JPS5463072A - Decapeptide derivative and its preparation - Google Patents

Decapeptide derivative and its preparation

Info

Publication number: JPS5463072A
Authority: JP; Japan
Prior art keywords: protecting group; carboxyl; derivative; compound; preparation
Prior art date: 1977-10-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP12763777A

Other languages

English (en)

Other versions

JPS6023680B2 (ja

Inventor

Yoshihiro Nakamizo

Kuniaki Sakado

Haruki Takai

Yoshikazu Isowa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sagami Chemical Research Institute

KH Neochem Co Ltd

Original Assignee

Kyowa Hakko Kogyo Co Ltd

Sagami Chemical Research Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-10-26

Filing date

1977-10-26

Publication date

1979-05-21

1977-10-26 Application filed by Kyowa Hakko Kogyo Co Ltd, Sagami Chemical Research Institute filed Critical Kyowa Hakko Kogyo Co Ltd

1977-10-26 Priority to JP52127637A priority Critical patent/JPS6023680B2/ja

1979-05-21 Publication of JPS5463072A publication Critical patent/JPS5463072A/ja

1985-06-08 Publication of JPS6023680B2 publication Critical patent/JPS6023680B2/ja

Status Expired legal-status Critical Current

Links

ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
OVBRGKZTKQSNRM-JTRKXDDTSA-N 2-[[(9s,12s,15s,21s,30s,33s)-9-[(3-amino-4-hydroxyphenyl)methyl]-33-(2-amino-2-oxoethyl)-21-carbamoyl-12-(2-methylpropyl)-8,11,14,17,19,23,29,32,35-nonaoxo-30-propan-2-yl-19$l^{4}-thia-7,10,13,16,22,28,31,34-octazaspiro[5.29]pentatriacontan-15-yl]methyl]p Chemical compound N([C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCCCCC(=O)N[C@H](C[S+]([O-])CC(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@H](C(N[C@@H](CC=1C=C(N)C(O)=CC=1)C(=O)N1)=O)CC(C)C)C(N)=O)C(C)C)C(=O)C21CCCCC2 OVBRGKZTKQSNRM-JTRKXDDTSA-N 0.000 abstract 1
108010010737 Ceruletide Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
229910006127 SO3X Inorganic materials 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical group 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
229930190815 caerulein Natural products 0.000 abstract 1
YRALAIOMGQZKOW-HYAOXDFASA-N ceruletide Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)[C@@H](C)O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-HYAOXDFASA-N 0.000 abstract 1
229960001706 ceruletide Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
230000009849 deactivation Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000004702 methyl esters Chemical class 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
235000019833 protease Nutrition 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
YRALAIOMGQZKOW-UHFFFAOYSA-N sulfated caerulein Natural products C=1C=CC=CC=1CC(C(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C1NC(=O)CC1)CC1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

JP52127637A 1977-10-26 1977-10-26 デカペプチド誘導体およびその製造法 Expired JPS6023680B2 (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP52127637A JPS6023680B2 (ja)	1977-10-26	1977-10-26	デカペプチド誘導体およびその製造法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP52127637A JPS6023680B2 (ja)	1977-10-26	1977-10-26	デカペプチド誘導体およびその製造法

Publications (2)

Publication Number	Publication Date
JPS5463072A true JPS5463072A (en)	1979-05-21
JPS6023680B2 JPS6023680B2 (ja)	1985-06-08

Family

ID=14965013

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP52127637A Expired JPS6023680B2 (ja)	1977-10-26	1977-10-26	デカペプチド誘導体およびその製造法

Country Status (1)

Country	Link
JP (1)	JPS6023680B2 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0106282A2 (en) *	1982-10-08	1984-04-25	Shionogi & Co., Ltd.	Production of caerulein intermediate

1977
- 1977-10-26 JP JP52127637A patent/JPS6023680B2/ja not_active Expired

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0106282A2 (en) *	1982-10-08	1984-04-25	Shionogi & Co., Ltd.	Production of caerulein intermediate
EP0106282A3 (en) *	1982-10-08	1986-05-14	Shionogi & Co., Ltd.	Production of caerulein intermediate

Also Published As

Publication number	Publication date
JPS6023680B2 (ja)	1985-06-08

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