KR20200015814A - 세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 - Google Patents

세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 Download PDF

Info

Publication number: KR20200015814A
Authority: KR; South Korea
Prior art keywords: bis; bismuth; antibiotic; thiol; compound
Prior art date: 2010-02-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

KR1020207003093A

Other languages

English (en)

Korean (ko)

Inventor

브렛 휴 제임스 베이커

Original Assignee

마이크로비온 코포레이션

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-02-03

Filing date

2011-02-03

Publication date

2020-02-12

2010-02-03 Priority claimed from PCT/US2010/023108 external-priority patent/WO2010091124A2/en

2011-02-03 Application filed by 마이크로비온 코포레이션 filed Critical 마이크로비온 코포레이션

2011-02-03 Priority claimed from PCT/US2011/023549 external-priority patent/WO2011097347A2/en

2020-02-12 Publication of KR20200015814A publication Critical patent/KR20200015814A/ko

Status Ceased legal-status Critical Current

Links

230000001580 bacterial effect Effects 0.000 title claims abstract description 70
238000011282 treatment Methods 0.000 title claims description 43
230000002421 anti-septic effect Effects 0.000 title description 5
229940064004 antiseptic throat preparations Drugs 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 250
239000003242 anti bacterial agent Substances 0.000 claims abstract description 142
229940088710 antibiotic agent Drugs 0.000 claims abstract description 136
238000000034 method Methods 0.000 claims abstract description 119
230000003115 biocidal effect Effects 0.000 claims abstract description 97
238000009472 formulation Methods 0.000 claims abstract description 67
BIGYLAKFCGVRAN-UHFFFAOYSA-N 1,3,4-thiadiazolidine-2,5-dithione Chemical compound S=C1NNC(=S)S1 BIGYLAKFCGVRAN-UHFFFAOYSA-N 0.000 claims abstract description 60
230000002195 synergetic effect Effects 0.000 claims abstract description 46
230000000845 anti-microbial effect Effects 0.000 claims abstract description 37
230000002708 enhancing effect Effects 0.000 claims abstract description 14
150000001875 compounds Chemical class 0.000 claims description 293
-1 BT compound Chemical class 0.000 claims description 102
241000894006 Bacteria Species 0.000 claims description 74
210000003491 skin Anatomy 0.000 claims description 73
239000003795 chemical substances by application Substances 0.000 claims description 68
208000015181 infectious disease Diseases 0.000 claims description 65
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims description 62
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 61
229910052797 bismuth Inorganic materials 0.000 claims description 61
210000001519 tissue Anatomy 0.000 claims description 52
239000000243 solution Substances 0.000 claims description 45
244000052616 bacterial pathogen Species 0.000 claims description 40
239000003814 drug Substances 0.000 claims description 34
239000002904 solvent Substances 0.000 claims description 32
150000003573 thiols Chemical class 0.000 claims description 32
235000019441 ethanol Nutrition 0.000 claims description 31
210000000981 epithelium Anatomy 0.000 claims description 30
RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 27
229960003085 meticillin Drugs 0.000 claims description 27
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 26
229930182566 Gentamicin Natural products 0.000 claims description 26
229960002518 gentamicin Drugs 0.000 claims description 26
229940079593 drug Drugs 0.000 claims description 25
229960004821 amikacin Drugs 0.000 claims description 24
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims description 24
239000011859 microparticle Substances 0.000 claims description 24
239000007864 aqueous solution Substances 0.000 claims description 23
229960000707 tobramycin Drugs 0.000 claims description 23
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 23
241000588724 Escherichia coli Species 0.000 claims description 22
230000002378 acidificating effect Effects 0.000 claims description 22
239000002647 aminoglycoside antibiotic agent Substances 0.000 claims description 21
210000001035 gastrointestinal tract Anatomy 0.000 claims description 21
ZRKMQKLGEQPLNS-UHFFFAOYSA-N 1-Pentanethiol Chemical compound CCCCCS ZRKMQKLGEQPLNS-UHFFFAOYSA-N 0.000 claims description 20
230000012010 growth Effects 0.000 claims description 20
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 20
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 20
208000035143 Bacterial infection Diseases 0.000 claims description 19
208000022362 bacterial infectious disease Diseases 0.000 claims description 19
SUVIGLJNEAMWEG-UHFFFAOYSA-N propane-1-thiol Chemical compound CCCS SUVIGLJNEAMWEG-UHFFFAOYSA-N 0.000 claims description 19
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
150000001621 bismuth Chemical class 0.000 claims description 18
239000007787 solid Substances 0.000 claims description 18
229930182555 Penicillin Natural products 0.000 claims description 17
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 17
108010059993 Vancomycin Proteins 0.000 claims description 17
230000032770 biofilm formation Effects 0.000 claims description 17
238000006243 chemical reaction Methods 0.000 claims description 17
229940049954 penicillin Drugs 0.000 claims description 17
229960003165 vancomycin Drugs 0.000 claims description 17
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 17
VYMPLPIFKRHAAC-UHFFFAOYSA-N 1,2-ethanedithiol Chemical compound SCCS VYMPLPIFKRHAAC-UHFFFAOYSA-N 0.000 claims description 16
LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims description 16
WQAQPCDUOCURKW-UHFFFAOYSA-N butanethiol Chemical compound CCCCS WQAQPCDUOCURKW-UHFFFAOYSA-N 0.000 claims description 16
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 16
229910052737 gold Inorganic materials 0.000 claims description 16
239000010931 gold Substances 0.000 claims description 16
239000002105 nanoparticle Substances 0.000 claims description 16
FETFXNFGOYOOSP-UHFFFAOYSA-N 1-sulfanylpropan-2-ol Chemical compound CC(O)CS FETFXNFGOYOOSP-UHFFFAOYSA-N 0.000 claims description 15
238000004519 manufacturing process Methods 0.000 claims description 15
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 claims description 14
239000002244 precipitate Substances 0.000 claims description 14
210000002345 respiratory system Anatomy 0.000 claims description 14
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 13
229960005091 chloramphenicol Drugs 0.000 claims description 13
229960002227 clindamycin Drugs 0.000 claims description 13
KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 13
230000005764 inhibitory process Effects 0.000 claims description 13
229930186147 Cephalosporin Natural products 0.000 claims description 12
241000194033 Enterococcus Species 0.000 claims description 12
UOZODPSAJZTQNH-UHFFFAOYSA-N Paromomycin II Natural products NC1C(O)C(O)C(CN)OC1OC1C(O)C(OC2C(C(N)CC(N)C2O)OC2C(C(O)C(O)C(CO)O2)N)OC1CO UOZODPSAJZTQNH-UHFFFAOYSA-N 0.000 claims description 12
229940124587 cephalosporin Drugs 0.000 claims description 12
150000001780 cephalosporins Chemical class 0.000 claims description 12
WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 claims description 12
229960003722 doxycycline Drugs 0.000 claims description 12
KZCOBXFFBQJQHH-UHFFFAOYSA-N octane-1-thiol Chemical compound CCCCCCCCS KZCOBXFFBQJQHH-UHFFFAOYSA-N 0.000 claims description 12
UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 claims description 12
229960001914 paromomycin Drugs 0.000 claims description 12
230000002265 prevention Effects 0.000 claims description 12
230000008569 process Effects 0.000 claims description 12
WMXCDAVJEZZYLT-UHFFFAOYSA-N tert-butylthiol Chemical compound CC(C)(C)S WMXCDAVJEZZYLT-UHFFFAOYSA-N 0.000 claims description 12
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 claims description 12
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims description 12
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
241000191963 Staphylococcus epidermidis Species 0.000 claims description 11
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 11
229960000723 ampicillin Drugs 0.000 claims description 11
210000004369 blood Anatomy 0.000 claims description 11
239000008280 blood Substances 0.000 claims description 11
150000004662 dithiols Chemical class 0.000 claims description 11
AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 11
244000052613 viral pathogen Species 0.000 claims description 11
XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 claims description 10
PMBXCGGQNSVESQ-UHFFFAOYSA-N 1-Hexanethiol Chemical compound CCCCCCS PMBXCGGQNSVESQ-UHFFFAOYSA-N 0.000 claims description 10
241000192125 Firmicutes Species 0.000 claims description 10
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 10
244000053095 fungal pathogen Species 0.000 claims description 10
229960003923 gatifloxacin Drugs 0.000 claims description 10
210000004907 gland Anatomy 0.000 claims description 10
230000002401 inhibitory effect Effects 0.000 claims description 10
229910017604 nitric acid Inorganic materials 0.000 claims description 10
229960002026 pyrithione Drugs 0.000 claims description 10
229960005322 streptomycin Drugs 0.000 claims description 10
ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims description 10
229930193140 Neomycin Natural products 0.000 claims description 9
108010087702 Penicillinase Proteins 0.000 claims description 9
241000589517 Pseudomonas aeruginosa Species 0.000 claims description 9
230000002538 fungal effect Effects 0.000 claims description 9
229960000318 kanamycin Drugs 0.000 claims description 9
229930027917 kanamycin Natural products 0.000 claims description 9
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims description 9
229930182823 kanamycin A Natural products 0.000 claims description 9
229960004927 neomycin Drugs 0.000 claims description 9
229950009506 penicillinase Drugs 0.000 claims description 9
230000010412 perfusion Effects 0.000 claims description 9
ZJLMKPKYJBQJNH-UHFFFAOYSA-N propane-1,3-dithiol Chemical compound SCCCS ZJLMKPKYJBQJNH-UHFFFAOYSA-N 0.000 claims description 9
FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims description 9
UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 claims description 9
ULGGZAVAARQJCS-UHFFFAOYSA-N 11-sulfanylundecan-1-ol Chemical compound OCCCCCCCCCCCS ULGGZAVAARQJCS-UHFFFAOYSA-N 0.000 claims description 8
SDAWVOFJSUUKMR-UHFFFAOYSA-N 12-sulfanyldodecanoic acid Chemical compound OC(=O)CCCCCCCCCCCS SDAWVOFJSUUKMR-UHFFFAOYSA-N 0.000 claims description 8
INOAASCWQMFJQA-UHFFFAOYSA-N 16-sulfanylhexadecanoic acid Chemical compound OC(=O)CCCCCCCCCCCCCCCS INOAASCWQMFJQA-UHFFFAOYSA-N 0.000 claims description 8
TWWSEEHCVDRRRI-UHFFFAOYSA-N 2,3-Butanedithiol Chemical compound CC(S)C(C)S TWWSEEHCVDRRRI-UHFFFAOYSA-N 0.000 claims description 8
SHLSSLVZXJBVHE-UHFFFAOYSA-N 3-sulfanylpropan-1-ol Chemical compound OCCCS SHLSSLVZXJBVHE-UHFFFAOYSA-N 0.000 claims description 8
241000194032 Enterococcus faecalis Species 0.000 claims description 8
VPIAKHNXCOTPAY-UHFFFAOYSA-N Heptane-1-thiol Chemical compound CCCCCCCS VPIAKHNXCOTPAY-UHFFFAOYSA-N 0.000 claims description 8
GIJGXNFNUUFEGH-UHFFFAOYSA-N Isopentyl mercaptan Chemical compound CC(C)CCS GIJGXNFNUUFEGH-UHFFFAOYSA-N 0.000 claims description 8
FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 8
241000193998 Streptococcus pneumoniae Species 0.000 claims description 8
229960001139 cefazolin Drugs 0.000 claims description 8
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims description 8
VTXVGVNLYGSIAR-UHFFFAOYSA-N decane-1-thiol Chemical compound CCCCCCCCCCS VTXVGVNLYGSIAR-UHFFFAOYSA-N 0.000 claims description 8
DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims description 8
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 8
WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
QJAOYSPHSNGHNC-UHFFFAOYSA-N octadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCCCS QJAOYSPHSNGHNC-UHFFFAOYSA-N 0.000 claims description 8
239000003910 polypeptide antibiotic agent Substances 0.000 claims description 8
230000003389 potentiating effect Effects 0.000 claims description 8
KJRCEJOSASVSRA-UHFFFAOYSA-N propane-2-thiol Chemical compound CC(C)S KJRCEJOSASVSRA-UHFFFAOYSA-N 0.000 claims description 8
GEKDEMKPCKTKEC-UHFFFAOYSA-N tetradecane-1-thiol Chemical compound CCCCCCCCCCCCCCS GEKDEMKPCKTKEC-UHFFFAOYSA-N 0.000 claims description 8
241000588747 Klebsiella pneumoniae Species 0.000 claims description 7
241000588767 Proteus vulgaris Species 0.000 claims description 7
241000191967 Staphylococcus aureus Species 0.000 claims description 7
241000607734 Yersinia <bacteria> Species 0.000 claims description 7
229940126574 aminoglycoside antibiotic Drugs 0.000 claims description 7
XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 claims description 7
229950006334 apramycin Drugs 0.000 claims description 7
229940032049 enterococcus faecalis Drugs 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 7
229940007042 proteus vulgaris Drugs 0.000 claims description 7
BDFAOUQQXJIZDG-UHFFFAOYSA-N 2-methylpropane-1-thiol Chemical compound CC(C)CS BDFAOUQQXJIZDG-UHFFFAOYSA-N 0.000 claims description 6
241000193738 Bacillus anthracis Species 0.000 claims description 6
241000193163 Clostridioides difficile Species 0.000 claims description 6
206010022653 Intestinal haemorrhages Diseases 0.000 claims description 6
241000589242 Legionella pneumophila Species 0.000 claims description 6
241000186367 Mycobacterium avium Species 0.000 claims description 6
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims description 6
241000607762 Shigella flexneri Species 0.000 claims description 6
241000607626 Vibrio cholerae Species 0.000 claims description 6
229940065181 bacillus anthracis Drugs 0.000 claims description 6
230000010261 cell growth Effects 0.000 claims description 6
229960001051 dimercaprol Drugs 0.000 claims description 6
238000007598 dipping method Methods 0.000 claims description 6
239000010419 fine particle Substances 0.000 claims description 6
229940124307 fluoroquinolone Drugs 0.000 claims description 6
229940115932 legionella pneumophila Drugs 0.000 claims description 6
235000019136 lipoic acid Nutrition 0.000 claims description 6
238000010422 painting Methods 0.000 claims description 6
238000005507 spraying Methods 0.000 claims description 6
229960002663 thioctic acid Drugs 0.000 claims description 6
RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 claims description 5
101710146739 Enterotoxin Proteins 0.000 claims description 5
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 5
229930189077 Rifamycin Natural products 0.000 claims description 5
RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 claims description 5
239000005516 coenzyme A Substances 0.000 claims description 5
229940093530 coenzyme a Drugs 0.000 claims description 5
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 5
235000018417 cysteine Nutrition 0.000 claims description 5
KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 claims description 5
WQABCVAJNWAXTE-UHFFFAOYSA-N dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 claims description 5
239000000147 enterotoxin Substances 0.000 claims description 5
231100000655 enterotoxin Toxicity 0.000 claims description 5
229960003292 rifamycin Drugs 0.000 claims description 5
HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical group OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims description 5
229940031000 streptococcus pneumoniae Drugs 0.000 claims description 5
230000035899 viability Effects 0.000 claims description 5
SRZXCOWFGPICGA-UHFFFAOYSA-N 1,6-Hexanedithiol Chemical compound SCCCCCCS SRZXCOWFGPICGA-UHFFFAOYSA-N 0.000 claims description 4
PGTWZHXOSWQKCY-UHFFFAOYSA-N 1,8-Octanedithiol Chemical compound SCCCCCCCCS PGTWZHXOSWQKCY-UHFFFAOYSA-N 0.000 claims description 4
GJRCLMJHPWCJEI-UHFFFAOYSA-N 1,9-Nonanedithiol Chemical compound SCCCCCCCCCS GJRCLMJHPWCJEI-UHFFFAOYSA-N 0.000 claims description 4
YRUJXAGQQTXCKX-UHFFFAOYSA-N 15-sulfanylpentadecanoic acid Chemical compound OC(=O)CCCCCCCCCCCCCCS YRUJXAGQQTXCKX-UHFFFAOYSA-N 0.000 claims description 4
IMQFZQVZKBIPCQ-UHFFFAOYSA-N 2,2-bis(3-sulfanylpropanoyloxymethyl)butyl 3-sulfanylpropanoate Chemical compound SCCC(=O)OCC(CC)(COC(=O)CCS)COC(=O)CCS IMQFZQVZKBIPCQ-UHFFFAOYSA-N 0.000 claims description 4
YAJYJWXEWKRTPO-UHFFFAOYSA-N 2,3,3,4,4,5-hexamethylhexane-2-thiol Chemical compound CC(C)C(C)(C)C(C)(C)C(C)(C)S YAJYJWXEWKRTPO-UHFFFAOYSA-N 0.000 claims description 4
UCJMHYXRQZYNNL-UHFFFAOYSA-N 2-Ethyl-1-hexanethiol Chemical compound CCCCC(CC)CS UCJMHYXRQZYNNL-UHFFFAOYSA-N 0.000 claims description 4
HCZMHWVFVZAHCR-UHFFFAOYSA-N 2-[2-(2-sulfanylethoxy)ethoxy]ethanethiol Chemical compound SCCOCCOCCS HCZMHWVFVZAHCR-UHFFFAOYSA-N 0.000 claims description 4
FVRYCPZDHKLBNR-UHFFFAOYSA-N 2-mercaptoindole Chemical compound C1=CC=C2NC(S)=CC2=C1 FVRYCPZDHKLBNR-UHFFFAOYSA-N 0.000 claims description 4
MPBLPZLNKKGCGP-UHFFFAOYSA-N 2-methyloctane-2-thiol Chemical compound CCCCCCC(C)(C)S MPBLPZLNKKGCGP-UHFFFAOYSA-N 0.000 claims description 4
ZMRFRBHYXOQLDK-UHFFFAOYSA-N 2-phenylethanethiol Chemical compound SCCC1=CC=CC=C1 ZMRFRBHYXOQLDK-UHFFFAOYSA-N 0.000 claims description 4
URJIJZCEKHSLHA-UHFFFAOYSA-N 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecane-1-thiol Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCS URJIJZCEKHSLHA-UHFFFAOYSA-N 0.000 claims description 4
MJQWABQELVFQJL-UHFFFAOYSA-N 3-Mercapto-2-butanol Chemical compound CC(O)C(C)S MJQWABQELVFQJL-UHFFFAOYSA-N 0.000 claims description 4
IKYAJDOSWUATPI-UHFFFAOYSA-N 3-[dimethoxy(methyl)silyl]propane-1-thiol Chemical compound CO[Si](C)(OC)CCCS IKYAJDOSWUATPI-UHFFFAOYSA-N 0.000 claims description 4
TZCFWOHAWRIQGF-UHFFFAOYSA-N 3-chloropropane-1-thiol Chemical compound SCCCCl TZCFWOHAWRIQGF-UHFFFAOYSA-N 0.000 claims description 4
DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 claims description 4
NIAAGQAEVGMHPM-UHFFFAOYSA-N 4-methylbenzene-1,2-dithiol Chemical compound CC1=CC=C(S)C(S)=C1 NIAAGQAEVGMHPM-UHFFFAOYSA-N 0.000 claims description 4
NEJMTSWXTZREOC-UHFFFAOYSA-N 4-sulfanylbutan-1-ol Chemical compound OCCCCS NEJMTSWXTZREOC-UHFFFAOYSA-N 0.000 claims description 4
PABCJNLBWRWMLO-UHFFFAOYSA-N 5-sulfanylpentanenitrile Chemical compound SCCCCC#N PABCJNLBWRWMLO-UHFFFAOYSA-N 0.000 claims description 4
UGZAJZLUKVKCBM-UHFFFAOYSA-N 6-sulfanylhexan-1-ol Chemical compound OCCCCCCS UGZAJZLUKVKCBM-UHFFFAOYSA-N 0.000 claims description 4
XJTWZETUWHTBTG-UHFFFAOYSA-N 8-sulfanyloctan-1-ol Chemical compound OCCCCCCCCS XJTWZETUWHTBTG-UHFFFAOYSA-N 0.000 claims description 4
FXFJFNVBVKPAPL-UHFFFAOYSA-N 9-sulfanylnonan-1-ol Chemical compound OCCCCCCCCCS FXFJFNVBVKPAPL-UHFFFAOYSA-N 0.000 claims description 4
WVDYBOADDMMFIY-UHFFFAOYSA-N Cyclopentanethiol Chemical compound SC1CCCC1 WVDYBOADDMMFIY-UHFFFAOYSA-N 0.000 claims description 4
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 4
241000588697 Enterobacter cloacae Species 0.000 claims description 4
108010024636 Glutathione Proteins 0.000 claims description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
241000187480 Mycobacterium smegmatis Species 0.000 claims description 4
241000187479 Mycobacterium tuberculosis Species 0.000 claims description 4
229910019142 PO4 Inorganic materials 0.000 claims description 4
241000194017 Streptococcus Species 0.000 claims description 4
IYPNRTQAOXLCQW-UHFFFAOYSA-N [4-(sulfanylmethyl)phenyl]methanethiol Chemical compound SCC1=CC=C(CS)C=C1 IYPNRTQAOXLCQW-UHFFFAOYSA-N 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
ADJJLNODXLXTIH-UHFFFAOYSA-N adamantane-1-thiol Chemical compound C1C(C2)CC3CC2CC1(S)C3 ADJJLNODXLXTIH-UHFFFAOYSA-N 0.000 claims description 4
VRPKUXAKHIINGG-UHFFFAOYSA-N biphenyl-4,4'-dithiol Chemical compound C1=CC(S)=CC=C1C1=CC=C(S)C=C1 VRPKUXAKHIINGG-UHFFFAOYSA-N 0.000 claims description 4
SMTOKHQOVJRXLK-UHFFFAOYSA-N butane-1,4-dithiol Chemical compound SCCCCS SMTOKHQOVJRXLK-UHFFFAOYSA-N 0.000 claims description 4
WJXDCSSGTLPZDK-UHFFFAOYSA-M butane-1-thiolate;copper(1+) Chemical compound [Cu+].CCCC[S-] WJXDCSSGTLPZDK-UHFFFAOYSA-M 0.000 claims description 4
LOCHFZBWPCLPAN-UHFFFAOYSA-N butane-2-thiol Chemical compound CCC(C)S LOCHFZBWPCLPAN-UHFFFAOYSA-N 0.000 claims description 4
MGFFVSDRCRVHLC-UHFFFAOYSA-N butyl 3-sulfanylpropanoate Chemical compound CCCCOC(=O)CCS MGFFVSDRCRVHLC-UHFFFAOYSA-N 0.000 claims description 4
230000003833 cell viability Effects 0.000 claims description 4
CMKBCTPCXZNQKX-UHFFFAOYSA-N cyclohexanethiol Chemical compound SC1CCCCC1 CMKBCTPCXZNQKX-UHFFFAOYSA-N 0.000 claims description 4
OPUQYSYDXPAUPW-UHFFFAOYSA-N cyclopenta-1,3-diene;6-cyclopenta-2,4-dien-1-ylhexane-1-thiol;iron(2+) Chemical compound [Fe+2].C=1C=C[CH-]C=1.SCCCCCC[C-]1C=CC=C1 OPUQYSYDXPAUPW-UHFFFAOYSA-N 0.000 claims description 4
229960002433 cysteine Drugs 0.000 claims description 4
229960003067 cystine Drugs 0.000 claims description 4
230000029087 digestion Effects 0.000 claims description 4
229960003180 glutathione Drugs 0.000 claims description 4
JSRUFBZERGYUAT-UHFFFAOYSA-N hexadecane-1,16-dithiol Chemical compound SCCCCCCCCCCCCCCCCS JSRUFBZERGYUAT-UHFFFAOYSA-N 0.000 claims description 4
ORTRWBYBJVGVQC-UHFFFAOYSA-N hexadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCS ORTRWBYBJVGVQC-UHFFFAOYSA-N 0.000 claims description 4
IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims description 4
FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 claims description 4
LDTLDBDUBGAEDT-UHFFFAOYSA-N methyl 3-sulfanylpropanoate Chemical compound COC(=O)CCS LDTLDBDUBGAEDT-UHFFFAOYSA-N 0.000 claims description 4
CKRXZOZYQYDWIQ-UHFFFAOYSA-N n-nonyl-3-sulfanylpropanamide Chemical compound CCCCCCCCCNC(=O)CCS CKRXZOZYQYDWIQ-UHFFFAOYSA-N 0.000 claims description 4
ZVEZMVFBMOOHAT-UHFFFAOYSA-N nonane-1-thiol Chemical compound CCCCCCCCCS ZVEZMVFBMOOHAT-UHFFFAOYSA-N 0.000 claims description 4
IGMQODZGDORXEN-UHFFFAOYSA-N pentadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCS IGMQODZGDORXEN-UHFFFAOYSA-N 0.000 claims description 4
KMTUBAIXCBHPIZ-UHFFFAOYSA-N pentane-1,5-dithiol Chemical compound SCCCCCS KMTUBAIXCBHPIZ-UHFFFAOYSA-N 0.000 claims description 4
239000010452 phosphate Substances 0.000 claims description 4
MEQLOUCDKZRWAO-UHFFFAOYSA-N s-(4-acetylsulfanylbutyl) ethanethioate Chemical compound CC(=O)SCCCCSC(C)=O MEQLOUCDKZRWAO-UHFFFAOYSA-N 0.000 claims description 4
QZCVGPWTKIYEIZ-UHFFFAOYSA-N s-(4-cyanobutyl) ethanethioate Chemical compound CC(=O)SCCCCC#N QZCVGPWTKIYEIZ-UHFFFAOYSA-N 0.000 claims description 4
YQZGQQAPWBBCSS-UHFFFAOYSA-N s-[11-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]undecyl] ethanethioate Chemical compound CC(=O)SCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO YQZGQQAPWBBCSS-UHFFFAOYSA-N 0.000 claims description 4
239000000741 silica gel Substances 0.000 claims description 4
229910002027 silica gel Inorganic materials 0.000 claims description 4
CCIDWXHLGNEQSL-UHFFFAOYSA-N undecane-1-thiol Chemical compound CCCCCCCCCCCS CCIDWXHLGNEQSL-UHFFFAOYSA-N 0.000 claims description 4
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
JJDNIFVXOIKYCT-UHFFFAOYSA-N 11-pyrrol-1-ylundecane-1-thiol Chemical compound SCCCCCCCCCCCN1C=CC=C1 JJDNIFVXOIKYCT-UHFFFAOYSA-N 0.000 claims description 3
FYEMIKRWWMYBFG-UHFFFAOYSA-N 8-sulfanyloctanoic acid Chemical compound OC(=O)CCCCCCCS FYEMIKRWWMYBFG-UHFFFAOYSA-N 0.000 claims description 3
241000588626 Acinetobacter baumannii Species 0.000 claims description 3
241000589513 Burkholderia cepacia Species 0.000 claims description 3
241000588914 Enterobacter Species 0.000 claims description 3
241000589989 Helicobacter Species 0.000 claims description 3
201000005010 Streptococcus pneumonia Diseases 0.000 claims description 3
108060008539 Transglutaminase Proteins 0.000 claims description 3
XFHIDPOTWOFDEM-UHFFFAOYSA-N [4-[4-(sulfanylmethyl)phenyl]phenyl]methanethiol Chemical group C1=CC(CS)=CC=C1C1=CC=C(CS)C=C1 XFHIDPOTWOFDEM-UHFFFAOYSA-N 0.000 claims description 3
235000019445 benzyl alcohol Nutrition 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
239000003306 quinoline derived antiinfective agent Substances 0.000 claims description 3
NJRXVEJTAYWCQJ-UHFFFAOYSA-N thiomalic acid Chemical compound OC(=O)CC(S)C(O)=O NJRXVEJTAYWCQJ-UHFFFAOYSA-N 0.000 claims description 3
102000003601 transglutaminase Human genes 0.000 claims description 3
201000008827 tuberculosis Diseases 0.000 claims description 3
ODMTYGIDMVZUER-UHFFFAOYSA-N undecane-1,11-dithiol Chemical compound SCCCCCCCCCCCS ODMTYGIDMVZUER-UHFFFAOYSA-N 0.000 claims description 3
YOZNBMSWVPXLKM-UHFFFAOYSA-N 11-sulfanylundecyl 2,2,2-trifluoroacetate Chemical compound FC(F)(F)C(=O)OCCCCCCCCCCCS YOZNBMSWVPXLKM-UHFFFAOYSA-N 0.000 claims description 2
FASSFROSROBIBE-UHFFFAOYSA-N 2-[2-[2-(11-sulfanylundecoxy)ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOCCCCCCCCCCCS FASSFROSROBIBE-UHFFFAOYSA-N 0.000 claims description 2
GQJXVHYUQPXZOL-UHFFFAOYSA-N 3,3,4,4,5,5,6,6,6-nonafluorohexane-1-thiol Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)CCS GQJXVHYUQPXZOL-UHFFFAOYSA-N 0.000 claims description 2
FOYJDMJLWTYTCC-UHFFFAOYSA-N 4-[2-(4-sulfanylphenyl)ethenyl]benzenethiol Chemical compound C1=CC(S)=CC=C1C=CC1=CC=C(S)C=C1 FOYJDMJLWTYTCC-UHFFFAOYSA-N 0.000 claims description 2
CMNQZZPAVNBESS-UHFFFAOYSA-N 6-sulfanylhexanoic acid Chemical compound OC(=O)CCCCCS CMNQZZPAVNBESS-UHFFFAOYSA-N 0.000 claims description 2
241000020730 Burkholderia cepacia complex Species 0.000 claims description 2
241000589602 Francisella tularensis Species 0.000 claims description 2
241000186359 Mycobacterium Species 0.000 claims description 2
LEILPQLVBYGUCB-NCGGTJAESA-N SB1[B][B][C@@H]2[B][C@H]([B]1)[B][B][B][B][B]2 Chemical compound SB1[B][B][C@@H]2[B][C@H]([B]1)[B][B][B][B][B]2 LEILPQLVBYGUCB-NCGGTJAESA-N 0.000 claims description 2
241000607479 Yersinia pestis Species 0.000 claims description 2
230000008029 eradication Effects 0.000 claims description 2
229940118764 francisella tularensis Drugs 0.000 claims description 2
239000012535 impurity Substances 0.000 claims description 2
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
GUTNLKRPYCTIHX-UHFFFAOYSA-H pravibismane Chemical compound S1CCS[Bi]1SCCS[Bi]1SCCS1 GUTNLKRPYCTIHX-UHFFFAOYSA-H 0.000 claims 4
XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims 2
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 2
210000002837 heart atrium Anatomy 0.000 claims 2
230000001629 suppression Effects 0.000 claims 2
229940126062 Compound A Drugs 0.000 claims 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
235000001484 Trigonella foenum graecum Nutrition 0.000 claims 1
244000250129 Trigonella foenum graecum Species 0.000 claims 1
239000000539 dimer Substances 0.000 claims 1
JEDBIVNXPYJQIU-UHFFFAOYSA-N s-(11-bromoundecyl) ethanethioate Chemical compound CC(=O)SCCCCCCCCCCCBr JEDBIVNXPYJQIU-UHFFFAOYSA-N 0.000 claims 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
239000003755 preservative agent Substances 0.000 abstract description 24
239000000725 suspension Substances 0.000 abstract description 21
230000000844 anti-bacterial effect Effects 0.000 abstract description 18
230000002335 preservative effect Effects 0.000 abstract description 6
208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
208000027136 gram-positive bacterial infections Diseases 0.000 abstract 1
206010052428 Wound Diseases 0.000 description 113
208000027418 Wounds and injury Diseases 0.000 description 113
230000000694 effects Effects 0.000 description 43
239000007788 liquid Substances 0.000 description 42
230000001684 chronic effect Effects 0.000 description 36
239000008194 pharmaceutical composition Substances 0.000 description 33
239000004599 antimicrobial Substances 0.000 description 32
210000004027 cell Anatomy 0.000 description 31
230000000813 microbial effect Effects 0.000 description 31
239000003921 oil Substances 0.000 description 31
230000001154 acute effect Effects 0.000 description 30
239000012049 topical pharmaceutical composition Substances 0.000 description 30
235000019198 oils Nutrition 0.000 description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 24
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 23
239000000126 substance Substances 0.000 description 22
230000029663 wound healing Effects 0.000 description 22
244000005700 microbiome Species 0.000 description 21
230000006378 damage Effects 0.000 description 20
230000000699 topical effect Effects 0.000 description 18
239000000499 gel Substances 0.000 description 17
239000000546 pharmaceutical excipient Substances 0.000 description 17
239000004480 active ingredient Substances 0.000 description 16
239000000843 powder Substances 0.000 description 16
239000004094 surface-active agent Substances 0.000 description 16
238000012384 transportation and delivery Methods 0.000 description 16
239000000284 extract Substances 0.000 description 15
229920001223 polyethylene glycol Polymers 0.000 description 15
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 14
239000000443 aerosol Substances 0.000 description 14
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 14
TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 description 14
239000002502 liposome Substances 0.000 description 14
239000012071 phase Substances 0.000 description 14
239000000758 substrate Substances 0.000 description 14
239000000654 additive Substances 0.000 description 13
230000004054 inflammatory process Effects 0.000 description 13
239000000463 material Substances 0.000 description 13
210000000214 mouth Anatomy 0.000 description 13
239000002245 particle Substances 0.000 description 13
235000002639 sodium chloride Nutrition 0.000 description 13
241000894007 species Species 0.000 description 13
210000000515 tooth Anatomy 0.000 description 13
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
206010061218 Inflammation Diseases 0.000 description 12
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 12
238000011200 topical administration Methods 0.000 description 12
241000700605 Viruses Species 0.000 description 11
230000015572 biosynthetic process Effects 0.000 description 11
238000004140 cleaning Methods 0.000 description 11
208000014674 injury Diseases 0.000 description 11
230000000670 limiting effect Effects 0.000 description 11
239000002674 ointment Substances 0.000 description 11
238000002360 preparation method Methods 0.000 description 11
241000124008 Mammalia Species 0.000 description 10
206010072170 Skin wound Diseases 0.000 description 10
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
239000000969 carrier Substances 0.000 description 10
238000011161 development Methods 0.000 description 10
230000018109 developmental process Effects 0.000 description 10
239000003937 drug carrier Substances 0.000 description 10
150000003839 salts Chemical class 0.000 description 10
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
239000000872 buffer Substances 0.000 description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
239000003085 diluting agent Substances 0.000 description 9
235000011187 glycerol Nutrition 0.000 description 9
229960005150 glycerol Drugs 0.000 description 9
230000035876 healing Effects 0.000 description 9
238000001727 in vivo Methods 0.000 description 9
108090000623 proteins and genes Proteins 0.000 description 9
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 8
108010013198 Daptomycin Proteins 0.000 description 8
239000002202 Polyethylene glycol Substances 0.000 description 8
239000004098 Tetracycline Substances 0.000 description 8
239000013543 active substance Substances 0.000 description 8
235000001014 amino acid Nutrition 0.000 description 8
229940024606 amino acid Drugs 0.000 description 8
150000001413 amino acids Chemical class 0.000 description 8
229940126575 aminoglycoside Drugs 0.000 description 8
230000008901 benefit Effects 0.000 description 8
229940021392 cubicin Drugs 0.000 description 8
DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 description 8
239000000839 emulsion Substances 0.000 description 8
239000003623 enhancer Substances 0.000 description 8
230000036541 health Effects 0.000 description 8
238000010348 incorporation Methods 0.000 description 8
230000001965 increasing effect Effects 0.000 description 8
238000002347 injection Methods 0.000 description 8
239000007924 injection Substances 0.000 description 8
239000010410 layer Substances 0.000 description 8
229960003907 linezolid Drugs 0.000 description 8
239000006072 paste Substances 0.000 description 8
229920000642 polymer Polymers 0.000 description 8
239000000047 product Substances 0.000 description 8
235000018102 proteins Nutrition 0.000 description 8
102000004169 proteins and genes Human genes 0.000 description 8
230000000241 respiratory effect Effects 0.000 description 8
238000001356 surgical procedure Methods 0.000 description 8
235000019364 tetracycline Nutrition 0.000 description 8
150000003522 tetracyclines Chemical class 0.000 description 8
239000000606 toothpaste Substances 0.000 description 8
239000000080 wetting agent Substances 0.000 description 8
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
241000282412 Homo Species 0.000 description 7
229920002125 Sokalan® Polymers 0.000 description 7
230000003214 anti-biofilm Effects 0.000 description 7
210000000988 bone and bone Anatomy 0.000 description 7
239000002537 cosmetic Substances 0.000 description 7
239000006071 cream Substances 0.000 description 7
230000002500 effect on skin Effects 0.000 description 7
239000000796 flavoring agent Substances 0.000 description 7
239000004615 ingredient Substances 0.000 description 7
239000006210 lotion Substances 0.000 description 7
238000005259 measurement Methods 0.000 description 7
235000015097 nutrients Nutrition 0.000 description 7
235000019645 odor Nutrition 0.000 description 7
208000028169 periodontal disease Diseases 0.000 description 7
239000003208 petroleum Substances 0.000 description 7
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 7
229960001225 rifampicin Drugs 0.000 description 7
210000002435 tendon Anatomy 0.000 description 7
FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 6
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 6
241000233866 Fungi Species 0.000 description 6
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 6
241001465754 Metazoa Species 0.000 description 6
206010048038 Wound infection Diseases 0.000 description 6
230000003110 anti-inflammatory effect Effects 0.000 description 6
239000003963 antioxidant agent Substances 0.000 description 6
235000006708 antioxidants Nutrition 0.000 description 6
230000009286 beneficial effect Effects 0.000 description 6
229960002100 cefepime Drugs 0.000 description 6
HVFLCNVBZFFHBT-ZKDACBOMSA-O cefepime(1+) Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-O 0.000 description 6
229960003405 ciprofloxacin Drugs 0.000 description 6
239000003086 colorant Substances 0.000 description 6
230000007423 decrease Effects 0.000 description 6
235000014113 dietary fatty acids Nutrition 0.000 description 6
229930195729 fatty acid Natural products 0.000 description 6
239000000194 fatty acid Substances 0.000 description 6
230000006870 function Effects 0.000 description 6
150000002430 hydrocarbons Chemical class 0.000 description 6
238000000338 in vitro Methods 0.000 description 6
210000002510 keratinocyte Anatomy 0.000 description 6
229960003376 levofloxacin Drugs 0.000 description 6
210000003041 ligament Anatomy 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
239000000693 micelle Substances 0.000 description 6
239000004005 microsphere Substances 0.000 description 6
229960004023 minocycline Drugs 0.000 description 6
210000000056 organ Anatomy 0.000 description 6
229960004063 propylene glycol Drugs 0.000 description 6
235000013772 propylene glycol Nutrition 0.000 description 6
235000020944 retinol Nutrition 0.000 description 6
239000011607 retinol Substances 0.000 description 6
229960003471 retinol Drugs 0.000 description 6
238000003756 stirring Methods 0.000 description 6
229960002180 tetracycline Drugs 0.000 description 6
229930101283 tetracycline Natural products 0.000 description 6
230000001225 therapeutic effect Effects 0.000 description 6
235000015112 vegetable and seed oil Nutrition 0.000 description 6
229940088594 vitamin Drugs 0.000 description 6
229930003231 vitamin Natural products 0.000 description 6
235000013343 vitamin Nutrition 0.000 description 6
239000011782 vitamin Substances 0.000 description 6
239000001993 wax Substances 0.000 description 6
229940061740 zyvox Drugs 0.000 description 6
GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
BSIMZHVOQZIAOY-SCSAIBSYSA-N 1-carbapenem-3-carboxylic acid Chemical compound OC(=O)C1=CC[C@@H]2CC(=O)N12 BSIMZHVOQZIAOY-SCSAIBSYSA-N 0.000 description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 5
239000004166 Lanolin Substances 0.000 description 5
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 5
208000025865 Ulcer Diseases 0.000 description 5
150000001298 alcohols Chemical class 0.000 description 5
125000000129 anionic group Chemical group 0.000 description 5
229940121363 anti-inflammatory agent Drugs 0.000 description 5
239000002260 anti-inflammatory agent Substances 0.000 description 5
235000010323 ascorbic acid Nutrition 0.000 description 5
239000011668 ascorbic acid Substances 0.000 description 5
230000004888 barrier function Effects 0.000 description 5
239000002585 base Substances 0.000 description 5
239000001768 carboxy methyl cellulose Substances 0.000 description 5
239000011248 coating agent Substances 0.000 description 5
238000000576 coating method Methods 0.000 description 5
230000001276 controlling effect Effects 0.000 description 5
206010012601 diabetes mellitus Diseases 0.000 description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
230000007613 environmental effect Effects 0.000 description 5
150000004665 fatty acids Chemical class 0.000 description 5
208000007565 gingivitis Diseases 0.000 description 5
239000012676 herbal extract Substances 0.000 description 5
229930195733 hydrocarbon Natural products 0.000 description 5
235000019388 lanolin Nutrition 0.000 description 5
229940039717 lanolin Drugs 0.000 description 5
229960000282 metronidazole Drugs 0.000 description 5
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 5
239000002324 mouth wash Substances 0.000 description 5
210000003205 muscle Anatomy 0.000 description 5
BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 5
239000003883 ointment base Substances 0.000 description 5
230000000399 orthopedic effect Effects 0.000 description 5
244000052769 pathogen Species 0.000 description 5
230000005855 radiation Effects 0.000 description 5
238000011084 recovery Methods 0.000 description 5
230000009467 reduction Effects 0.000 description 5
235000017557 sodium bicarbonate Nutrition 0.000 description 5
229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
229960002920 sorbitol Drugs 0.000 description 5
235000010356 sorbitol Nutrition 0.000 description 5
239000002562 thickening agent Substances 0.000 description 5
230000017423 tissue regeneration Effects 0.000 description 5
229940034610 toothpaste Drugs 0.000 description 5
230000008733 trauma Effects 0.000 description 5
231100000397 ulcer Toxicity 0.000 description 5
239000003981 vehicle Substances 0.000 description 5
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
244000144927 Aloe barbadensis Species 0.000 description 4
235000002961 Aloe barbadensis Nutrition 0.000 description 4
239000004475 Arginine Substances 0.000 description 4
206010006326 Breath odour Diseases 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
102000008186 Collagen Human genes 0.000 description 4
108010035532 Collagen Proteins 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 4
235000006679 Mentha X verticillata Nutrition 0.000 description 4
235000002899 Mentha suaveolens Nutrition 0.000 description 4
235000001636 Mentha x rotundifolia Nutrition 0.000 description 4
PHSRRHGYXQCRPU-AWEZNQCLSA-N N-(3-oxododecanoyl)-L-homoserine lactone Chemical compound CCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O PHSRRHGYXQCRPU-AWEZNQCLSA-N 0.000 description 4
VFFNZZXXTGXBOG-ZCFIWIBFSA-N N-butyryl-L-homoserine lactone Chemical compound CCCC(=O)N[C@@H]1CCOC1=O VFFNZZXXTGXBOG-ZCFIWIBFSA-N 0.000 description 4
208000004210 Pressure Ulcer Diseases 0.000 description 4
240000004808 Saccharomyces cerevisiae Species 0.000 description 4
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
208000002847 Surgical Wound Diseases 0.000 description 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 4
235000011399 aloe vera Nutrition 0.000 description 4
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
229960005070 ascorbic acid Drugs 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
230000003385 bacteriostatic effect Effects 0.000 description 4
ZPBUXMCXNANBKA-UHFFFAOYSA-N bismuth;1-sulfanylpropan-2-ol Chemical compound [Bi].CC(O)CS ZPBUXMCXNANBKA-UHFFFAOYSA-N 0.000 description 4
230000001680 brushing effect Effects 0.000 description 4
YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 4
239000002775 capsule Substances 0.000 description 4
125000002091 cationic group Chemical group 0.000 description 4
239000002738 chelating agent Substances 0.000 description 4
229920001436 collagen Polymers 0.000 description 4
239000000645 desinfectant Substances 0.000 description 4
239000002552 dosage form Substances 0.000 description 4
238000012377 drug delivery Methods 0.000 description 4
239000003974 emollient agent Substances 0.000 description 4
239000003995 emulsifying agent Substances 0.000 description 4
238000005516 engineering process Methods 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
239000012530 fluid Substances 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
235000003599 food sweetener Nutrition 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
235000008216 herbs Nutrition 0.000 description 4
239000003906 humectant Substances 0.000 description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
229910052500 inorganic mineral Inorganic materials 0.000 description 4
230000025693 interspecies quorum sensing Effects 0.000 description 4
150000002632 lipids Chemical class 0.000 description 4
229920002521 macromolecule Polymers 0.000 description 4
238000007726 management method Methods 0.000 description 4
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
235000010755 mineral Nutrition 0.000 description 4
239000011707 mineral Substances 0.000 description 4
229940051866 mouthwash Drugs 0.000 description 4
210000005036 nerve Anatomy 0.000 description 4
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
230000037361 pathway Effects 0.000 description 4
201000001245 periodontitis Diseases 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
230000035945 sensitivity Effects 0.000 description 4
239000007921 spray Substances 0.000 description 4
210000000434 stratum corneum Anatomy 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
235000000346 sugar Nutrition 0.000 description 4
239000003765 sweetening agent Substances 0.000 description 4
239000011732 tocopherol Substances 0.000 description 4
239000008158 vegetable oil Substances 0.000 description 4
230000037314 wound repair Effects 0.000 description 4
WZPBZJONDBGPKJ-VEHQQRBSSA-L 2-[(z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2s,3s)-2-methyl-4-oxo-1-sulfonatoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoate Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C([O-])=O)\C1=CSC(N)=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-L 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
241000195493 Cryptophyta Species 0.000 description 3
108020004414 DNA Proteins 0.000 description 3
102000016942 Elastin Human genes 0.000 description 3
108010014258 Elastin Proteins 0.000 description 3
241000628997 Flos Species 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 3
108010076876 Keratins Proteins 0.000 description 3
102000011782 Keratins Human genes 0.000 description 3
206010028980 Neoplasm Diseases 0.000 description 3
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
208000002565 Open Fractures Diseases 0.000 description 3
206010031252 Osteomyelitis Diseases 0.000 description 3
239000004365 Protease Substances 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
235000018936 Vitellaria paradoxa Nutrition 0.000 description 3
241001135917 Vitellaria paradoxa Species 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
229960001138 acetylsalicylic acid Drugs 0.000 description 3
229940048053 acrylate Drugs 0.000 description 3
230000002411 adverse Effects 0.000 description 3
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 3
229940087168 alpha tocopherol Drugs 0.000 description 3
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 3
229960003644 aztreonam Drugs 0.000 description 3
235000013871 bee wax Nutrition 0.000 description 3
239000012166 beeswax Substances 0.000 description 3
229940092738 beeswax Drugs 0.000 description 3
239000011230 binding agent Substances 0.000 description 3
210000004204 blood vessel Anatomy 0.000 description 3
239000011575 calcium Substances 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
229940106189 ceramide Drugs 0.000 description 3
229960000541 cetyl alcohol Drugs 0.000 description 3
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
229960001927 cetylpyridinium chloride Drugs 0.000 description 3
238000012512 characterization method Methods 0.000 description 3
229940112822 chewing gum Drugs 0.000 description 3
235000015218 chewing gum Nutrition 0.000 description 3
229960003260 chlorhexidine Drugs 0.000 description 3
230000015271 coagulation Effects 0.000 description 3
238000005345 coagulation Methods 0.000 description 3
230000001010 compromised effect Effects 0.000 description 3
210000002808 connective tissue Anatomy 0.000 description 3
230000007123 defense Effects 0.000 description 3
230000023753 dehiscence Effects 0.000 description 3
208000002925 dental caries Diseases 0.000 description 3
239000000551 dentifrice Substances 0.000 description 3
229940008099 dimethicone Drugs 0.000 description 3
239000004205 dimethyl polysiloxane Substances 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
201000010099 disease Diseases 0.000 description 3
239000006185 dispersion Substances 0.000 description 3
229920002549 elastin Polymers 0.000 description 3
210000002615 epidermis Anatomy 0.000 description 3
210000002919 epithelial cell Anatomy 0.000 description 3
229960003276 erythromycin Drugs 0.000 description 3
210000002744 extracellular matrix Anatomy 0.000 description 3
239000003925 fat Substances 0.000 description 3
235000019197 fats Nutrition 0.000 description 3
150000002191 fatty alcohols Chemical class 0.000 description 3
150000002195 fatty ethers Chemical class 0.000 description 3
210000002950 fibroblast Anatomy 0.000 description 3
235000019634 flavors Nutrition 0.000 description 3
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
230000002496 gastric effect Effects 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
239000003349 gelling agent Substances 0.000 description 3
239000008187 granular material Substances 0.000 description 3
235000012907 honey Nutrition 0.000 description 3
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
229960001680 ibuprofen Drugs 0.000 description 3
230000007124 immune defense Effects 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
210000000987 immune system Anatomy 0.000 description 3
230000008595 infiltration Effects 0.000 description 3
238000001764 infiltration Methods 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
229910052742 iron Inorganic materials 0.000 description 3
210000003734 kidney Anatomy 0.000 description 3
239000004816 latex Substances 0.000 description 3
229920000126 latex Polymers 0.000 description 3
229940091348 latex Drugs 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
239000003120 macrolide antibiotic agent Substances 0.000 description 3
239000011572 manganese Substances 0.000 description 3
239000012528 membrane Substances 0.000 description 3
210000004379 membrane Anatomy 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
244000000010 microbial pathogen Species 0.000 description 3
238000010369 molecular cloning Methods 0.000 description 3
210000004400 mucous membrane Anatomy 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
231100000344 non-irritating Toxicity 0.000 description 3
235000016709 nutrition Nutrition 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
230000001575 pathological effect Effects 0.000 description 3
230000035515 penetration Effects 0.000 description 3
229940067631 phospholipid Drugs 0.000 description 3
150000003904 phospholipids Chemical class 0.000 description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
235000015497 potassium bicarbonate Nutrition 0.000 description 3
239000011736 potassium bicarbonate Substances 0.000 description 3
229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
230000035755 proliferation Effects 0.000 description 3
239000003380 propellant Substances 0.000 description 3
150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 3
229930002330 retinoic acid Natural products 0.000 description 3
229940057910 shea butter Drugs 0.000 description 3
239000000377 silicon dioxide Substances 0.000 description 3
239000004332 silver Substances 0.000 description 3
229910052709 silver Inorganic materials 0.000 description 3
210000004927 skin cell Anatomy 0.000 description 3
230000037380 skin damage Effects 0.000 description 3
206010040872 skin infection Diseases 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
235000019333 sodium laurylsulphate Nutrition 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
210000002784 stomach Anatomy 0.000 description 3
150000005846 sugar alcohols Polymers 0.000 description 3
230000000475 sunscreen effect Effects 0.000 description 3
239000000516 sunscreening agent Substances 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
239000000375 suspending agent Substances 0.000 description 3
238000010189 synthetic method Methods 0.000 description 3
239000003826 tablet Substances 0.000 description 3
235000013616 tea Nutrition 0.000 description 3
238000012360 testing method Methods 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 3
229960000984 tocofersolan Drugs 0.000 description 3
229930003799 tocopherol Natural products 0.000 description 3
229960001295 tocopherol Drugs 0.000 description 3
231100000419 toxicity Toxicity 0.000 description 3
230000001988 toxicity Effects 0.000 description 3
230000014616 translation Effects 0.000 description 3
229960001727 tretinoin Drugs 0.000 description 3
235000019155 vitamin A Nutrition 0.000 description 3
239000011719 vitamin A Substances 0.000 description 3
235000019154 vitamin C Nutrition 0.000 description 3
239000011718 vitamin C Substances 0.000 description 3
235000019165 vitamin E Nutrition 0.000 description 3
239000011709 vitamin E Substances 0.000 description 3
239000000341 volatile oil Substances 0.000 description 3
229920001285 xanthan gum Polymers 0.000 description 3
235000010493 xanthan gum Nutrition 0.000 description 3
239000000230 xanthan gum Substances 0.000 description 3
229940082509 xanthan gum Drugs 0.000 description 3
235000004835 α-tocopherol Nutrition 0.000 description 3
239000002076 α-tocopherol Substances 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 description 2
DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 2
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 2
TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 2
AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
229910000497 Amalgam Inorganic materials 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 description 2
108010050820 Antimicrobial Cationic Peptides Proteins 0.000 description 2
102000014133 Antimicrobial Cationic Peptides Human genes 0.000 description 2
108010087765 Antipain Proteins 0.000 description 2
241000837162 Astragalus aureus Species 0.000 description 2
241000416162 Astragalus gummifer Species 0.000 description 2
208000035985 Body Odor Diseases 0.000 description 2
235000007689 Borago officinalis Nutrition 0.000 description 2
240000004355 Borago officinalis Species 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
235000003880 Calendula Nutrition 0.000 description 2
240000001432 Calendula officinalis Species 0.000 description 2
241000222122 Candida albicans Species 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
108010076119 Caseins Proteins 0.000 description 2
102000019034 Chemokines Human genes 0.000 description 2
108010012236 Chemokines Proteins 0.000 description 2
208000035473 Communicable disease Diseases 0.000 description 2
235000010919 Copernicia prunifera Nutrition 0.000 description 2
244000180278 Copernicia prunifera Species 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
229920000742 Cotton Polymers 0.000 description 2
235000003392 Curcuma domestica Nutrition 0.000 description 2
244000008991 Curcuma longa Species 0.000 description 2
102000004127 Cytokines Human genes 0.000 description 2
108090000695 Cytokines Proteins 0.000 description 2
241000701022 Cytomegalovirus Species 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 2
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
244000000626 Daucus carota Species 0.000 description 2
235000002767 Daucus carota Nutrition 0.000 description 2
206010011985 Decubitus ulcer Diseases 0.000 description 2
206010056340 Diabetic ulcer Diseases 0.000 description 2
240000002943 Elettaria cardamomum Species 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
241000194031 Enterococcus faecium Species 0.000 description 2
229920002444 Exopolysaccharide Polymers 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
241000711549 Hepacivirus C Species 0.000 description 2
241000701044 Human gammaherpesvirus 4 Species 0.000 description 2
241000725303 Human immunodeficiency virus Species 0.000 description 2
241000701806 Human papillomavirus Species 0.000 description 2
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
235000013628 Lantana involucrata Nutrition 0.000 description 2
240000005183 Lantana involucrata Species 0.000 description 2
240000003553 Leptospermum scoparium Species 0.000 description 2
235000016887 Leptospermum scoparium Nutrition 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
244000246386 Mentha pulegium Species 0.000 description 2
235000016257 Mentha pulegium Nutrition 0.000 description 2
235000004357 Mentha x piperita Nutrition 0.000 description 2
206010073456 Microcolon Diseases 0.000 description 2
235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
VFFNZZXXTGXBOG-UHFFFAOYSA-N N-butanoyl-L-homoserine lactone Natural products CCCC(=O)NC1CCOC1=O VFFNZZXXTGXBOG-UHFFFAOYSA-N 0.000 description 2
YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
208000001388 Opportunistic Infections Diseases 0.000 description 2
244000025272 Persea americana Species 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
235000009827 Prunus armeniaca Nutrition 0.000 description 2
244000018633 Prunus armeniaca Species 0.000 description 2
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
240000000528 Ricinus communis Species 0.000 description 2
235000004443 Ricinus communis Nutrition 0.000 description 2
241000714474 Rous sarcoma virus Species 0.000 description 2
235000003500 Ruscus aculeatus Nutrition 0.000 description 2
206010040070 Septic Shock Diseases 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
229910000831 Steel Inorganic materials 0.000 description 2
235000016639 Syzygium aromaticum Nutrition 0.000 description 2
244000223014 Syzygium aromaticum Species 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
244000269722 Thea sinensis Species 0.000 description 2
229920002807 Thiomer Polymers 0.000 description 2
235000007303 Thymus vulgaris Nutrition 0.000 description 2
240000002657 Thymus vulgaris Species 0.000 description 2
229920001615 Tragacanth Polymers 0.000 description 2
241000251539 Vertebrata <Metazoa> Species 0.000 description 2
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
229930003268 Vitamin C Natural products 0.000 description 2
229930003427 Vitamin E Natural products 0.000 description 2
235000009754 Vitis X bourquina Nutrition 0.000 description 2
235000012333 Vitis X labruscana Nutrition 0.000 description 2
240000006365 Vitis vinifera Species 0.000 description 2
235000014787 Vitis vinifera Nutrition 0.000 description 2
241000710886 West Nile virus Species 0.000 description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
235000006886 Zingiber officinale Nutrition 0.000 description 2
244000273928 Zingiber officinale Species 0.000 description 2
DSNRWDQKZIEDDB-GCMPNPAFSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-GCMPNPAFSA-N 0.000 description 2
238000005299 abrasion Methods 0.000 description 2
229960004308 acetylcysteine Drugs 0.000 description 2
230000009471 action Effects 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
235000004279 alanine Nutrition 0.000 description 2
229950010221 alexidine Drugs 0.000 description 2
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 2
239000003513 alkali Substances 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
230000004075 alteration Effects 0.000 description 2
150000001408 amides Chemical class 0.000 description 2
239000002280 amphoteric surfactant Substances 0.000 description 2
210000004102 animal cell Anatomy 0.000 description 2
230000008485 antagonism Effects 0.000 description 2
230000002924 anti-infective effect Effects 0.000 description 2
SDNYTAYICBFYFH-TUFLPTIASA-N antipain Chemical compound NC(N)=NCCC[C@@H](C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 SDNYTAYICBFYFH-TUFLPTIASA-N 0.000 description 2
210000000436 anus Anatomy 0.000 description 2
239000013011 aqueous formulation Substances 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
238000011882 arthroplasty Methods 0.000 description 2
239000003212 astringent agent Substances 0.000 description 2
CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
230000007921 bacterial pathogenicity Effects 0.000 description 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
210000000270 basal cell Anatomy 0.000 description 2
229960000686 benzalkonium chloride Drugs 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
239000007844 bleaching agent Substances 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
210000003123 bronchiole Anatomy 0.000 description 2
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
229960005069 calcium Drugs 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
229960003563 calcium carbonate Drugs 0.000 description 2
235000010216 calcium carbonate Nutrition 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
229940095731 candida albicans Drugs 0.000 description 2
229960002504 capsaicin Drugs 0.000 description 2
235000017663 capsaicin Nutrition 0.000 description 2
239000004202 carbamide Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
229940105329 carboxymethylcellulose Drugs 0.000 description 2
239000005018 casein Substances 0.000 description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
230000032823 cell division Effects 0.000 description 2
150000001783 ceramides Chemical class 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
230000004087 circulation Effects 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
230000000112 colonic effect Effects 0.000 description 2
239000000356 contaminant Substances 0.000 description 2
238000011109 contamination Methods 0.000 description 2
238000013270 controlled release Methods 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
235000003373 curcuma longa Nutrition 0.000 description 2
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
230000007547 defect Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
230000008021 deposition Effects 0.000 description 2
238000000151 deposition Methods 0.000 description 2
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 2
MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
239000002270 dispersing agent Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
239000000975 dye Substances 0.000 description 2
210000003238 esophagus Anatomy 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
230000002550 fecal effect Effects 0.000 description 2
229940013317 fish oils Drugs 0.000 description 2
SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 2
229960002390 flurbiprofen Drugs 0.000 description 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
235000013305 food Nutrition 0.000 description 2
235000020664 gamma-linolenic acid Nutrition 0.000 description 2
FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 2
239000007789 gas Substances 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
235000008397 ginger Nutrition 0.000 description 2
239000011521 glass Substances 0.000 description 2
210000004565 granule cell Anatomy 0.000 description 2
235000002532 grape seed extract Nutrition 0.000 description 2
235000009569 green tea Nutrition 0.000 description 2
238000000227 grinding Methods 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
239000010460 hemp oil Substances 0.000 description 2
229960004867 hexetidine Drugs 0.000 description 2
235000001050 hortel pimenta Nutrition 0.000 description 2
229960000890 hydrocortisone Drugs 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 description 2
229920001477 hydrophilic polymer Polymers 0.000 description 2
BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
210000002865 immune cell Anatomy 0.000 description 2
230000001771 impaired effect Effects 0.000 description 2
230000006872 improvement Effects 0.000 description 2
229960000905 indomethacin Drugs 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000007914 intraventricular administration Methods 0.000 description 2
230000007794 irritation Effects 0.000 description 2
229960003350 isoniazid Drugs 0.000 description 2
QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 2
210000001503 joint Anatomy 0.000 description 2
229940067606 lecithin Drugs 0.000 description 2
235000010445 lecithin Nutrition 0.000 description 2
239000000787 lecithin Substances 0.000 description 2
239000000944 linseed oil Substances 0.000 description 2
235000021388 linseed oil Nutrition 0.000 description 2
239000012669 liquid formulation Substances 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
229940041033 macrolides Drugs 0.000 description 2
210000002540 macrophage Anatomy 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229960001855 mannitol Drugs 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 2
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
235000010981 methylcellulose Nutrition 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000004530 micro-emulsion Substances 0.000 description 2
239000002480 mineral oil Substances 0.000 description 2
230000037230 mobility Effects 0.000 description 2
210000004877 mucosa Anatomy 0.000 description 2
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
239000006199 nebulizer Substances 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
229960003512 nicotinic acid Drugs 0.000 description 2
235000001968 nicotinic acid Nutrition 0.000 description 2
239000011664 nicotinic acid Substances 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
229960001774 octenidine Drugs 0.000 description 2
SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 2
229940114496 olive leaf extract Drugs 0.000 description 2
239000004006 olive oil Substances 0.000 description 2
235000008390 olive oil Nutrition 0.000 description 2
235000020660 omega-3 fatty acid Nutrition 0.000 description 2
229940012843 omega-3 fatty acid Drugs 0.000 description 2
239000006014 omega-3 oil Substances 0.000 description 2
150000002902 organometallic compounds Chemical class 0.000 description 2
RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 2
230000036407 pain Effects 0.000 description 2
LSTDYDRCKUBPDI-UHFFFAOYSA-N palmityl acetate Chemical compound CCCCCCCCCCCCCCCCOC(C)=O LSTDYDRCKUBPDI-UHFFFAOYSA-N 0.000 description 2
210000000496 pancreas Anatomy 0.000 description 2
229940101267 panthenol Drugs 0.000 description 2
235000020957 pantothenol Nutrition 0.000 description 2
239000011619 pantothenol Substances 0.000 description 2
230000001717 pathogenic effect Effects 0.000 description 2
230000007170 pathology Effects 0.000 description 2
239000002304 perfume Substances 0.000 description 2
230000002085 persistent effect Effects 0.000 description 2
229940124531 pharmaceutical excipient Drugs 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
239000000419 plant extract Substances 0.000 description 2
230000010287 polarization Effects 0.000 description 2
229920001983 poloxamer Polymers 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
229920005862 polyol Polymers 0.000 description 2
150000003077 polyols Chemical class 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
235000013824 polyphenols Nutrition 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
230000001737 promoting effect Effects 0.000 description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
238000001243 protein synthesis Methods 0.000 description 2
239000000376 reactant Substances 0.000 description 2
210000000664 rectum Anatomy 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
229960000885 rifabutin Drugs 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
230000028327 secretion Effects 0.000 description 2
230000036303 septic shock Effects 0.000 description 2
230000035939 shock Effects 0.000 description 2
229920002545 silicone oil Polymers 0.000 description 2
230000037384 skin absorption Effects 0.000 description 2
231100000274 skin absorption Toxicity 0.000 description 2
210000001626 skin fibroblast Anatomy 0.000 description 2
239000002002 slurry Substances 0.000 description 2
150000003384 small molecules Chemical class 0.000 description 2
229940005550 sodium alginate Drugs 0.000 description 2
235000010413 sodium alginate Nutrition 0.000 description 2
239000000661 sodium alginate Substances 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical class [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 2
239000008247 solid mixture Substances 0.000 description 2
150000003408 sphingolipids Chemical class 0.000 description 2
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
BILPUZXRUDPOOF-UHFFFAOYSA-N stearyl palmitate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC BILPUZXRUDPOOF-UHFFFAOYSA-N 0.000 description 2
239000010959 steel Substances 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
230000035882 stress Effects 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
229940124530 sulfonamide Drugs 0.000 description 2
150000003456 sulfonamides Chemical class 0.000 description 2
239000000829 suppository Substances 0.000 description 2
230000002459 sustained effect Effects 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
230000009885 systemic effect Effects 0.000 description 2
239000010677 tea tree oil Substances 0.000 description 2
229940111630 tea tree oil Drugs 0.000 description 2
229940040944 tetracyclines Drugs 0.000 description 2
DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 description 2
125000003396 thiol group Chemical group [H]S* 0.000 description 2
239000001585 thymus vulgaris Substances 0.000 description 2
230000000451 tissue damage Effects 0.000 description 2
231100000827 tissue damage Toxicity 0.000 description 2
230000007838 tissue remodeling Effects 0.000 description 2
235000010384 tocopherol Nutrition 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
238000013518 transcription Methods 0.000 description 2
230000035897 transcription Effects 0.000 description 2
230000000472 traumatic effect Effects 0.000 description 2
150000004072 triols Chemical class 0.000 description 2
235000013976 turmeric Nutrition 0.000 description 2
210000003932 urinary bladder Anatomy 0.000 description 2
229940046009 vitamin E Drugs 0.000 description 2
229940045997 vitamin a Drugs 0.000 description 2
230000002087 whitening effect Effects 0.000 description 2
235000010447 xylitol Nutrition 0.000 description 2
239000000811 xylitol Substances 0.000 description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
229960002675 xylitol Drugs 0.000 description 2
WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 2
PZZKGQBMBVYPGR-UHFFFAOYSA-N η-tocopherol Chemical compound OC1=C(C)C=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 PZZKGQBMBVYPGR-UHFFFAOYSA-N 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 description 1
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 description 1
DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 1
CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
VCOPTHOUUNAYKQ-WBTCAYNUSA-N (3s)-3,6-diamino-n-[[(2s,5s,8e,11s,15s)-15-amino-11-[(6r)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide;(3s)-3,6-diamino-n-[[(2s,5s,8 Chemical compound N1C(=O)\C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC(=O)[C@@H]1[C@@H]1NC(N)=NCC1.N1C(=O)\C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@@H]1[C@@H]1NC(N)=NCC1 VCOPTHOUUNAYKQ-WBTCAYNUSA-N 0.000 description 1
HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 1
KAKVFSYQVNHFBS-UHFFFAOYSA-N (5-hydroxycyclopenten-1-yl)-phenylmethanone Chemical compound OC1CCC=C1C(=O)C1=CC=CC=C1 KAKVFSYQVNHFBS-UHFFFAOYSA-N 0.000 description 1
WKJGTOYAEQDNIA-IOOZKYRYSA-N (6r,7r)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 WKJGTOYAEQDNIA-IOOZKYRYSA-N 0.000 description 1
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
FGYKUFVNYVMTAM-UHFFFAOYSA-N (R)-2,5,8-trimethyl-2-(4,8,12-trimethyl-trideca-3t,7t,11-trienyl)-chroman-6-ol Natural products OC1=CC(C)=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-UHFFFAOYSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 description 1
LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical compound CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 description 1
AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
PDFKFLNYRFAWOA-UHFFFAOYSA-N 1-fluoroquinolin-2-one Chemical compound C1=CC=C2C=CC(=O)N(F)C2=C1 PDFKFLNYRFAWOA-UHFFFAOYSA-N 0.000 description 1
ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
IKVISLWYYHGTTN-UHFFFAOYSA-N 11-bromoundecane-1-thiol Chemical compound SCCCCCCCCCCCBr IKVISLWYYHGTTN-UHFFFAOYSA-N 0.000 description 1
KFEASMMSZNLDSB-UHFFFAOYSA-N 12-(12-hydroxydodecoxy)dodecan-1-ol Chemical compound OCCCCCCCCCCCCOCCCCCCCCCCCCO KFEASMMSZNLDSB-UHFFFAOYSA-N 0.000 description 1
XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 1
SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 description 1
FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
KUXGUCNZFCVULO-UHFFFAOYSA-N 2-(4-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=C(OCCO)C=C1 KUXGUCNZFCVULO-UHFFFAOYSA-N 0.000 description 1
NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
QVRMIJZFODZFNE-UHFFFAOYSA-N 2-[dimethyl-[3-(octadecanoylamino)propyl]azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O QVRMIJZFODZFNE-UHFFFAOYSA-N 0.000 description 1
CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 1
SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
ZGVSZORIRFNOCF-UHFFFAOYSA-N 2-fluoro-7-nitro-9h-fluorene Chemical compound FC1=CC=C2C3=CC=C([N+](=O)[O-])C=C3CC2=C1 ZGVSZORIRFNOCF-UHFFFAOYSA-N 0.000 description 1
BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 description 1
KNUPSOXBESCJLY-UHFFFAOYSA-N 2-methoxy-1-phenylhexan-1-one Chemical compound CCCCC(OC)C(=O)C1=CC=CC=C1 KNUPSOXBESCJLY-UHFFFAOYSA-N 0.000 description 1
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
RZLZXKPCGOYHPS-UHFFFAOYSA-N 3h-dithiole;ethanol Chemical compound CCO.C1SSC=C1 RZLZXKPCGOYHPS-UHFFFAOYSA-N 0.000 description 1
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
229930183010 Amphotericin Natural products 0.000 description 1
QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
206010062542 Arterial insufficiency Diseases 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
235000007319 Avena orientalis Nutrition 0.000 description 1
235000007558 Avena sp Nutrition 0.000 description 1
108010077805 Bacterial Proteins Proteins 0.000 description 1
108010062877 Bacteriocins Proteins 0.000 description 1
108010081589 Becaplermin Proteins 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
239000004342 Benzoyl peroxide Substances 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
229920002498 Beta-glucan Polymers 0.000 description 1
235000018185 Betula X alpestris Nutrition 0.000 description 1
235000018212 Betula X uliginosa Nutrition 0.000 description 1
235000002992 Betula pubescens Nutrition 0.000 description 1
241001520764 Betula pubescens Species 0.000 description 1
241000271935 Bitis Species 0.000 description 1
208000019838 Blood disease Diseases 0.000 description 1
239000004604 Blowing Agent Substances 0.000 description 1
108010004032 Bromelains Proteins 0.000 description 1
LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
241000020731 Burkholderia multivorans Species 0.000 description 1
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
ZDHZPDWQZYZYCR-IHVLYLRMSA-N C(C)(=O)N[C@@H](CO)[C@H](O)\C(=C(\CCCCCCCCCCCCC)/Cl)\Cl Chemical compound C(C)(=O)N[C@@H](CO)[C@H](O)\C(=C(\CCCCCCCCCCCCC)/Cl)\Cl ZDHZPDWQZYZYCR-IHVLYLRMSA-N 0.000 description 1
XLBTWMLZCZZYRX-UHFFFAOYSA-N C(CCCCCCCCCCC)(=O)OCC(OC(CCCCCCCCCCC)=O)CO.C=CC Chemical compound C(CCCCCCCCCCC)(=O)OCC(OC(CCCCCCCCCCC)=O)CO.C=CC XLBTWMLZCZZYRX-UHFFFAOYSA-N 0.000 description 1
239000002126 C01EB10 - Adenosine Substances 0.000 description 1
YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
HTYVUMLKONJGAJ-KPNWGBFJSA-N CC(C)CCC[C@@H](C)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2[C@@](C)(CC[C@@H](C2)O)C2=CC1.C[N+](C)(C)CCOP([O-])(O)=O Chemical compound CC(C)CCC[C@@H](C)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2[C@@](C)(CC[C@@H](C2)O)C2=CC1.C[N+](C)(C)CCOP([O-])(O)=O HTYVUMLKONJGAJ-KPNWGBFJSA-N 0.000 description 1
239000001736 Calcium glycerylphosphate Substances 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241000144583 Candida dubliniensis Species 0.000 description 1
241000222173 Candida parapsilosis Species 0.000 description 1
241000222178 Candida tropicalis Species 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
108010065839 Capreomycin Proteins 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
241001466804 Carnivora Species 0.000 description 1
QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
108010087806 Carnosine Proteins 0.000 description 1
102000016938 Catalase Human genes 0.000 description 1
108010053835 Catalase Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
229940123150 Chelating agent Drugs 0.000 description 1
208000009043 Chemical Burns Diseases 0.000 description 1
241000532749 Cholus Species 0.000 description 1
241000206575 Chondrus crispus Species 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
208000032544 Cicatrix Diseases 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 description 1
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
235000005320 Coleus barbatus Nutrition 0.000 description 1
239000004821 Contact adhesive Substances 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
206010011409 Cross infection Diseases 0.000 description 1
241001337994 Cryptococcus <scale insect> Species 0.000 description 1
108010052832 Cytochromes Proteins 0.000 description 1
102000018832 Cytochromes Human genes 0.000 description 1
DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 description 1
DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 description 1
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
206010011878 Deafness Diseases 0.000 description 1
XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
206010048768 Dermatosis Diseases 0.000 description 1
229940090898 Desensitizer Drugs 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
208000008960 Diabetic foot Diseases 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
239000004097 EU approved flavor enhancer Substances 0.000 description 1
241000710945 Eastern equine encephalitis virus Species 0.000 description 1
235000018602 Elettaria cardamomum Nutrition 0.000 description 1
102400001368 Epidermal growth factor Human genes 0.000 description 1
101800003838 Epidermal growth factor Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
239000004386 Erythritol Substances 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
241001553290 Euphorbia antisyphilitica Species 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
102000009123 Fibrin Human genes 0.000 description 1
108010073385 Fibrin Proteins 0.000 description 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
102000016359 Fibronectins Human genes 0.000 description 1
108010067306 Fibronectins Proteins 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
240000006927 Foeniculum vulgare Species 0.000 description 1
235000004204 Foeniculum vulgare Nutrition 0.000 description 1
229930191892 Formycin Natural products 0.000 description 1
KBHMEHLJSZMEMI-UHFFFAOYSA-N Formycin A Natural products N1N=C2C(N)=NC=NC2=C1C1OC(CO)C(O)C1O KBHMEHLJSZMEMI-UHFFFAOYSA-N 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
206010017711 Gangrene Diseases 0.000 description 1
102000013382 Gelatinases Human genes 0.000 description 1
108010026132 Gelatinases Proteins 0.000 description 1
BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 1
108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229920002527 Glycogen Polymers 0.000 description 1
229930186217 Glycolipid Natural products 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
208000023329 Gun shot wound Diseases 0.000 description 1
206010019375 Helicobacter infections Diseases 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
241000700721 Hepatitis B virus Species 0.000 description 1
241000709721 Hepatovirus A Species 0.000 description 1
241001272567 Hominoidea Species 0.000 description 1
101000585553 Homo sapiens Glycodelin Proteins 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
206010020649 Hyperkeratosis Diseases 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000029462 Immunodeficiency disease Diseases 0.000 description 1
206010062016 Immunosuppression Diseases 0.000 description 1
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
PKPPDYGHKDIKBH-UHFFFAOYSA-N Isopropyl dodecanoic acid Chemical compound CCCCCCCCCC(=O)OC(C)C PKPPDYGHKDIKBH-UHFFFAOYSA-N 0.000 description 1
208000001126 Keratosis Diseases 0.000 description 1
FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 description 1
201000008225 Klebsiella pneumonia Diseases 0.000 description 1
QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
102000010445 Lactoferrin Human genes 0.000 description 1
108010063045 Lactoferrin Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 1
ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
208000005230 Leg Ulcer Diseases 0.000 description 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
238000005684 Liebig rearrangement reaction Methods 0.000 description 1
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
239000004367 Lipase Substances 0.000 description 1
102000004882 Lipase Human genes 0.000 description 1
108090001060 Lipase Proteins 0.000 description 1
239000000232 Lipid Bilayer Substances 0.000 description 1
108010028921 Lipopeptides Proteins 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
235000017945 Matricaria Nutrition 0.000 description 1
244000042664 Matricaria chamomilla Species 0.000 description 1
235000007232 Matricaria chamomilla Nutrition 0.000 description 1
102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
241000219470 Mirabilis Species 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
229930191564 Monensin Natural products 0.000 description 1
GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
206010028851 Necrosis Diseases 0.000 description 1
206010028885 Necrotising fasciitis Diseases 0.000 description 1
241000183666 Nepsera aquatica Species 0.000 description 1
CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 1
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
208000008589 Obesity Diseases 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
240000007817 Olea europaea Species 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
206010031264 Osteonecrosis Diseases 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
235000016856 Palma redonda Nutrition 0.000 description 1
108010019160 Pancreatin Proteins 0.000 description 1
241000282320 Panthera leo Species 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
206010033799 Paralysis Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
235000008673 Persea americana Nutrition 0.000 description 1
235000011236 Persea americana var americana Nutrition 0.000 description 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
241000131459 Plectranthus barbatus Species 0.000 description 1
206010035717 Pneumonia klebsiella Diseases 0.000 description 1
208000005374 Poisoning Diseases 0.000 description 1
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
241000288906 Primates Species 0.000 description 1
241000588770 Proteus mirabilis Species 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
206010037464 Pulpitis dental Diseases 0.000 description 1
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
206010067362 Radiation necrosis Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
244000178231 Rosmarinus officinalis Species 0.000 description 1
240000000353 Ruscus aculeatus Species 0.000 description 1
GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
206010039792 Seborrhoea Diseases 0.000 description 1
206010040030 Sensory loss Diseases 0.000 description 1
206010040047 Sepsis Diseases 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
108020004682 Single-Stranded DNA Proteins 0.000 description 1
206010040943 Skin Ulcer Diseases 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
206010040904 Skin odour abnormal Diseases 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
241000191984 Staphylococcus haemolyticus Species 0.000 description 1
241000192087 Staphylococcus hominis Species 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
241000122973 Stenotrophomonas maltophilia Species 0.000 description 1
PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
208000014151 Stomatognathic disease Diseases 0.000 description 1
208000004350 Strabismus Diseases 0.000 description 1
241000193985 Streptococcus agalactiae Species 0.000 description 1
241000193996 Streptococcus pyogenes Species 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
206010042971 T-cell lymphoma Diseases 0.000 description 1
208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 1
208000004509 Tooth Discoloration Diseases 0.000 description 1
206010044032 Tooth discolouration Diseases 0.000 description 1
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
208000000558 Varicose Ulcer Diseases 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
206010048031 Wound dehiscence Diseases 0.000 description 1
241000607447 Yersinia enterocolitica Species 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 description 1
HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
HHHRERFRNRFXOV-UHFFFAOYSA-N [4-(6-sulfanylhexoxy)phenyl]methanol Chemical compound OCC1=CC=C(OCCCCCCS)C=C1 HHHRERFRNRFXOV-UHFFFAOYSA-N 0.000 description 1
HBACXWCFUMREGQ-HKTIBRIUSA-N [Bi].SC[C@H](O)[C@H](O)CS Chemical compound [Bi].SC[C@H](O)[C@H](O)CS HBACXWCFUMREGQ-HKTIBRIUSA-N 0.000 description 1
241000222126 [Candida] glabrata Species 0.000 description 1
VTOSQJVMDJZKFV-UHFFFAOYSA-J [Na].[Sn](F)(F)(F)F Chemical class [Na].[Sn](F)(F)(F)F VTOSQJVMDJZKFV-UHFFFAOYSA-J 0.000 description 1
WREOTYWODABZMH-DTZQCDIJSA-N [[(2r,3s,4r,5r)-3,4-dihydroxy-5-[2-oxo-4-(2-phenylethoxyamino)pyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N(C=C\1)C(=O)NC/1=N\OCCC1=CC=CC=C1 WREOTYWODABZMH-DTZQCDIJSA-N 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
239000003082 abrasive agent Substances 0.000 description 1
239000006096 absorbing agent Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
229940048299 acetylated lanolin alcohols Drugs 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000012190 activator Substances 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
229950006790 adenosine phosphate Drugs 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
239000004964 aerogel Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910000287 alkaline earth metal oxide Inorganic materials 0.000 description 1
125000005250 alkyl acrylate group Chemical group 0.000 description 1
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
229960000458 allantoin Drugs 0.000 description 1
229940061720 alpha hydroxy acid Drugs 0.000 description 1
150000001280 alpha hydroxy acids Chemical class 0.000 description 1
150000004716 alpha keto acids Chemical class 0.000 description 1
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
235000020661 alpha-linolenic acid Nutrition 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
229940099583 aluminum starch octenylsuccinate Drugs 0.000 description 1
229940063655 aluminum stearate Drugs 0.000 description 1
OYGSFRHDRNJHBP-UHFFFAOYSA-K aluminum;5-oxopyrrolidine-2-carboxylate Chemical compound [Al+3].[O-]C(=O)C1CCC(=O)N1.[O-]C(=O)C1CCC(=O)N1.[O-]C(=O)C1CCC(=O)N1 OYGSFRHDRNJHBP-UHFFFAOYSA-K 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
229940009444 amphotericin Drugs 0.000 description 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
239000003945 anionic surfactant Substances 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
230000000922 anti-bactericidal effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
238000009635 antibiotic susceptibility testing Methods 0.000 description 1
239000002256 antimetabolite Substances 0.000 description 1
229910052787 antimony Inorganic materials 0.000 description 1
WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
238000013459 approach Methods 0.000 description 1
229960000271 arbutin Drugs 0.000 description 1
229940002359 arnica montana extract Drugs 0.000 description 1
229910052785 arsenic Inorganic materials 0.000 description 1
RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
229940003446 arsphenamine Drugs 0.000 description 1
VLAXZGHHBIJLAD-UHFFFAOYSA-N arsphenamine Chemical compound [Cl-].[Cl-].C1=C(O)C([NH3+])=CC([As]=[As]C=2C=C([NH3+])C(O)=CC=2)=C1 VLAXZGHHBIJLAD-UHFFFAOYSA-N 0.000 description 1
229940072107 ascorbate Drugs 0.000 description 1
235000010385 ascorbyl palmitate Nutrition 0.000 description 1
238000004500 asepsis Methods 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
239000000305 astragalus gummifer gum Substances 0.000 description 1
230000001363 autoimmune Effects 0.000 description 1
XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 1
229960004099 azithromycin Drugs 0.000 description 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
230000006399 behavior Effects 0.000 description 1
230000003542 behavioural effect Effects 0.000 description 1
230000009704 beneficial physiological effect Effects 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
235000019400 benzoyl peroxide Nutrition 0.000 description 1
229960003328 benzoyl peroxide Drugs 0.000 description 1
229940076810 beta sitosterol Drugs 0.000 description 1
229940066595 beta tocopherol Drugs 0.000 description 1
LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
239000011648 beta-carotene Substances 0.000 description 1
235000013734 beta-carotene Nutrition 0.000 description 1
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
229960002747 betacarotene Drugs 0.000 description 1
CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 description 1
229960001102 betamethasone dipropionate Drugs 0.000 description 1
SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 1
229960004311 betamethasone valerate Drugs 0.000 description 1
239000000227 bioadhesive Substances 0.000 description 1
239000003397 biobrane Substances 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
OAIWQXFETFYYAL-UHFFFAOYSA-N bismuth;2,3-bis(sulfanyl)propan-1-ol Chemical compound [Bi].OCC(S)CS OAIWQXFETFYYAL-UHFFFAOYSA-N 0.000 description 1
KQIBYJJNOAYYDX-UHFFFAOYSA-N bismuth;4-methylbenzene-1,2-dithiol Chemical compound [Bi].CC1=CC=C(S)C(S)=C1 KQIBYJJNOAYYDX-UHFFFAOYSA-N 0.000 description 1
UWKREORXVYDKQS-UHFFFAOYSA-N bismuth;butane-2,3-dithiol Chemical compound [Bi].CC(S)C(C)S UWKREORXVYDKQS-UHFFFAOYSA-N 0.000 description 1
AGMILJKWQPEQCU-UHFFFAOYSA-N bismuth;ethane-1,2-dithiol Chemical compound [Bi].SCCS AGMILJKWQPEQCU-UHFFFAOYSA-N 0.000 description 1
XDGVWDBSICZINK-UHFFFAOYSA-N bismuth;propane-1,3-dithiol Chemical compound [Bi].SCCCS XDGVWDBSICZINK-UHFFFAOYSA-N 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
230000036770 blood supply Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
235000019835 bromelain Nutrition 0.000 description 1
210000000621 bronchi Anatomy 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
235000014121 butter Nutrition 0.000 description 1
235000015155 buttermilk Nutrition 0.000 description 1
229960001948 caffeine Drugs 0.000 description 1
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
239000004227 calcium gluconate Substances 0.000 description 1
235000013927 calcium gluconate Nutrition 0.000 description 1
229960004494 calcium gluconate Drugs 0.000 description 1
UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
229940095618 calcium glycerophosphate Drugs 0.000 description 1
235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
239000001527 calcium lactate Substances 0.000 description 1
235000011086 calcium lactate Nutrition 0.000 description 1
229960002401 calcium lactate Drugs 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
208000035269 cancer or benign tumor Diseases 0.000 description 1
208000032343 candida glabrata infection Diseases 0.000 description 1
239000000828 canola oil Substances 0.000 description 1
235000019519 canola oil Nutrition 0.000 description 1
229960004602 capreomycin Drugs 0.000 description 1
235000013877 carbamide Nutrition 0.000 description 1
229940041011 carbapenems Drugs 0.000 description 1
229960004399 carbocisteine Drugs 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
235000005300 cardamomo Nutrition 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
229940044199 carnosine Drugs 0.000 description 1
CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
230000030833 cell death Effects 0.000 description 1
230000012292 cell migration Effects 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000008614 cellular interaction Effects 0.000 description 1
ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
229940073669 ceteareth 20 Drugs 0.000 description 1
229940049297 cetyl acetate Drugs 0.000 description 1
229940074979 cetyl palmitate Drugs 0.000 description 1
210000003467 cheek Anatomy 0.000 description 1
230000009920 chelation Effects 0.000 description 1
MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
229940114081 cinnamate Drugs 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
239000012459 cleaning agent Substances 0.000 description 1
238000011281 clinical therapy Methods 0.000 description 1
CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 1
229960004703 clobetasol propionate Drugs 0.000 description 1
238000010367 cloning Methods 0.000 description 1
229960004022 clotrimazole Drugs 0.000 description 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
230000009852 coagulant defect Effects 0.000 description 1
239000011280 coal tar Substances 0.000 description 1
239000008199 coating composition Substances 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
235000017471 coenzyme Q10 Nutrition 0.000 description 1
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
230000005757 colony formation Effects 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
229940125773 compound 10 Drugs 0.000 description 1
229940125797 compound 12 Drugs 0.000 description 1
229940126543 compound 14 Drugs 0.000 description 1
229940125758 compound 15 Drugs 0.000 description 1
229940125898 compound 5 Drugs 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
230000008602 contraction Effects 0.000 description 1
150000004696 coordination complex Chemical class 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
239000003246 corticosteroid Substances 0.000 description 1
229960001334 corticosteroids Drugs 0.000 description 1
BMCQMVFGOVHVNG-TUFAYURCSA-N cortisol 17-butyrate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O BMCQMVFGOVHVNG-TUFAYURCSA-N 0.000 description 1
ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
229960003338 crotamiton Drugs 0.000 description 1
DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 1
239000012043 crude product Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
229940086555 cyclomethicone Drugs 0.000 description 1
229960003077 cycloserine Drugs 0.000 description 1
AZSFNUJOCKMOGB-UHFFFAOYSA-K cyclotriphosphate(3-) Chemical compound [O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-K 0.000 description 1
238000001804 debridement Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000008260 defense mechanism Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000001934 delay Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
235000010389 delta-tocopherol Nutrition 0.000 description 1
210000003298 dental enamel Anatomy 0.000 description 1
239000002781 deodorant agent Substances 0.000 description 1
238000004332 deodorization Methods 0.000 description 1
230000001877 deodorizing effect Effects 0.000 description 1
230000000881 depressing effect Effects 0.000 description 1
210000004207 dermis Anatomy 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
238000013461 design Methods 0.000 description 1
229960000633 dextran sulfate Drugs 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
229940039227 diagnostic agent Drugs 0.000 description 1
239000000032 diagnostic agent Substances 0.000 description 1
MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical class C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
229940062933 dimethylsilanol hyaluronate Drugs 0.000 description 1
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
150000002009 diols Chemical class 0.000 description 1
FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
229960004960 dioxybenzone Drugs 0.000 description 1
229960000520 diphenhydramine Drugs 0.000 description 1
235000011180 diphosphates Nutrition 0.000 description 1
IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
229960002768 dipyridamole Drugs 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
229960000735 docosanol Drugs 0.000 description 1
KHAYCTOSKLIHEP-UHFFFAOYSA-N docosyl prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC(=O)C=C KHAYCTOSKLIHEP-UHFFFAOYSA-N 0.000 description 1
229960000878 docusate sodium Drugs 0.000 description 1
TWFQJFPTTMIETC-UHFFFAOYSA-N dodecan-1-amine;hydron;chloride Chemical compound [Cl-].CCCCCCCCCCCC[NH3+] TWFQJFPTTMIETC-UHFFFAOYSA-N 0.000 description 1
HJXPPCPJEYUQFQ-HNNXBMFYSA-N dodecyl (2s)-5-oxopyrrolidine-2-carboxylate Chemical compound CCCCCCCCCCCCOC(=O)[C@@H]1CCC(=O)N1 HJXPPCPJEYUQFQ-HNNXBMFYSA-N 0.000 description 1
XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 description 1
230000003828 downregulation Effects 0.000 description 1
239000000890 drug combination Substances 0.000 description 1
241001493065 dsRNA viruses Species 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
229940037395 electrolytes Drugs 0.000 description 1
230000003511 endothelial effect Effects 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
229960003720 enoxolone Drugs 0.000 description 1
239000002702 enteric coating Substances 0.000 description 1
238000009505 enteric coating Methods 0.000 description 1
231100000249 enterotoxic Toxicity 0.000 description 1
230000002242 enterotoxic effect Effects 0.000 description 1
229940116977 epidermal growth factor Drugs 0.000 description 1
FGYKUFVNYVMTAM-MUUNZHRXSA-N epsilon-Tocopherol Natural products OC1=CC(C)=C2O[C@@](CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-MUUNZHRXSA-N 0.000 description 1
229960002061 ergocalciferol Drugs 0.000 description 1
DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
230000003628 erosive effect Effects 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
229940009714 erythritol Drugs 0.000 description 1
235000019414 erythritol Nutrition 0.000 description 1
235000004626 essential fatty acids Nutrition 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 description 1
229960002001 ethionamide Drugs 0.000 description 1
HGCRMXNQSAARKC-UHFFFAOYSA-N ethyl 2-methyl-4-propylpyrimidine-5-carboxylate Chemical compound CCCC1=NC(C)=NC=C1C(=O)OCC HGCRMXNQSAARKC-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
229960004667 ethyl cellulose Drugs 0.000 description 1
DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
238000004299 exfoliation Methods 0.000 description 1
210000003414 extremity Anatomy 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
210000000887 face Anatomy 0.000 description 1
150000002194 fatty esters Chemical class 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
230000019305 fibroblast migration Effects 0.000 description 1
239000010408 film Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000021323 fish oil Nutrition 0.000 description 1
238000007667 floating Methods 0.000 description 1
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical class FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
229960000304 folic acid Drugs 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
235000019264 food flavour enhancer Nutrition 0.000 description 1
230000037406 food intake Effects 0.000 description 1
KBHMEHLJSZMEMI-KSYZLYKTSA-N formycin A Chemical compound N=1NC=2C(N)=NC=NC=2C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O KBHMEHLJSZMEMI-KSYZLYKTSA-N 0.000 description 1
YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 description 1
208000024386 fungal infectious disease Diseases 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
229960004675 fusidic acid Drugs 0.000 description 1
IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 description 1
FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
210000000232 gallbladder Anatomy 0.000 description 1
235000010382 gamma-tocopherol Nutrition 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
229910052732 germanium Inorganic materials 0.000 description 1
GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
208000024693 gingival disease Diseases 0.000 description 1
230000000762 glandular Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
229940096919 glycogen Drugs 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
229930182470 glycoside Natural products 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
150000002339 glycosphingolipids Chemical class 0.000 description 1
229940087559 grape seed Drugs 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
210000003780 hair follicle Anatomy 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
230000010370 hearing loss Effects 0.000 description 1
231100000888 hearing loss Toxicity 0.000 description 1
208000016354 hearing loss disease Diseases 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
208000014951 hematologic disease Diseases 0.000 description 1
208000018706 hematopoietic system disease Diseases 0.000 description 1
244000144980 herd Species 0.000 description 1
SNXYIOIMZXSIDC-UHFFFAOYSA-A hexadecasodium;phosphonato phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O SNXYIOIMZXSIDC-UHFFFAOYSA-A 0.000 description 1
XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 description 1
229940005740 hexametaphosphate Drugs 0.000 description 1
210000003630 histaminocyte Anatomy 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000005745 host immune response Effects 0.000 description 1
229960001524 hydrocortisone butyrate Drugs 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
229960004337 hydroquinone Drugs 0.000 description 1
150000001261 hydroxy acids Chemical class 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
229940113174 imidurea Drugs 0.000 description 1
229960002182 imipenem Drugs 0.000 description 1
ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
230000002519 immonomodulatory effect Effects 0.000 description 1
230000028993 immune response Effects 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
230000006698 induction Effects 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
230000010354 integration Effects 0.000 description 1
230000031891 intestinal absorption Effects 0.000 description 1
229940079905 intestinal adsorbents bismuth preparations Drugs 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
230000002262 irrigation Effects 0.000 description 1
238000003973 irrigation Methods 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
229940119170 jojoba wax Drugs 0.000 description 1
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
229960004125 ketoconazole Drugs 0.000 description 1
239000003835 ketolide antibiotic agent Substances 0.000 description 1
QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 description 1
229960001669 kinetin Drugs 0.000 description 1
BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
229960004705 kojic acid Drugs 0.000 description 1
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
238000002372 labelling Methods 0.000 description 1
229940089440 lactinol Drugs 0.000 description 1
239000000832 lactitol Substances 0.000 description 1
235000010448 lactitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
229960003451 lactitol Drugs 0.000 description 1
229940078795 lactoferrin Drugs 0.000 description 1
235000021242 lactoferrin Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940058690 lanosterol Drugs 0.000 description 1
CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
210000000867 larynx Anatomy 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
229940049918 linoleate Drugs 0.000 description 1
229960004488 linolenic acid Drugs 0.000 description 1
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
229940040461 lipase Drugs 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
208000018773 low birth weight Diseases 0.000 description 1
231100000533 low birth weight Toxicity 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
239000006166 lysate Substances 0.000 description 1
229960003646 lysine Drugs 0.000 description 1
235000018977 lysine Nutrition 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
229940045184 malt extract Drugs 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
238000013160 medical therapy Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
210000002752 melanocyte Anatomy 0.000 description 1
230000003061 melanogenesis Effects 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
210000002418 meninge Anatomy 0.000 description 1
230000003340 mental effect Effects 0.000 description 1
239000001525 mentha piperita l. herb oil Substances 0.000 description 1
239000001683 mentha spicata herb oil Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
238000013508 migration Methods 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
229960003632 minoxidil Drugs 0.000 description 1
239000003607 modifier Substances 0.000 description 1
230000004001 molecular interaction Effects 0.000 description 1
229960005358 monensin Drugs 0.000 description 1
GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
210000002200 mouth mucosa Anatomy 0.000 description 1
230000003232 mucoadhesive effect Effects 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
210000004165 myocardium Anatomy 0.000 description 1
210000000651 myofibroblast Anatomy 0.000 description 1
210000001087 myotubule Anatomy 0.000 description 1
229940105132 myristate Drugs 0.000 description 1
GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 description 1
229960000515 nafcillin Drugs 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
229940097496 nasal spray Drugs 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
210000003739 neck Anatomy 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
201000007970 necrotizing fasciitis Diseases 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
201000001119 neuropathy Diseases 0.000 description 1
230000007823 neuropathy Effects 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
235000005152 nicotinamide Nutrition 0.000 description 1
229960003966 nicotinamide Drugs 0.000 description 1
239000011570 nicotinamide Substances 0.000 description 1
IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
229960001907 nitrofurazone Drugs 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
231100001223 noncarcinogenic Toxicity 0.000 description 1
229940073555 nonoxynol-10 Drugs 0.000 description 1
229940073554 nonoxynol-30 Drugs 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
230000000050 nutritive effect Effects 0.000 description 1
229960000988 nystatin Drugs 0.000 description 1
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
235000020824 obesity Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
229960001679 octinoxate Drugs 0.000 description 1
229960003921 octisalate Drugs 0.000 description 1
WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
229940055577 oleyl alcohol Drugs 0.000 description 1
238000002515 oligonucleotide synthesis Methods 0.000 description 1
229940041672 oral gel Drugs 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
239000000668 oral spray Substances 0.000 description 1
229940041678 oral spray Drugs 0.000 description 1
239000007968 orange flavor Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000011368 organic material Substances 0.000 description 1
230000008520 organization Effects 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
229960001019 oxacillin Drugs 0.000 description 1
DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
229960001173 oxybenzone Drugs 0.000 description 1
BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
239000003973 paint Substances 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229940055695 pancreatin Drugs 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
235000019809 paraffin wax Nutrition 0.000 description 1
210000003695 paranasal sinus Anatomy 0.000 description 1
244000045947 parasite Species 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
229940100460 peg-100 stearate Drugs 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
208000011906 peptic ulcer disease Diseases 0.000 description 1
229940101070 pepto-bismol Drugs 0.000 description 1
231100000435 percutaneous penetration Toxicity 0.000 description 1
239000010702 perfluoropolyether Substances 0.000 description 1
230000003239 periodontal effect Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
230000035699 permeability Effects 0.000 description 1
125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000003209 petroleum derivative Substances 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
229960002036 phenytoin Drugs 0.000 description 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229940068065 phytosterols Drugs 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 description 1
229960002292 piperacillin Drugs 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
239000010773 plant oil Substances 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
239000001967 plate count agar Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
239000002574 poison Substances 0.000 description 1
231100000572 poisoning Toxicity 0.000 description 1
230000000607 poisoning effect Effects 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229960000502 poloxamer Drugs 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
108091033319 polynucleotide Proteins 0.000 description 1
102000040430 polynucleotide Human genes 0.000 description 1
239000002157 polynucleotide Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
229940094025 potassium bicarbonate Drugs 0.000 description 1
KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
229960002816 potassium chloride Drugs 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
235000010333 potassium nitrate Nutrition 0.000 description 1
239000004323 potassium nitrate Substances 0.000 description 1
239000001472 potassium tartrate Substances 0.000 description 1
229940111695 potassium tartrate Drugs 0.000 description 1
235000011005 potassium tartrates Nutrition 0.000 description 1
229960001896 pramocaine Drugs 0.000 description 1
DQKXQSGTHWVTAD-UHFFFAOYSA-N pramocaine Chemical compound C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 DQKXQSGTHWVTAD-UHFFFAOYSA-N 0.000 description 1
230000002028 premature Effects 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
238000012545 processing Methods 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
229940026235 propylene glycol monolaurate Drugs 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
239000011241 protective layer Substances 0.000 description 1
IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000010791 quenching Methods 0.000 description 1
230000000171 quenching effect Effects 0.000 description 1
235000005875 quercetin Nutrition 0.000 description 1
229960001285 quercetin Drugs 0.000 description 1
229960005442 quinupristin Drugs 0.000 description 1
WTHRRGMBUAHGNI-LCYNINFDSA-N quinupristin Chemical compound N([C@@H]1C(=O)N[C@@H](C(N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(=CC=2)N(C)C)C(=O)N2C[C@@H](CS[C@H]3C4CCN(CC4)C3)C(=O)C[C@H]2C(=O)N[C@H](C(=O)O[C@@H]1C)C=1C=CC=CC=1)=O)CC)C(=O)C1=NC=CC=C1O WTHRRGMBUAHGNI-LCYNINFDSA-N 0.000 description 1
108700028429 quinupristin Proteins 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000003642 reactive oxygen metabolite Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
238000002694 regional anesthesia Methods 0.000 description 1
229940116157 regranex Drugs 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000002787 reinforcement Effects 0.000 description 1
238000007634 remodeling Methods 0.000 description 1
230000008439 repair process Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
ZZPKZRHERLGEKA-UHFFFAOYSA-N resorcinol monoacetate Chemical compound CC(=O)OC1=CC=CC(O)=C1 ZZPKZRHERLGEKA-UHFFFAOYSA-N 0.000 description 1
230000004044 response Effects 0.000 description 1
229960000342 retinol acetate Drugs 0.000 description 1
235000019173 retinyl acetate Nutrition 0.000 description 1
239000011770 retinyl acetate Substances 0.000 description 1
229940108325 retinyl palmitate Drugs 0.000 description 1
235000019172 retinyl palmitate Nutrition 0.000 description 1
239000011769 retinyl palmitate Substances 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
235000019192 riboflavin Nutrition 0.000 description 1
239000002151 riboflavin Substances 0.000 description 1
229960002477 riboflavin Drugs 0.000 description 1
210000004708 ribosome subunit Anatomy 0.000 description 1
ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 description 1
229960003040 rifaximin Drugs 0.000 description 1
NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 description 1
IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
229960004555 rutoside Drugs 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
150000003902 salicylic acid esters Chemical class 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
229940119224 salmon oil Drugs 0.000 description 1
239000000523 sample Substances 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
235000017709 saponins Nutrition 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000037387 scars Effects 0.000 description 1
210000003786 sclera Anatomy 0.000 description 1
208000008742 seborrheic dermatitis Diseases 0.000 description 1
VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
229960005265 selenium sulfide Drugs 0.000 description 1
239000008299 semisolid dosage form Substances 0.000 description 1
230000001953 sensory effect Effects 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
239000004208 shellac Substances 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
229950005143 sitosterol Drugs 0.000 description 1
230000009759 skin aging Effects 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
231100000019 skin ulcer Toxicity 0.000 description 1
210000000329 smooth muscle myocyte Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229960003885 sodium benzoate Drugs 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229940082004 sodium laurate Drugs 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
AIMUHNZKNFEZSN-UHFFFAOYSA-M sodium;decane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCS([O-])(=O)=O AIMUHNZKNFEZSN-UHFFFAOYSA-M 0.000 description 1
DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
HRQDCDQDOPSGBR-UHFFFAOYSA-M sodium;octane-1-sulfonate Chemical compound [Na+].CCCCCCCCS([O-])(=O)=O HRQDCDQDOPSGBR-UHFFFAOYSA-M 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
229940075554 sorbate Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
229940037649 staphylococcus haemolyticus Drugs 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229960004274 stearic acid Drugs 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
235000021286 stilbenes Nutrition 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000004575 stone Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
229910052712 strontium Inorganic materials 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
159000000008 strontium salts Chemical class 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
238000012385 systemic delivery Methods 0.000 description 1
229940126703 systemic medication Drugs 0.000 description 1
230000008685 targeting Effects 0.000 description 1
AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 description 1
229960004267 taurolidine Drugs 0.000 description 1
229950007343 taurultam Drugs 0.000 description 1
150000003505 terpenes Chemical class 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
YVDPOVXIRVBNAL-UHFFFAOYSA-J tetrapotassium;phosphonatooxy phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OOP([O-])([O-])=O YVDPOVXIRVBNAL-UHFFFAOYSA-J 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
229960003053 thiamphenicol Drugs 0.000 description 1
OTVAEFIXJLOWRX-NXEZZACHSA-N thiamphenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 OTVAEFIXJLOWRX-NXEZZACHSA-N 0.000 description 1
239000010409 thin film Substances 0.000 description 1
FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 description 1
229960004089 tigecycline Drugs 0.000 description 1
229960005053 tinidazole Drugs 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
230000036367 tooth discoloration Effects 0.000 description 1
239000003860 topical agent Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000032258 transport Effects 0.000 description 1
230000008736 traumatic injury Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
229960003500 triclosan Drugs 0.000 description 1
CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 description 1
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
229940035936 ubiquinone Drugs 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
229940045136 urea Drugs 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
238000000489 vacuum metal deposition Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
235000001892 vitamin D2 Nutrition 0.000 description 1
239000011653 vitamin D2 Substances 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
229940084883 wheat amino acids Drugs 0.000 description 1
239000003357 wound healing promoting agent Substances 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1
229940098232 yersinia enterocolitica Drugs 0.000 description 1
239000010457 zeolite Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
239000011746 zinc citrate Substances 0.000 description 1
235000006076 zinc citrate Nutrition 0.000 description 1
229940068475 zinc citrate Drugs 0.000 description 1
239000011670 zinc gluconate Substances 0.000 description 1
235000011478 zinc gluconate Nutrition 0.000 description 1
229960000306 zinc gluconate Drugs 0.000 description 1
229940043810 zinc pyrithione Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
239000002888 zwitterionic surfactant Substances 0.000 description 1
RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
150000003952 β-lactams Chemical class 0.000 description 1
235000007680 β-tocopherol Nutrition 0.000 description 1
239000011590 β-tocopherol Substances 0.000 description 1
FGYKUFVNYVMTAM-WAZJVIJMSA-N β-tocotrienol Chemical compound OC1=CC(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-WAZJVIJMSA-N 0.000 description 1
239000002478 γ-tocopherol Substances 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
239000002446 δ-tocopherol Substances 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Otolaryngology (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Zoology (AREA)
Physiology (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Nutrition Science (AREA)
Molecular Biology (AREA)
Virology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)

KR1020207003093A 2010-02-03 2011-02-03 세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 Ceased KR20200015814A (ko)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/023108 WO2010091124A2 (en)	2009-02-03	2010-02-03	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
WOPCT/US2010/023108		2010-02-03
US37318810P	2010-08-12	2010-08-12
US61/373,188		2010-08-12
PCT/US2011/023549 WO2011097347A2 (en)	2010-02-03	2011-02-03	Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020197009488A Division KR102074444B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올

Publications (1)

Publication Number	Publication Date
KR20200015814A true KR20200015814A (ko)	2020-02-12

Family

ID=44356067

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
KR1020207003093A Ceased KR20200015814A (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020197009488A Active KR102074444B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020177034637A Active KR101966867B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020127022562A Active KR101821833B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020187019857A KR20180085042A (ko)	2010-08-12	2011-08-11	농업, 산업 및 다른 용도를 위한 방부제로서 비스무트-티올
KR1020137006121A KR20130132410A (ko)	2010-08-12	2011-08-11	농업, 산업 및 다른 용도를 위한 방부제로서 비스무트-티올

Family Applications After (5)

Application Number	Title	Priority Date	Filing Date
KR1020197009488A Active KR102074444B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020177034637A Active KR101966867B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020127022562A Active KR101821833B1 (ko)	2010-02-03	2011-02-03	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
KR1020187019857A KR20180085042A (ko)	2010-08-12	2011-08-11	농업, 산업 및 다른 용도를 위한 방부제로서 비스무트-티올
KR1020137006121A KR20130132410A (ko)	2010-08-12	2011-08-11	농업, 산업 및 다른 용도를 위한 방부제로서 비스무트-티올

Country Status (17)

Country	Link
EP (1)	EP2603083A4 (uk)
JP (7)	JP2013535506A (uk)
KR (6)	KR20200015814A (uk)
CN (2)	CN105766990B (uk)
AU (3)	AU2011289338B2 (uk)
BR (2)	BR112012019286A2 (uk)
CA (1)	CA2807993C (uk)
CL (2)	CL2013000430A1 (uk)
IL (3)	IL224684A (uk)
MX (4)	MX371047B (uk)
NZ (1)	NZ606634A (uk)
PH (2)	PH12013500267A1 (uk)
RU (2)	RU2018108411A (uk)
SG (3)	SG187801A1 (uk)
UA (1)	UA113616C2 (uk)
WO (1)	WO2012021754A2 (uk)
ZA (1)	ZA201301841B (uk)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010091124A2 (en)	2009-02-03	2010-08-12	Microbion Corporation	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
US9028878B2 (en)	2009-02-03	2015-05-12	Microbion Corporation	Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
KR20200015814A (ko) *	2010-02-03	2020-02-12	마이크로비온 코포레이션	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
ES2647499T3 (es) *	2013-03-18	2017-12-21	Theranovis Gmbh & Co. Kg	Composición para el cuidado bucal
RU2525200C1 (ru) *	2013-04-09	2014-08-10	Алексей Георгиевич Бородкин	Средство для защиты и заживления ран деревьев
KR101703732B1 (ko) *	2013-11-07	2017-02-07	(주)아모레퍼시픽	효소처리 동백나무 씨 오일을 포함하는 항염 조성물
WO2017145142A1 (en)	2016-02-25	2017-08-31	Nobio Ltd.	Micro and nanoparticulate compositions comprising anti-microbially active groups
JP7337778B2 (ja)	2017-08-30	2023-09-04	ノビオリミテッド	抗微生物粒子を含む組成物および医療機器
CN107950536A (zh) *	2017-12-04	2018-04-24	刘志伟	一种含百菌清的杀菌组合物
CN108839186B (zh) *	2018-05-15	2021-02-26	阜南县金威工艺品有限公司	一种桑枝编织品防霉处理方法
JP2021533194A (ja)	2018-07-31	2021-12-02	マイクロビオンコーポレーション	ビスマス・チオール組成物及び創傷を治療する方法
BR112021001731A2 (pt)	2018-07-31	2021-04-27	Microbion Corporation	composições de bismuto-tiol e métodos de uso
KR101990253B1 (ko) *	2018-11-22	2019-06-17	하봉호	컨테이너형 버섯재배장치
CN109997856B (zh) *	2019-04-15	2020-11-03	广西大学	一种小分子化合物的组合物及其应用
KR102126721B1 (ko) *	2019-07-16	2020-06-25	(주)인트론바이오테크놀로지	신규한 엔테로박터 애로진스 박테리오파지 Ent-AEP-1 및 이의 엔테로박터 애로진스 균과 엔테로박터 클로아카 균 증식 억제 용도
JP7458622B2 (ja) *	2019-09-18	2024-04-01	学校法人東京農業大学	抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法
CN110663672B (zh) *	2019-11-13	2024-04-26	南京林业大学	一种螺纹驱动的根部施药头
US11479655B2 (en)	2020-01-15	2022-10-25	The Boeing Company	Compositions for use with polysulfide sealants and related methods
KR102197719B1 (ko)	2020-05-07	2021-01-04	곽태진	갑오징어 양식 시스템
CN111856546B (zh) *	2020-06-23	2022-07-29	中国辐射防护研究院	一种关于海洋生物灰中Cs-137放化分析的制样方法
CN113969300B (zh) *	2020-07-23	2024-08-23	禾美生物科技(浙江)有限公司	一种桉树叶复合活性提取物工艺及其抗菌应用
CN112640907B (zh) *	2021-01-19	2021-11-16	西南大学	硫辛酸抑制植物真菌致病菌的新用途及防治柑橘果实采后真菌病害的方法
KR102431000B1 (ko) *	2021-07-22	2022-08-11	농업회사법인 주식회사 아그로비즈	아스피린과 벤조치아졸이 포함된 식물의 자가면역 증강제 조성물 및 이를 이용한 이용방법
EP4310192A1 (en) *	2022-07-21	2024-01-24	C4Diagnostics	Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents
CN115323778B (zh) *	2022-08-16	2023-07-18	汕头市润丰纺织科技实业有限公司	壳聚糖-i型胶原氨基酸复合抗菌整理液及其制备方法和抗菌面料
TR2022012983A2 (tr) *	2022-08-17	2022-09-21	Marmara Ueniv Strateji Gelis Dai Bsk Muhasebe Birimi	Kemi̇k rahatsizliklari ve/veya kirilmalari i̇çi̇n onarici ve tedavi̇ edi̇ci̇ özelli̇kte bi̇youyumlu bi̇r ürün ve söz konusu ürünün eldesi̇ i̇çi̇n bi̇r yöntem
CN115532295B (zh) *	2022-09-27	2023-07-25	苏州大学	含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用
KR102644907B1 (ko) *	2023-12-01	2024-03-07	(주)신용이엔씨	지반 보강을 위한 친환경 그라우팅용 조성물 및 이의 제조 방법

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2809971A (en) *	1955-11-22	1957-10-15	Olin Mathieson	Heavy-metal derivatives of 1-hydroxy-2-pyridinethiones and method of preparing same
JP3813644B2 (ja) *	1994-08-29	2006-08-23	英治安里	ビスマス錯体およびそれを含有する抗菌剤
US5928671A (en) *	1995-04-25	1999-07-27	Winthrop University Hospital	Method and composition for inhibiting bacteria
US6086921A (en) *	1995-04-25	2000-07-11	Wintrop-University Hospital	Metal/thiol biocides
US6017936A (en) *	1997-03-14	2000-01-25	Arch Chemicals, Inc.	Method for producing particles of pyrithione salts and particles so produced
US5999828A (en) *	1997-03-19	1999-12-07	Qualcomm Incorporated	Multi-user wireless telephone having dual echo cancellers
AU2003204105B2 (en) *	1997-10-28	2005-11-17	Winthrop-University Hospital	Metal/Thiol Biocides
AU2656799A (en) *	1998-02-04	1999-08-23	Winthrop-University Hospital	Metal-thiols as imminomodulating agents
US6465015B1 (en) *	1998-02-24	2002-10-15	Arch Chemicals, Inc.	Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles
TWI245763B (en) *	1998-04-02	2005-12-21	Janssen Pharmaceutica Nv	Biocidal benzylbiphenyl derivatives
AU1094300A (en) *	1998-09-23	2000-04-10	Phycogen, Inc.	Methods and compositions for treating receptor mediated diseases
US6682724B2 (en) *	1999-02-23	2004-01-27	Arch Chemcials, Inc.	Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles
US6630172B2 (en) *	2001-01-22	2003-10-07	Kareem I. Batarseh	Microbicidal composition containing potassium sodium tartrate
US6582719B2 (en) *	2001-02-02	2003-06-24	The Trustees Of Columbia University In The City Of New York	Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms
JP4357166B2 (ja) *	2002-10-21	2009-11-04	日揮触媒化成株式会社	抗菌・防黴・防藻性組成物
US7381751B2 (en) *	2003-08-26	2008-06-03	Shantha Sarangapani	Antimicrobial composition for medical articles
DE602005027229D1 (de) *	2004-10-25	2011-05-12	Celonova Biosciences Germany Gmbh	Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
JP4568232B2 (ja) *	2006-01-06	2010-10-27	秀和西松	人工骨頭保持具
JP2007332040A (ja) *	2006-06-12	2007-12-27	Shinshu Univ	カーボンナノチューブを含む抗菌剤とそれを用いた材料及び製剤
US20110008402A1 (en) *	2006-10-13	2011-01-13	Kane Biotech Inc.	Souluble b-n-acetylglucoseaminidase based antibiofilm compositions and uses thereof
AU2008207864B2 (en) *	2007-01-24	2013-07-11	Cook Biotech Incorporated	Biofilm-inhibiting medical products
US8343536B2 (en) *	2007-01-25	2013-01-01	Cook Biotech Incorporated	Biofilm-inhibiting medical products
KR20100020004A (ko) *	2007-05-18	2010-02-19	아지온 테크놀로지스, 인코포레이티드	생물활성 산 농약 조성물과 이들의 용도
EP2160152B1 (en) *	2007-06-01	2016-07-27	Arrow International, Inc.	Combined fibrinolytic and antimicrobial catheter and uses thereof
WO2009014549A1 (en) *	2007-07-25	2009-01-29	Celonova Biosciences, Inc.	Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
WO2010091124A2 (en) *	2009-02-03	2010-08-12	Microbion Corporation	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
KR20200015814A (ko) *	2010-02-03	2020-02-12	마이크로비온 코포레이션	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올

2011
- 2011-02-03 KR KR1020207003093A patent/KR20200015814A/ko not_active Ceased
- 2011-02-03 KR KR1020197009488A patent/KR102074444B1/ko active Active
- 2011-02-03 KR KR1020177034637A patent/KR101966867B1/ko active Active
- 2011-02-03 KR KR1020127022562A patent/KR101821833B1/ko active Active
- 2011-02-03 BR BR112012019286A patent/BR112012019286A2/pt not_active Application Discontinuation
- 2011-02-03 MX MX2016010269A patent/MX371047B/es unknown
- 2011-08-11 WO PCT/US2011/047490 patent/WO2012021754A2/en active Application Filing
- 2011-08-11 AU AU2011289338A patent/AU2011289338B2/en not_active Ceased
- 2011-08-11 KR KR1020187019857A patent/KR20180085042A/ko active Search and Examination
- 2011-08-11 SG SG2013010053A patent/SG187801A1/en unknown
- 2011-08-11 EP EP11817067.9A patent/EP2603083A4/en not_active Withdrawn
- 2011-08-11 NZ NZ606634A patent/NZ606634A/en not_active IP Right Cessation
- 2011-08-11 MX MX2013001581A patent/MX362785B/es active IP Right Grant
- 2011-08-11 CA CA2807993A patent/CA2807993C/en active Active
- 2011-08-11 KR KR1020137006121A patent/KR20130132410A/ko not_active Application Discontinuation
- 2011-08-11 SG SG10201506131RA patent/SG10201506131RA/en unknown
- 2011-08-11 RU RU2018108411A patent/RU2018108411A/ru not_active Application Discontinuation
- 2011-08-11 JP JP2013524237A patent/JP2013535506A/ja active Pending
- 2011-08-11 CN CN201610127111.8A patent/CN105766990B/zh active Active
- 2011-08-11 CN CN201180042863.XA patent/CN103096720B/zh active Active
- 2011-08-11 PH PH1/2013/500267A patent/PH12013500267A1/en unknown
- 2011-08-11 UA UAA201303059A patent/UA113616C2/uk unknown
- 2011-08-11 SG SG10202001032RA patent/SG10202001032RA/en unknown
- 2011-08-11 BR BR112013003127A patent/BR112013003127A2/pt not_active Application Discontinuation
- 2011-08-11 RU RU2013110493/10A patent/RU2013110493A/ru not_active Application Discontinuation
2012
- 2012-08-03 MX MX2019010863A patent/MX2019010863A/es unknown
2013
- 2013-02-08 MX MX2019001293A patent/MX2019001293A/es unknown
- 2013-02-12 CL CL2013000430A patent/CL2013000430A1/es unknown
- 2013-02-12 IL IL224684A patent/IL224684A/en active IP Right Grant
- 2013-03-11 ZA ZA2013/01841A patent/ZA201301841B/en unknown
2016
- 2016-01-08 JP JP2016003005A patent/JP6272366B2/ja active Active
- 2016-05-26 AU AU2016203475A patent/AU2016203475A1/en not_active Abandoned
- 2016-10-21 IL IL248446A patent/IL248446B/en active IP Right Grant
- 2016-12-14 PH PH12016502498A patent/PH12016502498A1/en unknown
2017
- 2017-07-21 JP JP2017141774A patent/JP2018008971A/ja active Pending
- 2017-10-10 CL CL2017002549A patent/CL2017002549A1/es unknown
- 2017-12-28 JP JP2017253007A patent/JP6685991B2/ja active Active
2018
- 2018-04-24 IL IL258908A patent/IL258908A/en unknown
- 2018-06-13 AU AU2018204190A patent/AU2018204190B2/en active Active
2019
- 2019-12-03 JP JP2019219070A patent/JP7097344B2/ja active Active
- 2019-12-13 JP JP2019225544A patent/JP2020063277A/ja active Pending
2021
- 2021-10-08 JP JP2021166416A patent/JP2022003090A/ja active Pending

Also Published As

Publication number	Publication date
CN105766990A (zh)	2016-07-20
BR112012019286A2 (pt)	2018-06-26
CA2807993C (en)	2023-03-14
JP6685991B2 (ja)	2020-04-22
CN105766990B (zh)	2019-08-02
JP2013535506A (ja)	2013-09-12
UA113616C2 (xx)	2017-02-27
KR101966867B1 (ko)	2019-04-08
PH12016502498A1 (en)	2018-06-11
ZA201301841B (en)	2024-10-30
IL248446B (en)	2018-05-31
JP2018076358A (ja)	2018-05-17
SG10202001032RA (en)	2020-04-29
CN103096720A (zh)	2013-05-08
AU2018204190A1 (en)	2018-07-05
KR101821833B1 (ko)	2018-01-25
EP2603083A2 (en)	2013-06-19
JP2018008971A (ja)	2018-01-18
JP2020055839A (ja)	2020-04-09
KR102074444B1 (ko)	2020-02-06
CN103096720B (zh)	2016-03-30
BR112013003127A2 (pt)	2016-06-28
SG187801A1 (en)	2013-03-28
KR20170136009A (ko)	2017-12-08
CL2013000430A1 (es)	2013-10-04
IL224684A (en)	2016-11-30
JP6272366B2 (ja)	2018-01-31
AU2018204190B2 (en)	2020-07-23
WO2012021754A2 (en)	2012-02-16
SG10201506131RA (en)	2015-09-29
MX362785B (es)	2019-02-12
MX2019001293A (es)	2019-07-04
KR20180085042A (ko)	2018-07-25
KR20190039607A (ko)	2019-04-12
MX2013001581A (es)	2013-03-20
MX2019010863A (es)	2019-11-05
IL258908A (en)	2018-06-28
CL2017002549A1 (es)	2018-05-11
RU2018108411A (ru)	2019-02-25
JP7097344B2 (ja)	2022-07-07
WO2012021754A3 (en)	2012-05-24
NZ606634A (en)	2015-01-30
JP2016117741A (ja)	2016-06-30
MX371047B (es)	2020-01-14
AU2011289338A1 (en)	2013-03-28
EP2603083A4 (en)	2014-10-22
KR20130132410A (ko)	2013-12-04
AU2016203475A1 (en)	2016-06-16
JP2022003090A (ja)	2022-01-11
PH12013500267A1 (en)	2017-07-19
AU2011289338B2 (en)	2015-01-22
CA2807993A1 (en)	2012-02-16
KR20130000386A (ko)	2013-01-02
RU2013110493A (ru)	2014-09-20
JP2020063277A (ja)	2020-04-23

Publication	Publication Date	Title
US20220016132A1 (en)	2022-01-20	Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
KR102074444B1 (ko)	2020-02-06	세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올
CA2788669C (en)	2021-05-25	Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US11564903B2 (en)	2023-01-31	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
AU2018204188B2 (en)	2020-07-23	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
AU2013202847B2 (en)	2016-06-16	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
BRPI1007885B1 (pt)	2024-08-20	Composição de bismuto-tiol, método para preparar dita composição e usos da mesma para o tratamento de infecção de uma superfície do tecido epitelial ou de uma ferida aguda, ferida crônica ou ferida de uma superfície do tecido epitelial por um biofilme bacteriano formado por um patógeno bacteriano

Legal Events

Date	Code	Title	Description
2020-01-31	A107	Divisional application of patent
2020-01-31	PA0104	Divisional application for international application	Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20200131 Application number text: 1020197009488 Filing date: 20190402
2020-02-12	PG1501	Laying open of application
2020-02-28	PA0201	Request for examination	Patent event code: PA02012R01D Patent event date: 20200228 Comment text: Request for Examination of Application
2020-04-01	E902	Notification of reason for refusal
2020-04-01	PE0902	Notice of grounds for rejection	Comment text: Notification of reason for refusal Patent event date: 20200401 Patent event code: PE09021S01D
2020-12-07	E601	Decision to refuse application
2020-12-07	PE0601	Decision on rejection of patent	Patent event date: 20201207 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20200401 Comment text: Notification of reason for refusal Patent event code: PE06011S01I