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JPS5724385A - Theobromine derivative and its preparation - Google Patents

Theobromine derivative and its preparation

Info

Publication number
JPS5724385A
JPS5724385A JP9681580A JP9681580A JPS5724385A JP S5724385 A JPS5724385 A JP S5724385A JP 9681580 A JP9681580 A JP 9681580A JP 9681580 A JP9681580 A JP 9681580A JP S5724385 A JPS5724385 A JP S5724385A
Authority
JP
Japan
Prior art keywords
formula
theobromine
trimethyl
reacting
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9681580A
Other languages
Japanese (ja)
Inventor
Hiroo Matsumoto
Kazutaka Arai
Kazuo Endo
Yoshikazu Yoshioka
Kenji Suzuki
Terukazu Fujii
Sei Kondo
Toshiyuki Takashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP9681580A priority Critical patent/JPS5724385A/en
Publication of JPS5724385A publication Critical patent/JPS5724385A/en
Pending legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NEW MATERIAL:The theobromine derivative of formula I (R1 and R2 are H or group of formula V).
EXAMPLE: 3,7-Dimethyl-1-[4-(2,4,6-trimethyl-1,3,5-trithian-2-yl)butyl]xanthine.
USE: Useful as a synthetic intermediate of pharmaceuticals. Excellent precursor of 1-(5'-oxohexyl)-3,7-dimethylxanthine (general name: pentoxifylline) which is a drug having vasodilating activity and erythrocyte deformation promoting activity.
PROCESS: The compound of formula I is prepared by (1) reacting 2,4,6-trimethyl- 1,3,5-trithiane of formula II with the dihalobutane of formula III (X1 and X2 are halogen) in the presence of a base to obtain the halogenated product of formula IV (R3 and R4 are H or 4-halobutyl), and (2) reacting the compound of formula V with theobromine in the presence of a base. The reactions are pref. carried out in a solvent such as diethyl ether.
COPYRIGHT: (C)1982,JPO&Japio
JP9681580A 1980-07-17 1980-07-17 Theobromine derivative and its preparation Pending JPS5724385A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9681580A JPS5724385A (en) 1980-07-17 1980-07-17 Theobromine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9681580A JPS5724385A (en) 1980-07-17 1980-07-17 Theobromine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5724385A true JPS5724385A (en) 1982-02-08

Family

ID=14175078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9681580A Pending JPS5724385A (en) 1980-07-17 1980-07-17 Theobromine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5724385A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091339A1 (en) 2002-04-24 2003-11-06 Asahi Kasei Chemicals Corporation Asphalt composition
US7696267B2 (en) 2003-10-21 2010-04-13 Asahi Kasei Chemicals Corporation Asphalt composition containing hydrogenated conjugated diene copolymer
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
KR20160122817A (en) 2014-05-08 2016-10-24 아사히 가세이 가부시키가이샤 Asphalt composition
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091339A1 (en) 2002-04-24 2003-11-06 Asahi Kasei Chemicals Corporation Asphalt composition
US7696267B2 (en) 2003-10-21 2010-04-13 Asahi Kasei Chemicals Corporation Asphalt composition containing hydrogenated conjugated diene copolymer
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
KR20160122817A (en) 2014-05-08 2016-10-24 아사히 가세이 가부시키가이샤 Asphalt composition

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