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JPS5533434A - Production of 6-dicyanomethylpurine nucleoside - Google Patents

Production of 6-dicyanomethylpurine nucleoside

Info

Publication number
JPS5533434A
JPS5533434A JP10625578A JP10625578A JPS5533434A JP S5533434 A JPS5533434 A JP S5533434A JP 10625578 A JP10625578 A JP 10625578A JP 10625578 A JP10625578 A JP 10625578A JP S5533434 A JPS5533434 A JP S5533434A
Authority
JP
Japan
Prior art keywords
nucleoside
dicyanomethylpurine
formula
methylsulfonylpurine
antitumorigenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10625578A
Other languages
Japanese (ja)
Other versions
JPS5842197B2 (en
Inventor
Toru Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP53106255A priority Critical patent/JPS5842197B2/en
Publication of JPS5533434A publication Critical patent/JPS5533434A/en
Publication of JPS5842197B2 publication Critical patent/JPS5842197B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:6-Dicyanomethylpurine nucleoside of formula I (Z is H, proticting group).
USE: Antitumorigenic agent or synthetic intermediate of 2-(9-β-D-ribofuranosylpurine-6-yl)-3-aminoacrylonitrile, which has antiallergic, antitumorigenic and peripheral vascular dilation activities.
PREPARATION: The reaction of 6-methylsulfonylpurine nucleoside of formula III (Y is H, protecting group) and malonitrile is effected at room temperature or by heating to refluxing in a solvent as tetrahydrofuran in the presence of a base as sodium hydroxide to produce the compound of formula I. The amount of the base used is 1W10, preferably 2W5 times the molar quantity of 6-methylsulfonylpurine nucleoside of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP53106255A 1978-09-01 1978-09-01 6↓-Method for producing dicyanomethylpurine nucleoside Expired JPS5842197B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53106255A JPS5842197B2 (en) 1978-09-01 1978-09-01 6↓-Method for producing dicyanomethylpurine nucleoside

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53106255A JPS5842197B2 (en) 1978-09-01 1978-09-01 6↓-Method for producing dicyanomethylpurine nucleoside

Publications (2)

Publication Number Publication Date
JPS5533434A true JPS5533434A (en) 1980-03-08
JPS5842197B2 JPS5842197B2 (en) 1983-09-17

Family

ID=14428984

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53106255A Expired JPS5842197B2 (en) 1978-09-01 1978-09-01 6↓-Method for producing dicyanomethylpurine nucleoside

Country Status (1)

Country Link
JP (1) JPS5842197B2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5519228A (en) * 1978-07-28 1980-02-09 Yamasa Shoyu Co Ltd 6-c substituted purine nucleoside and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5519228A (en) * 1978-07-28 1980-02-09 Yamasa Shoyu Co Ltd 6-c substituted purine nucleoside and its preparation

Also Published As

Publication number Publication date
JPS5842197B2 (en) 1983-09-17

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