[go: up one dir, main page]

KR850007802A - 펩타이드의 제조방법 - Google Patents

펩타이드의 제조방법 Download PDF

Info

Publication number
KR850007802A
KR850007802A KR1019850002458A KR850002458A KR850007802A KR 850007802 A KR850007802 A KR 850007802A KR 1019850002458 A KR1019850002458 A KR 1019850002458A KR 850002458 A KR850002458 A KR 850002458A KR 850007802 A KR850007802 A KR 850007802A
Authority
KR
South Korea
Prior art keywords
formula
protecting group
solid carrier
protected
group
Prior art date
Application number
KR1019850002458A
Other languages
English (en)
Other versions
KR870001145B1 (ko
Inventor
비드 다비드드
Original Assignee
에이.디. 도우마 프록시
아크조 엔. 브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에이.디. 도우마 프록시, 아크조 엔. 브이 filed Critical 에이.디. 도우마 프록시
Publication of KR850007802A publication Critical patent/KR850007802A/ko
Application granted granted Critical
Publication of KR870001145B1 publication Critical patent/KR870001145B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/15—Oxytocin or vasopressin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

펩타이드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 아미노기와 보호된 기타 반응기들을 갖는 아미노산 또는 펩타이드와 카복실기와 보호된 기타 반응기를 갖는 아미노산 또는 펩타이드를 통산의 방법으로 축합시켜 보호기 및/또는 고체상담체와 결합된 일반식(Ⅱ)의 펩타이드를 얻고 이어서 보호기 및/는고 체상담체를 제거하는 일반식(Ⅰ)의 펩타이드 제조방법.
    식(Ⅰ)중 A는 Arg, Cys 또는 Leu이고, R은 H-L-Cys-OH 또는 H-L-Axx-a-Cys-L-Pro-L-A-OH이다.
    식(Ⅱ)중 B는 수소, N-아실(C1-6)또는 N-보호기이고, Q는 하이드록시, 아실옥시(C1-18), 임의의 알칼-치환아미드기, 0-보호기 또는 고체상 담체이고, A'은 식(Ⅰ)의 A와 동일하거나 s-보호리실기 또는 구아나딘-보호아르지닐기이다. 단, 만일 Q가 고체상담체가 아닌 경우에는 적어도 하나의 보호기가 (B, Q 또는 A중 하나에)있어야 한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850002458A 1984-04-13 1985-04-12 펩타이드의 제조방법 KR870001145B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL8401187 1984-04-13
NL84001189 1984-04-13
NL84.01187 1984-04-13

Publications (2)

Publication Number Publication Date
KR850007802A true KR850007802A (ko) 1985-12-09
KR870001145B1 KR870001145B1 (ko) 1987-06-11

Family

ID=19843805

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850002458A KR870001145B1 (ko) 1984-04-13 1985-04-12 펩타이드의 제조방법

Country Status (13)

Country Link
US (1) US4623640A (ko)
EP (1) EP0161017B1 (ko)
JP (1) JPS60231697A (ko)
KR (1) KR870001145B1 (ko)
AU (1) AU574154B2 (ko)
CA (1) CA1250400A (ko)
DE (1) DE3560261D1 (ko)
DK (1) DK166154C (ko)
ES (1) ES542212A0 (ko)
FI (1) FI85275C (ko)
HU (1) HU192206B (ko)
IE (1) IE58407B1 (ko)
ZA (1) ZA852535B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238314A (en) * 1983-09-22 1988-06-21 James F. Callahan Process for preparing basic heptapeptide vasopressin antagonists
US4748154A (en) * 1985-12-24 1988-05-31 Takeda Chemical Industries, Ltd. Peptide derivatives, their production and use
JP2542241B2 (ja) * 1988-08-12 1996-10-09 富士レビオ株式会社 ペプチド
DE69013742T2 (de) * 1989-04-15 1995-03-23 Fujirebio Kk Peptide und diese Peptide enthaltende Wirkstoffe gegen Dementia.
DK53191D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
GB2269821B (en) * 1992-08-08 1996-06-05 Shanghai Inst Biochemistry Memory enhancing peptides and pharmaceutical compositions containing them
CN1154656C (zh) * 2000-06-30 2004-06-23 上海中科英泰生物技术有限公司 一类记忆增强肽和它们的用途
US7402157B2 (en) * 2001-12-19 2008-07-22 The Procter & Gamble Company Absorbent article having perception of depth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS171787B1 (ko) * 1973-11-09 1976-11-29
IE56021B1 (en) * 1982-10-13 1991-03-27 Akzo Nv Peptides

Also Published As

Publication number Publication date
US4623640A (en) 1986-11-18
AU574154B2 (en) 1988-06-30
DE3560261D1 (en) 1987-07-23
EP0161017B1 (en) 1987-06-16
JPS60231697A (ja) 1985-11-18
DK166154B (da) 1993-03-15
ZA852535B (en) 1985-11-27
DK165885D0 (da) 1985-04-12
ES8605769A1 (es) 1985-12-16
KR870001145B1 (ko) 1987-06-11
IE58407B1 (en) 1993-09-22
DK166154C (da) 1993-08-09
FI851488A0 (fi) 1985-04-12
CA1250400A (en) 1989-02-21
FI85275B (fi) 1991-12-13
ES542212A0 (es) 1985-12-16
FI85275C (fi) 1992-03-25
DK165885A (da) 1985-10-14
IE850829L (en) 1985-10-13
EP0161017A1 (en) 1985-11-13
HUT37804A (en) 1986-02-28
FI851488L (fi) 1985-10-14
HU192206B (en) 1987-05-28
AU4101285A (en) 1985-10-17

Similar Documents

Publication Publication Date Title
KR850003417A (ko) 폴리펩티드의 제조방법
DK524187D0 (da) Aminosyrechelaterede midler til udlevering til specifikke biologiske vaevssteder
ATE173275T1 (de) Von einem retrovirus aus der hiv-gruppe abgeleitete peptide und deren verwendung
ATE177757T1 (de) Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
KR830003528A (ko) 섬유형성 코폴리에스테르
TR199902997T2 (xx) "LH-RH peptit analoglar�, bunlar�n kullan�mlar� ve bunlar� i�eren farmas�tik terkipler"
KR890000517A (ko) 하이브리드 단백질 c 및 이의 제조방법
KR910016767A (ko) 신규한 펩티드
KR850007802A (ko) 펩타이드의 제조방법
KR840009069A (ko) 향정신성 펩티드류의 제조 방법
ATE282634T1 (de) Chaperonin 10
DE69926627D1 (de) Insulinartigen wachstumsfaktor bindendes protein -3 variante
IT1212508B (it) Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
DE69029377D1 (de) Substituierungsanaloge von magaininpeptiden
KR870000356A (ko) 메티오닐 단백질로부터 n-말단 메티오닌을 제거하는 방법
ES8703488A1 (es) Procedimiento para preparar peptidos
ATE131492T1 (de) Synthetische peptide und deren mischungen für den nachweis von hiv-antikörpern
HUP9701290A2 (hu) Javított tulajdonságú aprotininváltozatok
KR840002346A (ko) 펩타이드의 제조방법
KR860001882A (ko) 왁진 효능이 있는 폴리펩타이드
KR890008166A (ko) 융합 단백질의 선택적 분해 방법
EA200001252A1 (ru) КОМПОЗИЦИЯ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА-β-1A(IFN-β-1A) ЧЕЛОВЕКА
BR9714922A (pt) protease derivada de queratinócito
KR910007963A (ko) pST의 일부분에 대응하는 아미노산 서열을 갖는 펩티드, 그에 대한 항체 및 pST 활성에 효력을 더하는 방법
KR890013059A (ko) 이소아밀라제활성을 지닌 폴리펩티드 및 그 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19850412

PA0201 Request for examination
PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19870128

Patent event code: PE09021S01D

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19870515

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19870822

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19870915

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19870915

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 19900530

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 19910604

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 19920526

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 19930521

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 19930521

Start annual number: 7

End annual number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee