JPS6356881B2 - - Google Patents

Info

Publication number: JPS6356881B2
Authority: JP; Japan
Prior art keywords: general formula; proteoglucan; bonds; main chain; branched chains
Prior art date: 1983-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP58086470A

Other languages

English (en)

Japanese (ja)

Other versions

JPS59210901A (ja

Inventor

Hisatora Kuroda

Hiroaki Nanba

Kanichi Mori

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NIPPON KINOKO KENKYUSHO

Original Assignee

NIPPON KINOKO KENKYUSHO

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-17

Filing date

1983-05-17

Publication date

1988-11-09

1983-05-17 Application filed by NIPPON KINOKO KENKYUSHO filed Critical NIPPON KINOKO KENKYUSHO

1983-05-17 Priority to JP58086470A priority Critical patent/JPS59210901A/ja

1984-11-29 Publication of JPS59210901A publication Critical patent/JPS59210901A/ja

1988-11-09 Publication of JPS6356881B2 publication Critical patent/JPS6356881B2/ja

Status Granted legal-status Critical Current

Links

240000001080 Grifola frondosa Species 0.000 claims description 15
235000007710 Grifola frondosa Nutrition 0.000 claims description 15
235000001674 Agaricus brunnescens Nutrition 0.000 claims description 13
229920001503 Glucan Polymers 0.000 claims description 10
239000002246 antineoplastic agent Substances 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 9
238000003809 water extraction Methods 0.000 claims description 7
239000004480 active ingredient Substances 0.000 claims description 5
RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 3
239000003513 alkali Substances 0.000 claims description 3
239000000126 substance Substances 0.000 description 18
150000004676 glycans Chemical class 0.000 description 14
229920001282 polysaccharide Polymers 0.000 description 14
239000005017 polysaccharide Substances 0.000 description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
238000000034 method Methods 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
230000000052 comparative effect Effects 0.000 description 6
239000000047 product Substances 0.000 description 6
206010028980 Neoplasm Diseases 0.000 description 5
239000002244 precipitate Substances 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000463 material Substances 0.000 description 4
239000000203 mixture Substances 0.000 description 4
238000002054 transplantation Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
230000001093 anti-cancer Effects 0.000 description 3
229940041181 antineoplastic drug Drugs 0.000 description 3
238000004817 gas chromatography Methods 0.000 description 3
239000000843 powder Substances 0.000 description 3
102000003886 Glycoproteins Human genes 0.000 description 2
108090000288 Glycoproteins Proteins 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000009702 cancer cell proliferation Effects 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000002198 insoluble material Substances 0.000 description 2
238000012856 packing Methods 0.000 description 2
239000002994 raw material Substances 0.000 description 2
239000002195 soluble material Substances 0.000 description 2
DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 description 1
229920002498 Beta-glucan Polymers 0.000 description 1
101710154757 Exo-beta-1,3-glucanase Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229920001543 Laminarin Polymers 0.000 description 1
239000005717 Laminarin Substances 0.000 description 1
208000006268 Sarcoma 180 Diseases 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002303 glucose derivatives Chemical class 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
WJLUBOLDZCQZEV-UHFFFAOYSA-M hexadecyl(trimethyl)azanium;hydroxide Chemical compound [OH-].CCCCCCCCCCCCCCCC[N+](C)(C)C WJLUBOLDZCQZEV-UHFFFAOYSA-M 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
230000007721 medicinal effect Effects 0.000 description 1
238000006140 methanolysis reaction Methods 0.000 description 1
SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
229940117969 neopentyl glycol Drugs 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000008213 purified water Substances 0.000 description 1
229910021332 silicide Inorganic materials 0.000 description 1
FVBUAEGBCNSCDD-UHFFFAOYSA-N silicide(4-) Chemical compound [Si-4] FVBUAEGBCNSCDD-UHFFFAOYSA-N 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

JP58086470A 1983-05-17 1983-05-17 プロテオグルカン及びそれからなる抗ガン剤 Granted JPS59210901A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP58086470A JPS59210901A (ja)	1983-05-17	1983-05-17	プロテオグルカン及びそれからなる抗ガン剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58086470A JPS59210901A (ja)	1983-05-17	1983-05-17	プロテオグルカン及びそれからなる抗ガン剤

Publications (2)

Publication Number	Publication Date
JPS59210901A JPS59210901A (ja)	1984-11-29
JPS6356881B2 true JPS6356881B2 (fr)	1988-11-09

Family

ID=13887842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58086470A Granted JPS59210901A (ja)	1983-05-17	1983-05-17	プロテオグルカン及びそれからなる抗ガン剤

Country Status (1)

Country	Link
JP (1)	JPS59210901A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0500718A1 (fr) *	1989-11-09	1992-09-02	Byron A Donzis	Extrait de levure insoluble.
WO2009102008A1 (fr) *	2008-02-14	2009-08-20	Yukiguni Maitake Co., Ltd.	Substance de faible masse moléculaire provenant du champignon maïtaké et présentant une activité immunostimulante et une activité antitumorale

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6058925A (ja) *	1983-09-09	1985-04-05	Nippon Beet Sugar Mfg Co Ltd	抗腫瘍活性物質
JPS60255733A (ja) *	1984-05-30	1985-12-17	Nippon Beet Sugar Mfg Co Ltd	β−Ｄ−グルカン
ES2103276T3 (es) *	1989-09-08	1997-09-16	Alpha Beta Technology	Composicion para la activacion del sistema inmunitario.
US5622939A (en) *	1992-08-21	1997-04-22	Alpha-Beta Technology, Inc.	Glucan preparation
US5811542A (en) *	1989-09-08	1998-09-22	Alpha-Beta Technology, Inc.	Method for producing soluble glucans
WO1991003495A1 (fr) *	1989-09-08	1991-03-21	Alpha Beta Technology, Inc.	Procede de production de glucans solubles
US5488040A (en) *	1989-09-08	1996-01-30	Alpha-Beta Technology, Inc.	Use of neutral soluble glucan preparations to stimulate platelet production
JP2689244B2 (ja) *	1993-04-30	1997-12-10	株式会社雪国まいたけ	肝疾患改善剤の製造方法
JP2753935B2 (ja) *	1993-04-30	1998-05-20	株式会社雪国まいたけ	免疫抑制剤の製造方法
JP2732008B2 (ja) *	1993-04-30	1998-03-25	株式会社雪国まいたけ	育毛促進剤の製造方法
US5622940A (en) *	1994-07-14	1997-04-22	Alpha-Beta Technology	Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan
JPH08119874A (ja) *	1994-10-24	1996-05-14	Takumi Sogabe	エイズウィルス・癌細胞の抑制剤の製造方法
AUPN166195A0 (en)	1995-03-13	1995-04-06	Norvet Research Pty Limited	Process for glucan extraction
JP2859843B2 (ja) *	1996-03-08	1999-02-24	株式会社雪国まいたけ	マイタケから抽出した抗腫瘍物質
US6046323A (en) *	1997-07-29	2000-04-04	The Collaborative Group, Ltd.	Conformations of PPG-glucan
US6616928B1 (en)	1998-10-20	2003-09-09	Yukiguni Maitake Co., Ltd.	Active oxygen scavenger and cancer chemopreventer from Grifola
US6369216B1 (en)	1998-09-25	2002-04-09	Biopolymer Engineering Pharmaceutical, Inc.	Very high molecular weight β-glucans
AU6261999A (en)	1998-09-25	2000-04-17	Collaborative Group, Ltd., The	Very high molecular weight beta-glucans
JP2001097881A (ja) *	1999-09-28	2001-04-10	Yukiguni Maitake Co Ltd	マイタケ由来の発がん防止剤及び発がん防止用食品又は飼料
JP2005133069A (ja) *	2003-10-09	2005-05-26	Ichimasa Kamaboko Co Ltd	きのこ由来のβ−グルカン多糖類の取得方法ときのこ由来のβ−グルカン多糖類
JP5153188B2 (ja) *	2007-03-30	2013-02-27	小林製薬株式会社	Ｔｈ１／Ｔｈ２バランス改善剤
JP2011184306A (ja) *	2010-03-04	2011-09-22	Yukiguni Maitake Co Ltd	マイタケ属キノコ由来の食後過血糖の上昇を抑制する物質
CN103304680B (zh) *	2012-03-09	2017-02-08	中国科学院上海药物研究所	一种β‑葡聚糖、其提取方法及用途
CN104497161B (zh) *	2015-01-04	2016-09-14	华东理工大学	一种灰树花多糖的提纯方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5836395A (ja) *	1981-08-26	1983-03-03	Nippon Beet Sugar Mfg Co Ltd	多糖類の製造方法

1983
- 1983-05-17 JP JP58086470A patent/JPS59210901A/ja active Granted

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5836395A (ja) *	1981-08-26	1983-03-03	Nippon Beet Sugar Mfg Co Ltd	多糖類の製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0500718A1 (fr) *	1989-11-09	1992-09-02	Byron A Donzis	Extrait de levure insoluble.
EP0500718A4 (en) *	1989-11-09	1994-09-14	Byron A Donzis	Insoluble yeast extract
WO2009102008A1 (fr) *	2008-02-14	2009-08-20	Yukiguni Maitake Co., Ltd.	Substance de faible masse moléculaire provenant du champignon maïtaké et présentant une activité immunostimulante et une activité antitumorale

Also Published As

Publication number	Publication date
JPS59210901A (ja)	1984-11-29

Publication	Publication Date	Title
JPS6356881B2 (fr)	1988-11-09
EP1027061B1 (fr)	2005-05-25	Polysaccharides formateurs d'imine, leur preparation, et leur utilisation en tant qu'adjuvants et immunostimulants
US4454315A (en)	1984-06-12	Carboxymethylated derivatives of β-1,3-glucan
US3987166A (en)	1976-10-19	Treatment of tumors with glucan compositions in mice and rats
US3893996A (en)	1975-07-08	Hydroxyalkyl and mercaptoalkyl derivatives of {62 -(1{43 3) glucans
JPH06340701A (ja)	1994-12-13	高分岐度β−グルカン、その製造法及び用途
HU176828B (en)	1981-05-28	Process for producing nitrogen-containing polysaccharides of tumor-inhibiting activity
KR870001930B1 (ko)	1987-10-22	다당체 ron물질의 제조 방법
JPH026761B2 (fr)	1990-02-13
US4973581A (en)	1990-11-27	Glucan derivatives having tumoricidal activity
JP2630783B2 (ja)	1997-07-16	抗腫瘍作用を有する中性多糖体の製法
JP2838863B2 (ja)	1998-12-16	血糖上昇抑制剤
JPH0248000B2 (fr)	1990-10-23
US5185327A (en)	1993-02-09	Glucan derivatives having tumoricidal activity
JPS6377901A (ja)	1988-04-08	新規多糖類
JPH0314289B2 (fr)	1991-02-26
EP0173228A2 (fr)	1986-03-05	Composé polysaccharide RIN, sa préparation et son utilisation
JPH06312934A (ja)	1994-11-08	免疫抑制効果を有する物質の製造方法
JPS60155201A (ja)	1985-08-15	化学修飾多糖及びその製造法
JPS63307825A (ja)	1988-12-15	抗腫瘍剤及びその製法
JPH0645644B2 (ja)	1994-06-15	化学修飾多糖及びその製造法
KR19980058723A (ko)	1998-10-07	항종양 활성을 갖는 새로운 수용성 다당체 및 그의 제조방법
CA1094453A (fr)	1981-01-27	MEDICAMENTS ONCOLYTIQUES DERIVES DU .beta.-1-3-GLUCAN
EP0267335B1 (fr)	1992-03-25	Dérivés de glucanes
JPS60155202A (ja)	1985-08-15	化学修飾多糖及びその製造法