JPS5692875A - 2-aminoquinazoline derivative - Google Patents
2-aminoquinazoline derivativeInfo
- Publication number
- JPS5692875A JPS5692875A JP17243479A JP17243479A JPS5692875A JP S5692875 A JPS5692875 A JP S5692875A JP 17243479 A JP17243479 A JP 17243479A JP 17243479 A JP17243479 A JP 17243479A JP S5692875 A JPS5692875 A JP S5692875A
- Authority
- JP
- Japan
- Prior art keywords
- phenylquinazoline
- piperazinyl
- formula
- aminoquinazoline derivative
- imipramine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CZAAKPFIWJXPQT-UHFFFAOYSA-N quinazolin-2-amine Chemical class C1=CC=CC2=NC(N)=NC=C21 CZAAKPFIWJXPQT-UHFFFAOYSA-N 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- PEKUOJUNFKUHJH-UHFFFAOYSA-N 2-(4-methylpiperazin-1-yl)-4-phenylquinazoline Chemical compound C1CN(C)CCN1C1=NC(C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 PEKUOJUNFKUHJH-UHFFFAOYSA-N 0.000 abstract 1
- SFKMVPQJJGJCMI-UHFFFAOYSA-N 2-chloro-4-phenylquinazoline Chemical compound C=12C=CC=CC2=NC(Cl)=NC=1C1=CC=CC=C1 SFKMVPQJJGJCMI-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000000891 anti-reserpine Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960004801 imipramine Drugs 0.000 abstract 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:4-Phenyl-2-(1-piperazinyl)quinazoline of formula and its pharmacologically permissible salt.
USE: An antidepressant, etc. It has higher antireserpine activity than 2-(4-methyl-1- piperazinyl)-4-phenylquinazoline or commercialized imipramine.
PROCESS: 2-Chloro-4-phenylquinazoline is made to react with anhydrous piperazine by heating to afford the compound of formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17243479A JPS5692875A (en) | 1979-12-27 | 1979-12-27 | 2-aminoquinazoline derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17243479A JPS5692875A (en) | 1979-12-27 | 1979-12-27 | 2-aminoquinazoline derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5692875A true JPS5692875A (en) | 1981-07-27 |
| JPS6344150B2 JPS6344150B2 (en) | 1988-09-02 |
Family
ID=15941900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17243479A Granted JPS5692875A (en) | 1979-12-27 | 1979-12-27 | 2-aminoquinazoline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5692875A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540696A (en) * | 1982-02-08 | 1985-09-10 | Sanofi S.A. | 1-Piperazinyl 4-phenylquinazoline compounds having antidepressant properties and drugs containing same |
| US4695568A (en) * | 1984-01-05 | 1987-09-22 | Mitsubishi Chemical Industries Limited | Thieno[2,3-d]pyrimidine derivatives and salts thereof |
| WO2005087749A1 (en) * | 2004-03-15 | 2005-09-22 | Kyowa Hakko Kogyo Co., Ltd. | 2-aminoquinazoline derivative |
-
1979
- 1979-12-27 JP JP17243479A patent/JPS5692875A/en active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540696A (en) * | 1982-02-08 | 1985-09-10 | Sanofi S.A. | 1-Piperazinyl 4-phenylquinazoline compounds having antidepressant properties and drugs containing same |
| US4695568A (en) * | 1984-01-05 | 1987-09-22 | Mitsubishi Chemical Industries Limited | Thieno[2,3-d]pyrimidine derivatives and salts thereof |
| WO2005087749A1 (en) * | 2004-03-15 | 2005-09-22 | Kyowa Hakko Kogyo Co., Ltd. | 2-aminoquinazoline derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6344150B2 (en) | 1988-09-02 |
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