JP4812116B2 - Dissolution system and dissolution method using the same - Google Patents

Description

  The present invention relates to a dissolution system including a dissolution apparatus for dissolving a powder drug for dialysis at a predetermined concentration to obtain a dialysis stock solution, and a dissolution method using the dissolution system.

  Dialysis fluids used for the treatment of patients with renal failure in hospitals are generally divided into bicarbonate and acetic acid. Of these, bicarbonate-based dialysate does not contain sodium bicarbonate (hereinafter referred to as “bicarbonate”). It is prepared by mixing water with two types of drugs, called A agent and sodium bicarbonate (hereinafter referred to as B agent). In recent years, from the viewpoint of improving transportability, attempts have been made to dissolve these A agent and B agent powdered powder (hereinafter referred to as dialysis powder drug) before dialysis. With regard to B agent), the concentration tends to decrease over time, and it was difficult to prepare the next day after dialysis.

For this reason, dissolution work is required for each dialysis, and various types of dissolution apparatuses for dissolution have been proposed. For example, Patent Document 1 includes a dissolution tank (dilution tank) that dissolves a powder drug for dialysis and a storage tank (storage tank) that temporarily stores a dialysis stock solution generated in the dissolution tank. Has been disclosed. The dissolution apparatus sequentially feeds the dialysis stock solution accommodated in 1 to an artificial dialysate supply apparatus.
JP-A-57-159529

However, the melting system provided with the conventional melting apparatus has the following problems.
Because the dialysis stock solution that is dissolved and generated by a dissolution apparatus in a hospital or other medical institution is extremely large in volume and the number of patients is not constant, the amount used varies from day to day, and the reason is to avoid changes in the composition of the stock solution over time. , Generated in multiple batches. That is, when the stock solution for dialysis in the storage tank is reduced, an additional stock solution for dialysis is generated in the dissolution tank, and the situation where the stock solution for dialysis is insufficient is avoided.

  However, in a medical institution such as a normal hospital, a dialysis chamber in which a plurality of dialysis machines are installed and a lysis device that generates a dialysis stock solution (the dialysis stock solution (agent A and agent B) generated in the lysis device) To determine whether or not the dialysis stock solution in the storage tank is low, it is separate from the machine room where the dialysate supply device that mixes to produce the dialysate of a predetermined concentration is installed. There was a problem that medical personnel such as dialysis engineers had to frequently monitor both the dialysis room and the machine room.

  In addition, the medical staff visually determines the amount of the dialysis stock solution in the storage tank and determines whether or not additional generation is required. The dialysis treatment time for each patient is about 3 to 5 hours. Therefore, it is extremely difficult to predict a dialysis stock solution that will be used in the future. Therefore, in order to avoid interruption of dialysis treatment due to lack of dialysis stock solution, even if it seems that additional generation is not necessary just before the end of dialysis treatment, additional generation must be made just in case. There was also a problem that the stock solution for dialysis was highly likely to remain.

  By the way, the present applicant calculates the reduction rate of the dialysis stock solution in the storage tank, estimates the time until the dialysis stock solution in the storage tank becomes empty based on the reduction rate, and lacks the dialysis stock solution to be supplied. By determining whether or not to do so, it has been considered to avoid leaving a large amount of stock solution for dialysis. However, when it is applied to a so-called dissolution system for a large number of people, a reduction rate of the dialysis stock solution in the storage tank may not be obtained smoothly because a dialysate supply device is interposed.

  The dialysis fluid supply device is interposed between the lysis device and the dialysis device, and mixes the dialysis stock solution (agent A and agent B) produced by the lysis device to produce a dialysis fluid of a predetermined concentration. The dialysis fluid is supplied to the dialysis machine. Normally, when the dialysate capacity reaches the lower limit, the dialysis stock solution is supplied from the dissolution apparatus until the upper limit capacity is reached, and the upper limit capacity is reached. At that time, a dialysis fluid storage tank is provided in which the supply of the dialysis stock solution is stopped.

  Therefore, in the storage tank of the dissolution apparatus, a decrease period (a period during which the dialysis stock solution is supplied from the storage tank to the dialysate storage tank) during which the remaining amount of the dialysis stock solution decreases with time, and the remaining amount over time. There is a stagnation period (a period in which the supply of the dialysis stock solution from the storage tank to the dialysate storage tank is stopped) that has been stagnant without decreasing, and the remaining amount changes in a substantially step shape over time. There is a possibility that the reduction rate of the dialysis stock solution cannot be obtained with high accuracy, and the reliability of the determination as to whether or not the dialysis stock solution to be supplied is insufficient cannot be maintained.

  The present invention has been made in view of such circumstances, and can automatically and accurately determine whether or not to additionally produce a dialysis stock solution, and the situation where the dialysis stock solution is insufficient. The problem that a large amount of dialysis stock solution remains at the end of dialysis treatment can be avoided while accurately determining the rate of decrease of the dialysis stock solution in the storage tank, and the dialysis stock solution to be supplied is It is an object of the present invention to provide a melting system and a melting method using the melting system, which can further improve the reliability of determination of whether or not it is insufficient.

  The invention according to claim 1 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A dissolution apparatus having a storage tank for temporarily storing a stock solution, and a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialysis devices for performing dialysis treatment on a patient; While supplying a dialysis fluid having a predetermined concentration prepared by mixing a dialysis stock solution and a predetermined amount of water communicated with the stock solution supply line and fed from the stock solution supply line, When the dialysis fluid capacity reaches the lower limit, the dialysis stock solution is supplied from the stock solution supply line until the upper limit capacity is reached, and the supply of the dialysis stock solution is stopped when the upper limit capacity is reached. A dialysate supply device having a liquid storage tank The dissolution apparatus comprises: a stock solution amount detection means capable of continuously and in real time detecting a remaining amount of the dialysis stock solution in the storage tank; and a remaining amount detected by the stock solution amount detection means. A calculating means for calculating a rate of consumption of dialysate by the dialyzer based on the change point of the time course, calculating a reduction rate of the dialysis stock solution in the storage tank from the consumption rate, and a dialysis calculated by the calculating means And determining means for estimating whether or not the dialysis stock solution to be supplied is insufficient, while estimating the time until the dialysis stock solution in the storage tank becomes empty based on the decrease rate of the stock solution. And

  According to a second aspect of the present invention, in the dissolution system according to the first aspect, the calculating means is configured to dialyze the dialysate storage tank based on a change point of the temporal transition of the remaining amount detected by the stock solution amount detecting means. It is characterized in that the time until the amount of liquid accommodated reaches the lower limit from the upper limit is estimated, and the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.

  According to a third aspect of the present invention, in the dissolution system according to the first aspect, the computing means is configured to dialyze the dialysate storage tank based on a change point of the temporal change of the remaining amount detected by the stock solution amount detecting means. It is characterized in that the time until the amount of liquid accommodated reaches the upper limit from the lower limit is estimated, and the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.

  According to a fourth aspect of the present invention, in the dissolution system according to any one of the first to third aspects, the change point of the temporal transition is a decrease period in which the remaining amount of the dialysis stock solution decreases with time. And a stagnation period in which the remaining amount does not decrease with time and stagnates.

  According to a fifth aspect of the present invention, in the dissolution system according to any one of the first to third aspects, the change point of the temporal transition is that the remaining amount of the dialysis stock solution decreases at a predetermined rate with time. It is a boundary point between the first decreasing period and the second decreasing period in which the remaining amount decreases with time at a rate different from the first decreasing period.

  The invention described in claim 6 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a dialysis stock solution, and the dialysis drug obtained in the dissolution tank A dissolution apparatus having a storage tank for temporarily storing a stock solution, and a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialysis devices for performing dialysis treatment on a patient; While supplying a dialysis fluid having a predetermined concentration prepared by mixing a dialysis stock solution and a predetermined amount of water communicated with the stock solution supply line and fed from the stock solution supply line, When the dialysis fluid capacity reaches the lower limit, the dialysis stock solution is supplied from the stock solution supply line until the upper limit capacity is reached, and the supply of the dialysis stock solution is stopped when the upper limit capacity is reached. A dialysate supply device having a liquid storage tank A dissolution method using the dissolution system, wherein the remaining amount of the dialysis stock solution in the storage tank can be detected continuously and in real time, and the remaining amount detected in the stock solution detection step over time A calculation step of calculating a rate of consumption of dialysate by the dialyzer based on the change point of the dialysis device and calculating a rate of decrease of the dialysate stock solution in the storage tank from the consumption rate, and a dialysate solution calculated in the calculation step And a determination step of determining whether or not the dialysis stock solution to be supplied is insufficient, while estimating the time until the dialysis stock solution in the storage tank becomes empty based on the decrease rate of .

  The invention according to claim 7 is the dissolution method by the dissolution system according to claim 6, wherein the calculation step is based on a change point of the temporal transition of the remaining amount detected in the stock solution amount detection step. The time until the amount of dialysate contained in the storage tank reaches the lower limit from the upper limit is estimated, and the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.

  The invention according to claim 8 is the dissolution method by the dissolution system according to claim 6, wherein the calculation step is based on a change point of the temporal transition of the remaining amount detected in the stock solution amount detection step. The time until the amount of dialysate contained in the storage tank reaches the upper limit from the lower limit is estimated, and the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.

  A ninth aspect of the present invention is the dissolution method using the dissolution system according to any one of the sixth to eighth aspects, wherein the change point of the time-dependent transition is that the remaining amount of the dialysis stock solution decreases with time. And a stagnation period in which the remaining amount does not decrease with time and stagnates.

  A tenth aspect of the present invention is the dissolution method using the dissolution system according to any one of the sixth to eighth aspects, wherein the change point of the time-dependent transition is that the remaining amount of the dialysis stock solution is predetermined over time. It is a boundary point between a first decrease period that decreases at a rate and a second decrease period in which the remaining amount decreases with time at a rate different from the first decrease period.

  According to the invention of claim 1 or claim 6, based on the decrease rate of the dialysis stock solution, the time until the dialysis stock solution in the storage tank becomes empty is calculated and estimated, and the dialysis stock solution to be supplied is insufficient. Therefore, it is possible to automatically and accurately determine whether or not an additional dialysis solution should be generated, and at the end of dialysis treatment while avoiding a situation where the dialysis solution is insufficient. Therefore, it is possible to avoid the problem that a large amount of dialysis stock solution is left over.

  Further, according to claims 1 and 6 (claims 2 and 7, or claims 3 and 8 as well), the dialysis apparatus uses a change point of the time course of the remaining amount of the dialysis stock solution in the storage tank. Calculates the rate of dialysate consumption and calculates the rate of reduction of the dialysis stock solution in the storage tank from the rate of dialysate consumption. The reliability of the determination as to whether or not the stock solution is insufficient can be further improved.

  According to the invention of claim 4 or claim 9, the change point of the time course is the decrease period in which the remaining amount of the dialysis stock solution decreases with time, and the stagnation in which the remaining amount does not decrease with time Based on the change point, the rate of consumption of dialysate by the dialyzer is calculated, and the rate of decrease of the dialysis solution in the storage tank is calculated from the rate of dialysate consumption. The point can be easily grasped, and the consumption rate of the dialysate by the dialyzer and the reduction rate of the stock solution for dialysis in the storage tank can be determined more accurately.

  According to the fifth or tenth aspect of the present invention, the change point of the temporal transition is that the first decrease period in which the remaining amount of the dialysis stock solution decreases at a predetermined rate with time, and a ratio different from the first decrease period. Because this is the boundary point with the second decrease period in which the remaining amount decreases with time, the dialysis stock solution is supplied from the dissolution device without going through the dialysis fluid supply device, and a dialysate with a predetermined concentration is prepared from the dialysis stock solution. However, the present invention is also applicable to a dissolution system equipped with a personal dialysis device that can be supplied to a patient who is subjected to dialysis treatment.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The dissolution system according to the first embodiment is for obtaining a dialysis stock solution by dissolving a powder drug for dialysis at a predetermined concentration. As shown in FIG. 1, the dissolution apparatus 1 installed in a machine room and dialysis are provided. The liquid supply device 2 is mainly composed of a plurality of dialysis devices 4 (dialysis monitoring devices) and a central monitoring device 3 installed in a dialysis chamber separated from the machine room.

  The stock solution for dialysis (concentrated solutions of agent A and agent B) generated by the dissolving device 1 reaches the dialysate supply device 2 via the stock solution supply line L1 (L1a and L1b in FIG. 3), and has a predetermined concentration there. The dialysate is prepared, and the dialysate is supplied to each dialyzer 4 (dialysis monitoring device) via the dialysate supply lines L2 to L4. In addition, each dialysis apparatus 4 and the central monitoring apparatus 3 are electrically connected by wiring D1-D3, respectively.

  As shown in FIG. 2, the dissolving apparatus 1 includes a quantitative powder feeder 5, a dissolving tank 6, a storage tank 7, a level sensor 8 (stock solution amount detecting means), a calculating means 10, a determining means 11, and an input. It is mainly composed of the means 12. Although not shown, a dissolution apparatus having the same configuration as that shown in the figure is separately provided, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to produce each dialysis stock solution. It has come to be able to do.

  The fixed-quantity powder feeder 5 is for charging a predetermined amount of powder drug for dialysis (A agent or B agent) into the dissolution tank 6, and its driving source is electrically connected to the determination means 11. Based on a control signal from the determination means 11, a predetermined amount of the powder drug for dialysis can be put into the dissolution tank 6. The dissolution tank 6 is connected to the water supply source A via the water supply line L5, and the dissolution tank 6 is dissolved in the dissolution tank 6 by opening the electromagnetic valve Vw disposed in the water supply line L5. Water is supplied.

  The dissolution tank 6 is charged with a predetermined amount of the powder drug for dialysis and water from the above-described quantitative powder feeder 5 and the water supply source A, and dissolves and agitates the powder drug for dialysis to prepare a dialysis stock solution (for each drug). The float switch 9 is disposed at a predetermined position in the internal storage space. That is, when water for dissolution is supplied into the dissolution tank 6 and the supply of the water is stopped when the water level reaches the float switch 9, a certain amount of water can be accommodated in the dissolution tank 6. It is like that. The supplied water and the dialysis powder drug are agitated by a stirring means (not shown) to obtain a dialysis stock solution having a substantially uniform concentration.

  A transfer line L6 is extended from the lower bottom of the dissolution tank 6, a transfer pump P1 is disposed in the middle thereof, and a tip of the transfer line L6 is connected to the storage tank 7. Thereby, if the transfer pump P <b> 1 is driven, the stock solution for dialysis obtained in the dissolution tank 6 reaches the inside of the storage tank 7.

  The storage tank 7 is for temporarily storing the dialysis stock solution obtained in the dissolution tank 6, from which only the necessary amount of the dialysis stock solution is supplied to the dialysate supply device 2 (a plurality of dialysis devices 4 side) described later. It is configured to be supplied sequentially. From the bottom of the storage tank 7, a stock solution supply line L1 (strictly, stock solution supply lines L1a and L1b extending from two storage tanks) is extended, and the tip thereof is connected to the dialysate supply device 2. . That is, the dialysis stock solution in the storage tank 7 is sent to the dialysis fluid supply device 2 to be a dialysis fluid having a predetermined concentration and then supplied to each dialysis device 4.

  On the other hand, a level sensor 8 (stock volume detection means) composed of a pressure gauge or the like is disposed on the lower surface of the storage tank 7, and the level sensor 8 continuously and continuously determines the remaining amount of the dialysis stock solution in the storage tank 7. It is configured so that it can be detected in real time. The pressure gauge as the level sensor 8 can detect the liquid pressure of the dialysis stock solution in the storage tank 7 over time in terms of the pressure applied to the bottom surface of the storage tank 7, and based on the detected liquid pressure. The amount of dialysis stock solution (the amount of residual solution) can be detected continuously and in real time.

  By detecting the liquid level in the storage tank 7 (or the remaining amount of the dialysis stock solution itself) continuously and in real time, the rate of decrease in the liquid level (decrease rate of the dialysis stock solution) is detected. If possible, other detection means (such as an ultrasonic liquid level sensor or a magnetostrictive linear displacement sensor) may be used instead of the pressure gauge.

  The level sensor 8 as such stock solution amount detection means is electrically connected to the calculation means 10. This computing means 10 computes the rate of decrease of the dialysis stock solution in the storage tank 7 based on the remaining amount detected continuously and in real time by the level sensor 8 and the later-described dialysate consumption rate. That is, by detecting the liquid level of the dialysis stock solution in the storage tank 7 continuously and in real time, it is possible to determine the rate of decrease in the level (decrease rate of the dialysis stock solution), and for dialysis based on the rate of decrease. The consumption rate of the stock solution can be recognized. A more specific calculation method will be described later.

  As shown in FIG. 3, the dialysate supply device 2 is connected to a water supply line Lw in which water metering means 13 for measuring the amount of water flowing and the metering pump Pa (piston pump) flows. In addition, a stock solution line L1a for flowing the stock solution for dialysis obtained by dissolving the A agent and a metering pump Pb (piston pump) and a stock solution line for flowing the stock solution for dialysis obtained by dissolving the B agent are connected. L1b, the dialysate storage tank 14, and the liquid feeding pump P2 are mainly comprised. After the water in the water supply line Lw passes through the water metering means 13, the dialysis fluid from the stock solution lines L1a and L1b is mixed to prepare a dialysis fluid having a predetermined concentration, and then the dialysis fluid is put into the dialysis fluid storage tank 14. Will be reached. In the figure, a concentration measuring unit for measuring the concentration of the dialysate prepared and a heating unit for heating the dialysate are omitted.

  The dialysate storage tank 14 communicates with the stock solution supply lines L1a and L1b, and mixes the stock solution for dialysis sent from the stock solution supply lines L1a and L1b with a predetermined amount of water sent from the water supply line Lw. This is for supplying the dialysate 4 through the dialysate supply lines L2 to L4 while accommodating the prepared dialysate having a predetermined concentration. The dialysate storage tank 14 is provided with a float switch SH and a float switch SL, and it is possible to detect that the liquid level of the dialysate in the dialysate storage tank 14 has reached the upper limit or the lower limit. Has been.

  When the dialysate supply device 2 determines that the amount of dialysate stored in the dialysate storage tank 14 has reached the lower limit by detecting the liquid level with the float switch SL, the metering pumps Pa and Pb are turned on. Driving to supply the dialysis stock solution from the stock solution supply lines (L1a, L1b), water from the water metering means 13, preparation of the dialysate, and storage in the dialysate storage tank 14. . When the liquid level is detected by the float switch SH and it is determined that the amount of dialysate stored in the dialysate storage tank 14 has reached the upper limit, the metering pumps Pa and Pb are stopped, and the dialysis stock solution is removed. Stop supplying.

  That is, when the amount of dialysate stored in the dialysate storage tank 14 is between the upper limit and the lower limit, the supply of the dialysis stock solution and the water supply from the stock solution supply lines (L1a, L1b) is stopped, and When the lower limit is reached, the supply of the dialysis stock solution and the water supply from the stock solution supply lines (L1a, L1b) are started. In this way, the supply of the dialysis stock solution from the stock solution supply lines (L1a, L1b) is performed intermittently.

  However, the dialysate passes through the dialysate storage tank 14 so that the gas generated from the dialysate can be separated and removed. The dialysate from which the gas is separated and removed is driven by the liquid feed pump P2. Is supplied to each dialysis machine 4 via the dialysate supply lines L2 to L4. Thus, dialysis treatment is performed on the patient with the dialysate supplied to each dialysis machine 4. In addition, data related to dialysis treatment (treatment conditions, treatment time, and the like) is transmitted and received between each dialysis device 4 and the central monitoring device 3, so that optimal and safe treatment is performed.

  Here, since the supply of the dialysis stock solution from the stock solution supply lines (L1a, L1b) is intermittently performed, the remaining amount of the dialysis stock solution in the storage tank 7 in the dissolving device 6 is substantially reduced with time as shown in FIG. It will change in steps (that is, the supply is intermittent). Specifically, in the storage tank 7 of the dissolution apparatus 1, a decrease period T2 during which the remaining amount of the dialysis stock solution decreases over time (a period during which the dialysis stock solution is supplied from the storage tank 7 to the dialysate storage tank 14), There is a stagnation period T1 (period in which the supply of the dialysis stock solution from the storage tank 7 to the dialysate storage tank 14 is stopped) in which the remaining amount has not been decreased over time, and the remaining amount is substantially staircase as viewed over time. It changes in shape.

  The computing means 10 according to the present embodiment consumes the dialysate by the dialyzer 4 based on the change points (B1 to B6...) Of the remaining amount detected with the level sensor 8 (stock solution amount detecting means) over time. The rate can be obtained, and the rate of reduction of the dialysis stock solution in the storage tank 7 can be calculated from the consumption rate. Specifically, the calculation means 10 determines the change point of the slope (that is, the change point of the change of the remaining amount over time (eg, the change point of the remaining amount over time) from the change over time of the remaining amount as shown in FIG. By grasping B1 to B6...)), The stagnation period T1 and the decrease period T2 can be discriminated.

  As described above, the stagnation period T1 determined in this way is that the dialysate is supplied from the dialysate storage tank 14 to the dialyzer 4, although the dialysate stock solution is not supplied from the storage tank 7 to the dialysate storage tank 14. Therefore, the amount of dialysate in the dialysate storage tank 14 is the time from the upper limit to the lower limit, and the amount of dialysate from the upper limit to the lower limit is uniquely determined by the size of the dialysate storage tank 14. Since it is determined and known (this is referred to as “accommodated amount C” for convenience), the consumption rate of the dialysate is determined by an arithmetic expression of C / T1 (that is, known accommodated amount C ÷ stagnation period T1).

  Further, the calculating means 10 calculates the rate of reduction of the dialysis stock solution in the storage tank 7 (the rate of decrease of the liquid level) from the consumption rate of the dialysate obtained as described above, and determines the obtained rate of reduction as data. Transmit to means 11. The determination means 11 estimates the time until the dialysis stock solution in the storage tank 7 becomes empty (the remaining liquid is substantially 0) based on the decrease rate of the dialysis stock solution calculated by the calculation means 10 and the dialysis to be supplied. This is to determine whether or not the stock solution is insufficient.

  An input unit 12 is electrically connected to the determination unit 11, and a time at which all the dialysis treatments by the dialysis apparatus 4 are completed by the input unit 12 (scheduled time at which the dialysis treatment of all patients on the day is completed). It is configured to allow input. The input means 12 is also electrically connected to the computing means 10 and inputs a known amount of dialysate (accommodation amount C) from the upper limit to the lower limit of the dialysate storage amount in the dialysate storage tank 14. It is also getting.

  Therefore, the determination means 11 compares the estimated time (insufficient time) when the stock solution for dialysis in the storage tank 7 is emptied with the time (dialysis end time) when all the dialysis treatments by the dialysis device 4 are completed. If it is determined whether or not the time at which the time has elapsed has passed the dialysis end time, it can be determined whether or not the dialysis stock solution is insufficient. Specifically, if the time after the elapse of the shortage time does not exceed the dialysis end time, the additional dialysis stock solution is unnecessary. To be judged.

  The input unit 12 may be configured to input other data such as the number of patients on the day, and the determination unit 11 determines whether or not the dialysis stock solution is insufficient with reference to the input data. It may be. Moreover, if the arithmetic means 10, the determination means 11, and the input means 12 are provided in the central monitoring apparatus 3, the input by the input means 12 etc., even if a medical worker such as a dialysis engineer usually in the dialysis room does not go to the machine room. Is possible.

  The determination means 11, the quantitative powder feeder 5 and the electromagnetic valve Vw are electrically connected. When the determination means 11 determines that the dialysis stock solution to be supplied is insufficient, a predetermined control signal is sent to the quantitative powder. It is comprised so that it may transmit to the drive source of the feeder 5 and the electromagnetic valve Vw. As a result, on the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient, a predetermined amount of the dialysis powder drug and water are automatically added to the dissolution tank 6 to supply additional dialysis stock solution. Obtainable.

  Here, in order to obtain an additional undiluted dialysis solution in the dissolution tank 6, it takes a predetermined time for the introduction of water and the powder drug for dialysis, and for the dissolution and stirring operations. Therefore, in this embodiment, the time required to obtain an additional dialysis solution in the dissolution tank 6 is measured in advance, and a predetermined amount of dialysis is stored in the dissolution tank 6 at a timing that takes the required time into account. It will be controlled to automatically add the powder medicine and water.

Next, the operation of the melting apparatus according to this embodiment will be described.
First, in the input means 12, the known amount of dialysate (accommodation amount C) from the upper limit to the lower limit of the amount of dialysate stored in the dialysate storage tank 14 and the time when dialysis treatment by the dialyzer 4 is all completed. Enter (dialysis end time). Then, the electromagnetic valve Vw is opened, water is introduced into the dissolution tank 6 until the float switch 9 detects the liquid level, and a predetermined amount of dialysis powder drug is introduced from the quantitative powder feeder 5, and the dialysis is performed. Dissolve and stir the powder powder for dialysis to obtain a stock solution for dialysis. Usually, in the dissolution apparatus as in this embodiment, the volume that can be dissolved is only an amount corresponding to the amount of water determined by the float switch 9, and the amount of dialysis stock solution (for example, produced from one bag of dialysis powder medicine) In the case of the B stock solution, 11.34 L, and in the case of the A stock solution, 9 L) is set.

  Thereafter, the transfer pump P <b> 1 is driven to transfer the entire amount of the dialysis stock solution in the dissolution tank 6 to the storage tank 7. Then, when dialysis treatment is started, the dialysis solution supply device 2 is supplied to the dialysis solution supply device 2 via the stock solution supply line L1, where a dialysis solution having a predetermined concentration is prepared, and the prepared dialysis solution is supplied. While being accommodated in the dialysate storage tank 14, the dialysis treatment is performed on the patient by being supplied to each dialysis apparatus 4. In the process of supplying the dialysis stock solution by the dissolution apparatus 1 as described above, the remaining amount (liquid level) of the dialysis stock solution in the storage tank 7 is detected continuously and in real time by the level sensor 8 (stock solution detection step), The detected value is transmitted to the calculation means 10.

  Based on the remaining amount of the dialysis stock solution detected by the level sensor 8, the calculation means 10 determines the change points (B1 to B6...) Of the temporal transition of the remaining amount detected in the stock solution amount detection step. Then, by grasping the stagnation period T1, the consumption rate of the dialysate is obtained by the calculation formula C / T1 (the capacity C is input as described above), and from the consumption rate, the inside of the storage tank 7 is obtained. The reduction rate of the dialysis stock solution is calculated (calculation step).

  The reduction rate obtained in the calculation step is transmitted to the determination means 11, and the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated from the reduction rate, and the estimated time and input are input. The dialysis end time input by means 12 is compared to determine whether or not the dialysis stock solution to be supplied is insufficient (determination step). In the present embodiment, for example, the time required for obtaining an additional dialysis solution is measured in advance, and the dissolution operation is performed until the time required for the determination means 11 to determine whether the additional necessity is required. It is configured to wait and then perform the melting operation.

  When it is determined in the determination step that the dialysis stock solution is insufficient, a control signal is transmitted to the drive source of the quantitative powder feeder 5 and the electromagnetic valve Vw, and a predetermined amount of dialysis powder drug and water are automatically supplied to the dissolution tank 6. To obtain additional stock solution for dialysis. However, as described above, the control signal waits until just before the time necessary to obtain an additional dialysis solution, and is then transmitted.

  As described above, the dissolution system applied in the present embodiment is for a large number of people having the dialysate supply device 2 (feeding dialysate prepared respectively from a single dialysate supply device to a plurality of dialysers) Therefore, the dialysate adjustment is usually performed intermittently, and the remaining amount of the dialysis stock solution in the storage tank 7 also changes intermittently. Even in such a case, the dialysis stock solution that changes intermittently The consumption rate of the dialysate can be obtained from the remaining amount, and the reduction rate of the stock solution for dialysate can be obtained accurately.

  In addition, as the dialysis treatment approaches, the number of patients on whom dialysis treatment is performed decreases sequentially, so that the rate of decrease in the dialysis stock solution also decreases. Therefore, it is preferable that the determination unit 11 determines whether or not the addition is necessary at a late stage (final stage) in which the dialysis treatment is performed. That is, as described above, the dialysis stock solution obtained by one dissolution is 9 L in the case of the A stock solution. Therefore, assuming that the A stock solution actually used per day is 200 L, 198 L of dialysis stock solution is used. The determination means 11 does not perform the determination until 22 dissolution operations (until the predetermined time elapses) when the dialysis is produced, and when the dialysis end time is about to be determined, the necessity of addition is determined based on the time. Also good. Although it is difficult to accurately grasp the amount of dialysis stock solution (200 L) used in the practice, for example, the dissolution operation is continued until roughly 15 bags (9 L × 15 bags = 135 L) stock solution is prepared. Thereafter, the dissolution may be continued while making an additional necessity determination based on the dialysis end time.

  Furthermore, when the dialysis stock solution remains in the dissolution tank 6, it is not necessary to further generate an additional dialysis stock solution. It is preferable that the dialysis stock solution does not remain.

  According to the present embodiment, the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated based on the decrease rate of the dialysis stock solution, and whether or not the dialysis stock solution to be supplied is insufficient. Therefore, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated, and to avoid a situation where the dialysis stock solution is insufficient, at the end of dialysis treatment, The problem that the stock solution remains can be avoided.

  Further, the dialysis fluid consumption rate by the dialyzer 4 is calculated based on the change points (B1 to B6...) Of the remaining amount of the dialysis undiluted solution in the storage tank 7 with time, and the storage tank is calculated from the dialysis fluid consumption rate. Since the reduction rate of the dialysis stock solution in 7 is calculated, the reduction rate of the dialysis stock solution in the storage tank 7 is accurately obtained, and the reliability of the determination as to whether or not the dialysis stock solution to be supplied is insufficient is further improved. Can be made.

  In addition, on the condition that it is determined that the dialysis stock solution to be supplied by the determination means 11 or the determination process is insufficient, a predetermined amount of powdered drug and water for dialysis are automatically added to the dissolution tank 6 for additional dialysis. Since the stock solution is obtained, the burden on medical personnel such as dialysis engineers can be reduced, and workability can be further improved. Furthermore, the determination means 11 or the determination step compares the estimated time when the dialysis stock solution in the storage tank 7 is emptied with the time when all the dialysis treatments by the dialysis device 4 are completed, and whether or not the dialysis stock solution is insufficient. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy.

  Furthermore, the changing point of the transition over time is a boundary point (B1 to B1) between a decrease period T2 in which the remaining amount of the dialysis stock solution decreases with time and a stagnation period T1 in which the remaining amount does not decrease with time. B6...), For example, the change point can be easily and accurately grasped as compared with the case where the change point is a boundary point of a period that decreases with time. Therefore, the rate of consumption of the dialysate by the dialyzer is calculated based on the accurately recognized change point, and the rate of decrease in the stock solution for dialysis in the storage tank 7 is calculated from the rate of consumption of the dialysate. The consumption rate of the dialysate according to 4 and the reduction rate of the stock solution for dialysis in the storage tank can be determined more accurately.

  In particular, in this embodiment, since the capacity of the dissolution tank 6 is relatively small as described above (11.34 L for the B stock solution and 9 L for the A stock solution), the time required for one dissolution is short. It has become. For this reason, it is possible to delay the timing taking into account the time required to obtain an additional dialysis stock solution, to further improve the determination accuracy, and because the amount of dissolution at one time is small, the dialysis stock solution is wasted. Can be further reduced. In addition, according to this embodiment, even if it does not calculate | require correctly the usage-amount of the undiluted | stock solution for dialysis, it is made to operate | move so that it may melt | dissolve less than the anticipated usage-amount, and when a shortage arises, it can carry out additional dissolution automatically.

Next, a second embodiment according to the present invention will be described.
As in the first embodiment, the dissolution system according to the present embodiment includes a plurality of dialysis devices installed in a dialysis chamber separated from the dissolution device 1 and the dialysate supply device 2 installed in the machine chamber and the machine chamber. The apparatus 4 (dialysis monitoring apparatus) and the central monitoring apparatus 3 are mainly configured (see FIG. 1), and the dissolution apparatus 1 includes a dissolution tank 6, a storage tank 7, as shown in FIG. It mainly comprises a level sensor 8 (stock solution amount detection means), a calculation means 10, a determination means 11, an input means 12, and a notification means 16.

  The dissolution tank 6 is provided with a float type sensor 15 composed of a float shaft and a float in a part of the internal storage space so that the level of the supplied water can be detected by opening the electromagnetic valve Vw. It has become. Further, the dissolution tank 6 according to the present embodiment does not have means for automatically feeding the powder drug for dialysis like the quantitative powder feeder of the first embodiment, and is accommodated in a bottle or a bag. The powder drug for dialysis is manually added.

  The notifying unit 16 notifies that the additional dialysis solution is necessary in the dissolution tank 6 on the condition that the determination unit 11 determines that the dialysis stock solution to be supplied is insufficient. The notification means 16 may display a message indicating that an additional dialysis solution is necessary, for example, on a display means such as a screen, or may be notified by lighting or blinking with an LED or the like. Further, a speaker or the like may be provided separately and a warning sound may be emitted from the speaker. The notification means 16 may be installed either in the machine room or in the dialysis room. However, if it is installed in the dialysis room, the medical staff such as a dialysis engineer who is usually in the dialysis room can be surely alerted. it can.

Next, the operation of the melting apparatus according to this embodiment will be described.
First, in the input means 12, the known amount of dialysate (accommodation amount C) from the upper limit to the lower limit of the amount of dialysate stored in the dialysate storage tank 14 and the time when dialysis treatment by the dialyzer 4 is all completed. Enter (dialysis end time). Then, the electromagnetic valve Vw is opened manually, and water is poured into the dissolution tank 6 until the float switch 15 detects a desired liquid level, and a predetermined amount of powder drug for dialysis is manually poured. The dialysis powder drug is dissolved and stirred to obtain a dialysis stock solution.

  Usually, in the dissolution apparatus as in the present embodiment, the capacity of the dissolution tank 6 is relatively large (usually 100 to 200 L) in order to avoid that a medical worker such as a dialysis engineer frequently has to go to the machine room. On the other hand, the storage tank 7 is set to be relatively small (usually about 50 L) in order to avoid an increase in the size of the entire apparatus.

  Thereafter, the transfer pump P <b> 1 is driven to transfer the entire amount of the dialysis stock solution in the dissolution tank 6 to the storage tank 7. Then, when dialysis treatment is started, the dialysis solution supply device 2 is supplied to the dialysis solution supply device 2 via the stock solution supply line L1, where a dialysis solution having a predetermined concentration is prepared, and the prepared dialysis solution is supplied. The dialysis treatment is performed on the patient by being supplied to each dialysis apparatus 4.

  In the process of supplying the dialysis stock solution by the dissolution apparatus 1 as described above, as in the first embodiment, the stock solution amount detection step by the level sensor 8, the computation step by the computation means 10, and the determination step by the judgment means 11 are performed. . When it is determined that the dialysis stock solution is insufficient in the determination step, a predetermined notification is made by the notification means 16, and according to this, a medical worker such as a dialysis engineer manually opens the electromagnetic valve Vw to obtain a desired amount. While supplying water, a predetermined amount of powdered drug for dialysis is charged into the dissolution tank 6 manually to obtain an additional dialysis solution.

  Also in the present embodiment, as in the first embodiment, the time until the dialysis stock solution in the storage tank 7 becomes empty is calculated and estimated based on the decrease rate of the dialysis stock solution, and the dialysis stock solution to be supplied Therefore, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated and to avoid dialysis stock shortage. It is possible to avoid the problem that a large amount of dialysis stock solution remains at the end of the process.

  Further, the dialysis fluid consumption rate by the dialyzer 4 is calculated based on the change points (B1 to B6...) Of the remaining amount of the dialysis stock solution in the storage tank 7 with time, and the storage tank is calculated from the dialysis fluid consumption rate. Since the reduction rate of the dialysis stock solution in 7 is calculated, the reduction rate of the dialysis stock solution in the storage tank 7 is accurately obtained, and the reliability of the determination as to whether or not the dialysis stock solution to be supplied is insufficient is further improved. Can be made. That is, the consumption rate of the dialysate can be determined from the remaining amount of the dialysate stock solution that changes intermittently, and the reduction rate of the dialysate stock solution can be accurately determined.

Next, a third embodiment according to the present invention will be described.
As in the previous embodiment, the dissolution system according to the present embodiment includes a dissolution apparatus 1 and a dialysate supply apparatus 2 installed in the machine room, and a plurality of dialysis apparatuses installed in a dialysis chamber isolated from the machine room. 4 (dialysis monitoring device) and the central monitoring device 3 (see FIG. 1). As shown in FIG. 6, the dissolving device 1 includes a dissolving tank 17, a storage tank 18, and a level. It is mainly composed of a sensor 19 (stock solution amount detection means), a calculation means 10, a determination means 11, and an input means 12.

  In addition, the same code | symbol shall be attached | subjected to the component similar to previous embodiment, and the detailed description shall be abbreviate | omitted. Further, as in the previous embodiment, dissolution devices having the same configuration as in FIG. 5 are separately disposed, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to prepare each dialysis stock solution. As shown in FIG. 1, a dialysis stock solution is supplied from each dissolving device to the dialysate supply device 2.

  The dissolution tank 17 has float switches SH (for upper limit detection) and SL (for lower limit detection) in a part of the internal storage space, and determines the water level supplied by opening the electromagnetic valve Vw. It is comprised so that. The dissolution tank 17 and the storage tank 18 are provided side by side, and both are connected by a transfer line L8 to which an electromagnetic valve V is connected. That is, if the electromagnetic valve V is opened, the dialysis stock solution in the dissolution tank 17 is fed into the storage tank 18 by gravity.

  The middle of the transfer line L8 and the upper part of the dissolution tank 17 are connected by a circulation line L7. A circulation pump P3 is connected to the middle of the circulation line L7, and a bottle B containing a powder drug for dialysis. Can be connected. Thus, if the circulation pump P3 is driven in a state where the electromagnetic valve V is closed, the water in the dissolution tank 17 circulates in the circulation line L7 and the bottle B, so that the dissolution and stirring are performed and a uniform concentration is obtained. A dialysis stock solution can be obtained. The bottle B is configured to be automatically replaced from an empty one to one containing a new dialysis powder drug when additional dissolution is required.

  Further, the determination means 11 according to the present embodiment is electrically connected to the drive source of the electromagnetic valve Vw and the circulation pump P3, and when the determination means 11 determines that the dialysis stock solution to be supplied is insufficient, The electromagnetic valve Vw is opened to automatically supply water into the dissolution tank 17, and the circulation pump P3 is driven to circulate the water in the circulation line L7 and the bottle B. It can be dissolved while stirring.

  However, in FIG. 6, symbol L <b> 9 indicates an aeration line extending from the upper part of the dissolution tank 17 and the storage tank 18, and the electromagnetic valve V is opened so that the dialysis stock solution in the dissolution tank 17 enters the storage tank 18. In the process of being transferred, the air existing in the storage tank 18 is discharged, and the air can be introduced into the dissolution tank 17 by the amount of the dialysis stock solution decreased in the dissolution tank 17.

  Also in the present embodiment, as in the previous embodiment, in the process of supplying the dialysis stock solution by the dissolution apparatus 1, the stock solution amount detection step by the level sensor 8, the computation step by the computation means 10, and the judgment step by the judgment means 11 are performed. Since the dialysis fluid consumption rate is calculated by the dialyzer 4 based on the change points (B1 to B6...) Of the remaining amount of the dialysis stock solution in the storage tank 18 over time, the dialysis fluid consumption rate is calculated. From this, the reduction rate of the dialysis stock solution in the storage tank 18 can be calculated. Therefore, the reduction rate of the dialysis stock solution in the storage tank 18 can be obtained with high accuracy, and the reliability in determining whether or not the dialysis stock solution to be supplied is insufficient can be further improved.

  Although the present embodiment has been described above, the present invention is not limited thereto. For example, as shown in FIG. 7, a personal dialysis machine 20 (a dialysis fluid such as a dialysis fluid supply device is prepared in each dialysis device). It may be applied to a device provided with a means for providing According to such a dissolution system, the dialysis stock solution prepared by the dissolution apparatus 1 is configured to be supplied to both each dialysis apparatus 4 (multi-person dialysis apparatus) and the personal dialysis apparatus 20. In each dialysis device 4, a dialysis stock solution is intermittently supplied via the dialysate supply device 2, while in the personal dialysis device 20, a dialysis stock solution is continuously supplied.

  In this case, the time-dependent transition of the dialysis stock solution in the storage tank in the dissolution apparatus is, as shown in FIG. 8, the first decrease period T4 in which the remaining amount of the dialysis stock solution decreases over time at a predetermined rate (the dissolution apparatus The period during which the supply of the dialysis stock solution from the storage tank to the dialysate storage tank is stopped and the supply of the dialysis stock solution from the storage tank to the personal dialysis device is maintained), which is different from the first decrease period T4 A second decrease period T3 (a period during which the dialysis stock solution is supplied from the dissolution apparatus storage tank to the dialysate storage tank and the personal dialysis apparatus) in which the remaining amount decreases with time at a ratio (a large ratio in the present embodiment). Will be formed.

  However, the boundary point between the first decrease period T4 and the second decrease period T3 corresponds to the change points (B1 to B5...) Of the above-described embodiment, and if the first decrease period T4 is determined at the change points, The reduction ratio of the stock solution for dialysis in the storage tank can be calculated by the method as in the embodiment. That is, from the first decrease period T4, the consumption rate of the dialysate in the multi-person dialyzer (dialyzer 4) can be determined, and the decrease amount (V1) of the dialysate stock solution in the first decrease period T4 is determined. If the numerical value obtained by converting the decrease amount V1 into dialysate is used, the consumption rate of the dialysate in the personal dialyzer can be obtained.

  For example, if an arithmetic expression C / T4 (where C is the amount of the dialysate storage tank as in the above embodiment) is used, the consumption rate of the dialysate in the multi-person dialyzer (dialyzer 4) can be obtained. If the arithmetic expression of (V1 converted into dialysate) / T4 is used, the consumption rate of the dialysate in the personal dialyzer can be obtained. From the rate of dialysate consumption determined in this way, the rate of decrease of the dialysis stock solution in the storage tank in the dissolution apparatus is calculated, and the dialysis stock solution in the storage tank is emptied based on the rate of decrease of the dialysis stock solution. It is possible to determine whether or not the dialysis stock solution to be supplied is insufficient.

  As described above, the change point of the time-dependent transition of the remaining amount of the dialysate detected by the stock solution amount detecting means includes the first decrease period in which the remaining amount of the dialysate stock solution decreases at a predetermined rate with time, Since it is a boundary point with the second decrease period in which the remaining amount decreases with time at a rate different from the one decrease period, the dialysis stock solution is supplied from the dissolution apparatus 1 without going through the dialysate supply apparatus 2, and for the dialysis The present invention can also be applied to a dissolution system equipped with a personal dialysis device that can be supplied to a patient to be subjected to dialysis treatment while preparing a dialysis solution having a predetermined concentration from the stock solution.

  Furthermore, in the above-described embodiment, by grasping the stagnation period T1, the consumption rate of the dialysate is obtained by an arithmetic expression C / T1 (the capacity C is input as described above), and the consumption It is configured to calculate the rate of decrease of the dialysis stock solution in the storage tank 7 from the speed. Instead, it is detected based on the remaining amount of the dialysis stock solution detected by a level sensor (stock solution amount detection means). A change point (B1 to B6...) Of the remaining amount of the remaining amount over time may be determined to grasp the decrease period T2.

  In this case, the consumption rate of the dialysate can be obtained by an arithmetic expression (“amount obtained by converting V2 into dialysate” −C) / T2 (C: known accommodation amount). However, as shown in FIG. 4, V2 is derived from the remaining amount decreased between the change points B1 and B2 (the same applies to B3 and B4, B5 and B6...). For example, the ratio (dilution ratio) by which the dialysis stock solution is diluted in the dialysate storage tank can be set to a value obtained by multiplying V2.

  Stock volume detection means (stock volume detection process) capable of detecting the remaining amount of the dialysis stock solution in the storage tank continuously and in real time, and the remaining amount detected over time by the stock volume detection means (stock volume detection process) Calculate the dialysis fluid consumption rate by the dialysis machine based on the change point of the transition, and calculate with the calculation means (calculation step) and the calculation means (calculation step) to calculate the reduction rate of the dialysis stock solution in the storage tank from the consumption rate A determination means (determination step) for estimating a time until the dialysis stock solution in the storage tank is emptied based on the reduced rate of the dialysis stock solution and determining whether or not the dialysis stock solution to be supplied is insufficient. As long as it is a melting system and a melting method using the same, it can also be applied to a mode in which other functions are added.

The schematic diagram which shows the melt | dissolution system in embodiment (common to 1st-3rd embodiment) of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 1st Embodiment of this invention. The schematic diagram which shows the structure of the dialysate supply apparatus in embodiment (common to 1st-3rd embodiment) of this invention. The graph which shows the time-dependent transition of the residual amount of the stock solution for dialysis in the storage tank of the dissolution apparatus in the embodiment of the present invention (common to the first to third embodiments). The schematic diagram which shows the structure of the melt | dissolution apparatus in the 2nd Embodiment of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 3rd Embodiment of this invention. The schematic diagram which shows the melt | dissolution system in other embodiment of this invention. The graph which shows the time-dependent transition of the residual amount of the stock solution for dialysis in the storage tank of the dissolution apparatus in the other embodiment

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Dissolution apparatus 2 Dialysate supply apparatus 3 Central monitoring apparatus 4 Dialysis apparatus (dialysis monitoring apparatus)
5 Quantitative powder feeder 6 Dissolution tank 7 Storage tank 8 Level sensor (stock volume detection means)
DESCRIPTION OF SYMBOLS 9 Float switch 10 Calculation means 11 Judgment means 12 Input means 13 Water measurement means 14 Dialysate storage tank 15 Float type sensor 16 Notification means 17 Dissolution tank 18 Storage tank 19 Level sensor (raw solution amount detection means)
20 Personal dialyzer B1-B6 ... Change point T1 Stagnation period T2 Decrease period T3 Second decrease period T4 First decrease period L1 (L1a, L1b) Stock solution supply line L2-L4 Dialysate supply line L5 Water supply line L6 Transfer line L7 Circulation line L8 Transfer line L9 Ventilation line

Claims (10)

A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and a storage tank that temporarily stores the stock solution for dialysis obtained in the dissolution tank And a dissolution apparatus having a stock solution supply line for supplying the stock solution for dialysis accommodated in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient,
While supplying a dialysis fluid having a predetermined concentration prepared by mixing a dialysis stock solution and a predetermined amount of water communicated with the stock solution supply line and fed from the stock solution supply line, When the dialysis fluid capacity reaches the lower limit, the dialysis stock solution is supplied from the stock solution supply line until the upper limit capacity is reached, and the supply of the dialysis stock solution is stopped when the upper limit capacity is reached. A dialysate supply device having a dialysate storage tank;
A melting system comprising:
The dissolution apparatus comprises:
Stock solution amount detection means capable of continuously and in real time detecting the remaining amount of the dialysis stock solution in the storage tank;
Calculate the consumption rate of the dialysate by the dialyzer based on the change point of the time course of the remaining amount detected by the stock solution amount detection means, and calculate the decrease rate of the dialysis stock solution in the storage tank from the consumption rate Computing means for
Judgment of estimating whether or not the dialysis stock solution to be supplied is insufficient while estimating the time until the dialysis stock solution in the storage tank becomes empty based on the decrease rate of the dialysis stock solution calculated by the calculation means Means,
A melting system comprising:   The calculation means estimates the time until the amount of dialysate stored in the dialysate storage tank reaches the lower limit from the upper limit based on the change point of the time course of the remaining amount detected by the stock solution amount detection means, 2. The dissolution system according to claim 1, wherein a rate of consumption of dialysate by the dialyzer is calculated based on the estimated time.   The calculation means estimates the time until the amount of dialysate stored in the dialysate storage tank reaches the upper limit from the lower limit based on the change point of the time course of the remaining amount detected by the stock solution amount detection means, 2. The dissolution system according to claim 1, wherein a rate of consumption of dialysate by the dialyzer is calculated based on the estimated time.   The change point of the time course is a boundary point between a decrease period in which the remaining amount of the dialysis stock solution decreases with time and a stagnation period in which the remaining amount does not decrease with time and stagnates. The dissolution system according to any one of claims 1 to 3.   The change points of the time course are the first decrease period in which the remaining amount of the dialysis stock solution decreases over time at a predetermined rate, and the second decrease in which the remaining amount decreases over time at a rate different from the first decrease period. It is a boundary point with a period, The melt | dissolution system as described in any one of Claims 1-3 characterized by the above-mentioned. A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and a storage tank that temporarily stores the stock solution for dialysis obtained in the dissolution tank And a dissolution apparatus having a stock solution supply line for supplying the stock solution for dialysis accommodated in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient,
While supplying a dialysis fluid having a predetermined concentration prepared by mixing a dialysis stock solution and a predetermined amount of water communicated with the stock solution supply line and fed from the stock solution supply line, When the dialysis fluid capacity reaches the lower limit, the dialysis stock solution is supplied from the stock solution supply line until the upper limit capacity is reached, and the supply of the dialysis stock solution is stopped when the upper limit capacity is reached. A dialysate supply device having a dialysate storage tank;
A melting method with a melting system comprising:
A stock solution amount detection step capable of continuously and in real time detecting the remaining amount of the stock solution for dialysis in the storage tank;
Calculate the consumption rate of the dialysate by the dialyzer based on the change point of the time course of the remaining amount detected in the stock solution amount detection step, and calculate the decrease rate of the dialysis stock solution in the storage tank from the consumption rate An arithmetic process to perform,
Judgment that estimates the time until the dialysis stock solution in the storage tank becomes empty based on the decrease rate of the dialysis stock solution calculated in the calculation step and determines whether or not the dialysis stock solution to be supplied is insufficient Process,
A melting method using a melting system.   The calculation step estimates the time until the amount of dialysate accommodated in the dialysate storage tank reaches the lower limit from the upper limit based on the change point of the temporal transition of the remaining amount detected in the stock solution amount detection step, The dissolution method by the dissolution system according to claim 6, wherein the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.   The calculation step estimates the time until the amount of dialysate stored in the dialysate storage tank reaches the upper limit from the lower limit based on the change point of the time course of the remaining amount detected in the stock solution amount detection step, The dissolution method by the dissolution system according to claim 6, wherein the consumption rate of the dialysate by the dialyzer is calculated based on the estimated time.   The change point of the time course is a boundary point between a decrease period in which the remaining amount of the dialysis stock solution decreases with time and a stagnation period in which the remaining amount does not decrease with time and stagnates. The melting method by the melt | dissolution system as described in any one of Claims 6-8.   The change points of the time course are the first decrease period in which the remaining amount of the dialysis stock solution decreases over time at a predetermined rate, and the second decrease in which the remaining amount decreases over time at a rate different from the first decrease period. It is a boundary point with a period, The melt | dissolution method by the melt | dissolution system as described in any one of Claims 6-8 characterized by the above-mentioned.

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