401A1 (ko)
FI (1) FI81589C (ko)
GR (1) GR80227B (ko)
HU (1) HU190973B (ko)
IE (1) IE57730B1 (ko)
IL (1) IL72717A (ko)
NO (1) NO167867C (ko)
PT (1) PT79094B (ko)
SU (1) SU1423000A3 (ko)
YU (1) YU45907B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
DE3436819A1 (de) * 1984-10-06 1986-04-17 Hoechst Ag, 6230 Frankfurt Arzneimittel mit grf-wirkung
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
AU599922B2 (en) * 1985-09-10 1990-08-02 Natinco Nv Improving carcass quality
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
EP0289186A3 (en) * 1987-04-23 1990-04-04 International Minerals And Chemical Corporation Process for increasing the growth rate and enhancing the feed efficiency of meat producing livestock
FR2622455B1 (fr) * 1987-11-04 1991-07-12 Agronomique Inst Nat Rech Application du facteur de stimulation de la secretion de l'hormone de croissance humaine, de ses fragments actifs et des analogues correspondants, pour augmenter la production laitiere et le poids des nouveau-nes chez les mammiferes
JPH01174387A (ja) * 1987-12-28 1989-07-10 Onoda Cement Co Ltd ヤギの成長ホルモン
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
AU2004245469B2 (en) 2003-05-01 2008-07-03 Boehringer Ingelheim Animal Health USA Inc. Canine GHRH gene, polypeptides and methods of use
CA2965696A1 (en) * 2014-11-12 2016-05-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment of hormonal disorders of growth
WO2017038866A1 (ja) * 2015-09-04 2017-03-09 株式会社ピカコーポレイション 伸縮装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ204456A (en) * 1982-06-16 1987-05-29 Salk Inst For Biological Studi Synthetic pancreatic growth-hormone releasing factor
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides

Also Published As

Publication number Publication date
NO843381L (no) 1985-03-01
DK161835C (da) 1992-01-20
DK161835B (da) 1991-08-19
AR248284A1 (es) 1995-07-12
DE3461641D1 (en) 1987-01-22
FI81589B (fi) 1990-07-31
AU3244984A (en) 1985-03-07
CS251085B2 (en) 1987-06-11
JPS6072900A (ja) 1985-04-24
AU577542B2 (en) 1988-09-29
DK413084D0 (da) 1984-08-29
EP0137689A1 (en) 1985-04-17
ES8606401A1 (es) 1986-04-01
KR900006560B1 (ko) 1990-09-13
EG17263A (en) 1991-08-30
IE57730B1 (en) 1993-03-24
HU190973B (en) 1986-12-28
YU148884A (en) 1988-04-30
SU1423000A3 (ru) 1988-09-07
IE842199L (en) 1985-02-28
FI81589C (fi) 1990-11-12
EP0137689B1 (en) 1986-12-10
YU45907B (sh) 1992-09-07
PT79094A (en) 1984-09-01
IL72717A (en) 1988-01-31
PT79094B (en) 1986-08-14
NO167867B (no) 1991-09-09
FI843355A0 (fi) 1984-08-24
HUT35000A (en) 1985-05-28
ES535455A0 (es) 1986-04-01
IL72717A0 (en) 1984-11-30
GR80227B (en) 1985-01-02
JPH0676437B2 (ja) 1994-09-28
FI843355L (fi) 1985-03-01
DK413084A (da) 1985-03-01
DD228266A5 (de) 1985-10-09
NO167867C (no) 1991-12-18

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