JP7129829B2 - Phosphatidylinositol-containing cosmetics or skin preparations for external use - Google Patents

Description

TECHNICAL FIELD The present invention relates to a cosmetic or external preparation for skin containing a phospholipid composition comprising phosphatidylinositol and lecithin, a polyhydric alcohol, and water.

Lecithin is a general term for glycerophospholipids obtained from animals or plants, and is widely used as a natural emulsifier in foods, cosmetics, pharmaceuticals, and the like. The constituents of lecithin are classified according to the structure of the polar group attached to the phosphate group, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), and phosphatidic acid (PA). is known to be the major component. In recent years, research has focused on the functions and efficacy of each of these, among which it is known that PIs are deeply involved in intracellular and extracellular signaling functions. Physiological effects such as reduction and increase in HDL cholesterol have been reported. As for cosmetic applications, physiological actions such as increasing the amount of hyaluronic acid in the skin (Patent Document 1) and enhancing Nrf2 activity (Patent Document 2) have been reported. When using PI as an active ingredient in various applications, it is important to obtain a composition containing PI at a high concentration. However, there are problems in terms of manufacturing complexity and cost. On the other hand, recently, a method for efficiently producing PI using phospholipase B that specifically acts on phospholipids other than PI has been developed (Patent Documents 4 and 5), and a composition containing a high concentration of PI is industrially produced. It has become possible to obtain it widely and inexpensively, and further applications of PI are expected. However, PI is inferior to other phospholipids in emulsifying power, and it is very difficult to uniformly disperse PI alone in water. As a method for solving such problems, for example, a method of using a polyoxyethylene-based surfactant in combination (Patent Document 6) is known. There is concern, and a method that does not use a synthetic surfactant has been desired.

Techniques for dispersing phospholipids in water using polyhydric alcohols are already known (for example, Patent Documents 7 and 8), but techniques for dispersing phosphatidylinositol using polyhydric alcohols were not known. . Moreover, the influence of the specific polyhydric alcohol on the transparency and dispersion stability when phosphatidylinositol is dispersed using a polyhydric alcohol has not been known at all.

WO2009/110205 JP 2011-168541 A JP-A-60-246305 WO2007/010892 JP 2015-27260 JP 2012-77000 JP-A-60-153938 JP H11-130651

The inventors of the present invention conducted various studies on phosphatidylinositol, which had not been widely used for cosmetics, and found that it has various physiological activities, including hitherto unknown effects, and that it can be used as an active ingredient in cosmetics. found to be very useful. On the other hand, they have found that it is very difficult to incorporate them into cosmetics due to their low dispersibility in water. Accordingly, an object of the present invention is to provide a cosmetic or an external preparation for skin in which phosphatidylinositol is simply and stably dispersed in water without using a synthetic surfactant.

The inventors of the present invention have made intensive studies to solve the above problems, and found that a cosmetic or topical skin preparation containing the following components (A) to (C) solves the above problems. completed.
(A) Phospholipid composition comprising the following components (A1) and (A2): (A1) phosphatidylinositol (A2) lecithin (B) polyhydric alcohol (C) water

By using the present invention, phosphatidylinositol can be easily and stably dispersed in water without using a synthetic surfactant, and by using a specific polyhydric alcohol, excellent transparency and dispersion stability can be obtained. Cosmetics or external preparations for skin can be easily obtained. In addition, the cosmetic or external preparation for skin of the present invention exhibits excellent bioactive effects such as hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action, and collagen production promoting action.

The present invention is a cosmetic or external preparation for skin containing the following components (A) to (C) as essential components.
(A) Phospholipid composition comprising the following components (A1) and (A2): (A1) phosphatidylinositol (A2) lecithin (B) polyhydric alcohol (C) water

Phosphatidylinositol (hereinafter also referred to as PI) of the component (A1) used in the present invention is a type of phospholipid present in plants such as soybean, rapeseed, sunflower, corn, and palm in the natural world. contained in lecithin extracted from By fractionating such lecithin by solvent fractionation, column purification, or a method using an enzyme, which will be described later, it is possible to obtain a composition containing PI at a high concentration. A PI-containing composition can be used as component (A1). As the high-concentration PI-containing composition, one having a PI content of 40% by weight or more, preferably 50% by weight or more, is preferably used. As a method for producing a high-concentration PI-containing composition, in addition to the long-known solvent fractionation and column purification, phospholipase B that specifically acts on phospholipids other than PI is used, and PIs such as PC, PE, and PA are used. A method of selectively hydrolyzing phospholipids other than phospholipids and then extracting the remaining PI with a solvent has been developed (Patent Documents 4 and 5). For this reason, it is possible to industrially obtain a composition containing a high concentration of PI at a low cost, and Soybrain PI50 (manufactured by Unitech Foods) is sold as a commercial product. Such commercial products can be preferably used in the present invention.

The component (A2) lecithin used in the present invention includes natural lecithin obtained from plants such as soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, and barley, and egg yolk, and hydrogenated products thereof. can be exemplified. Furthermore, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These may be used alone or in combination of two or more. In general, natural plant-derived lecithins contain about 30% by weight of phosphatidylcholine (hereinafter also referred to as PC), and lecithins with a higher PC content by solvent fractionation are commercially available. In the present invention, it is preferable to use one with a higher PC content from the viewpoint of improving dispersibility. Good to have. As described above, plant-derived lecithin contains about 10 to 20% of PI, but lecithin whose PC content is increased by solvent fractionation contains almost no PI because it is removed during the fractionation process. Therefore, in order to obtain a PI-containing phospholipid composition with a high PC content, it is necessary to mix a high-concentration PI-containing composition with a PC-enriched lecithin. Lecithin obtained from egg yolk naturally contains about 70% by weight of PC (PI is not included), so it can be preferably used as the component (A2). preferable. From the viewpoint of improving the feeling of use of the cosmetic composition or external preparation for skin of the present invention, it is preferable to use a mixture of hydrogenated lecithin and non-hydrogenated lecithin as the component (A2). The mixing ratio of hydrogenated lecithin and non-hydrogenated lecithin is preferably 99:1 to 70:30, more preferably 97:3 to 80:20 by weight.

In the present invention, component (A2) is used for the purpose of assisting dispersion of component (A1). The mixing ratio of components (A1) and (A2) in the present invention is not particularly limited, but it is preferable to mix them in a weight ratio of 5:95 to 50:50, preferably 10:90 to 40:60.

The amount of component (A) used in the present invention is not particularly limited, but is preferably 0.001 to 5% by weight from the viewpoint of the dispersion stability and transparency of the obtained cosmetic or topical skin preparation. is 0.005 to 2% by weight, most preferably 0.01 to 1% by weight.

The polyhydric alcohol of component (B) used in the present invention is used for the purpose of easily and stably dispersing component (A) in water. Specific examples of component (B) include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 2-methyl-1, 3-propanediol, 3-methyl-1,3-butanediol (isopentyldiol), tetramethylene glycol, hexylene glycol, caprylyl glycol, 1,2-pentanediol (pentylene glycol), 1,2-hexane Dihydric alcohols such as diols, 1,2-heptanediol, 1,2-octanediol and 1,2-decanediol; Trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, mannitol, and pentaerythritol; glyceryl ethers such as ethylglycerin, butylglycerin, hexylglycerin, and ethylhexylglycerin; diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene Examples include polyhydric alcohol polymers such as glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used alone or in combination of two or more. Among these, glycerin, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, hexylene glycol, 1, and 2-pentanediol and 1,2-hexanediol are preferred. From the viewpoint of the transparency and dispersion stability of the obtained cosmetic or topical skin preparation, one or more selected from among hexylene glycol, 1,2-pentanediol and 1,2-hexanediol is essential. It is preferable to include as By containing such an essential polyhydric alcohol, it is possible to obtain a cosmetic composition or an external preparation for skin that is excellent not only in initial dispersibility but also in transparency and dispersion stability. In order to obtain a cosmetic or topical skin preparation having a transparent appearance, such an essential polyhydric alcohol should be contained in the component (B) in an amount of 20% by weight or more, preferably 25% by weight or more, most preferably 28% by weight. It is desirable to contain it in the above density|concentration.

In the cosmetic or external preparation for skin of the present invention, the term "transparent in appearance" means that when a sample is placed in a glass bottle with a diameter of 3.5 cm and observed from the side, the background of the liquid can be seen through. To tell. When measuring turbidity with a spectrophotometer, a sample is placed in a cell with a thickness of 1 cm, and the transmittance is 60% or more when measured at a wavelength of 600 nm.

The blending ratio of the components (A) and (B) used in the present invention is 1:5 to 1:200 by weight from the viewpoint of obtaining a cosmetic composition or topical skin preparation having excellent transparency and dispersion stability. , preferably in a ratio of 1:10 to 1:150.

The component (C) water used in the present invention is not particularly limited as long as it can be used in general cosmetics, such as purified water, ion-exchanged water, distilled water, natural water, deep sea water, and hydrogen water. can be used. Moreover, the pH may be adjusted with an acid, an alkali, a buffer, a chelating agent, or the like, or a preservative may be added.

For the purpose of improving the dispersion stability, the cosmetic composition or external preparation for skin of the present invention may further contain sterols or triterpenes as component (D). Specific examples of component (D) include animal-derived sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, desmosterol; stigmasterol, sitosterol, campesterol, brassicasterol, and mixtures thereof such as phytosterol. Plant-derived sterols; microorganism-derived sterols such as ergosterol; γ-oryzanol; ursolic acid; glycyrrhetinic acid; These may be used alone or in combination of two or more. Among these, cholesterol, phytosterol, and γ-oryzanol are preferred. The amount of component (D) is not particularly limited, but the weight ratio of components (A) and (D) is 200:1 to 1:1, preferably 100:1 to 2:1. They should be blended in proportions.

As a method for producing the cosmetic or topical skin preparation of the present invention, first, the components (A) and (B) or the components (A), (B) and (D) are stirred and mixed while heating to obtain a polyhydric alcohol. It can be prepared by preparing a dispersion and adding water to the resulting polyhydric alcohol dispersion while stirring, or by adding the polyhydric alcohol dispersion to water while stirring. By such a method, phosphatidylinositol, which is difficult to disperse in water by itself, can be easily and stably dispersed in water, and an aqueous dispersion having excellent transparency and dispersion stability can be obtained. .

Phosphatidylinositol, which is the component (A1) of the present invention, is excellent in hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action, collagen production promoting action, etc. as described in Japanese Patent Application No. 2018-083875. The PI-containing cosmetic or topical preparation for skin of the present invention also has an excellent physiological activity.

The cosmetic composition or external preparation for skin of the present invention may optionally contain water and additive components usually blended in cosmetics, such as oily bases, surfactants, alcohols, moisturizers, polymers, thickeners, and gels. agent, antioxidant, antiseptic, bactericide, chelating agent, pH adjuster/acid/alkali, UV absorber, whitening agent, solvent, exfoliating/dissolving agent, antipruritic, anti-inflammatory agent, antiperspirant, cooling agent agents, antihistamines, astringents, stimulants, hair growth agents/blood circulation promoters, reducing agents/oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes , nucleic acids, hormones, inorganic powders, fragrances, pigments, etc. may be contained to such an extent that the effects of the present invention are not impaired.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, higher alcohols such as dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts thereof, nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax , ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado Oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat. Vegetable oils such as germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; Animal oils and fats such as horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as spermaceti, lanolin, and orange roughy oil; liquid lanolin, reduced lanoli lanolins such as adsorption purified lanolin, lanolin acetate, acetic acid liquid lanolin, hydroxyl lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, acetic acid (cetyl/lanolyl) ester; lecithin, phosphatidylcholine , phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salts, phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybeans Phospholipid derivatives such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl -di (cholesteryl/behenyl/octyldodecyl) L-glutamate, di (cholesteryl/octyldodecyl) N-lauroyl-L-glutamate, di (phytosteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, N-lauroyl- L-glutamic acid di(phytosteryl/octyldodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, isostearic acid phytosteryl, Sterol esters such as soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, and long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid/cholesterol complex and phospholipid/phytosterol complex; myristic acid Octyldodecyl, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate , isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyl oleate Rudodecyl, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil, isopropyl myristate, isopropyl palmitate, palmitin Octyl Acid, Isopropyl Isostearate, Isopropyl Lanolin Fatty Acid, Methylheptyl Laurate, Methylheptyl Myristate, Methylheptyl Palmitate, Methylheptyl Isostearate, Diethyl Sebacate, Diisopropyl Sebacate, Dioctyl Sebacate, Diisopropyl Adipate, Dibutyl Sebacate Monoalcohol carboxylic acid esters such as octyl, diisobutyl adipate, dioctyl adipate, dioctyl succinate, and triethyl citrate; Acid esters; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic/capric triglyceryl, tri(caprylic/capric/myristic/stearic) glyceryl, hydrogenated Rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, dioctanoic acid 2-butyl-2-ethyl-1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylol (isostearate/sebacate) Propane, pentaerythrityl triethylhexanoate, (hydroxystearic acid/stearic acid/rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonisostearate, deca (erucic acid/isostearic acid/ricinoleic acid) Polyglyceryl-8, (hexyldecanoic acid/sebacic acid) diglyceryl oligoester, glycol distearate ethylene glycol), polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dinopentanoate and 2,4-diethyl-1,5-pentanediol dinopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, dimer dilinoleate (phytosteryl/behenyl), dimer dilinoleate (phytosteryl/isostearyl/cetyl/stearyl/behenyl ), dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil of dimer dilinoleate, hydroxyalkyl dimer dilinoleyl ether, or other dimer acids or dimer diols derivatives of; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (Lauramide DEA), lauric acid monoisopropanolamide (Lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), fatty acid alkanolamides such as coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone ( high polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin , silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphoric acid-modified silicones, sulfuric acid modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone silicones such as silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, polysiloxane/oxyalkylene copolymers; perfluorodecane, Fluorinated oils such as perfluorooctane and perfluoropolyether are preferred.

Moisturizers and texture improvers include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol/propylene glycol copolymer, and polymers thereof; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Sugars and derivatives thereof such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , caronin sulfate, keratosulfate, dermatan sulfate; white fungus extract, white fungus polysaccharide; fructans such as inulin and levan; fucoidan; urea; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids such as amine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen decomposition Peptides, Hydrolyzed Collagen, Hydroxypropylammonium Chloride Hydrolyzed Collagen, Elastin-Degraded Peptides, Keratin-Degraded Peptides, Hydrolyzed Keratin, Conchiolin-Degraded Peptides, Hydrolyzed Conchiolin, Silk-Proteolytic Peptides, Hydrolyzed Silk, Sodium Lauroyl Hydrolyzed Silk, Soy Protein peptides such as proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides and derivatives thereof; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides and palmitoyl tetrapeptides; silylation Peptides; lactic acid bacteria culture, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract witch hazel water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, rose rose extract, yarrow extract, eucalyptus extract, melilot extract and other animal and plant extracts, natural ceramides (types 1, 2, 3, 4, 5, 6), ceramides such as hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and sugar-ceramide-containing extracts are preferred.

Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, and the like. There is no particular limitation on the HLB of the surfactant, and a surfactant with a low HLB of about 1 to a surfactant with a high HLB of about 20 can be used, and a combination of a low HLB and a high HLB is also preferred. Examples of preferred surfactants include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; Sodium sulfate, polyoxyethylene alkyl sulfates such as triethanolamine laureth sulfate; sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines, sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoyl alanine triethanolamine , acyl amino acid salts such as dilauroyl glutamic acid lysine Na; polyoxyethylene alkyl ether acetate salts such as sodium laureth acetate; succinate ester salts such as lauroyl monoethanolamide sodium succinate; fatty acid alkanolamide ether carboxylate; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as hydrogenated coconut oil fatty acid sodium glycerol sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; Alkyl sulfosuccinates such as disodium lauryl acid and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, and alkyl ether sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkylbenzenesulfonates such as sodium benzenesulfonate, triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; Alkyl sulfoacetates; Alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate and sodium monooleth phosphate; Alkyl phosphate salts such as potassium lauryl phosphate; Sodium caseinate; Phosphates; Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Anionic surfactants, etc.; nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxy ethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyldodeceth (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil and hydrogenated castor oil derivatives such as oxyethylene hydrogenated castor oil maleic acid; Polyoxyethylene phytosterol; Polyoxyethylene cholesterol; Polyoxyethylene cholestanol; Polyoxyethylene lanolin; Polyoxyethylene reduced lanolin; Propylene cetyl ether, polyoxyethylene/polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene/polyoxypropylene monobutyl ether, polyoxyethylene/polyoxypropylene hydrogenated lanolin, polyoxyethylene/polyoxypropylene glycerin ether, etc. Polyoxyethylene/polyoxypropylene alkyl ether; Polyoxyethylene/polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glyceryl stearate Ceryl, Glyceryl Isostearate, Glyceryl Palmitate, Glyceryl Myristate, Glyceryl Oleate, Glyceryl Cocoate, Monocottonseed Glycerol, Glyceryl Monoerucate, Glyceryl Sesquioleate, α,α'-Glyceryl Pyroglutamate Oleate, Monostearin Glycerin fatty acid partial esters such as acid glycerin malic acid; 2, polyglyceryl-10 destearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10 , polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-oleate-2, 3, 4, 5, 6, 8, 10, polyglyceryl dioleate- 6, polyglycerol fatty acid esters such as polyglyceryl-2 trioleate and polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol moieties Fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan Sorbitan fatty acid esters such as trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid esters, methylglucoside fatty acid esters, sugar derivative partial esters such as trehalose undecylenate; caprylyl Alkyl glucosides such as glucoside; Alkyl polyglycosides; Glycolipids such as mannosylerythritol lipids; Lanolin alcohol; Reduced lanolin; Olei Polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene propylene glycol fatty acid esters; Polyoxyethylenes such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as monooleate; Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate ; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid ester; Oxyethylene alkyl ether fatty acid esters; Polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol and batyl alcohol; Oxyethylene alkylamine; tetrapolyoxyethylene/tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil Fatty Acid Diethanolamide (Cocamide DEA), Lauric Acid Monoethanolamide (Lauramide MEA), Lauric Acid Diethanolamide (Lauramide DEA), Lauric Acid Monoisopropanolamide (Lauramide MIPA), Palmitic Acid Monoethanolamide (Partamide MEA), Palmitic Acid Diethanolamide fatty acid alkanolamides such as de (partamide DEA) and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide and behenamine oxide; alkylethoxydimethylamines oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolyol; silicone-based nonionic surfactants such as ether-modified silicones, polysiloxane/oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants include behentrimonium chloride and steartrimonium chloride , cetrimonium chloride, lauryltrimonium chloride and the like; alkyltrimethylammonium bromide such as stearyltrimonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; Fatty acid amidoamines such as stearamidoethyldiethylamine and salts thereof; Alkyl ether amines such as stearoxypropyldimethylamine and salts or quaternary salts thereof; Long-chain branched fatty acids (12-31) aminopropylethyldimethylammonium ethyl sulfate, lanolin ethyl sulfate Fatty acid amide-type quaternary ammonium salts such as fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine monium salts; ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; silicone-based cationic surfactants such as modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone; fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; Alkylsulfobetaine such as dimethyltaurine; Sulfuric acid betaine such as alkyldimethylaminoethanol sulfate; Phosphate betaine such as alkyldimethylaminoethanol phosphate; Phospholipids such as lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; Silicone-based amphoteric surfactants, etc.; polymeric surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid/methacrylate alkyl copolymers; and silicone-based various surfactants.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcelleran, karaya gum, tororo mallow, cara gum, tragacanth gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , chitosan, agar, cassava extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethyl Cellulose and its derivatives such as ammonium sulfate cellulose, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenylsuccinate, etc. starch derivatives; sodium alginate, alginic acid derivatives such as propylene glycol alginate; Polyoxypropylene copolymer; Amphoteric methacrylic acid ester copolymer such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine methacrylate) copolymer; (dimethicone/vinyl dimethicone) cross Polymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salt such as sodium salt, acrylic acid/methacrylic acid ester copolymer; acrylic acid/alkyl methacrylate copolymer Polymer: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride/acrylamide copolymer such as polyquaternium-7, acrylic acid/diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39・Acrylic acid/methyl acrylate/chloride such as diallyldimethylammonium chloride/acrylamide copolymer, acrylic acid/cationized methacrylic acid ester copolymer, acrylic acid/cationized methacrylic acid amide copolymer, polyquaternium-47, etc. methacrylamidopropyltrimethylammonium copolymer, chloride methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; Polymer of 2-methacryloyloxyethylphosphorylcholine and copolymer with butyl methacrylate copolymer; acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; acrylic-silicone graft copolymers and other silicone-based copolymers; salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, Bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructo-oligosaccharide fatty acid esters are preferred.

Solvents/propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Classes: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether glycol ethers such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate and propylene glycol monoethyl ether acetate; glycol ether esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation freon; LPG, dimethyl ether, and carbon dioxide are preferred.

Antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; It is mentioned as. Preferred reducing agents include thioglycolic acid, cysteine, cysteamine, and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diols; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, phenylphenol sodium; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion is preferable, but when used as an antibacterial agent or antiseptic for the purpose of preserving, from the viewpoint of the safety of cosmetics or external skin preparations, phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-alkanediols such as diols and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether are more preferably used.

Chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and salts such as its sodium salt; Sodium oxalate; Polyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphoric acid; Sodium citrate, citric acid, alanine, dihydroxyethylglycine , gluconic acid, ascorbic acid, succinic acid and tartaric acid are preferred. pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, and monoethanol. Amines, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxide Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferred.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with various surface treatment agents such as silicone such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate・Organic powders and surface-treated powders of various sizes and shapes, such as polymethyl methacrylate layered powder, polyethylene terephthalate/aluminum/epoxy layered powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc., organic and inorganic Composite powders are preferred. Examples of inorganic salts include sodium chloride-containing salts such as table salt, common salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum/potassium sulfate (alum), aluminum/ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate, phosphoric acid Potassiums, calcium phosphates, and magnesium phosphates are preferred.

UV absorbers include para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester. Benzoic acid-based UV absorbers such as esters, N,N-dimethylpara-aminobenzoic acid butyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester; Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid and salicylic acid UV absorbers such as sodium salts thereof, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamic acid-based UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof;2, 4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' -benzophenones such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone UV absorber; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-( 3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid and urocanic acid derivatives such as ethyl urocanate 2-(2′-hydroxy-5′-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionic acid Preferable examples include hydantoin derivatives such as 2-ethylhexyl, phenylbenzimidasozole sulfonic acid, terephthalylidene dicamfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, B vitamins such as choline; vitamin Cs such as ascorbic acid and salts thereof such as sodium; vitamin D; Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbyl phosphate sodium salt and ascorbyl phosphate magnesium salt, ascorbyl tetra Ascorbic acid fatty acid esters such as isopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbyl ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and fatty acid esters thereof , ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopheryl acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate, tocotrienols, and other various vitamin derivatives are preferred. It is mentioned as.

Antiphlogistic and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhizic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; , mugwort leaf extract and the like are preferred. Hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as assembly extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; , borneol, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide, benzyl nicotinate Derivatives such as ester-inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, and minoxidil are preferred. It is mentioned as. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoting agents, stimulating agents, analgesics, and cell activators include retinols, retinoic acids, and retinoin. tocopheryl acid; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives such as glycosides and esters thereof, hydroxycapric acid, long-chain α-hydroxy fatty acids, α- or long-chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine, etc. and their derivatives; , astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, antioxidants and active oxygen scavengers such as fullerenes; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; Polyphenols such as anthocyanidins, chlorogenic acid, and apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; shogaol, gingerol; menthol, camphor, cedrol and other flavoring substances and derivatives thereof; capsaicin, vanillin and the like and their derivatives; insect repellents such as diethyltoluamide; mentioned.

Plant/animal/microorganism extracts include iris extract, angelica keiskei extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, and ginkgo biloba extract. , inchkou extract, fennel extract, turmeric extract, oolong tea extract, urticaria extract, age extract, Echinashi leaf extract, trillium extract, Scutellaria root extract, Phellodendron bark extract, Coptis extract, Barley extract, Panax ginseng extract, Hypericum extract, Dead nettle extract, Ononis extract , Dutch mustard extract, orange extract, seawater dried matter, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, kakkon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, wormwood extract, oat extract, karkade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiwi extract, cloud ear extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guava extract, kujin extract, gardenia extract, kumazasa extract, clara extract, walnut Extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract, Gennoshoko extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice Fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, cowberry extract, rhinoceros extract, rhinoceros extract, rhinoceros extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, sansha extract, Japanese pepper extract, shiitake extract, reed extract, licorice extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, white birch extract, white fungus extract, horsetail extract, stevia extract, fermented stevia, Nishikawayanagi extract, Ivy extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, neem extract, jersey extract, sage extract, rhubarb extract, dai Sunflower extract, turmeric extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cinnamon extract, chimp extract, tea tree oil, sweet tea extract, capsicum extract, angelica extract, calendula officinalis extract, tonin extract, spruce extract, Houttuynia cordata extract, tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietalia extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifidobacterium extract, Loquat extract, coltsfoot extract, coltsfoot extract, coltsfoot extract, bukuryo extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, botan extract, hop extract, mica extract, pine extract, horse chestnut extract , Asian skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract , Reishi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, burnet extract and the like are preferred.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors and the like. Examples of exfoliating/dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and the like. Examples of antiperspirants include aluminum chlorohydroxy, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum/potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

Fragrances include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-e-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecenal, Estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , isobornyl acetate, geranyl acetate, dimethylbenzyl carbyl acetate, styraryl acetate, cedryl acetate, terpinel acetate, p-t-butylcyclohexyl acetate, betiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineol, cinnamaldehyde, styrax Resinoids, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli Alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , peppermint oil, pepper oil, heliotropine, bergamot oil, benzyl benzoate, borneol, myresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-mentone, eucalyptus oil, β-ionone, lime oil , lavender oil, D-limonene, linalool, lilal, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils and other synthetic fragrances and natural Perfumes and various blended perfumes are preferred.

Colorants/colorants/dyes/pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203 and Blue No. 204. , Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red 104-1, red 105-1, red 106, red 2, red 3, red 201, red 202, red 203, red 204, red 205, red 206, red 207 , Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red 228, Red 230-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503 , Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow Legal dyes such as No. 405, Yellow No. 406, Yellow No. 407, and Yellow No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher Inorganic black pigments such as black iron oxide and low order titanium oxide; Inorganic pigments such as mango violet and cobalt violet Purple pigments; Inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; Inorganic blue pigments such as ultramarine blue and Prussian blue; Titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored oxide Pearl pigments such as titanium-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; Quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin and other naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin and other natural pigments and dyes; p-phenylenediamine, toluene-2,5 - oxidation dye intermediates such as diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, etc. and salts thereof autooxidative dyes such as indolines; and dihydroxyacetone are preferred.

Preferable examples of water include ordinary water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

In addition to these, the Standards for Cosmetic Ingredients, Standards for Ingredients by Cosmetic Type, List of Ingredients Displayed by the Japan Cosmetic Industry Association, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Standards for Quasi-drug Ingredients, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, food additives compendium, etc., and in Japanese and foreign patent publications and patent publication publications (including publication publications and republication) that belong to the classification of A61K7 and A61K8 in the international patent classification IPC Known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as those described, can be contained in known combinations and blending ratios and blending amounts.

Types of the cosmetics of the present invention include hair cosmetics, skin cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin preparations for external use such as ointments, and the like. The cosmetic of the present invention can be produced according to ordinary methods.

To explain the types of the cosmetic composition or skin external preparation of the present invention in more detail, hair cosmetic compositions include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, rinse-integrated shampoos, and the like. Rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tick, hair cream, hair blow, split ends coat , hair oils, permanent wave agents, straight permanent agents, oxidative hair dyes, hair bleach, hair color pretreatments, hair color aftertreatments, perm pretreatments, perm aftertreatments, hair manicures, and hair growth agents.

Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layer lotion; emollient lotion, moisturizing lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer - Emulsions, massage lotions, cleansing lotions, protective emulsions, sun protection, sun protectors, UV care milk, sunscreens, make-up lotions, keratin smoothers, elbow lotions, hand lotions, body lotions, etc.; emollient creams, nourishing creams, Nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, exfoliating Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and anti-ultraviolet essences; Face wash such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, cleansing powder, facial cleansing powder; Soaps such as shaving soaps and synthetic toilet soaps are preferred.

Preferred examples of makeup cosmetics include powders/powder powders, foundations, lipsticks, lip glosses, blushers, eyeliners, mascara, eyeshadows, eyebrows, eyebrows, nail enamels, enamel removers, and nail treatments. .

Perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, paste perfume, fragrant powder, perfumed soap, body lotion, and bath oil are preferable examples of fragrant cosmetics.

Body cosmetics include body cleansers such as body shampoo, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays, and deodorant sticks, decolorants, hair removal agents, bath agents, and insect repellent sprays. Repellers are preferred.

In addition, external skin preparations can be used in dosage forms such as ointments, patches, lotions, liniments, and liquid coatings. It can also be used as an intraoral cosmetic such as toothpaste and mouthwash.

Formulations of the cosmetic or external preparation for skin of the present invention include emulsions such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, and O/W/O type. type cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-type cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder-type cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics Preferable dosage forms include cosmetics, emulsified polymer type cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

The present invention will be described in more detail by the following examples, but the present invention is not limited to these.

Lotions containing the components (A) to (C) of the present invention with the compositions shown in Tables 1 to 5 were prepared by the following method. The initial dispersibility, transparency, and dispersion stability of the resulting lotions were evaluated by the following methods, and the results are shown in the lower column of each table.

<Preparation method>
Components (A) and (B) were previously stirred and mixed at 80° C. to prepare a polyhydric alcohol dispersion. The resulting polyhydric alcohol dispersion was added with stirring to an aqueous solution of methylparaben and component (C) which had been heated and dissolved at 80°C, and stirred with a homomixer (75°C, 5000 rpm, 15 minutes). , cooled.

<Initial Dispersibility>
The dispersion state of the obtained lotion immediately after preparation was visually observed, and the initial dispersibility was evaluated according to the following evaluation criteria.

○: uniformly dispersed ×: not uniformly dispersed

<Transparency>
The transmittance of the lotion was measured using a spectrophotometer (cell thickness 1 cm, wavelength 600 nm). In addition, the lotion was placed in a glass bottle with a diameter of 3.5 cm, the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria.

○: Behind the liquid can be seen through △: Behind the liquid can be slightly seen through ×: Behind the liquid cannot be seen through

<Dispersion stability>
The obtained lotion was subjected to a storage stability test at 50° C./1 month, and dispersion stability was evaluated according to the following evaluation criteria.

○: Evenly dispersed even after storage △: Almost evenly dispersed even after storage ×: Not evenly dispersed after storage, or sedimentation occurs

From the results in Tables 1 to 3, it was found that component (A) could be easily dispersed in water using component (B). In particular, when 1,2-pentanediol, 1,2-hexanediol, and hexylene glycol (essential polyhydric alcohol) were used as component (B), it was found to be extremely excellent in transparency and dispersion stability (implementation Examples 1-3). In addition to using the essential polyhydric alcohol alone, it is possible to obtain excellent transparency and dispersion stability by using it in combination with other polyhydric alcohols that have been inferior in transparency and dispersion stability. was found (Examples 7 to 11). It was also found that 25% by weight or more of these essential polyhydric alcohols should be contained in the component (B) in order to obtain a lotion with excellent transparency (Examples 12 to 14).

From the results in Table 4, it was found that when the proportion of component (A1) in component (A) was high, initial dispersion was not possible (Comparative Example 2). It was also found that initial dispersion could not be achieved even when the ratio of component (B) to component (A) was low (Comparative Example 3). Furthermore, from the results in Table 5, it was found that the higher the PC content in the component (A2), the better the transparency and dispersion stability (Examples 19 to 21).

Cosmetics described below were prepared. The obtained cosmetic had excellent moisturizing properties and permeation, prevented fine wrinkles and rough skin, and made the skin look plump and bright.

Example 22 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.02
Hydrogenated lecithin (PC content 97%) 0.05
Lecithin (PC content 92%) 0.01
BG 2.0
Glycerin 3.0
1,2-Pentanediol 3.0
Part B Purified water 40.0
Part C Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Glucosylceramide 0.5
Tremoist-TP (Nippon Fine Chemicals) 0.1
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that totals 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 23 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Polyglycerin-10 1.0
Diglycerin 2.0
Glycerin 8.0
1,2-Pentanediol 4.0
Plandool-LG2 (Nippon Fine Chemicals) 0.01
Plandool-ISS (Nippon Fine Chemicals) 0.01
Part B Purified water 50.0
Part C maltitol liquid 1.0
Betaine 0.5
α-glucan oligosaccharide 0.1
Sodium hyaluronate 0.5
Tuberose polysaccharide 0.01
Hydroxypropyl methylcellulose stearoxy ether 0.05
(Acrylates/C10-30 alkyl acrylate) crosspolymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, they were dispersed using a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Kogyo Co., Ltd.). After cooling, the pre-mixed Part C was added to obtain a uniform liquid.

Example 24 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Phytopresome-MEL (Nippon Fine Chemicals) 0.05
BG 5.0
Glycerin 10.0
1,2-Hexanediol 5.0
Part B Purified water 40.0
Part C Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
PEG/PPG/polybutylene glycol-8/5/3 glycerin 0.5
Xanthan gum 0.05
Glucosyltrehalose 0.5
Polyquaternium-51 0.5
Hydrolyzed Yeast Extract 1.0
Licorice extract 0.05
Aloe extract 0.05
Souhakuhi Extract 0.2
Pentetate pentasodium 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that totals 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 25 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Glycerin 8.0
Hexylene glycol 5.0
Lysolecithin 0.03
Phytopresome Cera23 (Nippon Fine Chemicals) 0.05
Part B Purified water 60.0
Part C Hydrolyzed Collagen 0.05
Hydrolyzed sodium hyaluronate 0.05
Citric acid 0.01
Na citrate 0.09
Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Sodium pyrrolidonecarboxylate 0.1
Inositol 0.2
Arginine 0.1
Alanine 0.1
Betaine 0.1
EDTA-2Na 0.05
Phenoxyethanol 0.4
Purified water Amount that totals 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare an aqueous dispersion. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 26 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
Propanediol 5.0
Glycerin 10.0
1,2-Pentanediol 10.0
Phytopresome Lipo-Q (Nippon Fine Chemicals) 0.05
Phytopresome Asta (Nippon Fine Chemicals) 0.05
LUSPLAN PI-DA (Nippon Fine Chemicals) 0.05
Plandool-DP (Nippon Fine Chemicals) 0.05
Phytosterol 0.05
Tocopherol 0.02
Part B Purified water 60.0
Part C Mannitol 1.0
PEG-30 1.0
Hydrolyzed Collagen 0.1
Urea 0.1
Chondroitin sulfate Na 0.05
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Sorbitol 0.5
Phenoxyethanol 0.2
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, they were dispersed using a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Kogyo Co., Ltd.). After cooling, the pre-mixed Part C was added to obtain a uniform liquid.

Example 27 Whitening lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
Phytosterol 0.05
Glycerin 8.0
1,2-Pentanediol 8.0
Part B 3-O-ethylascorbic acid (Nippon Fine Chemicals) 1.0
Arbutin (Nippon Fine Chemicals) 1.0
Purified water 30.0
Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Ethanol 3.0
Inulin 2.0
Methylgluceth-10 2.0
Glycyrrhizic acid 2K 0.05
Tremoist-TP (Nippon Fine Chemicals) 0.02
Xanthan gum 0.03
Phenoxyethanol 0.2
Methylparaben 0.15
Edetate Na 0.2
Citric acid 0.1
Na citrate Amount that makes pH 4.5 Part C Purified water Amount that makes the total 100－－－－－－－－－－－－－－－－－－ －－－－－－－－－
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare an aqueous dispersion. After cooling, the pre-mixed part B was added to obtain a uniform liquid.

Example 28 Whitening lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
1,2-Pentanediol 5.0
Oryzanol 0.1
Part B Tranexamic acid (Nippon Fine Chemicals) 2.0
3-O-ethylascorbic acid (Nippon Fine Chemicals) 1.0
Ascorbic acid 2-glucoside 1.0
Phytic acid 0.30
Purified water 20.0
Scutellaria root extract 0.2
Peony extract 0.2
Tripropylene glycol 2.0
DPG 2.0
Maltose 1.0
Carbomer 0.01
Glutamic acid 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Na citrate Appropriate amount Part C Purified water Total amount to be 100 －－－－－－－－－－－－－－－－－－－－－－－－－－－ ----
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and part C were each heated to 70° C., and part A was added while stirring part C with a homomixer (7000 rpm) to prepare an aqueous dispersion. After cooling, the pre-mixed part B was added to obtain a uniform liquid.

Example 29 Gel lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 10.0
1,2-Pentanediol 5.0
Sorbitol liquid (70%) 5.0
Polyglyceryl-10 Laurate 0.4
Part B Niacinamide 1.0
Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Neosolue-Aqua (Nippon Fine Chemicals) 1.0
Diglycerin 3.0
Tripropylene glycol 3.0
PEG-60 3.0
Purified water 10.0
Part C Pullulan 0.2
Ethylhexylglycerin 0.2
Polymethacryloyllysine 0.05
Tremoist-SL (Nippon Fine Chemical) 1.0
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Xanthan gum 0.05
Sodium hyaluronate 0.01
Carbomer 0.06
K hydroxide 0.05
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 70°C and dispersed uniformly. Part C was mixed, stirred well, homogenized and heated to about 70°C. Part B was stirred with a propeller to prepare a mixture. Part C was added to part A, the mixture was stirred at about 70°C using a homomixer, cooled to about 40°C, and the mixture of part B was added.

Example 30 Transparent gel

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 5.0
1,2-Hexanediol 3.0
PPG-6 decyltetradeceth-30 0.2
PEG-30 phytosterol 0.3
Phytopresome MEL (Nippon Fine Chemicals) 0.8
Purified water 40.0
Part B PEG-4M 0.2
Methylgluceth-10 1.0
Pyridoxine hydrochloride 0.05
Ethylhexylglycerin 0.2
Phenoxyethanol 0.4
Tremoist-TP (Nippon Fine Chemicals) 0.01
Hydrolyzed Collagen 0.01
Purified water Total amount to be 100 Part C Pentetate 5Na 0.05
(dimethyltaurate ammonium acrylate/vinylpyrrolidone) copolymer 0.05
(Acrylates/C10-30 alkyl acrylate) crosspolymer 0.15
Arginine 0.25
Purified water 20.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle solution. Part C was mixed into a viscous liquid. Part B was mixed to form a uniform liquid. Part A and part B were added to part C and made uniform.

Example 31 Scalp Lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Phytosterol 0.01
Glycerin 6.0
1,2-hexanediol 1.0
Part B Purified water 50.0
Part C Neosolue-Aqulio (Nippon Fine Chemicals) 1.0
Tocopherol Acetate 0.05
Menthol 0.1
Betaine 0.2
Assembly extract 0.1
Tamasaki Tsutsurugi Root Extract 0.003
Hinokitiol 0.1
PCA-Na 0.1
Carbomer 0.01
K hydroxide 0.01
Pentetate pentasodium 0.05
Methylparaben 0.1
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer (7000 rpm) to prepare a nanovesicle solution. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 32 Hair restorer

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
1,2-Pentanediol 5.0
Phytopresome MEL (Nippon Fine Chemicals) 1.0
Part B Neosolue-Aquilio (Nippon Fine Chemicals) 0.5
DPG 2.0
Lactic acid 0.1
Tremoist-TP (Nippon Fine Chemicals) 0.01
Purified water 50.0
Part C Ethanol 10.0
Menthol 0.1
Menthyl glyceryl ether 0.15
Panthenyl ethyl ether 0.2
Camphor 0.1
Cordyceps Extract 1.0
Assembly Extract 1.0
Loquat Leaf Extract 1.0
Hydrolyzed hyaluronic acid 0.02
Sodium cyclic lysophosphatidate 0.001
Capsicum extract 0.01
Betaine 0.3
Trehalose 0.2
Cymene-5-ol 0.1
Tocopherol Acetate 0.05
β-Glycyrrhetinic acid 0.05
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare a nanovesicle liquid. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 33 Whitening emulsion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandool-H (Nippon Fine Chemicals) 1.0
Plandool-LG3 (Nippon Fine Chemicals) 1.0
Plandool-DP (Nippon Fine Chemicals) 1.0
LUSPLAN DD-DA5 (Nippon Fine Chemical) 0.2
LUSPLAN DD-DA7 (Nippon Fine Chemical) 0.2
Cetyl ethylhexanoate (Nippon Fine Chemicals) 7.0
Diethylhexyl succinate (Nippon Fine Chemicals) 3.0
Cetanol 1.2
Myristyl alcohol 2.0
Oleyl alcohol 1.0
Part B Stealoxy hydroxypropyl methylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Phytocompo-C (Nippon Fine Chemicals) 1.0
1,2-Pentanediol 3.0
Glycerin 8.0
Part D 3-O-ethylascorbic acid (Nippon Fine Chemicals) 1.0
Tranexamic acid (Nippon Fine Chemicals) 2.0
Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid 0.1
Sodium citrate Amount that makes pH 4.5 Purified water Amount that makes the total 100 －－－－－－－－－－－－－－－－－－－－－－－－－ -----
(Preparation method)
Part A and part E were each heated to about 70° C. and dissolved uniformly. Part B was stirred to form a viscous liquid. Part C was heated to about 70° C. and evenly dispersed. After adding part A while stirring part C with a homodisper, part E was added while stirring. Part D and part B were added at about 50° C. and dissolved uniformly by stirring.

Example 34 Emulsion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Glycerin 3.0
1,2-Pentanediol 5.0
BG 3.0
LP70H (Nippon Fine Chemicals) 0.1
Phytocompo-PP (Nippon Fine Chemicals) 1.5
Part B Triethylhexanoin (Nippon Fine Chemicals) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl alcohol 1.0
Arachyl alcohol 0.1
Jojoba Alcohol 3.0
chimyl alcohol 0.3
Serachyl alcohol 0.1
Hexyldecanol 0.5
Part C BG 5.0
(Hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer
0.2
Tremoist-TP (Nippon Fine Chemicals) 0.03
Carbomer 0.1
Purified water 30.0
Part D Neosolue-Aqua (Nippon Fine Chemicals) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A, part B, and part D were mixed, heated to about 70° C., and uniformly dissolved and dispersed. Part C is mixed and stirred to viscosity. After adding part B while stirring part A with a homodisper, part D was added and emulsified. Upon cooling to about 50°C, add Part C, stir and cool to about 40°C.

Example 35 Skin care cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Sugar squalane 10.0
Stearic acid 1.0
Plandool-ISS (Nippon Fine Chemicals) 1.0
Plandool-SUN (Nippon Fine Chemicals) 1.0
Jojoba Oil 3.0
behenyl alcohol 2.0
PEG-20 glyceryl isostearate 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl-10 oleate 1.0
Part B Acrylic acid-alkyl methacrylate copolymer 0.1
K hydroxide 0.07
(acryloyldimethyltaurate ammonium/
Beheneth methacrylate-25) Crosspolymer 0.2
Tremoist-SL (Nippon Fine Chemical) 1.0
Purified water 20.0
Hydrolyzed poly γ-glutamic acid K 0.1
Sodium polyglutamate 0.1
Oligopeptide-24 0.05
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 9.0
1,2-Pentanediol 10.0
PEG-8 5.0
PEG-2M 2.0
Ethylhexylglyceryl 0.8
DPG 1.5
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A and part C were mixed, heated to about 70° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to a viscous liquid. While stirring part C with a homomixer, part A was added and emulsified. Upon cooling to about 50°C, add Part B, stir and cool to about 40°C.

Example 36 Skin care cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Olive oil 1.5
Shea butter 1.0
Dimethicone 10 cSt 1.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 3.0
Diisostearyl malate (Nippon Fine Chemicals) 5.0
LUSPLAN DD-DHR (Nippon Fine Chemicals) 1.0
LUSPLAN DD-IS (Nippon Fine Chemicals) 1.0
Cholesteryl 12-hydroxystearate 0.1
Cetearyl glucoside 1.2
behenyl alcohol 1.5
Ascorbyl Tetrahexyldecanoate 7.0
Cetanol 2.5
Polyglyceryl-2 distearate 0.8
Sorbitan stearate 0.3
PEG-60 hydrogenated castor oil 1.0
Polyglyceryl-10 oleate 1.0
Part B Acrylic acid-alkyl methacrylate copolymer 0.1
K hydroxide 0.07
(VP/Eicosene) Copolymer 0.2
Tremoist-SL (Nippon Fine Chemical) 1.0
Purified water 20.0
Sodium hyaluronate 0.1
Panthenol 0.05
Glycyrrhizinate 2K 0.1
Succinoyl atelocollagen 0.01
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Lysolecithin 0.02
Glycerin 9.0
1,2-Hexanediol 3.0
1,2-pentanediol 1.5
Sorbitol 2.0
Multitose 2.0
Glyceryl caprylate 0.8
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A and part C were mixed, heated to about 70° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to a viscous liquid. While stirring part C with a homomixer, part A was added and emulsified. Upon cooling to about 50°C, add Part B, stir and cool to about 40°C.

Example 37 Cleansing Cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandool-LG2 (Nippon Fine Chemicals) 1.0
LUSPLAN SR-DP4 (Nippon Fine Chemical) 0.2
Neosolue-MP (Nippon Fine Chemicals) 0.2
Diethylhexyl adipate (Nippon Fine Chemicals) 0.5
Diisobutyl adipate (Nippon Fine Chemicals) 0.5
Diethylhexyl succinate (Nippon Fine Chemicals) 1.0
PEG-12 Isostearate 3.0
Sorbeth-30 tetraisostearate 1.5
Polyoxyethylene sorbitan oleate 0.3
Polyglyceryl-10 Laurate 0.3
Microcrystalline wax 2.0
PPG-9 diglyceryl 1.0
Seresin 3.0
Tocopherol 0.05
Part B Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 9.0
Diglycerin 3.0
1,2-Pentanediol 3.0
Neosolue-Aqua (Nippon Fine Chemicals) 0.5
Neosolue-Aqulio (Nippon Fine Chemicals) 0.5
DPG 5.0
Edetate 3Na 0.02
Phenoxyethanol 0.5
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was dissolved by heating to about 80°C. Part B was warmed to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

Example 38 Cleansing Foam

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A K stearate 10.0
Potassium palmitate 10.0
Potassium myristate 10.0
Potassium Laurate 4.0
Lauroyl sarcosine isopropyl 0.8
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
Plandool-G (Nippon Fine Chemicals) 0.05
PEG-150 10.0
1,2-Pentanediol 10.0
Glyceryl monostearate 1.0
PEG-40 hydrogenated castor oil 0.5
Part B Tremoist-SL (Nippon Fine Chemical) 1.0
Inulin 0.3
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Purified water Amount to make a total of 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was dissolved by heating to about 80°C. Part B was warmed to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

Example 39 Cleansing Foam

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Lecithin (PC content 92%) 0.01
(coconut fatty acid/hydrogenated beef tallow fatty acid) sodium glutamate 20.0
Cocoyl methyl taurine Na 5.0
Cocamidopropyl Betaine 5.0
Lauryl Glucoside 2.0
PEG-9 glyceryl laurate 2.0
Plandool-LG2 (Nippon Fine Chemicals) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
1,2-Pentanediol 10.0
Glycerin 14.0
Part B Glyceryl Caprylate 1.0
Hexanediol 1.0
Polyquaternium-51 1.0
Tremoist-SL (Nippon Fine Chemical) 1.0
Inulin 0.3
Microcrystalline cellulose 0.3
Polyquaternium-7 0.8
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was dissolved by heating to about 80°C. Part B was warmed to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

Example 40 Body Shampoo

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Cocoyl methyl taurine Na 10.0
Lauroyl Hydrolyzed Silk Na 6.0
Lauroyl methylalanine Na 10.0
Sodium cocoamphoacetate (30%) 4.0
Cocamidopropyl betaine (30%) 10.0
Olefin (C14-16) sulfonate Na 5.0
Polyquaternium-10 1.3
Hydroxypropyl methylcellulose 0.3
Sodium Acetyl Hyaluronate 0.02
Cocamide DEA 3.0
1,2-Pentanediol 5.0
Glycerin 5.0
Methylparaben 0.2
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
All the ingredients were heated to about 80° C. and uniformly stirred and mixed.

Example 41 Non-Silicone Shampoo

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Plandool-LG2 (Nippon Fine Chemicals) 0.03
Diethylhexyl succinate (Nippon Fine Chemicals) 0.01
Neosolue-AquaS (Nippon Fine Chemicals) 0.1
Tremoist-SL (Nippon Fine Chemical) 0.5
Sodium laureth-4 carboxylate (28%) 10.0
Laureth-6 carboxylic acid 4.0
Cocamidopropyl betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Coconut Fatty Acid PEG-7 Glyceryl 5.0
Na hydroxide 1% liquid 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
1,2-Pentanediol 5.0
Phenoxyethanol 0.4
Sodium benzoate 0.2
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
All the ingredients were heated to about 80° C. and uniformly stirred and mixed.

Example 42 Leave-in hair treatment

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Polyquaternium-37 2.0
Squalane 2.0
PPG-3 caprylyl ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
sunflower seed wax 0.1
Polyethylene wax 0.1
Mokurou 0.2
Seresin 0.1
PG Dicaprate 1.0
almond oil 0.5
Ethylhexyl Ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Neosolue-DP (Nippon Fine Chemicals) 0.2
Tocopherol Acetate 0.02
Erucalactone MCT (Nippon Fine Chemicals) 2.0
Dipentaerythrityl Tripolyhydroxystearate 1.5
PPG-5 Phytosteryl 0.5
1,2-Pentanediol 5.0
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed hyaluronic acid 0.1
Panthenol 0.1
Hydroxypropyltrimonium Hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyltrehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Amount for a total of 100 Hydroxypropyl starch phosphate 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part C was evenly dispersed and warmed to about 80°C. Next, part A was heated to about 80° C. and dissolved. Part A was added to part C while stirring, and after mixing uniformly, the mixture was cooled to about 40°C. Part B was then added respectively and mixed uniformly.

Example 43 Non-Silicone Hair Treatment

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandool-LG2 (Nippon Fine Chemicals) 0.5
Propanediol 3.0
behenamidopropyl dimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Isododecane 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamidomethyl MEA 0.8
Caesalpinia spinosa hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Erucalactone DES (Nippon Fine Chemicals) 2.0
Glycerin 1.0
Part B Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
1,2-Pentanediol 3.0
Purified water 20.0
Part C Phenoxyethanol 0.4
Tremoist-SL (Nippon Fine Chemical) 1.0
Lactic acid 0.4
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A and part C were each uniformly mixed at about 80°C. Part B was uniformly dispersed at about 70°C. Part C was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50°C. Part B was added and mixed uniformly.

Example 44 Shampoo for Dandruff

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
PPG-3 caprylyl ether 0.2
Lauroyl methylalanine Na (30%) 13.0
Cocamidopropyl betaine (30%) 20.0
Cocoyl glutamic acid TEA (30%) 5.0
Cocamide DEA 1.0
1,2-Pentanediol 3.0
Glycerin 1.0
Glyceryl Caprylate 0.4
Glyceryl undecylenate 0.1
Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Sorbitol 1.6
Miconazole nitrate 0.75
Glycol Distearate 1.5
Polyquaternium-7 0.3
Part B Sodium Benzoate 0.4
Na chloride 0.2
Purified water 100 in total Part C Assembly extract 3.0
Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Polyquaternium-47 0.1
Piroctone Olamine 0.1
Purified water 9.7
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80° C. and dissolved uniformly. Part A was placed in a separate container and heated to dissolve. Gradually add part B to part A, mix evenly and add part C at about 60°C.

Example 45 Shampoo

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Diisostearyl malate (Nippon Fine Chemicals) 0.3
Cocoyl sarcosine Na 10.0
Sodium cocoyl glutamate (30%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Glycol distearate 0.5
Stealoxypropyldimethylamine 0.5
Neosolue-AquaS (Nippon Fine Chemicals) 0.5
Isostearic acid 0.3
Glyceryl undecylenate 0.5
BG 0.1
Cocamidomethyl MEA 3.0
Phenoxyethanol 0.6
Part B Citric acid 0.1
Methylparaben 0.2
EDTA-2Na 0.1
Purified water 100 in total Part C Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Tremoist-SL (Nippon Fine Chemical) 3.0
Purified water 6.7
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly mixed at about 80°C. Part B, which was set aside separately, was heated to about 60° C. and homogenized. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50°C. Further, part C was added and mixed uniformly.

Example 46 Leave-on Hair Treatment

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Neosolue-Aqulio (Nippon Fine Chemicals) 2.0
Cetrimonium chloride (25%) 3.8
Isostearic acid 0.02
Erucalactone DES (Nippon Fine Chemicals) 1.0
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
1,2-hexanediol 2.0
Phenoxyethanol 0.5
Part B Ethanol 5.0
Part C Hydrolyzed Keratin 0.2
Hydrolyzed silk 0.1
Hydrolyzed Conchiolin 0.1
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Purified water Amount that makes a total of 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part C was warmed to about 80° C. and dissolved. Next, part A was heated to about 80° C. and dissolved. Part A was added to part C while stirring, and after mixing uniformly, the mixture was cooled to about 40°C. Part B was then added and mixed evenly.

Example 47 Sunscreen cosmetics

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (97% PC content) 0.1
Phytocompo-PP (Nippon Fine Chemicals) 1.0
1,2-Pentanediol 9.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl Salicylate 4.0
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-butyl methoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Nippon Fine Chemicals) 2.0
Diisobutyl adipate (Nippon Fine Chemicals) 2.0
behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandool-MAS (Nippon Fine Chemicals) 1.0
Plandool-LG1 (Nippon Fine Chemicals) 0.5
Plandool-LG4 (Nippon Fine Chemicals) 0.5
Plandool-S (Nippon Fine Chemicals) 0.5
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Fine Chemicals) 1.0
Methylparaben Appropriate amount Water Total amount to be 100 Part D Carbomer (2%) 5.0
Tremoist-SL (Nippon Fine Chemical) 10.0
Water-dispersed titanium dioxide 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Disperse part A evenly. Part B and part C are heated to about 70° C. and melted. After gradually adding part B to part A, gradually add part C and emulsify. Cool while stirring, add part D at 45°C and stir.

In the above formulation, the details of the ingredients described in the product names are as follows.
〇Plandool-H: dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
〇Plandool-S: dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
〇 Plandool-G: dimer dilinoleyl bis(behenyl/isostearyl/phytosteryl) dimer dilinoleate
○ Plandool-DP: Bis-diglyceryl polyacyl adipate-2
〇 Plandool-ISS: Phytosteryl isostearate 〇 Plandool-SUN: Sunflower seed oil fatty acid phytosteryl 〇 Plandool-MAS: Macadamia nut oil fatty acid phytosteryl 〇 Plandool-LG1: Lauroyl glutamate di(phytosteryl/octyldodecyl/behenyl)
○ Plandool-LG2: Lauroyl glutamate di(phytosteryl/octyldodecyl)
○ Plandool-LG3: Lauroyl glutamate di(phytosteryl/octyldodecyl/behenyl)
○ Plandool-LG4: Lauroyl glutamate di(phytosteryl/octyldodecyl/behenyl)
〇 LUSPLAN DD-IS: dimer dilinoleyl diisostearate 〇 LUSPLAN PI-DA: di(isostearyl/phytosteryl) dimer dilinoleate
〇 LUSPLAN DD-DHR: dimer dilinoleyl hydrogenated rosin condensate 〇 LUSPLAN DD-DA5: dimer dilinoleyl dimer dilinoleate 〇 LUSPLAN DD-DA7: dimer dilinoleyl dimer dilinoleate 〇 LUSPLAN SR-DM4: dye Dimer dilinoleyl dilinoleate, tri(caprylic/capric)glyceryl 〇 LUSPLAN SR-DP4: Dimer dilinoleyl dimer dilinoleate, pentaerythrityl tetraisostearate 〇 Neosolue-Aqulio: Bisethoxydiglycol cyclohexanedicarboxylate ○ Neosolue-Aqua: (Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin ○ Neosolue-AquaS: (Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, glycerin ○ Neosolue-MP: Dineopentanoate methyl pentanediol ○ Neosolue -DE: diethylpentanediol dineopentanoate 〇 Neosolue-MCT: tri (caprylic/capric) glyceryl 〇 Phytocompo-PP: hydrogenated lecithin, phytosterols 〇 Phytocompo-C: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3 , ceramide 6II
〇 Phytopresome Asta: hydrogenated lecithin, phytosterols, astaxanthin 〇 Phytopresome Lipo-Q: hydrogenated lecithin, phytosterols, lipoic acid, coenzyme Q10
○ Phytopresome Cera23: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3
〇 Phytopresome MEL: glycolipid, hydrogenated lecithin, BG, purified water 〇 Erucalactone MCT: γ-docosalactone, tri (caprylic/capric) glyceryl 〇 Erucalactone DES: γ-docosalactone, diethyl sebacate 〇 Tremoist- TP: White fungus polysaccharide ○ Tremoist-SL: White fungus polysaccharide aqueous solution (1%)
○ LP70H: hydrogenated lysolecithin

Claims (7)

It contains the following components (A) to (C) , the weight ratio of components (A1) and (A2) is 5:95 to 50:50, and the content of component (A) is 0.001 to 5 weights % and the weight ratio of components (A) and (B) is 1:5 to 1:200 .
(A) A phospholipid composition comprising the following components (A1) and (A2): (A1) phosphatidylinositol (A2) lecithin with a phosphatidylcholine (PC) content of 50 to 99% by weight (B) polyhydric alcohol (C) water 2. The cosmetic or topical preparation for skin according to claim 1, wherein the lecithin of component (A2) is a mixture of hydrogenated lecithin and non-hydrogenated lecithin. Claim 1 or 2 , wherein the polyhydric alcohol of component (B) essentially contains one or more selected from 1,2-pentanediol, 1,2-hexanediol and hexylene glycol. Cosmetics or skin external preparations according to. 4. The cosmetic or external preparation for skin according to any one of claims 1 to 3 , further comprising sterols or triterpenes as component (D). 5. The cosmetic or topical preparation for skin according to any one of claims 1 to 4 , further comprising an antioxidant as component (E). 6. The cosmetic or topical preparation for skin according to any one of claims 1 to 5 , which contains no surfactant other than component (A). 7. The cosmetic or external preparation for skin according to any one of claims 1 to 6 , which has a transparent appearance.