JP7551323B2 - Skin flora balance improver - Google Patents

Description

The present invention relates to an agent for improving the balance of resident skin bacteria, which contains lanolin fatty acid or its salt as an active ingredient.

A wide variety of microorganisms called skin flora live on human skin and play a part in maintaining the health of the skin. Staphylococcus epidermidis is known as the main skin flora. Staphylococcus epidermidis breaks down sebum to produce glycerin and fatty acids, which prevents the skin from drying out and regulates the pH to suppress the growth of various bacteria. It has also been reported that it promotes the production of antibacterial peptides. Thus, Staphylococcus epidermidis is known as a good bacterium that maintains the health of the skin. On the other hand, Staphylococcus aureus is also a bacterium that normally resides on the skin, but is known as a bad bacterium with strong pathogenicity. In healthy skin, no problems arise due to the normal biological defense function, but it is known that if Staphylococcus aureus proliferates for some reason, it can cause skin diseases. For example, it has been reported that in skin with rough skin, the balance between Staphylococcus epidermidis and Staphylococcus aureus is disrupted compared to when the skin is healthy, with a decrease in Staphylococcus epidermidis and an increase in Staphylococcus aureus. In particular, in atopic dermatitis, it has been reported that Staphylococcus epidermidis is greatly reduced at the site of inflammation, with Staphylococcus aureus dominating the majority of the area. Therefore, improving the balance between Staphylococcus epidermidis and Staphylococcus aureus is thought to be effective in preventing or improving these symptoms.

Patent Documents 1 and 2 state that certain fatty acids or salts thereof have antibacterial properties against Staphylococcus aureus. However, although it is stated that these fatty acids do not exhibit antibacterial properties against Staphylococcus epidermidis, their effect on the proliferation of Staphylococcus epidermidis has not been confirmed.

JP 2006-206582 A JP 2012-144453 A

The objective of the present invention is to provide a skin flora balance improver that has a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus.

As a result of investigations aimed at solving the above problems, the inventors discovered that lanolin fatty acids or salts thereof have a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus, and thus completed the present invention. In other words, the present invention provides an agent for improving the balance of resident skin bacteria that contains lanolin fatty acids or salts thereof as an active ingredient.

The skin resident flora balance improving agent of the present invention has a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. Therefore, it can be preferably used as a skin resident flora balance improving agent.

The present invention relates to an agent for improving the balance of resident skin bacteria, which contains lanolin fatty acid or its salt as an active ingredient.

The lanolin fatty acid used in the present invention is a fatty acid obtained by hydrolysis of wool fat secreted on the surface of sheep's wool. Wool fat may be used as is, but lanolin obtained by further refining wool fat through filtration, bleaching, deodorization, dehydration, solvent extraction, centrifugation, distillation, etc. may also be used. As lanolin, commercially available refined lanolin, liquid lanolin, hard lanolin, reduced lanolin, adsorbed refined lanolin, etc. can be used.

The method of hydrolysis of wool fat or lanolin is not particularly limited and known methods can be used, for example, it can be obtained by hydrolysis with an alkali. The alkalis used are generally sodium hydroxide, potassium hydroxide, etc., but other alkalis may also be used. Hydrolysis may also be performed with an acid such as hydrochloric acid, sulfuric acid, or phosphoric acid. The hydrolyzed wool fat or lanolin is separated by solvent extraction or the like, and the soap portion of the fatty acid is neutralized with an acid to form a free fatty acid, thereby obtaining the desired lanolin fatty acid. The main components of the lanolin fatty acid obtained in this way are approximately 7% by mass of normal fatty acid, 22% by mass of iso fatty acid, 29% by mass of anteiso fatty acid, 25% by mass of α-hydroxy normal fatty acid, 3% by mass of α-hydroxyiso fatty acid, 1% by mass of α-hydroxyanteiso fatty acid, 3% by mass of ω-hydroxy normal fatty acid, 1% by mass of ω-hydroxyiso fatty acid, and 1% by mass of ω-hydroxyanteiso fatty acid, and the number of carbon atoms is also a wide distribution from 9 to 33, making it a fatty acid with a very complex composition. Lanolin fatty acids include soft lanolin fatty acids and hard lanolin fatty acids whose compositions have been further altered by operations such as solvent fractionation and distillation, and either lanolin fatty acid can be used in the present invention, but from the viewpoint of economy, lanolin fatty acid or soft lanolin fatty acid is preferred, and from the viewpoint of exerting the effects of the present invention, soft lanolin fatty acid is more preferred. Soft lanolin fatty acid is a lanolin fatty acid obtained by hydrolyzing liquid lanolin, or by extracting relatively low molecular weight components from lanolin fatty acid by operations such as solvent extraction, centrifugation, and distillation, and has a melting point of about 35 to 55°C. In addition, as the soft lanolin fatty acid, the method described in JP-A-6-234994, specifically, a method in which lanolin fatty acid or a lower alcohol ester of lanolin fatty acid is treated with boric acid to convert the hydroxy fatty acid in the lanolin fatty acid into a borate ester, which is then separated as a fraction by molecular distillation, or a method in which lanolin fatty acid is heat-treated to convert the hydroxy fatty acid in the lanolin fatty acid into a lactide, which is then separated as a fraction by molecular distillation, and a lanolin fatty acid containing a large amount of non-hydroxy fatty acid components of lanolin fatty acid (commercially available Ecolano FA-NH is sold by Nippon Fine Chemical Co., Ltd.) can also be preferably used. In addition, as the soft lanolin fatty acid, lanolin fatty acid in which the content of 18-methyleicosanoic acid is increased by a method such as molecular distillation can also be preferably used.

The lanolin fatty acid used in the present invention can exert its effect even in the form of a salt, so it may be used as a salt. Examples of the salts of lanolin fatty acid used in the present invention include salts of the above-mentioned lanolin fatty acid with metals such as Li, Na, K, Ca, Ba, Mg, Al, Fe, Co, Zn, Ti, Sn, Pb, Cu, Ag, and Au; salts of basic amino acids such as lysine, arginine, histidine, and ornithine; and salts of nitrogen-containing bases such as ammonium, triethylamine, monoethanolamine, diethanolamine, triethanolamine, pyridine, imidazole, and guanidine. Among these, salts with metals selected from Na, K, Ca, Mg, Al, and Zn; salts with basic amino acids selected from lysine, arginine, histidine, and ornithine; and salts with nitrogen-containing bases selected from ammonium, triethanolamine, and guanidine are preferred, with salts with Na, K, Ca, Zn, ammonium, triethanolamine, arginine, or guanidine being more preferred. These lanolin fatty acid salts may be used alone or in combination of two or more.

As shown in the examples described below, the lanolin fatty acid or its salt of the present invention has a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. Therefore, it can be used as an active ingredient of a skin resident flora balance improving agent. The skin resident flora balance improving agent of the present invention may consist of the active ingredient itself, or may be dissolved, dispersed or mixed in a general base, such as water, gel, polyhydric alcohol, petrolatum, paraffin, vegetable oil, silicone oil, etc., in addition to the active ingredient. In addition, various additives can be used in combination as necessary. There are no particular limitations on the additives that can be used as long as they are commonly used to obtain the desired dosage form, and known ones such as excipients, colorants, thickeners, binders, disintegrants, dispersants, stabilizers, gelling agents, antioxidants, surfactants, preservatives, moisturizers, and pH adjusters can be appropriately selected and used.

The method of administering the skin flora balance improving agent containing the lanolin fatty acid or a salt thereof of the present invention as an active ingredient to a living body includes oral administration, administration by injection, transdermal administration, etc., but transdermal administration is preferred. The dosage is not particularly limited as long as it is an amount that can obtain the effects of the present invention, and may be adjusted appropriately depending on the dosage form of the preparation, the application site, age, sex, etc. In addition, it may be administered by being incorporated as one component of a pharmaceutical product as an active ingredient that exerts the desired effect. In the case of pharmaceutical products, it can be incorporated into oral preparations such as tablets, capsules, granules, powders, liquids, and suspensions; external preparations such as dermatological preparations, patches, eye drops, nasal drops, oral preparations, and suppositories; and parenteral preparations such as drops and injections.

The lanolin fatty acid or its salt used in the present invention can be preferably used as an active ingredient for improving the balance of resident skin bacteria, and can also be used as one component of cosmetics or topical skin preparations. There are no particular limitations on the amount of the lanolin fatty acid or its salt of the present invention that can be blended into cosmetics or topical skin preparations, and it is usually 0.01 to 30.0% by weight, preferably 0.05 to 20.0% by weight.

The cosmetic or topical skin preparation of the present invention may contain water and additives that are usually blended into cosmetic preparations, such as oily bases, moisturizers and texture enhancers, surfactants, polymers, thickeners and gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant, animal and microbial extracts, UV absorbers, antibacterial and preservatives, chelating agents, pH adjusters, acids and alkalis, solvents and propellants, antipruritics, keratin peeling and dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory and anti-inflammatory agents, hair growth agents, blood circulation promoters and stimulants, hormones, anti-wrinkle and anti-aging agents, irritation relief agents, cooling agents, warming agents, powders, dyes, colorants, dyes and pigments, fragrances, etc., to an extent that does not impair the effects of the present invention.

Oily bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxyethyl ether, glyceryl ... Higher fatty acids such as cystearic acid, palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and the like, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and sodium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomers, polyisobutene, hydrogenated polyisobutene Hydrocarbons such as polybutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, and hazelnut. Vegetable fats and oils such as tallow oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats and oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale wax, lanolin, orange roughy oil, etc.; liquid lanolin, reduced lanolin, adsorbed and purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin Lanolins such as lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, and cetyl-lanolyl acetate esters; phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salt, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; cholesterol sterols such as dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/ esters such as 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex; Octyldodecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, dicaprylyl carbonate, dimethicone Hexyldecyl octanoate, Octyldodecyl erucate, Hydrogenated castor oil isostearate, Ethyl oleate, Ethyl avocado oil fatty acid, Isopropyl myristate, Isopropyl palmitate, Octyl palmitate, Isopropyl isostearate, Isopropyl lanolinate, Methylheptyl laurate, Methylheptyl myristate, Methylheptyl palmitate, Methylheptyl isostearate, Diethyl sebacate, Diisopropyl sebacate, Dioctyl sebacate, Diisopropyl adipate, Dibutyloctyl sebacate, Diisobutyl adipate, Di succinate Monoalcohol carboxylates such as octyl, triethyl citrate, etc.; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, diisostearyl malate, etc.; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri(caprylic acid/capric acid), glyceryl tri(caprylic acid/capric acid/myristic acid/stearic acid), hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosandioate, Trimethylolpropane dioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate/sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearic acid/stearic acid/rosin acid) polyhydric alcohol fatty acid esters such as diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca(erucic acid/isostearate/ricinoleic acid) polyglyceryl-8, diglyceryl oligoester (hexyldecanoic acid/sebacic acid), glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dimer dilinoleate; dimer acid or dimer diol derivatives such as diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, phytosteryl/behenyl dimer dilinoleate, phytosteryl/isostearyl/cetyl/stearyl/behenyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, and hydroxyalkyl dimer dilinoleyl ether; coconut oil fatty acid monoethanolamide (COCAMIDE ME) A), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), and other fatty acid alkanolamides; dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethicone), Preferred examples include silicones such as cyclopentasiloxane, decamethylcyclopentasiloxane, phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethyl aminopropyl methicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane-oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

Moisturizing agents and texture improvers include polyols and polymers thereof such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid/tetradecanedioic acid), polyglyceryl-10 tetradecanedioic acid, and bisethoxydiglycol cyclohexanedicarboxylate; sorbitol, xylitol, and the like. sugar alcohols such as maltitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated cyclodextrins), β-glucan, chitin, chitosan, Heparin and derivatives, sugars and their derivatives such as pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharides ; organic acids such as citric acid, tartaric acid, lactic acid, and salts thereof; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine, and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen decomposition peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin decomposition peptides, keratin decomposition peptides, hydrolyzed keratin, conchiolin decomposition peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, lauroyl glycine, ... Hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein hydrolyzed peptide, acylated peptide, and other protein peptides and their derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture liquid, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphoryl Preferred examples include animal and plant extracts such as alcolin; placenta extract, alastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose rouge extract, yarrow extract, eucalyptus extract, and melilot extract; and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and glycoceramide-containing extracts.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. There is no particular limitation on the HLB of the surfactant, and surfactants from a low HLB of about 1 to a high HLB of about 20 can be used, and it is also preferable to combine surfactants with low and high HLBs. Preferred examples of the surfactant include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfate salts such as sodium laureth sulfate and triethanolamine laureth sulfate; and acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl glutamate methyl alanine. ; acylamino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, triethanolamine cocoyl alanine, and sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glycerides such as sodium hydrogenated coconut oil fatty acid glycerin sulfate olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecylbenzene sulfonate; alkyl naphthalene sulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethiones acid salts; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate salts; fatty acid amide ether phosphate salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, and cyclic lysophosphatidic acid or salts thereof; silicone-based anionic surfactants such as carboxylate-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants such as laureth (polyoxyethylene lauryl ether). polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as polyoxyethylene ethyl ethers, ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkyl phenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene Castor oil and hydrogenated castor oil derivatives such as diethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; PPG (Poly)glycerin polyoxypropylene glycol such as -9 diglyceryl; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl monocottonseed oil fatty acid, glyceryl monoerucate, glyceryl sesquioleate, glyceryl α,α'-oleate pyroglutamate, glyceryl monostearate malate and other glyceryl fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6, 10 distearate, polyglyceryl-2 tristearate, polyglyceryl-10 decatenate, polyglyceryl-2, 3, 4, 5 isostearate , 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate, and other polyglycerin fatty acid esters; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters esters; maltitol partial fatty acid esters; maltitol ethers; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; partial esters of sugar derivatives such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene Polyoxyethylene fatty acid mono- and diesters such as diethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene-propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate. Ethylene sorbitan fatty acid esters; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene sorbitol beeswax and other polyoxyethylene animal and vegetable oils and fats; isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, batyl alcohol and other alkyl glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene ethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (paltamide MEA), palmitic acid diethanolamide (paltamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide, cocamine oxide, stearamine oxide, alkyl dimethylamine oxides such as behenamine oxide and alkyl ethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as alkyl trimethyl ammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyl trimethyl ammonium bromides such as stearyltrimonium bromide; dialkyl dimethyl amine oxides such as distearyldimonium chloride and dicocodimonium chloride; Ammonium chloride; fatty acid amidoamines and their salts, such as stearamidopropyl dimethylamine and stearamidoethyl diethylamine; alkyl ether amines and their salts or quaternary salts, such as stearoxypropyl dimethylamine; fatty acid amide-type quaternary ammonium salts, such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyl dimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyl dimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine monium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts, such as cetylpyridinium chloride. imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; silicone-based cationic surfactants such as amino-modified silicones, cationic modified silicones, cationic modified and polyether modified silicones, and amino-modified and polyether modified silicones, etc.; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyldimethyl tauryl betaines such as lauryl dimethyl tauryl betaine; Preferred examples of the surfactant include alkyl sulfobetaines such as urin; sulfate type betaines such as alkyldimethylaminoethanol sulfate esters; phosphate type betaines such as alkyldimethylaminoethanol phosphate esters; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxide lecithin; silicone-based amphoteric surfactants; and polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, gum tragacanth, and acrylic acid/alkyl methacrylate copolymers; and various silicone-based surfactants.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellan, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its salts such as sodium salt, alginic acid and its salts such as sodium salt, mannan; starches such as rice, corn, potato and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, etc. cellulose, chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder, etc.; soluble starch, carboxymethyl starch, methylhydroxypropylcellulose, cellulose sulfate ... Starch-based polymers such as hydroxypropyl starch and methyl starch, starch derivatives such as hydroxypropyltrimonium starch chloride and corn starch aluminum octenylsuccinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylic acid ester copolymers such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine oxide methacrylate) copolymer; (dimethicone/vinyl dimethicone) crosspolymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; polyvinyl acetate partially saponified product, maleic acid copolymer; vinylpyrrolidone-dialkylamino methacrylate copolymer; alkyl copolymers; acrylic resin alkanolamines; polyesters, water-dispersible polyesters; polyacrylamides; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salts, acrylic acid-methacrylic acid ester copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymers such as polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymers such as polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymers, acrylic acid-cationized methacrylic acid amide copolymers, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, methacrylic acid chloride choline ester polymers; cationized oligosaccharides, cationized dextran, guar hydroxypropyl Preferred examples include cationic polysaccharides such as propyltrimonium chloride; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers; polymer emulsions such as acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride particles), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

Preferable examples of antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride. Preferable examples of reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferable examples of oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Examples of antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; Preferred examples of ascorbic acid derivatives include ascorbic acid sulfate and tocopheryl ascorbyl phosphate; vitamin A such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; vitamin E such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, quercetin, and apple polyphenol; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloid.

Examples of skin whitening agents include hydroquinone glycosides and their esters, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters, such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid esters, such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid. ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, cetyl tranexamate, and tranexamic acid amide; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and cholines; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; and vitamin B such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate. Preferred examples include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate, tocotrienol, and various other vitamin derivatives.

Plant, animal and microbial extracts include iris extract, angelica extract, asparagus extract, avocado extract, amacha extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, inchiko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica extract, echinacea leaf extract, enmeiso extract, scutellaria extract, and oubak extract. Extract, Coptis japonica extract, Barley extract, Panax ginseng extract, Hypericum extract, Lamium extract, Ononis extract, Dutch mustard extract, Orange extract, Dried seawater, Seaweed extract, Oyster leaf extract, Chinese yarrow extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomilla recutita extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karkade extract, Licorice extract, Oil-soluble Licorice extract, kiwi extract, kiō extract, wood ear extract, cinchona extract, cucumber extract, kiri leaf extract, guanosine, guava extract, sophora root extract, gardenia extract, kumazasa extract, sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentiana extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, Coffee extract, Burdock extract, Rice extract, Fermented rice extract, Fermented rice bran extract, Rice germ oil, Comfrey extract, Collagen, Cowberry extract, Chinese laurel extract, Bupleurum extract, Umbilical cord extract, Saffron extract, Salvia extract, Soapwort extract, Bamboo extract, Crataegus crenata extract, Sandalwood extract, Japanese pepper extract, Shiitake mushroom extract, Rehmannia root extract, Lithospermum root extract, Perilla extract, Tilia extract, Meadowsweet extract, Jatoba extract, Peony Extract, Ginger Extract, Calamus Root Extract, Birch Extract, White Jew's ... Poppo extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, hikio Preferred examples of extracts include koshi extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur bud extract, bupleurum extract, butcher's broom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, myocarpus extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid butyl ester, and N,N-dimethyl para-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid and its sodium salts, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl Cinnamic acid-based ultraviolet absorbers such as pyrcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocurin), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimeth benzophenone-based ultraviolet absorbers such as oxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2' -Hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidazol sulfonic acid, terephthalidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives are preferred.

Antibacterial and preservative agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, and benzalkonium chloride. , benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions are preferred, but when used as an antibacterial agent or preservative for the purpose of preservation, it is more preferred to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether, from the viewpoint of safety of cosmetics or topical skin preparations.

Preferred examples of chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetates); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

Preferred examples of pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and di Preferred examples of the propellant include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation fluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance P inhibitors, etc. Examples of keratin peeling/dissolving agents include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine, glycolic acid, etc. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, etc. Examples of cooling agents include menthol, methyl salicylate, etc. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, caffeine, etc. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, etc. Examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and disodium adenosine triphosphate.

Preferred examples of anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred examples of hair growth drugs, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Zinger tincture, Zinger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E, and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid, and derivatives such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and glycosides thereof, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, etc.

Anti-wrinkle and anti-aging agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid 2-glucoside; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate. ; Vitamin A such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, panthenol, soybean saponin, revelastrol, isoflavone, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolyzate, adenosine 5' monophosphate, phosphatidylinositol, trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate Na, tranexamic acid, and derivatives thereof are preferred.

Preferred examples of the irritation-relieving agents include mannosylerythritol lipid, diethylene glycol oligomer ester of dimer dilinoleic acid, diisostearyl malate, N-acyl-L-glutamic acid, trehalose mono fatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, polypropylene glycol, etc. Preferred examples of the cooling agent include menthol, camphor, menthyl lactate, monomenthyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, peppermint oil, and derivatives thereof. Preferred examples of warming agents include vanillin and its derivatives, nonanoic acid vanillylamide, shogaol, gingerol, capsicum tincture, capsicum extract, nicotinic acid derivatives such as benzyl nicotinate, methyl nicotinate, phenyl nicotinate, and tocopherol nicotinate, capsaicin, watercress extract, Japanese pepper extract, ginger extract, and canthari extract.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red ocher, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica Preferred examples of the inorganic powder include inorganic powders of various sizes and shapes, such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing mica, fine particle composite powder, gold, and aluminum, and inorganic powders obtained by treating these with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, and Teflon (registered trademark) powder, as well as surface-treated powders and organic-inorganic composite powders. Preferred examples of inorganic salts include sodium chloride-containing salts such as table salt, ordinary salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, ferrous sulfate, and copper sulfate; sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

Colorants, colorants, dyes and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402 No., Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 20 No. 5, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow 40 Legal dyes such as No. 5, Yellow No. 406, Yellow No. 407, Yellow No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; lenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red ocher) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide coated mica, titanium dioxide coated bismuth oxychloride, titanium dioxide coated talc, colored titanium dioxide coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; astaxanthin, alizari Preferred examples include anthraquinones such as benzoquinone, anthocyanidin, β-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin, and other naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

Fragrances include acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe super, isobutyl quinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, Geranyl acetate, dimethylbenzylcarbinyl acetate, styralyl acetate, cedryl acetate, terpinel acetate, p-t-butylcyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrol. Lux resinoids, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, alpha-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol Preferred examples include synthetic and natural fragrances such as oleic acid, balsam of Peru, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

Preferred examples of water include tap water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

In addition to these, it is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, ratios, and amounts, such as ingredients listed in the Cosmetic Raw Materials Standards, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Materials Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Official Specification, etc., and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) that fall into the International Patent Classification IPC classifications A61K7 and A61K8.

Types of the cosmetic of the present invention include hair cosmetics, skin cosmetics, make-up cosmetics, fragrance cosmetics, body cosmetics, etc. The cosmetic of the present invention can be produced according to a conventional method.

To explain the types of cosmetics of the present invention in more detail, preferred hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, and rinse-integrated shampoo; hair care products such as rinse, conditioner, treatment, hair pack, hair mist, and hair oil; hair styling products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and hair styling products; hair dye products such as color lotion, hair color treatment, hair manicure, and oxidation hair dye; hair tonic, hair liquid, hair blow, split end coat, permanent wave agent, straight perm agent, hair bleach, hair color pre-treatment, hair color after-treatment, perm pre-treatment, perm after-treatment, and hair growth agent.

Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, and liposome lotion; emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, and other skin care products. Preferred examples include creams such as moisturizing cream and keratin softening cream; gels such as moisturizing gel, whitening gel, and all-in-one gel; beauty serums such as moisturizing essence, whitening essence, moisturizing serum, and whitening serum; sunscreens such as sun protect, sun protector, UV care milk, and sunscreen; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; makeup removers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, and cleansing oil; and facial cleansers such as paste facial cleansing foam, gel facial cleansing foam, foam facial cleansing foam, facial cleansing powder, cosmetic soap, transparent soap, medicated soap, liquid soap, and shaving soap.

Preferred examples of makeup cosmetics include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eye shadow, eyebrow pencil, eyebrow pencil, nail enamel, enamel remover, and nail treatment.

Preferred examples of aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfume paste, aromatic powder, perfumed soap, body lotion, and bath oil.

Preferred examples of body cosmetics include body cleansers such as body shampoos, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays and deodorant sticks, bleaches, depilatories, bath additives, and insect repellents such as insect repellent sprays.

Preferred types of skin topical preparations of the present invention include ointments, lotions, creams or gels for skin application, patches, liniments, liquid application agents, etc. They can also be used as oral cosmetic products such as toothpaste and mouthwash.

Preferred formulations of the cosmetic or topical skin preparation of the present invention include emulsion-type cosmetics such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, and O/W/O type, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-type cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsion polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

The present invention will be described in more detail below using examples, but the present invention is not limited to these examples.

<Evaluation of bacterial growth or growth inhibition>
Staphylococcus epidermidis, which had been pre-cultured in advance, was suspended in physiological saline to a concentration of 1 x 10 ⁸ cfu/mL to prepare a bacterial solution. Next, the bacterial solution was added to an SCD liquid medium to which lanolin fatty acid listed in Table 1 had been added to a concentration of 200 μg/mL, to give a concentration of 1 x 10 ⁷ cfu/mL, and the mixture was aerobically cultured at 37°C for 18 hours. The liquid medium after the culture was diluted with LP dilution solution to an appropriate bacterial cell concentration, added to an SCD agar medium, and aerobically cultured at 37°C for 18 hours. As a control, a medium to which lanolin fatty acid had not been added was similarly cultured. The bacterial growth or growth inhibition was evaluated by visually checking the number of colonies on the agar medium after the culture. The evaluation criteria were as follows, and the results are shown in Table 1. A similar test was also performed on Staphylococcus aureus, and the results are shown in Table 1.

Evaluation criteria: ++: The number of colonies increased compared to the control. +: The number of colonies increased slightly compared to the control. ±: The number of colonies did not change compared to the control. -: The number of colonies decreased slightly compared to the control. --: The number of colonies decreased compared to the control.

The results in Table 1 confirm that lanolin fatty acids or their salts have a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus.

The formulation of a cosmetic product containing the skin resident flora balance improving agent of the present invention is shown below.

Example 1 Lotion
Component Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.5
BG 4.0
Glycerin 2.0
Inositol 0.5
Dipotassium glycyrrhizinate 0.01
Ethanol 3.0
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Neosolue-DiSM (Nippon Fine Chemicals) 0.1
Polysorbate-80 1.0
Decyl glucoside 0.5
Citric acid 0.1
Sodium citrate: Amount required to achieve a pH of 4.5 Ca carbonate: 0.2
Disodium edetate 0.1
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (total: 100) Part B Xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemicals) 0.1
Purified water 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part B was mixed to prepare a viscous liquid. Part A was heated to about 80°C and dissolved uniformly. Part B was slowly added to part A while stirring, and after cooling to 40°C, part C was added to prepare a uniform liquid.

Example 2 Lotion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.3
Diglycerin 3.0
Hydrolyzed Hyaluronic Acid 0.01
Arginine 0.05
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Neosolue-Aquilio (Nippon Fine Chemicals) 0.5
Neosolue-DiSM (Nippon Fine Chemicals) 0.2
PEG-400 1.5
PEG-32 2.0
PPG-6 Decyltetradeceth-30 0.2
PEG-60 hydrogenated castor oil 0.2
PEG-30 Phytosterol 0.1
Cocoyl hydrolyzed collagen K 0.5
Betaine 0.5
Pullulan 0.5
Tremoist-TP (Nippon Fine Chemicals) 0.01
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Glyceryl Caprate 0.5
Purified water Total amount to 100 Part B Tranexamic acid (Nippon Fine Chemical) 1.0
Citric acid 0.01
Sodium citrate 0.05
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A was heated to about 80° C. and mixed uniformly. Part B was added to make a uniform liquid.

Example 3 Moisturizing lotion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.3
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Neosolue-Aquilio (Nippon Fine Chemicals) 0.5
Neosolue-DiSM (Nippon Fine Chemicals) 0.1
Diglycerin 2.0
Polyglyceryl-10 Laurate 0.3
Polyglyceryl-10 Decaoleate 0.6
Polyglyceryl-2 diisostearate 0.3
Betaine 1.0
Pyridoxine palmitate 0.1
Part B: Dipotassium glycyrrhizinate 0.1
PCA Zinc 0.3
Alginate Ca 0.1
Phenoxyethanol 0.4
Tremoist-TP (Nippon Fine Chemicals) 0.01
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Parts A and B were heated to make a homogeneous liquid. Part B was gradually added to Part A while stirring, and the mixture was cooled.

Example 4 Gel lotion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl Behenate 0.8
Isostearic acid 0.3
PEG-30 Phytosterol 0.1
Part B: Soft lanolin fatty acid (Nippon Seika) arginine salt 0.3
Pullulan 0.2
Ethylhexylglycerin 0.4
1,2-Hexanediol 0.1
Polymethacryloyl lysine 0.05
Polylysine 0.2
Ornithine 0.2
Allantoin 0.1
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Calcium pantothenate 0.2
Sodium Hyaluronate 0.01
Carbomer 0.06
Potassium hydroxide 0.05
Purified water Total amount to 100 C part Tremoist-TP (Nippon Fine Chemical) 0.1
(Acrylate dimethyl taurate ammonium/vinyl pyrrolidone) copolymer
0.05
(Acrylates/C10-30 alkyl acrylate) crosspolymer
0.05
Purified water 30.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A was heated to about 70° C. and dispersed uniformly. Part B was mixed and thoroughly stirred to homogenize, and then heated to about 70° C. Part B was added to part A, stirred at about 70° C. using a homomixer, cooled to about 40° C., and part C was added.

Example 5 Whitening emulsion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 2.0
Plandool-LG3 (Nippon Fine Chemicals) 2.0
Plandool-H (Nippon Fine Chemical) 2.0
Plandool-DP (Nippon Fine Chemicals) 1.0
Plandool-MAS (Nippon Fine Chemicals) 1.0
Isopropyl palmitate (Nippon Fine Chemicals) 5.0
Cetanol 1.2
Phenyl Trimethicone 3.0
Isopropyl myristate (Nippon Fine Chemicals) 3.0
Mineral Oil 2.0
Hydrogenated polyisobutene 1.0
Part B: Stearoxy hydroxypropyl methylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical) 1.0
Pentylene glycol 3.0
Glycerin 8.0
Part D 3-O-ethyl ascorbic acid (Nippon Fine Chemicals) 1.0
Arbutin (Nippon Fine Chemicals) 1.0
Salicylic acid 0.5
Purified water 5.0
Part E Phytic acid 0.5
Guanidine 1.0
Lysine 0.2
Citric acid 0.1
Sodium citrate: amount to make the pH 4.5 Purified water: amount to make a total of 100 ----------------------------------- ---
(Preparation Method)
Part A and Part E were heated to about 70° C. and dissolved uniformly. Part B was stirred to make a viscous liquid. Part C was heated to about 70° C. and dispersed uniformly. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Parts D and B were added at about 50° C., and were dissolved uniformly by stirring.

Example 6 Whitening emulsion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.5
Plandool-H (Nippon Fine Chemical) 1.0
Diethylhexyl sebacate (Nippon Fine Chemicals) 5.0
Diethylhexyl succinate (Nippon Fine Chemicals) 5.0
Lauroyl Lysine 0.2
Cetanol 1.2
Phenyl Trimethicone 3.0
Ethylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
Part B: Stearoxy hydroxypropyl methylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical) 1.0
Pentylene glycol 2.0
1,2-Hexanediol 1.0
BG 5.0
Glycerin 8.0
Part D Arbutin (Nippon Fine Chemicals) 1.0
Tranexamic acid (Nippon Fine Chemicals) 1.0
Glabridin 0.1
Purified water 5.0
Part E Sodium sulfite 0.05
Phytic acid 0.5
Arginine 1.0
Lysine 0.2
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A and Part E were heated to about 70° C. and dissolved uniformly. Part B was stirred to make a viscous liquid. Part C was heated to about 70° C. and dispersed uniformly. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Parts D and B were added at about 50° C., and were dissolved uniformly by stirring.

Example 7 Emulsion Component Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Hydrogenated lysophospholipid (Nippon Fine Chemicals) 0.1
Part B Ecolano FA-NH (Nippon Fine Chemical) 1.0
Trioctanoin (Nippon Fine Chemicals) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemicals) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl alcohol 1.0
Arachyl alcohol 0.1
Jojoba Alcohol 3.0
Chiral alcohol 0.3
Selachyl alcohol 0.1
Hexyldecanol 0.5
Part C (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer
0.2
Tremoist-TP (Nippon Fine Chemicals) 0.03
Carbomer 0.1
Purified water 20.0
D part Neosolue-AquaS (Nippon Fine Chemical) 0.5
Polyquaternium-51 1.0
Ascorbyl Glucoside 1.0
Potassium hydroxide 0.3
Phenoxyethanol 0.4
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Parts A, B and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to make a viscous liquid. Part A was mixed in a homodisperser. After adding part B with stirring, part D was added and emulsified. After cooling to about 50°C, part C was added and cooled to about 40°C with stirring.

Example 8 Skin care cream Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.3
Squalane 5.0
Stearic acid 1.0
Plandool-ISS (Nippon Fine Chemical) 1.0
Macadamia nut oil 3.0
Hydrogenated Jojoba Oil 2.0
Vaseline 2.0
Stearyl glycyrrhetinate 0.05
Olive oil fatty acid cetearyl 1.0
Sorbitan olive oil fatty acid 0.8
Lanolin fatty acid arginine salt 1.5
Polyglyceryl-10 Oleate 1.0
Part B: Acrylic acid/alkyl methacrylate copolymer 0.1
Potassium hydroxide 0.07
(Acryloyldimethyltaurate ammonium /
Beheneth-25) Methacrylate Crosspolymer 0.2
Tremoist-SL (Nippon Fine Chemicals) 1.0
Purified water 10.0
Hydrolyzed poly-γ-glutamic acid K 0.1
Sodium polyglutamate 0.1
Oligopeptide-24 0.05
Part C Inulin-SC (Nippon Fine Chemical) 1.0
Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
Nicotinamide 2.0
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A and part C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to make a viscous liquid. Part C was emulsified by adding part A while stirring with a homomixer. After cooling to about 50°C, part B was added and stirred to cool to about 40°C.

Example 9 Skin care cream Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemicals) 2.5
Part B Soft lanolin fatty acid (Nippon Seika) 0.2
Olive oil 1.5
Shea butter 1.0
Neosolue-DiSM (Nippon Fine Chemicals) 5.0
Sucrose stearate 0.8
Cetearyl Glucoside 1.2
Behenyl Alcohol 1.5
Ceramide 2 0.01
Ceramide 3 0.01
Ceramide 5 0.01
Ceramide 6 0.01
Retinol Palmitate 0.01
Ascorbyl Tetrahexyldecanoate 7.0
Isopropyl Lauroyl Sarcosine 2.0
Hydrogenated Cocoglycerides 3.0
Cetanol 2.5
Sorbitan stearate 0.8
Part C Xanthan gum 0.05
Tremoist-SL (Nippon Fine Chemicals) 1.0
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed Collagen 0.5
Sodium pyrosulfite 0.03
Aluminum potassium sulfate 0.05
Nicotinamide 1.0
Arbutin (Nippon Fine Chemicals) 1.0
Tranexamic acid (Nippon Fine Chemicals) 1.0
D Division Neosolue-Aquilio (Nippon Fine Chemicals) 1.0
Propanediol 3.0
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A, part B, and part D were mixed and heated to about 70°C, and were dissolved and dispersed uniformly. Part C was mixed and stirred to obtain a viscous liquid. Part B was added to part A while stirring with a homodisper, and then part D was added to emulsify. The mixture was cooled to about 50°C, and part C was added, stirred, and cooled to about 40°C.

Example 10 Skin care cream Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 2.0
Plandool-LG2 (Nippon Fine Chemicals) 2.0
Plandool-H (Nippon Fine Chemical) 2.0
Squalane 8.0
Behenyl Alcohol 1.0
Plandool-ISS (Nippon Fine Chemical) 1.0
γ-oryzanol 0.2
Macadamia nut oil 3.0
Hydrogenated Jojoba Alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Sorbitan olive oil fatty acid 0.8
Polyglyceryl-10 Oleate 1.0
Polyglyceryl-10 Laurate 0.5
Part B: Acrylic acid/alkyl methacrylate copolymer 0.1
Potassium hydroxide 0.07
Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.05
(Ammonium acryloyldimethyltaurate/Beheneth-25 methacrylate)
Crosspolymer 0.05
Tremoist-TP (Nippon Fine Chemicals) 0.02
Purified water 10.0
Sodium polyglutamate 0.1
Oligopeptide-24 0.05
C part Neosolue-Aqua (Nippon Fine Chemical) 1.0
Tranexamic acid (Nippon Fine Chemicals) 1.0
Mannosyl Erythritol Lipid 0.2
Diglycerin 5.0
Propanediol 3.0
PEG-8 2.0
Sodium pyrosulfite 0.03
Methylparaben 0.1
Phenoxyethanol 0.3
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A and part C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to make a viscous liquid. Part C was emulsified by adding part A while stirring with a homomixer. After cooling to about 50°C, part B was added and stirred to cool to about 40°C.

Example 11 Cleansing cream Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 5.0
Plandool-LG2 (Nippon Fine Chemicals) 2.0
Plandool-S (Nippon Fine Chemicals) 2.0
Neosolue-Aquilio (Nippon Fine Chemicals) 2.0
Diisostearyl malate 6.0
Diethylhexyl succinate (Nippon Fine Chemicals) 2.0
Neosolue-DiSM (Nippon Fine Chemicals) 2.0
Mineral oil 23.0
Diethylhexyl sebacate (Nippon Fine Chemicals) 10.0
PEG-25 hydrogenated castor oil 3.0
PEG-20 Glyceryl Triisostearate 4.0
PEG-12 isostearate 3.0
Sorbitan Sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Polyglyceryl-6 stearate 0.5
Glyceryl stearate 1.0
Microcrystalline Wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B Neosolue-AquaS (Nippon Fine Chemical) 1.0
Diglycerin 3.0
DPG 5.0
Disodium edetate 0.02
Phenoxyethanol 0.5
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A was weighed out and dissolved by heating to about 80° C. Part B was weighed out and heated to about 80° C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40° C.

Example 12 Facial cleanser Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.5
Plandool-LG2 (Nippon Fine Chemicals) 2.0
Potassium stearate 10.0
Potassium palmitate 10.0
Potassium myristate 10.0
Potassium Laurate 4.0
Titanium dioxide 1.0
Talc 0.5
Isopropyl Lauroyl Sarcosine 0.8
PEG1500 10.0
Glycerin 15.0
Glyceryl Monostearate 1.0
POE(20) Sorbitan Monostearate 2.0
Part B Tremoist-TP (Nippon Fine Chemical) 0.02
Hydroxypropyl methylcellulose 0.05
Tuberose polysaccharide 0.05
Cationic guar gum 0.05
Dipotassium glycyrrhizinate 0.05
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Glyceryl Caprylate 0.5
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A was weighed out and dissolved by heating to about 80° C. Part B was weighed out and heated to about 80° C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40° C.

Example 13 Hand cream Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 1.0
Neosolue-DiSM (Nippon Fine Chemicals) 8.0
Ecolano CLE-S (Nippon Fine Chemical) 5.0
LUSPLAN DD-DA7 (Nippon Fine Chemicals) 0.5
Squalane 8.0
Macadamia nut oil 0.5
Rosehip Oil 1.0
Meadowfoam Oil 1.0
Vaseline 15.0
Microcrystalline Wax 2.0
Glyceryl Stearate 2.0
Cetanol 2.0
Cetyl phosphate 1.0
Lanolin Alcohol 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
Propanediol 5.0
Phenoxyethanol 0.3
Ethylhexylglycerin 0.5
Sodium hydroxide 0.5
Water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part B was heated to about 70°C and dissolved. Part A was placed in a separate container and heated to about 80°C and dissolved. Part A was added to part B while stirring with a homomixer to emulsify. After emulsification, it was cooled to about 40°C.

Example 14 Facial cleanser Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Potassium Cocoyl Glycine 5.0
Sodium Lauroyl Glutamate 4.0
Sodium methyl cocoyl taurate 2.0
Decyl glucoside 3.0
Cocamidopropyl Betaine 2.0
Betaine 1.0
Potassium stearate 1.0
Ecolano FA-NH (Nippon Fine Chemicals) Arginine Salt 3.0
Isopropyl Lauroyl Sarcosine 0.8
PPG-Arginine 5.0
Glycerin 15.0
Plandool-SUN (Nippon Fine Chemical) 0.2
Glyceryl Monostearate 1.0
Part B Inulin-SC (Nippon Fine Chemical) 1.0
Tremoist-TP (Nippon Fine Chemicals) 0.02
Phytopresome MEL (Nippon Fine Chemicals) 1.0
Hydroxypropyl methylcellulose 0.2
Ecolano CA-NH (Nippon Fine Chemical) 0.1
Phenoxyethanol 0.5
Purified water Amount that adds up to 100 ---------------------------------
(Preparation Method)
Part A was dissolved by heating to about 80° C. Part B was heated to about 80° C. Part B was gradually added to part A while stirring, and after mixing, it was cooled to 40° C.

Example 15 Lipstick Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Soft lanolin fatty acid (Nippon Seika) 4.0
Hydrogenated polyisobutene 6.0
LUSPLAN DD-DA7 (Nippon Fine Chemicals) 3.0
Polybutene 8.0
Polyethylene 5.0
Ethyl cellulose 0.2
Synthetic Wax 1.2
Shea Butter 3.0
Iron oxide 2.3
Mica 1.5
Titanium dioxide 2.5
Red 202 1.5
Cetyl ethylhexanoate (Nippon Fine Chemicals) 5.0
Sorbitan Sesquioleate 1.0
Tocopherol 0.05
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
All ingredients were heated to about 80° C., mixed uniformly, and then cooled to room temperature.

Example 16 Foundation Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 1.0
Isododecane 10.0
Capric/caprylic triglyceride (Nippon Fine Chemical) 4.0
Ethylhexyl methoxycinnamate 3.0
Plandool-SUN (Nippon Fine Chemical) 1.0
Plandool-LG2 (Nippon Fine Chemicals) 1.0
Plandool-LG4 (Nippon Fine Chemicals) 1.0
Vaseline 1.0
Isotridecyl isononanoate 2.0
Ascorbyl Tetrahexyldecanoate 0.1
Dextrin palmitate 0.3
Sorbitan isostearate 1.5
Calcium stearate 1.0
Tribehenin 0.5
(Butyl acrylate/glycol dimethacrylate) crosspolymer,
Silica, (Methyl methacrylate/glycol dimethacrylate) crosspolymer mixture
2.0
Boron nitride 1.0
Polysorbate 20 2.0
PEG-60 hydrogenated castor oil 1.0
Disteardimonium Hectorite (20%) 2.5
Polypropylsilsesquioxane Cyclopentasiloxane Mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium dioxide 10.0
Iron oxide 1.5
B Section DPG 4.0
Maltitol (75% liquid) 1.0
Neosolue-AquaS (Nippon Fine Chemicals) 0.4
Sodium chloride 1.0
BG 1.0
Tremoist-SL (Nippon Fine Chemicals) 1.0
Histidine 0.7
Ethanol 0.5
Purified water Amount that adds up to 100 -------------------------------------------------
(Preparation Method)
Part A was heated to about 70°C and thoroughly stirred to disperse uniformly. Part B was heated to about 70°C and homogenized, after which part B was added to part A, stirred and emulsified at about 70°C, and cooled to about 40°C.

Example 17 Sunscreen cosmetic Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Soft lanolin fatty acid (Nippon Seika) 0.5
Ethylhexyl methoxycinnamate 7.0
Diethylamino hydroxybenzoyl hexyl benzoate 7.0
Behenyl Alcohol 4.0
Plandool-LG1 (Nippon Fine Chemicals) 0.5
Plandool-MAS (Nippon Fine Chemicals) 1.0
Part C Inulin-SC (Nippon Fine Chemical) 0.3
Purified water (total: 100) D part Xanthan gum 0.2
Sodium Hyaluronate 0.01
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A was uniformly dispersed. Parts B and C were each heated to about 70°C to dissolve. Part B was gradually added to part A, and then part C was gradually added to emulsify. The mixture was cooled with stirring, and part D was added at 45°C and mixed uniformly.

Example 18 Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.2
Isopropyl palmitate (Nippon Fine Chemicals) 0.2
Diethylhexyl sebacate (Nippon Fine Chemicals) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
TEA-Cocoyl Glutamate (30%) 3.0
Lauryl Hydroxysultaine (30%) 7.0
Potassium laurate 1.0
Glycol distearate 0.5
Stearoxypropyldimethylamine 0.5
PPG-17 0.3
Neopentyl glycol diethylhexanoate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Steareth-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
Phenoxyethanol 0.4
EDTA-2Na 0.05
Phosphoric acid 0.03
Sodium benzoate 0.3
Purified water Total amount to 100 D part Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemicals) 0.02
Purified water 6.7
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A and part B, which had been mixed in advance, were mixed uniformly at about 80° C. (Part E). Part C, which had been set aside, was heated to about 60° C. and homogenized. Part C was gradually added to part E while stirring, and after uniform mixing, the mixture was cooled to about 50° C. Part D was further added and mixed uniformly.

Example 19 Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.2
Isopropyl palmitate (Nippon Fine Chemicals) 0.2
Diethylhexyl sebacate (Nippon Fine Chemicals) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
TEA-Cocoyl Glutamate (30%) 3.0
Lauryl Hydroxysultaine (30%) 7.0
Potassium laurate 1.0
Glycol distearate 0.5
Stearoxypropyldimethylamine 0.5
PPG-17 0.3
Neopentyl glycol diethylhexanoate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Steareth-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
EDTA-2Na 0.05
Phosphoric acid 0.03
Sodium benzoate 0.5
Purified water Total amount to 100 D part Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemicals) 0.02
Purified water 6.7
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A and part B, which had been mixed in advance, were mixed uniformly at about 80° C. (Part E). Part C, which had been set aside, was heated to about 60° C. and homogenized. Part C was gradually added to part E while stirring, and after uniform mixing, the mixture was cooled to about 50° C. Part D was further added and mixed uniformly.

Example 20 Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.2
Isopropyl palmitate (Nippon Fine Chemicals) 0.2
Diethylhexyl sebacate (Nippon Fine Chemicals) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
TEA-Cocoyl Glutamate (30%) 3.0
Lauryl Hydroxysultaine (30%) 7.0
Potassium laurate 1.0
Glycol distearate 0.5
Stearoxypropyldimethylamine 0.5
Dimethicone (10,000 cSt) 0.1
PEG-9 Dimethicone 0.1
PPG-17 0.3
Neopentyl glycol diethylhexanoate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Steareth-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
Methylparaben 0.2
EDTA-2Na 0.05
Phosphoric acid 0.03
Purified water Total amount to 100 D part Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemicals) 0.02
Purified water 6.7
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A and part B, which had been mixed in advance, were mixed uniformly at about 80° C. (Part E). Part C, which had been set aside, was heated to about 60° C. and homogenized. Part C was gradually added to part E while stirring, and after uniform mixing, the mixture was cooled to about 50° C. Part D was further added and mixed uniformly.

Example 21 Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.5
Oleic acid 0.3
TEA Lauroyl Glutamate 3.0
Sodium Cocoyl Methylalanine 1.0
Hydrogenated palm oil fatty acid PEG-200 glyceryl 1.0
Coco Betaine (25%) 8.0
Glycerin 1.0
Polysorbate 20 0.5
Coconut oil fatty acid PEG-7 glyceryl 0.4
PPG-2 Cocamide 0.3
PEG-40 hydrogenated castor oil 1.0
Tocopherol 0.03
Bisabolol 0.01
Part B Inulin-SC (Nippon Fine Chemical) 1.5
Sodium benzoate 0.4
Sodium chloride 0.5
3-O-Ethyl ascorbic acid (Nippon Fine Chemicals) 0.1
Purified water (total amount: 100) Polyquaternium-10 0.3
Part C Phenoxyethanol 0.6
Phenethyl alcohol 0.2
Ethylhexylglycerin 0.2
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A and Part B, which had been mixed and dissolved in advance, were mixed uniformly at about 80° C. The mixture was gradually cooled with stirring, and Part C was added at 60° C.

Example 22 Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) Arginine salt 0.4
Diethyl sebacate (Nippon Fine Chemicals) 0.5
Isostearyl alcohol 0.1
Sodium methyl cocoyl taurate (30%) 8.0
Cocamidopropyl Betaine (30%) 5.0
Sodium Laureth Sulfate (25%) 6.0
Laureth-2 1.0
Sorbeth-60 Tetraoleate 3.5
Caprylyl glucoside 0.3
Polylysine 0.2
Cocamide DEA 3.0
PEG-20 hydrogenated castor oil 0.5
Neopentyl glycol diheptanoate 0.3
Ethyl oleate 0.3
Glyceryl Caprate 0.5
Part B EDTA-2Na 0.05
Propanediol 0.5
Purified water Total amount to 100 C part NanoRepair-CMC5 (Nippon Fine Chemical) 8.0
Polyquaternium-10 0.1
Guar Hydroxypropyltrimonium Chloride 0.3
Tromethamine 0.3
Arginine 0.5
Sodium hydroxide 0.1
Sodium chloride 0.3
Aphanothece saccharum polysaccharide 0.1
Purified water 19.3
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part B was heated to about 80°C and dissolved uniformly. Part A was placed in a separate container and heated to dissolve. Part B was gradually added to part A and mixed uniformly, and part C was added at about 60°C.

Example 23 Body Shampoo Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.2
Plandool-G (Nippon Fine Chemicals) 0.2
Cocamidopropyl Betaine 7.0
Potassium Cocoyl Glycine 5.0
Cocamide DEA 2.0
PEG-80 Sorbitan Laurate 3.0
Sodium Lauroyl Glutamate 4.0
DPG 2.5
Coconut oil alkyl glucoside 3.0
Glycerin 10.0
Cetanol 0.2
PEG-8 3.0
Pentylene glycol 2.0
Part B EDTA-2Na 0.05
Etidronate Trisodium 0.10
Iodide propynyl butylcarbamate 0.01
Methylparaben 0.15
Purified water Total amount to 100 C parts (styrene/alkyl acrylate) copolymer 0.2
Guar Hydroxypropyltrimonium Chloride 0.5
Phenoxyethanol 0.5
Purified water 8.8
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part B was heated to about 80°C and dissolved uniformly. Part A was placed in a separate container and heated to dissolve. Part B was gradually added to part A and mixed uniformly, and part C was added at about 60°C.

Example 24 Cleansing Balm Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Ethylhexyl palmitate Amount that totals 100 Cetyl ethylhexanoate (Nippon Fine Chemicals) 10.0
Ecolano FA-NH (Nippon Fine Chemical) 1.0
Plandool-LG3 (Nippon Fine Chemicals) 0.2
Plandool-S (Nippon Fine Chemicals) 0.5
PEG-20 Glyceryl Triisostearate 14.0
Alkyl (C12,14)oxyhydroxypropyl arginine HCl 0.3
Cocoyl arginine ethyl PCA 0.3
Polyethylene 5.5
Microcrystalline Wax 2.0
Phenoxyethanol 0.5
Tocopherol 0.05
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
All ingredients were weighed out and mixed at about 90°C with stirring until uniform.

Example 25 Cleansing oil Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Soft lanolin fatty acid (Nippon Seika) 5.0
Neosolue-Aquilio (Nippon Fine Chemicals) 2.0
Cetyl ethylhexanoate (Nippon Fine Chemicals) 9.0
Mineral oil 14.0
Glycerin 16.0
BG 5.0
PEG-8 Glyceryl Isostearate 14.0
PEG-7 glyceryl coconut oil fatty acid 14.0
Polyglyceryl-2 diisostearate 1.5
EDTA-2Na 0.1
Citric acid 0.01
Sodium citrate 0.09
Purified water Amount that adds up to 100 ---------------------------------
(Preparation Method)
All ingredients were weighed out and mixed at room temperature until homogenous.

Example 26 Scalp lotion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Ecolano FA-NH (Nippon Fine Chemicals) Arginine Salt 0.2
Glycerin 4.0
Pentylene glycol 2.0
Maltitol Liquid 0.5
Glycyrrhetinic acid 0.05
PPG-5 Phytosterol 0.1
Betaine 0.2
Carrot extract 0.1
Swertia japonica extract 0.1
Tamasakizurafuji Root Extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
All ingredients were weighed out and mixed at room temperature until homogenous.

Example 27 Scalp lotion Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) arginine salt 0.4
Glycerin 2.0
Neosolue-AquaS (Nippon Fine Chemicals) 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
3-O-Ethyl ascorbic acid (Nippon Fine Chemicals) 0.3
Sodium Hyaluronate 0.01
Tremoist-SL (Nippon Fine Chemicals) 0.5
Caprylyl Proline 0.3
Raffinose 0.2
Arginine 0.5
Serine 0.1
Glycine 0.1
Purified water Total amount is 100 B part Ethanol 10.0
Methylparaben 0.1
Menthol 0.1
Menthoxypropanediol 0.1
Ethyl dicarboethoxypantothenate 0.2
Camphor 0.1
Carrot Extract 1.0
Swertia japonica extract 1.0
Glycosyl trehalose 0.5
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Each component of part A and part B was weighed out and mixed uniformly. Part B was added to part A and mixed uniformly.

Example 28 Scalp Treatment Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.8
Neosolue-Aquilio (Nippon Fine Chemicals) 2.0
Stearamidopropyl dimethylamine 0.8
Cetanol 3.0
Caprylyl glucoside (50%) 0.8
Part B: Dipotassium glycyrrhizinate 0.1
Hydrolyzed Keratin 0.1
Rosemary Extract 0.1
Artemisia capillaris extract 0.2
Pyridoxine hydrochloride 0.1
Part C Lactic acid 0.3
Glycerin 4.0
Phenoxyethanol 0.5
Purified water Amount that adds up to 100 ---------------------------------
(Preparation Method)
Parts A and C were heated to about 80° C. and dissolved. Part A was added to part C while stirring, and mixed uniformly, and then cooled to about 40° C. Next, part B was added and mixed uniformly.

Example 29 Scalp treatment Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ecolano FA-NH (Nippon Fine Chemical) 0.4
Diethylhexyl sebacate (Nippon Fine Chemicals) 4.0
Neosolue-Aquilio (Nippon Fine Chemicals) 1.0
Behentrimonium chloride (80%) 0.5
Behenyl Alcohol 1.0
Stearyl Alcohol 2.0
Glyceryl stearate 1.0
Lanolin wax 1.0
Dimethicone (10,000cs) 1.0
Tridecyl neopentanoate 0.5
Myristyl isooctanoate 0.3
Neopentyl glycol diethylhexanoate 0.3
Ethyl oleate 0.3
Glyceryl triisostearate 0.3
Trimethylolpropane triisostearate 0.3
Broccoli seed oil 0.3
Sphinganine 0.01
Glycerin 1.0
Part B Arginine 0.4
Sodium hydroxide 0.05
Phenoxyethanol 0.5
Purified water (total amount is 100) Part C NanoRepair-CMC5 (Nippon Fine Chemical) 0.5
Polyquaternium-39 0.5
Part D Carrageenan 0.1
Hydroxypropyl chitosan 0.05
Hydroxypropyl methylcellulose 0.1
Tuberose polysaccharide 0.1
Tremoist-TP (Nippon Fine Chemicals) 0.005
Purified water 20.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Parts A and B were heated to about 80° C. and dissolved. Part D was dispersed to form a viscous liquid. Part A was added to part B while stirring, and after uniform mixing, it was cooled to about 40° C. Next, parts C and D were added and mixed uniformly.

Example 30 Scalp treatment Ingredients Amount (wt%)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Soft lanolin fatty acid (Nippon Seika) 0.4
Squalane 3.0
Neosolue-Aquilio (Nippon Fine Chemicals) 1.0
Ethanol 40.0
Stearyl glycyrrhetinate 0.02
PPG-3 Caprylyl Ether 0.3
Erucalactone DES (Nippon Fine Chemicals) 1.5
PEG/PPG-20/20 Dimethicone 0.2
PEG-12 Dimethicone 0.4
Tocopherol 0.05
Hydrogenated Retinol 0.1
Pyridoxine tris(hexyldecanoate) 0.05
Bisglyceryl ascorbate 0.3
Hexyl 3-glyceryl ascorbate 0.3
Part B Triethanolamine 0.1
Tromethamine 0.1
(Acrylates/alkyl acrylate (C10-30)) crosspolymer 0.4
Carboxyvinyl polymer 0.05
(Acryloyldimethyltaurate ammonium/VP) copolymer 0.05
(Ammonium acryloyldimethyltaurate/beheneth-25 methacrylate) crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Purified water Total amount to 100 Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemicals) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation Method)
Part A was heated to about 50°C and dissolved. Next, part B was uniformly dispersed to form a viscous liquid. Part A was added to part B while stirring and mixed uniformly. Next, part C was added and mixed uniformly.

In the above formulation, details of the ingredients listed by product name are as follows:
Ecolano CA-NH: Quaternium-33, BG
○Ecolano CLE-S: Cholesteryl lanolinate ○Inulin-SC: Inulin ○LUSPLAN DD-DA7: Dimer dilinoleyl dimer dilinoleate ○LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, tri(caprylic acid/capric acid)glyceryl ○ NanoRepair-CMC5: Ceramide 1, ceramide 2, ceramide 3, ceramide 5, ceramide 6, cholesterol, quaternium-33-containing composition ○ Neosolue-DiSM: Diisostearyl malate ○ Neosolue-Aquilio: Bisethoxydiglycol cyclohexanedicarboxylate ○ Neosolue-AquaS: (eicosane diacid/tetradecanedioic acid) polyglyceryl-10, glycerin ○ Plandool-H: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
○Plandool-S: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
○Plandool-G: Dimer dilinoleyl bis(behenyl/isostearyl/phytosteryl) dimer dilinoleate
Plandool-DP: Bis-diglyceryl polyacyladipate-2
○Plandool-ISS: Phytosteryl isostearate ○Plandool-SUN: Phytosteryl sunflower seed oil fatty acid ○Plandool-MAS: Phytosteryl macadamiate ○Plandool-LG1: Phytosteryl/octyldodecyl/behenyl lauroyl glutamate
〇Plandool-LG2: di(phytosteryl/octyldodecyl) lauroyl glutamate
○Plandool-LG3: Lauroyl glutamate di(phytosteryl/octyldodecyl/behenyl)
○Plandool-LG4: Lauroyl glutamate di(phytosteryl/octyldodecyl/behenyl)
Phytocompo-PP: hydrogenated lecithin, phytosterols Phytocompo-C: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6 II
Phytopresome MEL: glycolipids, hydrogenated lecithin, BG, purified water Erucalactone DES: γ-docosalactone, diethyl sebacate Tremoist-TP: Tremella fuciformis polysaccharide Tremoist-SL: Tremella fuciformis polysaccharide aqueous solution (1%)

Claims (3)

A skin flora balance improver that contains soft lanolin fatty acid arginine salt as an active ingredient and is characterized by having a proliferation effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. A cosmetic or topical skin preparation for improving rough skin, comprising the skin resident flora balance improving agent according to claim 1. A cosmetic or topical skin preparation for improving atopic dermatitis, comprising the skin resident flora balance improving agent according to claim 1.