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JPS5463072A - Decapeptide derivative and its preparation - Google Patents

Decapeptide derivative and its preparation

Info

Publication number
JPS5463072A
JPS5463072A JP12763777A JP12763777A JPS5463072A JP S5463072 A JPS5463072 A JP S5463072A JP 12763777 A JP12763777 A JP 12763777A JP 12763777 A JP12763777 A JP 12763777A JP S5463072 A JPS5463072 A JP S5463072A
Authority
JP
Japan
Prior art keywords
protecting group
carboxyl
derivative
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12763777A
Other languages
Japanese (ja)
Other versions
JPS6023680B2 (en
Inventor
Yoshihiro Nakamizo
Kuniaki Sakado
Haruki Takai
Yoshikazu Isowa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Sagami Chemical Research Institute filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP52127637A priority Critical patent/JPS6023680B2/en
Publication of JPS5463072A publication Critical patent/JPS5463072A/en
Publication of JPS6023680B2 publication Critical patent/JPS6023680B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:Decapeptide derivative of formula I [X1 is H, amino-protecting group; Y1,2 are carboxyl-protecting group; Y3 is NH2, carboxyl-protecting group; Z1 is H, OH-protecting group. SO3X (X is alkali metal such as K, Na, base such as triethylamine, H); Z2 is H, OH-protecting group].
EXAMPLE: A compound II (Z is benzyloxycarbonyl; Bzl is benzyl).
USE: Raw material of caerulein which is a physiologically active peptide.
PROCESS: The compound I can be prepared by the fragment condensation of 1 mole of a tetrapeptide derivative III (Y4 is OH, carboxyl-protecting group such as methyl ester) with 1-2 moles of a hexapeptide derivative IV or its acid salt, in the presence of proteinase, in an aqueous medium of pH2-11, at a temperature lower than the deactivation temp. of the enzyme, for about several tens sec. to 20 hours.
COPYRIGHT: (C)1979,JPO&Japio
JP52127637A 1977-10-26 1977-10-26 Decapeptide derivatives and their production method Expired JPS6023680B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP52127637A JPS6023680B2 (en) 1977-10-26 1977-10-26 Decapeptide derivatives and their production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52127637A JPS6023680B2 (en) 1977-10-26 1977-10-26 Decapeptide derivatives and their production method

Publications (2)

Publication Number Publication Date
JPS5463072A true JPS5463072A (en) 1979-05-21
JPS6023680B2 JPS6023680B2 (en) 1985-06-08

Family

ID=14965013

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52127637A Expired JPS6023680B2 (en) 1977-10-26 1977-10-26 Decapeptide derivatives and their production method

Country Status (1)

Country Link
JP (1) JPS6023680B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106282A2 (en) * 1982-10-08 1984-04-25 Shionogi & Co., Ltd. Production of caerulein intermediate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106282A2 (en) * 1982-10-08 1984-04-25 Shionogi & Co., Ltd. Production of caerulein intermediate
EP0106282A3 (en) * 1982-10-08 1986-05-14 Shionogi & Co., Ltd. Production of caerulein intermediate

Also Published As

Publication number Publication date
JPS6023680B2 (en) 1985-06-08

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