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JPS5461170A - Preparation of coerulein and its analogs - Google Patents

Preparation of coerulein and its analogs

Info

Publication number
JPS5461170A
JPS5461170A JP12763677A JP12763677A JPS5461170A JP S5461170 A JPS5461170 A JP S5461170A JP 12763677 A JP12763677 A JP 12763677A JP 12763677 A JP12763677 A JP 12763677A JP S5461170 A JPS5461170 A JP S5461170A
Authority
JP
Japan
Prior art keywords
protective group
novel
formula
salts
coerulein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12763677A
Other languages
Japanese (ja)
Other versions
JPS5828868B2 (en
Inventor
Yoshihiro Nakamizo
Kuniaki Sakado
Haruki Takai
Yoshikazu Isowa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Sagami Chemical Research Institute filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP52127636A priority Critical patent/JPS5828868B2/en
Publication of JPS5461170A publication Critical patent/JPS5461170A/en
Publication of JPS5828868B2 publication Critical patent/JPS5828868B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To obtain coerulein and its analogs of high purity and activity, which are physiologically active peptides and function test agents for bile ducts and pancreas, by easy punification with sligth side reactions, by removing protective groups form novel decapeptide derivatives or their salts having the protective groups.
CONSTITUTION: Novel decapeptide derivatives of formula I: [X1 H, amino protective group; Y1 and Y2 are carboxyl protective group; Y3 is NH2 or carboxyle protective group; Y1 and Y2 are carboxyle protective group. Y3 is NH2 or carboxyl protective group; Z1 is H or hydroxyl protective group in the side chain, -SO3X (X is alkali metal; base, e.g. triethylamine, etc., or H); Z2 is H or hydroxyl protective group in the side chain] or thier salts are subjected to removal of protective groups, preferably the novel compound of formula II: (Z is benzyloxycarbonyl; Bzl is benzyl group) or their salts are cotalytically reduced, to give coerulein and its analogs. The novel starting compounds of formaula I are obtained by fragment condensation of novel compounds of formula III: (Y4 is OH or methyl ester, etc.) with novel compounds of formula IV
COPYRIGHT: (C)1979,JPO&Japio
JP52127636A 1977-10-26 1977-10-26 Method for producing caerulein and its analogs Expired JPS5828868B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP52127636A JPS5828868B2 (en) 1977-10-26 1977-10-26 Method for producing caerulein and its analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52127636A JPS5828868B2 (en) 1977-10-26 1977-10-26 Method for producing caerulein and its analogs

Publications (2)

Publication Number Publication Date
JPS5461170A true JPS5461170A (en) 1979-05-17
JPS5828868B2 JPS5828868B2 (en) 1983-06-18

Family

ID=14964988

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52127636A Expired JPS5828868B2 (en) 1977-10-26 1977-10-26 Method for producing caerulein and its analogs

Country Status (1)

Country Link
JP (1) JPS5828868B2 (en)

Also Published As

Publication number Publication date
JPS5828868B2 (en) 1983-06-18

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