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KR840000477A - 헨테트 라콘타펩티드 crj 및 그 동족체와 관련된 펩티드류의 제조 방법 - Google Patents

헨테트 라콘타펩티드 crj 및 그 동족체와 관련된 펩티드류의 제조 방법 Download PDF

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Publication number
KR840000477A
KR840000477A KR1019820002541A KR820002541A KR840000477A KR 840000477 A KR840000477 A KR 840000477A KR 1019820002541 A KR1019820002541 A KR 1019820002541A KR 820002541 A KR820002541 A KR 820002541A KR 840000477 A KR840000477 A KR 840000477A
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glu
gln
leu
ala
lys
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KR1019820002541A
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KR890002774B1 (ko
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워어커 베일쥬니어 윌리 (외 3)
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델버어트 어어니스트 그란쯔
더솔크 인스티튜트훠 바이올로지칼 스터디이즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Developing Agents For Electrophotography (AREA)
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Abstract

내용 없음

Description

헨테트 라콘타펩티드 CRJ 및 그 동족체와 관련된 펩티드류의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. (a) 하기구조의 펩티드 중간체를 생성하고
  2. (b) 상기 폴리펩티드 중간체로부터 보호기 및 임의로 공유결합된 수지지지체를 제거하여 폴리펩티드를 얻고 생성된 폴리펩티드를 그의 무독성염으로 변화시키는 것으로 구성된 펩티드화합물의 제조 방법.
  3. X1-R1-Pro-Pro-Ile-Ser(X2)-R6-Asp(X5)-Leu-R11(X2)-R12-R13-Leu-Arg(X3)-R17-R18-R19-Glu(X5)-R21-R22-Lys(X6)-R24-R25-R26-R27-R28-Gln(X4)-Ala-R32-R33-Asn(X|4)-Arg(X3)-R36-Leu-Leu-Asp(X5)-R40-R41-X7
  4. 상기 구조에서
  5. R1은 Ser-Gln-Glu 또는 pGlu-Gly 또는 Gln-Glu 또는 Glu 또는 D-Ser-Gln-Glu 또는 D-pGlu-Gly 또는 des R1이며; R8,R12,R19,R24및 R40은 Leu,Ile,Ala,Gly,Val,Nle,Phe,Gln으로 구성된 군으로부터 선택되며; R11은 Thr 또는 Ser 이며; R13은 His,Tyr 또는 Glu이며; R17은 Glu 또는 Lys이며; R18은 Val 또는 Met이며; R21은 Met,Met(0),Ile,Ala,Leu,Gly,Nle,Val,Phe 또는 Gln이며; R22는 Thr 또는 Glu이며; R25는 Asp 또는 Glu이며; R26은 Gln 또는 Lys이며; R27은 Leu,Ile,Ala,Gly,Val,Nle,Phe,Asp,Asn,Gln 또는 Glu이며; R28은 Ala 또는 Lys이며; R32는 His,Tyr 또는 Ala이며; R33은 Ser,Asn,Thr 또는 Ala이며; R36은 Lys 또는 Len이며; R41은 Ala,Ile,Gly,Val,Leu,Nle,Phe,Gln 또는 des R41이며; 단 R13이 His 일때 R17은 Glu,R18은 Val,R22는 Thr,R26은 Gln,R28은 Ala,R36은 Lys이며, R13이 Glu,R17이 Lys,R18b이 Met,R22가 Glu,R26이 Lys,R32가 Ala이고 R36이 Leu 일때, R1이 pGlu-Gly이 아니거나 R8이 He이 아니거나 R11이 Thr 이거나 R12가 Leu이 아니거나 R|19가 He이 아니거나 R21이 He이 아니거나 R24가 Glu이 아니거나 R27이 Glu가 아니거나 R33이 Asn이 아니거나 R40이 Thr이 아니거나 또는 R41이 Ile이 아니어야 하며;
  6. X1은 수소 또는 α-아미노 보호기이며;
  7. X2는 수소 또는 Ser 또는 Thr 잔기의 알콜성 히드록실기 보호기이며;
  8. X3은 수소 또는 또는 Arg의 구아니디노기 보호기이며;
  9. X4는 수소 또는 Gln 또는 Asn의 아미도기 보호기이며;
  10. X5는 수소 또는 Asp 또는 Glu의 카복실기 보호기이며;
  11. X6는 수소 또는 Lys와 측쇄아미노기 보호기이며;
  12. X7은 OH,OCH3, 에스테르류, 아미드류, 히드라지드류, -0-CH2-, 폴리스티렌수지지지체 및-0-CH2-벤질-폴리스티렌 수지지지체이며, 단 X1-X7모두가 수소거나 OH 여서는 안된다.
  13. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202541A 1981-06-08 1982-06-07 헨테트라콘타펩티드 crf 및 그 동족체와 관련된 펩티드류의 제조방법 KR890002774B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27162481A 1981-06-08 1981-06-08
US271624 1981-06-08
US271,624 1981-06-08

Publications (2)

Publication Number Publication Date
KR840000477A true KR840000477A (ko) 1984-02-22
KR890002774B1 KR890002774B1 (ko) 1989-07-28

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KR8202541A KR890002774B1 (ko) 1981-06-08 1982-06-07 헨테트라콘타펩티드 crf 및 그 동족체와 관련된 펩티드류의 제조방법

Country Status (15)

Country Link
EP (1) EP0067608B1 (ko)
JP (1) JPS57212149A (ko)
KR (1) KR890002774B1 (ko)
AT (1) ATE6505T1 (ko)
AU (1) AU554676B2 (ko)
CA (1) CA1243301A (ko)
DE (1) DE3260057D1 (ko)
DK (1) DK156957C (ko)
ES (1) ES8401446A1 (ko)
GR (1) GR75679B (ko)
IE (1) IE53488B1 (ko)
IL (1) IL65937A (ko)
NZ (1) NZ200711A (ko)
PH (1) PH20364A (ko)
ZA (1) ZA823635B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190081081A (ko) 2017-12-29 2019-07-09 (주)에스엠테크 디아민 화합물과 알루미네이트계 화합물을 포함하는 광물 미분쇄용 분쇄조제 조성물 및 이를 사용한 광물의 미분쇄방법

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153845B1 (en) * 1984-02-23 1993-04-21 The Salk Institute For Biological Studies Crf analogs
CA1341051C (en) * 1988-09-23 2000-07-11 Jean Edouard Frederic Rivier Crf antagonists
ZA898329B (en) * 1988-11-14 1990-07-25 Salk Inst For Biological Studi Fish crf
US5235036A (en) * 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
DE4110422A1 (de) * 1991-03-29 1992-10-01 Bissendorf Peptide Gmbh Arzneimittel enthaltend humanes corticotropin-releasing hormon (crh) und/oder dessen derivate und/oder glucocorticoide natuerlicher und/oder synthetischer provenienz
WO1996008265A1 (en) * 1994-09-12 1996-03-21 The Trustees Of The University Of Pennsylvania Corticotropin release inhibiting factor and methods of using same
US6039956A (en) * 1994-09-12 2000-03-21 Pennsylvania, Trustees Of The University Of, The Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
WO2019159957A1 (ja) 2018-02-16 2019-08-22 Jnc株式会社 重合性化合物、重合性組成物、重合体及びフォトレジスト用組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190081081A (ko) 2017-12-29 2019-07-09 (주)에스엠테크 디아민 화합물과 알루미네이트계 화합물을 포함하는 광물 미분쇄용 분쇄조제 조성물 및 이를 사용한 광물의 미분쇄방법

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GR75679B (ko) 1984-08-02
ES512892A0 (es) 1983-12-01
DE3260057D1 (en) 1984-04-12
ATE6505T1 (de) 1984-03-15
IL65937A0 (en) 1982-09-30
KR890002774B1 (ko) 1989-07-28
JPS57212149A (en) 1982-12-27
IE821330L (en) 1982-12-08
AU554676B2 (en) 1986-08-28
NZ200711A (en) 1986-02-21
DK254982A (da) 1982-12-09
IL65937A (en) 1986-09-30
ES8401446A1 (es) 1983-12-01
ZA823635B (en) 1983-03-30
DK156957C (da) 1990-03-19
DK156957B (da) 1989-10-23
IE53488B1 (en) 1988-11-23
EP0067608A1 (en) 1982-12-22
AU8445582A (en) 1982-12-16
PH20364A (en) 1986-12-04
CA1243301A (en) 1988-10-18
EP0067608B1 (en) 1984-03-07
JPS642600B2 (ko) 1989-01-18

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