JP7210161B2 - Cosmetics containing tranexamic acid or external preparations for skin - Google Patents

Description

The present invention relates to a cosmetic or topical skin preparation containing (A) tranexamic acid or a derivative thereof or a salt thereof, (B) a reducing sugar or a derivative thereof, and (C) an acidic component.

Tranexamic acid has a hemostatic effect and an anti-inflammatory effect, so it is used as an active ingredient in pharmaceuticals, and is also widely used in cosmetics and external skin preparations because it has a rough skin improving effect and a whitening effect. In addition, saccharides are ingredients widely used in cosmetics and external skin preparations for the purpose of moisturizing, moisturizing, and skin conditioning. However, when tranexamic acid and sugars, especially sugars having a reducing end (reducing sugars) are used in combination, there is a problem that coloration occurs due to heat or aging.

As a solution to the above problems, for example, Patent Document 1 discloses that a composition containing tranexamic acids and sugars contains inorganic acids or salts thereof, organic acids or salts thereof, alcohols, vitamins or derivatives thereof, A chelating agent and a cosmetic composition containing one or more selected from plant-, seaweed- or animal-derived components are disclosed. Although external preparations containing amino acids have been disclosed, they are not necessarily satisfactory.

JP 2014-62077 A JP 2016-27037 A

The problem to be solved by the present invention is to provide a cosmetic or topical skin preparation containing tranexamic acid or a derivative thereof or a salt thereof and a reducing sugar, wherein discoloration due to heat or aging is suppressed. That's what it is.

As a result of extensive studies to solve the above problems, the present inventors have found that (A) tranexamic acid or derivatives thereof or salts thereof, (B) reducing sugars or derivatives thereof, and (C) acidic components are used in combination. By doing so, the inventors have found that coloration due to heat or aging is suppressed, and have completed the present invention.

The cosmetic or topical skin preparation of the present invention is sufficiently inhibited from discoloration due to heat or aging, and can reduce concerns about discoloration when tranexamic acid and reducing sugar are used in combination.

The cosmetic or external preparation for skin of the present invention contains the following components (A) to (C) as essential components.
(A) tranexamic acid or derivatives thereof or salts thereof (B) reducing sugars or derivatives thereof (C) acidic components

To explain the component (A) tranexamic acid or a derivative thereof or a salt thereof used in the cosmetic or external skin preparation of the present invention, tranexamic acid is also called trans-4-aminomethylcyclohexane-1-carboxylic acid. It is a compound that has both an amino group and a carboxyl group in its molecule. The tranexamic acid used in the present invention may be formulated as it is or in the form of a salt. Component (A) may be a tranexamic acid derivative, and specific examples thereof include ester derivatives such as tranexamic acid cetyl ester; and amide derivatives such as tranexamic acid methylamide. The amount of the component (A) of the present invention to be added to the cosmetic or external preparation for skin is not particularly limited as long as the desired effect and efficacy of the component (A) can be exhibited. 0.001 to 10% by weight, preferably 0.01 to 5% by weight.

The reducing sugar or derivative thereof of the component (B) used in the cosmetic or external preparation for skin of the present invention is not particularly limited as long as it is a sugar having a reducing terminal or a derivative thereof. Specifically, reducing sugars include glucose, fructose, mannose, galactose, xylose, fucose, arabinose, lactose, maltose, cellobiose and the like. Examples of reducing sugar derivatives include glycosides in which reducing sugars are glycons, and acylated reducing sugars. These may be used alone or in combination of two or more. The amount of the component (B) of the present invention to be added to the cosmetic or external preparation for skin is not particularly limited as long as it can exhibit the desired effects and efficacy of the component (B). 0.001 to 20% by weight, more preferably 0.01 to 10% by weight.

Specific examples of the acidic component (C) used in the cosmetic composition or external skin preparation of the present invention include phosphoric acid, phosphorous acid, pyrophosphoric acid, metaphosphoric acid, hypophosphorous acid, sulfuric acid, sulfurous acid, pyrophosphoric acid, Inorganic acids such as sulfurous acid and hydrochloric acid and their esters; Malonic acid, succinic acid, fumaric acid, maleic acid, glutaric acid, adipic acid, phytic acid, etidronic acid, edetic acid, pentetic acid, hydroxyethylethylenediaminetriacetic acid, benzoic acid, phthalic acid, gallic acid, cinnamic acid, salicylic acid , organic acids such as glutamic acid and aspartic acid; polyacrylic acid, polymethacrylic acid, alkyl acrylate methacrylate copolymer, carboxyvinyl polymer, carboxymethylcellulose, hyaluronic acid, carrageenan, pectin, gum arabic, xanthan gum, gellan gum, agar, Acidic polymer compounds such as white fungus polysaccharides can be mentioned. These acidic components may be in the form of salts with organic bases such as arginine, histidine and guanidine. These may be used alone or in combination of two or more. Among these, phosphoric acid, pyrosulfite, hydrochloric acid, citric acid, phytic acid, malic acid, succinic acid, fumaric acid, gluconolactone, etidronic acid, edetic acid, pentetic acid, salicylic acid, glutamic acid, aspartic acid, polyacrylic acid , polymethacrylic acid, alkyl acrylate methacrylate copolymer, carboxyvinyl polymer, and the like.

The coloring caused by the combination of tranexamic acid and reducing sugar is considered to be a kind of browning phenomenon generally called Maillard reaction. The Maillard reaction is a generic term for a reaction mechanism in which a compound (amino acid, peptide, protein, etc.) having a reducing sugar and an amino group produces a brown substance (melanoidin) by heating or the like. In the present invention, the acidic component of component (C) suppresses the coloring of tranexamic acid and reducing sugar because the amino group of tranexamic acid and the acidic component form a salt through a neutralization reaction, protect the amino group, and reduce the amino group. This is thought to be for suppressing the attack on sugar. From this point of view, in the cosmetic composition or external preparation for skin of the present invention, the amount of component (C) is 0.1 to 10 equivalents, preferably 0.2 to 5 equivalents, relative to 1 equivalent of the amino group of tranexamic acid. It is preferable to blend in the range of the equivalent amount.

In the cosmetic composition or external preparation for skin of the present invention, inorganic bases such as sodium hydroxide, potassium hydroxide and calcium hydroxide may reduce the effects of the present invention. The reason for this is that since such an inorganic base is stronger than the amino group of tranexamic acid, the acidic component of component (C) formed a salt preferentially with the inorganic base rather than with the amino group. This is because the effect of protecting the amino group described above is no longer exhibited. Therefore, in the cosmetic or topical skin preparation of the present invention, the inorganic base is preferably contained in a base equivalent less than the acid equivalent of component (C). On the other hand, it is desirable to contain the inorganic base in an amount of 0.5 equivalents or less, preferably 0.2 equivalents or less, more preferably 0.1 equivalents or less. There is no particular limitation on the amount of the organic base component that is weaker in basicity than the amino group. From this point of view, the pH of the cosmetic or topical skin preparation of the present invention is preferably on the acidic side, specifically in the range of 3 to 7, preferably 3.5 to 6.5. should be

The cosmetic composition of the present invention, in addition to the essential ingredients of the present invention, may optionally contain water and additive components usually blended in cosmetics, such as oily bases, surfactants, alcohols, and moisturizing agents. , polymer/thickening/gelling agent, antioxidant, antiseptic, bactericide, chelating agent, pH adjuster/acid/alkali, UV absorber, whitening agent, solvent, exfoliating/dissolving agent, antipruritic, Antiphlogistic agents, antiperspirants, cooling agents, antihistamines, astringents, stimulants, hair growth agents/blood circulation promoters, reducing agents/oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their Derivatives, organic acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments, etc. can be blended.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, higher alcohols such as dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts thereof, nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax , ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado Oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat. Vegetable oils such as germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; Animal oils and fats such as horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as spermaceti, lanolin, and orange roughy oil; liquid lanolin, reduced lanoli lanolins such as adsorption purified lanolin, lanolin acetate, acetic acid liquid lanolin, hydroxyl lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, acetic acid (cetyl/lanolyl) ester; lecithin, phosphatidylcholine , phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salts, phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybeans Phospholipid derivatives such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl -di (cholesteryl/behenyl/octyldodecyl) L-glutamate, di (cholesteryl/octyldodecyl) N-lauroyl-L-glutamate, di (phytosteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, N-lauroyl- L-glutamic acid di(phytosteryl/octyldodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, isostearic acid phytosteryl, Sterol esters such as soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, and long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid/cholesterol complex and phospholipid/phytosterol complex; myristic acid Octyldodecyl, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate , isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyl oleate Rudodecyl, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil, isopropyl myristate, isopropyl palmitate, palmitin Octyl Acid, Isopropyl Isostearate, Isopropyl Lanolin Fatty Acid, Methylheptyl Laurate, Methylheptyl Myristate, Methylheptyl Palmitate, Methylheptyl Isostearate, Diethyl Sebacate, Diisopropyl Sebacate, Dioctyl Sebacate, Diisopropyl Adipate, Dibutyl Sebacate Monoalcohol carboxylic acid esters such as octyl, diisobutyl adipate, dioctyl adipate, dioctyl succinate, and triethyl citrate; Acid esters; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic/capric triglyceryl, tri(caprylic/capric/myristic/stearic) glyceryl, hydrogenated Rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, dioctanoic acid 2-butyl-2-ethyl-1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylol (isostearate/sebacate) Propane, pentaerythrityl triethylhexanoate, (hydroxystearic acid/stearic acid/rosin acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonisostearate, deca (erucic acid/isostearic acid/ricinoleic acid) Polyglyceryl-8, (hexyldecanoic acid/sebacic acid) diglyceryl oligoester, glycol distearate ethylene glycol), polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dinopentanoate and 2,4-diethyl-1,5-pentanediol dinopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, dimer dilinoleate (phytosteryl/behenyl), dimer dilinoleate (phytosteryl/isostearyl/cetyl/stearyl/behenyl ), dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil of dimer dilinoleate, hydroxyalkyl dimer dilinoleyl ether, or other dimer acids or dimer diols derivatives of; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (Lauramide DEA), lauric acid monoisopropanolamide (Lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), fatty acid alkanolamides such as coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone ( high polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin , silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphoric acid-modified silicones, sulfuric acid modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone silicones such as silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, polysiloxane/oxyalkylene copolymers; perfluorodecane, Fluorinated oils such as perfluorooctane and perfluoropolyether are preferred.

Moisturizers and texture improvers include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol/propylene glycol copolymer, and polymers thereof; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Sugars and derivatives thereof such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , caronin sulfate, keratosulfate, dermatan sulfate; white fungus extract, white fungus polysaccharide; fructans such as inulin and levan; fucoidan; urea; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids such as amine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen decomposition Peptides, Hydrolyzed Collagen, Hydroxypropylammonium Chloride Hydrolyzed Collagen, Elastin-Degraded Peptides, Keratin-Degraded Peptides, Hydrolyzed Keratin, Conchiolin-Degraded Peptides, Hydrolyzed Conchiolin, Silk-Proteolytic Peptides, Hydrolyzed Silk, Sodium Lauroyl Hydrolyzed Silk, Soy Protein peptides such as proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides and derivatives thereof; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides and palmitoyl tetrapeptides; silylation Peptides; lactic acid bacteria culture, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract witch hazel water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, rose rose extract, yarrow extract, eucalyptus extract, melilot extract and other animal and plant extracts, natural ceramides (types 1, 2, 3, 4, 5, 6), ceramides such as hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and sugar-ceramide-containing extracts are preferred.

Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, and the like. There is no particular limitation on the HLB of the surfactant, and a surfactant with a low HLB of about 1 to a surfactant with a high HLB of about 20 can be used, and a combination of a low HLB and a high HLB is also preferred. Examples of preferred surfactants include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; Sodium sulfate, polyoxyethylene alkyl sulfates such as triethanolamine laureth sulfate; sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines, sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoyl alanine triethanolamine , acyl amino acid salts such as dilauroyl glutamic acid lysine Na; polyoxyethylene alkyl ether acetate salts such as sodium laureth acetate; succinate ester salts such as lauroyl monoethanolamide sodium succinate; fatty acid alkanolamide ether carboxylate; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as hydrogenated coconut oil fatty acid sodium glycerol sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; Alkyl sulfosuccinates such as disodium lauryl acid and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, and alkyl ether sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkylbenzenesulfonates such as sodium benzenesulfonate, triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; Alkyl sulfoacetates; Alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate and sodium monooleth phosphate; Alkyl phosphate salts such as potassium lauryl phosphate; Sodium caseinate; Phosphates; Fatty acid amide ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Anionic surfactants, etc.; nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxy ethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyldodeceth (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil and hydrogenated castor oil derivatives such as oxyethylene hydrogenated castor oil maleic acid; Polyoxyethylene phytosterol; Polyoxyethylene cholesterol; Polyoxyethylene cholestanol; Polyoxyethylene lanolin; Polyoxyethylene reduced lanolin; Propylene cetyl ether, polyoxyethylene/polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene/polyoxypropylene monobutyl ether, polyoxyethylene/polyoxypropylene hydrogenated lanolin, polyoxyethylene/polyoxypropylene glycerin ether, etc. Polyoxyethylene/polyoxypropylene alkyl ether; Polyoxyethylene/polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glyceryl stearate Glycerol such as ceryl, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil, monocottonseed glycerol, glyceryl monoerucate, glyceryl sesquioleate, α,α'-pyroglutamic acid glyceryl oleate Fatty acid partial esters; polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate-2, polyglyceryl destearate- 10, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate , polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-oleate-2, 3, 4, 5, 6, 8, 10, polyglyceryl dioleate-6, polyglyceryl trioleate- 2, polyglycerin fatty acid esters such as polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2- Sorbitan fatty acid esters such as diglycerol sorbitan ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid esters, methyl glucoside fatty acid esters, sugar derivative partial esters such as trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; polyglycosides; glycolipids such as mannosylerythritol lipid; lanolin alcohol; reduced lanolin; Fatty acid mono and and diesters; polyoxyethylene/propylene glycol fatty acid esters; polyoxyethylenes such as polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate Glycerin fatty acid esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate , polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; Polyoxyethylene animal and vegetable oils and fats such as oxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol and batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxy Ethylene/tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), Lauric Acid Monoethanolamide (Lauramide MEA), Lauric Acid Diethanolamide (Lauramide DEA), Lauric Acid Monoisopropanolamide (Lauramide MIPA), Palmitic Acid Monoethanolamide (Partamide MEA), Palmitic Acid Diethanolamide (Partamide DEA), Coconut Oil fatty acid alkanolamides such as fatty acid methylethanolamide (cocamide methyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; Polyether-modified silicone such as dimethicone copolyol, polysiloxane Oxyalkylene copolymers, polyglycerin-modified silicones, silicone-based nonionic surfactants such as sugar-modified silicones; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryl alkyltrimethylammonium chloride such as trimonium chloride; alkyltrimethylammonium bromide such as stearyltrimonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; Fatty acid amidoamines and their salts; Alkyl ether amines such as stearoxypropyldimethylamine and their salts or quaternary salts; Ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium, Ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium fatty acid amide type quaternary ammonium salts such as; polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidinium salt; alkyl ether amine monium salt; salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; , cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, and the like, silicone-based cationic surfactants, etc.; ,N-dimethyl amino acid betaines; fatty acid amide alkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; Betaine; sulfuric acid betaine such as alkyldimethylaminoethanol sulfate; phosphate betaine such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphin Phospholipids such as sphingophospholipids such as gomelin, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; Silicone-based amphoteric surfactants and the like; polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid/methacrylate alkyl copolymers, and various silicone-based surfactants.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcelleran, karaya gum, tororo mallow, cara gum, tragacanth gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , chitosan, agar, cassava extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethyl Cellulose and its derivatives such as ammonium sulfate cellulose, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenylsuccinate, etc. starch derivatives; sodium alginate, alginic acid derivatives such as propylene glycol alginate; Polyoxypropylene copolymer; Amphoteric methacrylic acid ester copolymer such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine methacrylate) copolymer; (dimethicone/vinyl dimethicone) cross Polymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salt such as sodium salt, acrylic acid/methacrylic acid ester copolymer; acrylic acid/alkyl methacrylate copolymer Polymer: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride/acrylamide copolymer such as polyquaternium-7, acrylic acid/diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39・Acrylic acid/methyl acrylate/chloride such as diallyldimethylammonium chloride/acrylamide copolymer, acrylic acid/cationized methacrylic acid ester copolymer, acrylic acid/cationized methacrylic acid amide copolymer, polyquaternium-47, etc. methacrylamidopropyltrimethylammonium copolymer, chloride methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; Polymer of 2-methacryloyloxyethylphosphorylcholine and copolymer with butyl methacrylate copolymer; acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; acrylic-silicone graft copolymers and other silicone-based copolymers; salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, Bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructo-oligosaccharide fatty acid esters are preferred.

Solvents/propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Classes: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether glycol ethers such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate and propylene glycol monoethyl ether acetate; glycol ether esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation freon; LPG, dimethyl ether, and carbon dioxide are preferred.

Antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; It is mentioned as. Preferred reducing agents include thioglycolic acid, cysteine, cysteamine, and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diols; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, phenylphenol sodium; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion is preferable, but when used as an antibacterial agent or antiseptic for the purpose of preserving, from the viewpoint of the safety of cosmetics or external skin preparations, phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-alkanediols such as diols and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether are more preferably used.

Chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and salts such as its sodium salt; Sodium oxalate; Polyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphoric acid; Sodium citrate, citric acid, alanine, dihydroxyethylglycine , gluconic acid, ascorbic acid, succinic acid and tartaric acid are preferred. pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, and monoethanol. Amines, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxide Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferred.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with various surface treatment agents such as silicone such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate・Organic powders and surface-treated powders of various sizes and shapes, such as polymethyl methacrylate layered powder, polyethylene terephthalate/aluminum/epoxy layered powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc., organic and inorganic Composite powders are preferred. Examples of inorganic salts include sodium chloride-containing salts such as table salt, common salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum/potassium sulfate (alum), aluminum/ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate, phosphoric acid Potassiums, calcium phosphates, and magnesium phosphates are preferred.

UV absorbers include para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester. Benzoic acid-based UV absorbers such as esters, N,N-dimethylpara-aminobenzoic acid butyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester; Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid and salicylic acid UV absorbers such as sodium salts thereof, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamic acid-based UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof;2, 4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' -benzophenones such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone UV absorber; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-( 3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid and urocanic acid derivatives such as ethyl urocanate 2-(2′-hydroxy-5′-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionic acid Preferable examples include hydantoin derivatives such as 2-ethylhexyl, phenylbenzimidasozole sulfonic acid, terephthalylidene dicamfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, B vitamins such as choline; vitamin Cs such as ascorbic acid and salts thereof such as sodium; vitamin D; Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbyl phosphate sodium salt and ascorbyl phosphate magnesium salt, ascorbyl tetra Ascorbic acid fatty acid esters such as isopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbyl ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and fatty acid esters thereof , ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopheryl acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate, tocotrienols, and other various vitamin derivatives are preferred. It is mentioned as.

Antiphlogistic and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhizic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; , mugwort leaf extract and the like are preferred. Hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as assembly extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; , borneol, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide, benzyl nicotinate Derivatives such as ester-inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, and minoxidil are preferred. It is mentioned as. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoting agents, stimulating agents, analgesics, and cell activators include retinols, retinoic acids, and retinoin. tocopheryl acid; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives such as glycosides and esters thereof, hydroxycapric acid, long-chain α-hydroxy fatty acids, α- or long-chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine, etc. and their derivatives; , astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, antioxidants and active oxygen scavengers such as fullerenes; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; Polyphenols such as anthocyanidins, chlorogenic acid, and apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; shogaol, gingerol; menthol, camphor, cedrol and other flavoring substances and derivatives thereof; capsaicin, vanillin and the like and their derivatives; insect repellents such as diethyltoluamide; mentioned.

Plant/animal/microorganism extracts include iris extract, angelica keiskei extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, and ginkgo biloba extract. , inchkou extract, fennel extract, turmeric extract, oolong tea extract, urticaria extract, age extract, Echinashi leaf extract, trillium extract, Scutellaria root extract, Phellodendron bark extract, Coptis extract, Barley extract, Panax ginseng extract, Hypericum extract, Dead nettle extract, Ononis extract , Dutch mustard extract, orange extract, seawater dried matter, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, kakkon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, wormwood extract, oat extract, karkade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiwi extract, cloud ear extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guava extract, kujin extract, gardenia extract, kumazasa extract, clara extract, walnut Extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract, Gennoshoko extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice Fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, cowberry extract, rhinoceros extract, rhinoceros extract, rhinoceros extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, sansha extract, Japanese pepper extract, shiitake extract, reed extract, licorice extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, white birch extract, white fungus extract, horsetail extract, stevia extract, fermented stevia, Nishikawayanagi extract, Ivy extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, neem extract, jersey extract, sage extract, rhubarb extract, dai Sunflower extract, turmeric extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cinnamon extract, chimp extract, tea tree oil, sweet tea extract, capsicum extract, angelica extract, calendula officinalis extract, tonin extract, spruce extract, Houttuynia cordata extract, tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietalia extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifidobacterium extract, Loquat extract, coltsfoot extract, coltsfoot extract, coltsfoot extract, bukuryo extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, botan extract, hop extract, mica extract, pine extract, horse chestnut extract , Asian skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract , Reishi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, burnet extract and the like are preferred.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors and the like. Examples of exfoliating/dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and the like. Examples of antiperspirants include aluminum chlorohydroxy, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum/potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

Fragrances include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-e-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecenal, Estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , isobornyl acetate, geranyl acetate, dimethylbenzyl carbyl acetate, styraryl acetate, cedryl acetate, terpinel acetate, p-t-butylcyclohexyl acetate, betiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineol, cinnamaldehyde, styrax Resinoids, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli Alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , peppermint oil, pepper oil, heliotropine, bergamot oil, benzyl benzoate, borneol, myresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-mentone, eucalyptus oil, β-ionone, lime oil , lavender oil, D-limonene, linalool, lilal, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils and other synthetic fragrances and natural Perfumes and various blended perfumes are preferred.

Colorants/colorants/dyes/pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203 and Blue No. 204. , Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red 104-1, red 105-1, red 106, red 2, red 3, red 201, red 202, red 203, red 204, red 205, red 206, red 207 , Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red 228, Red 230-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503 , Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow Legal dyes such as No. 405, Yellow No. 406, Yellow No. 407, and Yellow No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher Inorganic black pigments such as black iron oxide and low order titanium oxide; Inorganic pigments such as mango violet and cobalt violet Purple pigments; Inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; Inorganic blue pigments such as ultramarine blue and Prussian blue; Titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored oxide Pearl pigments such as titanium-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; Quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin and other naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin and other natural pigments and dyes; p-phenylenediamine, toluene-2,5 - oxidation dye intermediates such as diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, etc. and salts thereof autooxidative dyes such as indolines; and dihydroxyacetone are preferred.

Preferable examples of water include ordinary water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

In addition to these, the Standards for Cosmetic Ingredients, Standards for Ingredients by Cosmetic Type, List of Ingredients Displayed by the Japan Cosmetic Industry Association, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Standards for Quasi-drug Ingredients, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, food additives compendium, etc., and in Japanese and foreign patent publications and patent publication publications (including publication publications and republication) that belong to the classification of A61K7 and A61K8 in the international patent classification IPC Known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as those described, can be contained in known combinations and blending ratios and blending amounts.

Examples of the cosmetic or external skin preparation of the present invention include hair cosmetics, skin cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, and external skin preparations such as ointments. From the viewpoint of exhibiting the effect of the present invention, it can be preferably used for hair cosmetics and skin cosmetics. The cosmetic of the present invention can be produced according to ordinary methods.

To explain the types of the cosmetic composition or skin external preparation of the present invention in more detail, hair cosmetic compositions include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, rinse-integrated shampoos, and the like. Rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tick, hair cream, hair blow, split ends coat , hair oils, permanent wave agents, straight permanent agents, oxidative hair dyes, hair bleach, hair color pretreatments, hair color aftertreatments, perm pretreatments, perm aftertreatments, hair manicures, and hair growth agents.

Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layer lotion; emollient lotion, moisturizing lotion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizer - Emulsions, massage lotions, cleansing lotions, protective emulsions, sun protection, sun protectors, UV care milk, sunscreens, make-up lotions, keratin smoothers, elbow lotions, hand lotions, body lotions, etc.; emollient creams, nourishing creams, Nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, exfoliating Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and anti-ultraviolet essences; Face wash such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, cleansing powder, facial cleansing powder; Soaps such as shaving soaps and synthetic toilet soaps are preferred.

Preferred examples of makeup cosmetics include powders/powder powders, foundations, lipsticks, lip glosses, blushers, eyeliners, mascara, eyeshadows, eyebrows, eyebrows, nail enamels, enamel removers, and nail treatments. .

Perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, paste perfume, fragrant powder, perfumed soap, body lotion, and bath oil are preferable examples of fragrant cosmetics.

Body cosmetics include body cleansers such as body shampoo, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays, and deodorant sticks, decolorants, hair removal agents, bath agents, and insect repellent sprays. Repellers are preferred.

In addition, external skin preparations can be used in dosage forms such as ointments, patches, lotions, liniments, and liquid coatings. It can also be used as an intraoral cosmetic such as toothpaste and mouthwash.

Formulations of the cosmetic or external preparation for skin of the present invention include emulsions such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, and O/W/O type. type cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-type cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder-type cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics Preferable dosage forms include cosmetics, emulsified polymer type cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

The present invention will be described in more detail by the following examples, but the present invention is not limited to these.

Lotions were prepared by blending component (A) tranexamic acid, component (B) maltose, and components corresponding to component (C) in the compositions shown in Tables 1 to 3 (Examples 1 to 18). For comparison, a lotion containing no component (C) was prepared (Comparative Example 1). No coloration was observed in any of the lotions immediately after preparation. These lotions were stored at 50° C. for 2 weeks, and the appearance after storage was visually observed to confirm the presence or absence of coloring. The degree of coloring was evaluated according to the following five grades, and the results are shown in Tables 1-3.

＋++ ・・・Very colored ++ ・・・Colored ＋ ・・・Slightly colored ± ・・・Slightly colored - ・・・No coloration

From the results in Tables 1 to 3, it was found that the lotion containing component (C) was less colored than the lotion containing no component (C).

The following cosmetics were prepared by blending the components (A) to (C) of the present invention. All of the obtained cosmetics were inhibited from being colored.

Example 19

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Tranexamic acid 2.00
Phytic acid 0.30
Purified water 18.00
Part B Arbutin 4.00
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.20
Part C Maltose 1.00
Dipropylene glycol 4.00
absolute ethanol 5.00
Glycerin 5.00
Sodium hyaluronate 0.20
Pyrosulfite 0.10
Phosphoric acid Appropriate amount Disodium edetate 0.10
Phenoxyethanol 0.30
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and evenly dissolved. Part C was mixed and heated to about 70° C. to dissolve uniformly. Part C was cooled to 40° C. and parts A and B were mixed and homogenized.

Example 20 Lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A 1,3-butylene glycol 4.00
Diglycerin 2.00
Glycerin 1.00
Methylparaben 0.10
Part B Tranexamic acid 2.00
Etidronic acid 0.10
Malic acid 0.10
Salicylic acid 0.10
Purified water 18.00
Part C Bisethoxydiglycol cyclohexanedicarboxylate (Neosolue-Aqulio: Nippon Fine Chemical Co., Ltd.) 0.50
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.20
Hyaluronic acid 0.10
glucose 0.10
Fructose 0.10
Mannose 0.10
Disodium edetate 0.10
Sodium pyrosulfite 0.10
Phenoxyethanol 0.20
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A, part B, and part C were separately taken and mixed uniformly. Part A and part B were added to part C and homogenized.

Example 21 Emulsion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/
behenyl) (Plandool-H: Nippon Fine Chemical Co., Ltd.) 1.00
N-lauroylmethyl-L-glutamic acid di(phytosteryl behenyl
2-octyldodecyl) (Plandool-LG1: Nippon Fine Chemical) 0.50
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Fine Chemical) 0.50
Hydrogenated palm oil 1.00
Diethylhexyl succinate 0.50
Stearyl alcohol 0.50
Behenyl alcohol 0.80
Lipophilic glyceryl monostearate 0.60
Self-emulsifying propylene glycol stearate 0.40
Polyoxyethylene glyceryl isostearate 0.40
Diglyceryl triisostearate 0.60
Ethyl parahydroxybenzoate 0.10
Part B Carboxyvinyl polymer 0.20
Purified water 10.00
Part C xanthan gum 0.06
Purified water 10.00
Part D White fungus polysaccharide (Tremoist-SL: Nippon Fine Chemical) 5.00
Part E Tranexamic acid 2.00
Citric acid 0.20
Methyl paraoxybenzoate 0.10
Propylene glycol 2.00
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.50
Glycerin 1.00
Cyclohexanedicarboxylic acid bisethoxydiglycol (Neosolue-Aqulio: Nippon Fine Chemical) 1.00
Disodium edetate 0.10
Xylose 0.02
Fucose 0.02
Phenoxyethanol 0.10
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and heated to about 70° C. to dissolve uniformly. Part C was mixed and stirred to a viscous liquid. Part E was mixed and evenly dissolved. Add part E to part A, stir to emulsify, cool and add part B, part C and part D at about 50° C. and stir to homogenize.

Example 22 Gel

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ethanol 5.00
Ethylhexyl methoxycinnamate 0.01
Polyglycerin-10 0.2
1,3-butylene glycol 6.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B Alkyl acrylate methacrylate copolymer 1.00
Carboxyvinyl polymer 0.20
Lactose 0.20
Maltose 0.20
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
Glutamic acid 0.20
Aspartic acid 0.20
Pentetic acid (diethylenetriaminepentaacetic acid) 0.06
Citric acid 0.05
Sodium citrate Appropriate amount Purified water Amount to make a total of 100 －－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－ -
(Preparation method)
Part A was mixed and evenly dissolved. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Add part A and part C to part B and stir to homogenize.

Example 23 Gel

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A PEG-30 0.20
Dipropylene glycol 1.00
Ethanol 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Part B Carboxyvinyl polymer 0.20
Xanthan gum 0.20
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.20
Carboxymethylcellulose 0.80
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.15
Glutamic acid 0.10
Pentetic acid (diethylenetriaminepentaacetic acid) 0.10
Hydrolyzed Collagen 0.05
Fructose 0.05
Mannose 0.05
Lactose 0.05
Lactic acid 0.05
Na lactate Appropriate amount Na sulfite 0.10
Bisethoxydiglycol cyclohexanedicarboxylate (Neosolue-Aqulio: Nippon Fine Chemical) 0.50
Betaine 0.20
Sorbitol 0.05
Trehalose 3.00
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and evenly dissolved. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Add part A and part B to part C and stir to homogenize.

Example 24 Gel

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A 1,3-BG 4.00
Glycerin 1.00
Hexylene glycol 1.00
Pentylene glycol 1.00
Hydrogenated lecithin, phytosterols, ceramide 2,
(Phytopresome-Cera2: Nippon Fine Chemical) 0.30
Part B (Acryloyldimethyltaurine/beheneth-25 methacrylate) copolymer
0.20
Gellan gum 0.05
Carboxymethylcellulose 0.50
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.05
Purified water 20.00
Part C Tranexamic acid 2.00
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.20
Olive leaf extract 0.05
Horse chestnut extract 0.05
Glycosyltrehalose 0.05
Arbutin 0.20
Phytic acid 0.20
Glutamic acid 0.20
Succinic acid 0.10
Fumaric acid 0.05
Na fumarate appropriate amount HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.15
Bisethoxydiglycol cyclohexanedicarboxylate (Neosolue-Aqulio: Nippon Fine Chemical) 0.50
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and heated to about 70° C. to dissolve uniformly. Add part C to part A, stir with a homomixer, dissolve uniformly, cool, add part B at about 50° C., and homogenize.

Example 25 Emulsion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cetanol 0.20
Squalane 0.05
Jojoba oil 0.05
Diethylhexyl succinate 0.20
Polyglyceryl-10 isostearate 0.10
Behenes-30 0.05
Ethylhexyl methoxycinnamate 0.05
Tocopherol 0.05
Part B Carboxymethylcellulose 0.20
Xanthan gum 0.20
Hyaluronic acid 0.03
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
Chondroitin sulfate Na 0.20
HEDTA-3Na (hydroxyethylethylenediaminetriacetic acid) 0.01
Sorbitol 3.00
Succinic acid 0.03
Sodium succinate Appropriate amount Diglycerin 0.15
Maltose 0.20
Xylose 0.15
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Add part C to part A, stir to emulsify, cool and add part B at about 50° C., and stir to homogenize.

Example 26 Cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A batyl alcohol 2.00
Squalane 2.00
Glyceryl tri-2-ethylhexanoate 2.00
Diethylhexyl Sebacate 2.00
Stearic acid 1.00
Macadamia nut oil fatty acid phytosteryl (Plandool-MAS: Nippon Fine Chemical) 1.00
Natural Vitamin E 0.05
Behenyl alcohol 2.00
Lipophilic glyceryl monostearate 1.00
Polyglyceryl oleate-10 0.10
Ethylparaben 0.15
Methylpolysiloxane 0.50
Polyoxyethylene cetyl ether 2.00
Hydrogenated lecithin, phytosterol complex (Phytocompo-PP: Nippon Fine Chemical) 1.00
Part B Carboxyvinyl polymer 0.20
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Gluconolactone 0.10
Succinic acid 0.01
Na succinate Appropriate amount 1,3-butylene glycol 0.15
glucose 0.20
Maltose 0.20
Fructose 0.20
Sohakuhi extract 0.20
Etidronic acid (60%) 0.10
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.20
Glycerin 0.20
Inositol 0.10
Methylparaben 0.10
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and heated to about 70° C. to dissolve uniformly. Add part C to part A, stir to emulsify, cool and add part B at about 50° C., and stir to homogenize.

Example 27 Cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Jojoba oil 2.00
dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/
behenyl) (Plandool-H: Nippon Fine Chemical Co., Ltd.) 1.00
Phytosteryl/octyldodecyl/behenyl lauroyl glutamate
(Plandool-LG3: Nippon Fine Chemical) 1.00
PEG-60 glyceryl isostearate 0.70
Polyglyceryl-2 diisostearate 0.50
Macadamia Nut Oil Fatty Acid Phytosteryl 1.00
Propylene glycol monostearate 0.60
behenyl alcohol 1.20
Self-emulsifying glyceryl monostearate 1.20
Ethylparaben 0.15
Dimethicone 20cs 1.00
PEG-60 hydrogenated castor oil 0.30
Part B Carboxymethylcellulose 0.20
Carboxyvinyl polymer 0.20
(acryloyl dimethyl taurine/beheneth-25 methacrylate) polymer
0.30
Purified water 20.00
Part C Tranexamic acid 2.00
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical Co., Ltd.) 1.00
Arbutin 1.00
Ascorbyl glucoside 1.00
Phytic acid 0.05
Gluconate 0.05
Pyrosulfite 0.05
Citric acid 0.05
Na citrate Appropriate amount Dipotassium glycyrrhizinate 0.20
Ethylenediaminetetraacetic acid diNa 0.10
1,3-butylene glycol 1.00
Glycerin 2.00
Bisethoxydiglycol cyclohexanedicarboxylate (Neosolue-Aqulio: Nippon Fine Chemical) 0.50
Methylparaben 0.10
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and heated to about 70° C. to dissolve uniformly. Add part C to part A, stir to emulsify, cool and add part B at about 50° C., and stir to homogenize.

Example 28 Emollient Cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A: Di(phytosteryl/octyldodecyl) lauroyl glutamate
(Plandool-LG2: Nippon Fine Chemical) 1.00
Dimer dilinoleyl dimer dilinoleate (LUSPLAN DD-DA7: Nippon Fine Chemical Co., Ltd.) 1.00
Liquid paraffin 2.50
Behenyl alcohol 2.00
Dimethicone (10cs) 1.50
Methylphenylpolysiloxane 0.50
Glyceryl Laurate 1.50
Stearyl alcohol 1.20
PG stearate (SE) 1.00
PEG-60 glyceryl isostearate 1.00
Ethylhexyl methoxycinnamate 0.20
Ethylparaben 0.10
Part B Carboxymethylcellulose 0.30
Alkyl acrylic acid methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.20
1,3-butylene glycol 6.00
Trisodium ethylenediamine disuccinate 0.30
Pentetic acid (diethylenetriaminepentaacetic acid) 0.05
Fumaric acid Appropriate amount Na fumarate Appropriate amount Caprylyl glucoside 1.00
Ethyl glucoside 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and heated to about 70° C. to dissolve uniformly. After adding part C to part A and emulsifying with a homomixer, the mixture was cooled and added to part B at about 50° C. and stirred to homogenize.

Example 29 Lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
(Phytocompo-C: Nippon Fine Chemical) 0.30
1,2-Pentanediol 3.00
Glycerin 6.00
Part B Tranexamic acid 2.00
Ascorbyl glucoside 0.50
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.50
Phytic acid 0.30
Glutamic acid 0.20
Purified water 20.0
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
BG 5.00
Tripropylene glycol 2.00
DPG 2.00
Maltose 1.00
Glucose 0.01
Phenoxyethanol 0.20
Methylparaben 0.15
Citric acid 0.10
Na citrate Appropriate amount Part C Carboxyvinyl polymer 0.01
Purified water Amount that totals 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part C was mixed to prepare a viscous liquid. Each of parts A and B was heated to 70° C., and part A was added while stirring part B with a homomixer to prepare a nanovesicle liquid. After cooling, the pre-mixed part C was added to obtain a uniform liquid.

Example 30 Emulsion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Sorbitan stearate 0.50
PEG-10 stearate 0.50
Polysorbate 60 0.50
Phytosteryl isostearate (Plandool-ISS: Nippon Fine Chemical) 1.00
Cetyl ethylhexanoate 3.70
Cetanol 1.20
Dimethicone (10cs) 1.00
Methylphenylpolysiloxane 0.50
1,2-hexanediol/caprylyl glycol 0.50
Ethylparaben 0.10
Part B (acryloyldimethyltaurate ammonium/VP) copolymer 0.05
Stealoxyhydroxypropyl methylcellulose 0.10
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Edetic acid 0.02
Etidronic acid 0.02
Purified water 18.00
Part D 1,3-butylene glycol 3.00
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
Maltose 1.00
Xylose 1.00
Lactose 1.00
Glycerin 1.00
Phenoxyethanol 0.20
Methylparaben 0.15
Citric acid 0.01
Na citrate 0.09
Xanthan gum 0.10
Carboxyvinyl polymer 0.15
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Part D was mixed and heated to about 70° C. to dissolve uniformly. Add part D to part A, emulsify with a homomixer, cool, add part C and part B at about 50° C., and stir to homogenize.

Example 31 Liquid foundation

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glyceryl stearate (SE) 1.00
PG stearate (SE) 1.00
Phytosteryl/octyldodecyl lauroyl glutamate
(Plandool-LG2: Nippon Fine Chemical) 0.50
Cetyl octanoate 6.00
Diethylhexyl succinate 2.00
Tocopherol 0.10
Propylparaben 0.10
Titanium oxide/iron oxide mixture (FDP-W-007 manufactured by Toshiki Pigment Co., Ltd.) 18.00
Mica 7.00
Octyl para-methoxycinnamate 5.00
Trimethylsiloxysilicate 3.00
Cyclomethicone 7.00
Phenylmethicone 5.00
Part B (acryloyldimethyltaurate ammonium/VP) copolymer 0.20
Carboxymethylcellulose 0.05
(acryloyl dimethyl taurine/beheneth-25 methacrylate) copolymer
0.15
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.04
Succinic acid 0.05
Sodium succinate Appropriate amount Purified water 18.00
Part D (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
Xanthan gum 0.20
Etidronic acid 0.05
4Na glutamate diacetate 1.20
Maltose 1.00
1,3-butylene glycol 5.00
Pentylene glycol 3.00
Methylparaben 0.05
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Part D was mixed and heated to about 70° C. to dissolve uniformly. Add part D to part A, emulsify with a homomixer, cool, add part C and part B at about 50° C., and stir to homogenize.

Example 32 Moisturizing lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A (acryloyldimethyltaurate ammonium/VP) copolymer 0.30
Carboxymethyl cellulose Na 0.20
Purified water 20.00
Part B Tranexamic acid 2.00
Phytic acid 0.04
Etidronic acid 0.03
Purified water 18.00
Part C (eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
1,3-butylene glycol 1.00
Glycerin 2.00
Citric acid 0.01
Sodium citrate Appropriate amount Ubiquinone 0.03
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Fine Chemical) 0.03
Sorbeth-60 tetraoleate 0.12
PEG-60 hydrogenated castor oil 0.03
PEG-30 glyceryl isostearate 0.03
Methylparaben 0.20
Fragrance Trace Maltose 1.00
Caprylyl glucoside 1.00
Inulin 0.50
Ethanol 7.00
Triclosan 0.05
4Na glutamate diacetate 0.80
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and stirred to a viscous liquid. Part B was mixed and evenly dissolved. Part C was mixed and heated to about 70° C. to dissolve uniformly. After cooling, add part A and part B to part C at about 50° C. and stir to homogenize.

Example 33 Deodorant Lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Purified Water Total 100 (Styrene/DVB) Copolymer 0.20
Maltose 0.50
Lactose 0.50
Benzalkonium chloride 0.05
Na chloride 0.10
Carboxyvinyl polymer 0.02
Alkyl acrylic acid methacrylate copolymer 0.10
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
Glycerin 0.50
Hydrochloric acid 0.01
Na hydroxide Appropriate amount Tranexamic acid 2.00
Etidronic acid 0.05
Phytic acid 1.00
Part B Ethanol 50.00
Methylparaben 0.20
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Both parts A and B were dissolved at room temperature, and part B was gradually added to part A with stirring to homogenize the mixture.

Example 34 Moisture pack

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Polyvinyl alcohol 13.00
Acryloyldimethyltaurate ammonium/VP) copolymer 0.80
Stealoxy hydroxypropyl methylcellulose 2.00
Sodium alginate 0.50
1,3-butylene glycol 3.00
K Alginate 0.50
(styrene/vinylpyrrolidone) copolymer 1.50
Part B dimer dilinoleyl bis(behenyl/isostearyl/
Phytosteryl) (Plandool-G: Nippon Fine Chemical) 0.10
Phytosteryl/octyldodecyl lauroyl glutamate
(Plandool-LG2: Nippon Fine Chemical) 0.20
Tranexamic acid 2.00
Salicylic acid 0.04
Phytic acid 0.04
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical) 0.20
PCA glycereth-25 isostearate 1.50
Ethanol 8.00
PEG/PPG-5/30 copolymer 1.00
Oleth-10 Phosphate DEA 1.00
Glycyrrhizic acid 2K 0.05
Arginine 0.05
Tocopherol 0.10
Methylparaben 0.20
Sodium hyaluronate 0.05
Na chloride 0.30
Hydroxyethylethylenediamine triacetic acid 0.20
Ethylhexylglycerin 0.02
Maltose 0.50
Fucose 0.50
Mannose 0.50
Fumaric acid 0.05
Sodium fumarate Appropriate amount Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－ -
(Preparation method)
Part A is heated and swollen at 50°C. Gradually add Part B to Part A with stirring and mix uniformly.

Example 35 Lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Tranexamic acid 2.00
Phytic acid 0.10
Polyacrylic acid 0.02
Carboxymethylcellulose 0.05
Gum Arabic 0.03
Purified water 20.00
Part B Dipropylene glycol 2.00
1,3-butylene glycol 2.00
Arbutin 3.00
Ascorbyl glucoside 0.50
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical Co., Ltd.) 1.00
Pyrrolidone carboxylic acid 0.10
Serine 0.10
Glycine 0.10
Betaine 0.10
Royal jelly extract 0.10
Nicotinamide 0.10
Citric acid 0.10
Na citrate Appropriate amount Ethanol 8.00
Polyglyceryl-3 diisostearate 0.10
Glycolipid, hydrogenated lecithin, BG, purified water 1.00
(Phytopresome MEL: Nippon Fine Chemical)
Bisethoxydiglycol cyclohexanedicarboxylate 0.50
(Neosolue-Aqulio: Nippon Fine Chemical)
Phenoxyethanol 0.20
Photosensitive element No. 301 0.01
Methylparaben 0.10
EDTA-2Na 0.10
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and stirred to a viscous liquid. Part B was mixed and evenly dissolved. Part A was added to part B and dissolved uniformly by stirring.

Example 36 Serum

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A (acryloyldimethyltaurate ammonium/VP) copolymer 0.30
Sodium hyaluronate 0.40
Alkyl acrylic acid methacrylate copolymer 0.30
Purified water 20.00
Part B Tranexamic acid 2.00
Etidronic acid 0.07
Phytic acid 0.20
Purified water 18.00
Part C Glycyrrhizic Acid 2K 0.10
Dipropylene glycol 2.00
1,3-butylene glycol 5.00
Succinic acid 0.05
Na succinate Appropriate amount White jellyfish polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.20
Maltose 1.00
Arbutin 1.00
3-O-ethyl ascorbic acid (VC ethyl: Nippon Fine Chemical Co., Ltd.) 1.00
Glycolipid, hydrogenated lecithin, BG, purified water 1.00
(Phytopresome MEL: Nippon Fine Chemical)
Ethanol 5.00
Phenoxyethanol 0.20
Methylparaben 0.10
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and stirred to a viscous liquid. Part B was mixed and evenly dissolved. Part C was mixed and heated to about 70° C. to dissolve uniformly. After cooling, add part A and part B to part C at about 50° C. and stir to homogenize.

Example 37 Skin care cream

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.00
Squalane 3.00
Jojoba oil 3.00
Palm kernel oil 3.10
Glyceryl stearate 2.30
PEG-60 glyceryl isostearate 1.40
PG stearate (SE) 1.30
Polyglyceryl-10 triisostearate 0.50
Stearyl alcohol 3.00
Behenyl alcohol 2.00
Dimethicone 1.50
Phytosteryl/octyldodecyl lauroyl glutamate
(Plandool-LG2: Nippon Fine Chemical) 1.00
Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) (Plandool-H: Nippon Fine Chemical) 1.00
Bis-diglyceryl polyacyl adipate-2 0.50
(Plandool-DP: Nippon Fine Chemical)
Sunflower seed oil fatty acid phytosteryl 0.50
(Plandool-SUN: Nippon Fine Chemical)
Ethylparaben 0.10
Part B Stealoxy hydroxypropyl methylcellulose 0.20
Gellan gum 0.50
Alkyl acrylic acid methacrylate copolymer 0.30
Purified water 20.00
Part C Tranexamic acid 2.00
Phytic acid 0.05
Etidronic acid 0.08
Glutamic acid 0.10
Glycine 0.10
Proline 0.10
Betaine 0.10
Purified water 18.00
Part D Arbutin 3.00
Inulin 0.50
Methylparaben 0.15
Citric acid 0.01
Sodium citrate Appropriate amount Purified water Total amount of 100 －－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－ -
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and stirred to a viscous liquid. Part C was mixed and evenly dissolved. Part D was mixed and heated to about 70° C. to dissolve uniformly. Add part D to part A, emulsify with a homomixer, cool, add part C and part B at about 50° C., and stir to homogenize.

Example 38 Oil in lotion

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Hydrogenated lecithin (Phytocompo-SP: Nippon Fine Chemical) 1.00
Glycerin 10.00
1,3-butylene glycol 3.00
Part B dimer dilinoleyl bis(behenyl/isostearyl/
Phytosteryl) (Plandool-G: Nippon Fine Chemical) 0.10
Glyceryl tri-2-ethylhexanoate (IOTG: Nippon Fine Chemical) 0.30
Squalane 0.30
Cetanol 0.30
Diethylhexyl succinate 0.20
Dimethicone 0.20
Methylgluceth-10 3.00
Part C White fungus polysaccharide (Tremoist-SL: Nippon Fine Chemical) 3.00
(Acrylates/alkyl acrylate (C10-30)) crosspolymer
0.06
K hydroxide Appropriate amount Purified water 20.00
Part D Propylene glycol 5.00
Maltose 1.00
Phenoxyethanol 0.20
Methylparaben 0.10
Tranexamic acid 2.00
Phytic acid 0.04
Purified water Total 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was mixed and heated to about 70° C. to dissolve uniformly. Part B was mixed and heated to about 70° C. to dissolve uniformly. Part C was mixed and stirred to a viscous liquid. Add Part C to Part A, stir and add Part D. Cool and at about 50° C. add part B and stir to homogenize.

Example 39 Cleansing Gel

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A 1,2-pentanediol 1.00
Cetyl ethylhexanoate (Nippon Fine Chemicals) 10.00
Diisobutyl adipate (Nippon Fine Chemicals) 3.00
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 1.00
Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) (Plandool-H: Nippon Fine Chemical) 1.00
Dihydrocholeth-30 (Nippon Fine Chemicals) 2.00
Polyglyceryl-10 dilaurate 5.00
PEG-25 hydrogenated castor oil 20.00
Octyldodeceth-20 15.00
Glycerin 16.00
BG 5.00
Part B Tranexamic acid 0.50
Phytic acid 0.20
Citric acid 0.10
Maltose 0.50
Arbutin 0.20
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.20
Phenoxyethanol 0.50
Purified water Amount that makes a total of 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was dissolved by heating to about 80°C. Part B was warmed to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

Example 40 Body Shampoo

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Tranexamic acid 0.50
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 0.01
Cocoyl methyl taurine Na 10.00
Lauroyl Hydrolyzed Silk Na 6.00
Lauroyl methylalanine Na 10.00
Sodium cocoamphoacetate (30%) 4.00
Cocamidopropyl Betaine (30%) 10.00
Olefin (C14-16) sulfonate Na 5.00
Polyquaternium-10 1.30
Guar hydroxypropyltrimonium chloride 0.80
Sodium Acetyl Hyaluronate 0.02
Cocamide DEA 3.00
Phytic acid 0.20
Pentetic acid 0.10
Glutamic acid 0.20
Maltose 0.50
glucose 0.50
Betaine 0.20
Inulin 0.50
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.05
Glycerin 5.00
Methylparaben 0.20
Purified water Amount that makes a total of 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
All the ingredients were heated to about 80° C. and uniformly stirred and mixed.

Example 41 Sunscreen cosmetics

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Hydrogenated lecithin, Phytosterols (Phytocompo-PP: Nippon Fine Chemical) 1.00
BG 5.00
1,2-Pentanediol 5.00
Glycerin 9.00
Part B Octocrylene 4.00
Octyl salicylate 4.00
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-butyl methoxydibenzoylmethane 1.00
Diethylhexyl sebacate (Nippon Fine Chemicals) 3.00
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 2.00
Diisobutyl adipate (Nippon Fine Chemicals) 2.00
Diethylhexyl succinate (Nippon Fine Chemicals) 2.00
Behenyl alcohol 2.00
Cetearyl alcohol 2.00
Macadamia nut oil fatty acid phytosteryl (Nippon Seika) 1.00
Tocopherol 0.05
Part C Tranexamic acid 1.00
Phytic acid 0.20
Edetic acid 0.20
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 1.00
(Neosolue-Aqua: Nippon Fine Chemical)
Maltose 0.20
Methylparaben Appropriate amount Water Total amount to be 100 Part D Carboxyvinyl polymer (2%) 5.00
White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.20
Water-dispersed titanium oxide 5.00
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was evenly dispersed. Part B and part C were heated to about 70° C. and dissolved. After gradually adding part B to part A, part C was gradually added and emulsified. The mixture was cooled while stirring, and part D was added at 45°C and stirred.

Example 42 Skin care balm

Ingredient Amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Stearic acid 30.00
Arginine 0.70
Tranexamic acid 2.00
Phytic acid 0.20
(Eicosanedioic acid/tetradecanedioic acid) polyglyceryl-10 2.00
(Neosolue-Aqua: Nippon Fine Chemical)
Bis-diglyceryl polyacyl adipate-2 0.50
(Plandool-DP: Nippon Fine Chemical)
Maltose 0.20
Glycerin 3.00
BG 5.00
Sodium benzoate 0.30
Water Amount that sums to 100－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
All components were weighed, heated to 80° C., dissolved, cooled to 60° C. with stirring, and filled.

Claims (3)

A cosmetic or external skin preparation containing the following components (A) to (C) and having a pH of 3.5 to 6.5.
(A) tranexamic acid or a salt thereof (B) one or more selected from mannose, galactose, xylose, fucose, arabinose, lactose, maltose and cellobiose
(C) one or more selected from salicylic acid, glutamic acid, guanidine hydrochloride and carboxyvinyl polymer 2. The cosmetic or external preparation for skin according to claim 1, wherein the component (B) is maltose . 3. The cosmetic composition or external preparation for skin according to claim 1, wherein the inorganic base is contained in a base equivalent less than the acid equivalent of component (C).