JP2016106906A - Blood purification system - Google Patents

Abstract

Blood that can accurately and automatically measure the concentration of dialysate supplied from the dialysate supply means to the blood purification means during blood purification treatment, and can determine the suitability of the dialysate concentration more accurately. Provide a purification system. A plurality of blood purification means 1 to which a blood purification device for performing blood purification treatment on a patient is attached, dialysate supply means 2 capable of supplying dialysate to each of the blood purification means 1, and dialysate In a blood purification system comprising a supply flow path H for circulating and supplying the dialysate from the supply means 2 to each blood purification means 1, it is contained in the dialysate flowing through the supply flow path H during blood purification treatment. Concentration measuring means (M1 to M3) capable of measuring the concentration of the individual components over time. [Selection] Figure 1

Description

  The present invention relates to a blood purification system comprising a plurality of blood purification means to which a blood purification device for performing blood purification treatment on a patient is attached, and a dialysate supply means capable of supplying a dialysate to each of the blood purification means. It is about.

  In general, in a blood purification system, dialysate supply means is installed in a machine room at a medical site such as a hospital, blood purification means (dialysis monitoring device) is installed in a dialysis room (treatment room), and these dialysate supplies are provided. The means and the blood purification means are connected by a pipe. The dialysate supply means prepares a dialysate having a predetermined concentration, and a plurality of blood purification means are provided with blood purifiers (dialyzers) for performing dialysis treatment on a patient, and are prepared by the dialysate supply means. Blood purification treatment (dialysis treatment) is performed by introducing the dialysate through a pipe and supplying it to a blood purifier.

  That is, the dialysate supply means installed in the machine room is distributed to a plurality of blood purification means installed in the dialysis room and the dialysate is sent, and the dialysate is supplied to the dialyzer in each blood purification means for treatment. Is configured to be performed. The blood purification system that supplies the dialysate prepared by the dialysate supply means to each monitoring device for dialysis is usually referred to as a “dialysis treatment central system”.

  However, as a conventional blood purification system, a conductivity meter capable of measuring the conductivity of the dialysate supplied from the dialysate supply device is provided and used for treatment based on the conductivity measured by the conductivity meter. What can be judged whether the density | concentration of the dialysate (dialysate supplied to a dialyzer) to be performed is appropriate is mentioned (for example, refer patent document 1). That is, since the dialysate is an electrolyte substance, the suitability of the approximate concentration can be determined by measuring the conductivity.

JP 2006-280776 A

  However, in the conventional blood purification system, although the conductivity of the dialysate can be measured to determine the suitability of the dialysate concentration, individual components (for example, sodium, potassium or calcium) contained in the dialysate However, there is a possibility that the concentration of the individual components may be inappropriate even if the conductivity is an appropriate value, and there is a problem that the accuracy of proper determination of the dialysate is not sufficient. In addition, before blood purification treatment, the operator may extract the dialysate prepared by the dialysate supply means with a syringe or the like, and measure the individual components of the dialysate as the extracted sampling. There is a problem that the work is troublesome and it is difficult to measure the concentration during the blood purification treatment. Even if the concentration of individual components changes due to equipment failure during dialysis, if the change in conductivity is small, dialysis may continue without noticing it.

  The present invention has been made in view of such circumstances, and can accurately and automatically measure the concentration of dialysate supplied from the dialysate supply means to the blood purification means during blood purification treatment. An object of the present invention is to provide a blood purification system that can determine the suitability of concentration more accurately.

  The invention according to claim 1 is a plurality of blood purification means to which a blood purification device for performing blood purification treatment on a patient is attached, dialysate supply means capable of supplying dialysate to each of the blood purification means, In a blood purification system comprising a supply flow path for distributing and supplying dialysate from the dialysate supply means to each blood purification means, contained in the dialysate flowing through the supply flow path during blood purification treatment It is characterized by having a concentration measuring means capable of measuring the concentration of the individual components over time.

  According to a second aspect of the present invention, in the blood purification system according to the first aspect of the present invention, the concentration measuring means includes a drawing channel that can draw dialysate flowing through the supply channel, and dialysis drawn through the drawing channel. A concentration measuring unit capable of measuring the concentration of the individual components while containing the liquid, and an injection pump or a shut-off valve disposed in the drawing channel and for feeding the dialysate to the concentration measuring unit To do.

  According to a third aspect of the present invention, in the blood purification system according to the first or second aspect, the concentration measuring means is adapted to add dialysis to the concentration of individual components contained in the dialysate flowing through the supply channel. The osmotic pressure, pH, and conductivity of the liquid can be measured.

  According to a fourth aspect of the present invention, in the blood purification system according to any one of the first to third aspects, a cleaning liquid or a disinfecting liquid can be supplied from the dialysate supply means to each blood purification means. The concentration measuring means can measure the concentration of the individual components contained in the cleaning liquid or the disinfecting liquid.

  According to a fifth aspect of the present invention, in the blood purification system according to any one of the first to fourth aspects, the concentration measuring means determines the concentration of the carbonic acid component contained in the dialysate flowing through the supply channel. In addition to being able to measure, an injection means for injecting the carbonic acid component into the supply channel based on the measured concentration of the carbonic acid component is provided.

  According to the first aspect of the present invention, the blood concentration treatment means is capable of measuring the concentration of the individual components contained in the dialysate flowing through the supply channel during the blood purification treatment. The concentration of the dialysate supplied from the dialysate supply means to the blood purification means can be measured accurately and automatically, and the suitability of the dialysate concentration can be determined more accurately.

  According to the second aspect of the present invention, the concentration measuring means measures the concentration of the individual component while accommodating the dialysis fluid that can be drawn into the dialysis fluid that flows through the supply passage, and the dialysis fluid that is drawn through the drawing passage. A concentration measuring unit that can be used, and an infusion pump or a shut-off valve that is disposed in the drawing-in channel and feeds the dialysate into the concentration measuring unit. The concentration of the dialysate to be measured can be measured more accurately and smoothly.

  According to the invention of claim 3, the concentration measuring means can measure the osmotic pressure, pH, and conductivity of the dialysate in addition to the concentration of the individual components contained in the dialysate flowing through the supply channel. In addition to the suitability of the concentration of dialysate flowing through the supply channel, the suitability of osmotic pressure, pH, and conductivity can also be determined.

  According to the invention of claim 4, it is possible to supply the cleaning liquid or the disinfecting liquid from the dialysate supplying means to each blood purification means, and the concentration measuring means determines the concentration of the individual components contained in the cleaning liquid or the disinfecting liquid. Since measurement can be performed, whether or not the concentration of the cleaning solution or the disinfecting solution supplied from the dialysate supplying unit to the blood purification unit during cleaning or disinfection can be accurately determined.

  According to the invention of claim 5, the concentration measuring means can measure the concentration of the carbonic acid component contained in the dialysate flowing through the supply flow channel, and the supply flow channel based on the measured concentration of the carbonic acid component. Since the injection means capable of injecting the carbonic acid component is provided, the injection means can replenish even if the carbonic acid component decreases in the course of the dialysis fluid flowing through the supply flow path, and the concentration of the carbonic acid component is kept constant at all times. Can keep.

1 is an overall schematic diagram showing a blood purification system according to an embodiment of the present invention. Schematic diagram showing the configuration of blood purification means in the blood purification system Schematic diagram showing concentration measuring means in the blood purification system Schematic diagram showing another embodiment of the concentration measuring means in the blood purification system Flow chart showing the control content of the blood purification system (determination of proper concentration of individual components) Flow chart showing control contents of the blood purification system (determination of carbonic acid component decrease) Overall schematic view showing a blood purification system according to another embodiment of the present invention.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification system according to the present embodiment is for producing a predetermined concentration of dialysate from a dialysate stock solution and supplying the dialysate to a plurality of blood purification means. As shown in FIG. A plurality of blood purification means 1 installed in a dialysis room (treatment room) at a medical site, a dialysate supply device 2 installed in a machine room at the medical site, each blood purification means 1 and a dialysate supply means 2, Are mainly composed of a supply flow path H, a concentration measuring means (M1 to M3), and an injection means 12.

  The blood purification means 1 is called a monitoring device. A dialyzer 3 (blood purifier) for performing blood purification treatment (hemodialysis treatment) on a patient is attached, and dialysis supplied from the dialysate supply device 2. A plurality of liquids are provided along the supply flow path H for supplying the liquid to the dialyzer 3. The blood purification means 1 is provided with a touch panel that can perform hemodialysis treatment and other control content (cleaning or disinfection) instructions and a predetermined display.

  More specifically, each of the plurality of blood purification means 1 installed in the dialysis chamber has a pipe L1 drawn from a supply flow path H extending from the dialysate supply device 2, as shown in FIG. A pipe L2 connected to a drainage means (not shown) is provided, and a duplex pump 8 is disposed across the pipes L1 and L2. Among these, the pipe L1 in the blood purification means 1 is provided with an electric conductivity sensor 5 for measuring the electric conductivity of dialysate or the like flowing through the pipe L1, a liquid pressure detecting sensor 6 for detecting the supply pressure of the liquid, and the like. Has been. In the figure, reference numeral 7 denotes a control means, and the control means 7 performs various controls for causing blood purification treatment.

  Further, a dialysate introduction line L4 communicated with the pipe L1 and a dialysate discharge line L5 communicated with the pipe L2 are extended from the duplex pump 8, and the distal end of the dialysate introduction line L4 via the coupler C is extended. Can be connected to the dialysate inlet 3a of the dialyzer 3, and the tip of the dialysate discharge line L5 can be connected to the dialysate outlet 3b of the dialyzer 3 via the coupler C. In this way, each blood purification means 1 is provided with a dialyzer 3 corresponding to the patient, and the dialyzer 3 is connected to a blood circuit 4 for circulating the patient's blood extracorporeally. Become.

  The pump chamber of the dual pump 8 is divided into a liquid feeding side pump chamber connected to the pipe L1 and a discharge side pump chamber connected to the pipe L2 by a single plunger (not shown). By reciprocating, the dialysate or the washing solution sent to the liquid feed side pump chamber is supplied to the dialyzer 3 and the dialysate in the dialyzer 3 is sucked into the discharge side pump chamber. Furthermore, a pipe L3 that connects the pipe L2 and the dialysate discharge line L5 while bypassing the duplex pump 8 is formed in the blood purification means 1, and a water removal pump 9 is disposed in the middle of the pipe L3. Has been. By driving the water removal pump 9, it is possible to perform water removal on the blood of the patient flowing in the dialyzer 3.

  Instead of the dual pump 8, a so-called chamber type may be used, and sensors such as the conductivity sensor 5 and the hydraulic pressure detection sensor 6 may be provided with arbitrary ones or other general purpose sensors. You may add something. Furthermore, in the present embodiment, the sensors are arranged in the pipe L1, but may be arranged in another pipe (for example, the pipe L4). For example, sensors such as the electrical conductivity sensor 5 and the hydraulic pressure detection sensor 6 may be disposed on either or both of the pipe L1 and the pipe L4.

  The dialysate supply means 2 can prepare a dialysate having a predetermined concentration using, for example, clean water obtained by a water treatment device (not shown) and a dialysate stock solution prepared by a dissolution device (not shown) and blood. The dialysate prepared for each of the purification means 1 can be supplied. That is, the dialysate supply means 2 is connected to each of the plurality of blood purification means 1 via the supply flow path H, and dialysate and wash water are connected to each of the blood purification means 1 via the supply flow path H. In addition, a desired liquid such as a disinfectant can be supplied. In addition, the undiluted solution for dialysis applied in this embodiment is prepared by dissolving a drug (agent A) that does not contain powdered sodium bicarbonate with clean water, so that the solution A is converted to a drug composed of powdered sodium bicarbonate ( The B stock solution is obtained by dissolving the B agent) with clean water, but the A stock solution and B stock solution provided as liquids may be stored in a tank or the like and used as they are. That is, the dialysate supply means 2 can obtain a dialysate by mixing and diluting the A stock solution, B stock solution and clean water obtained as described above. Each can be supplied.

  Furthermore, the dialysate supply means 2 according to the present embodiment is electrically connected to concentration measuring means (M1 to M3), which will be described in detail later, and based on the measurement values of these concentration measuring means (M1 to M3). If the determination unit 10 determines whether the concentration of the individual components of the dialysate flowing through the supply flow path H is appropriate, and the determination unit 10 determines that the concentration of the individual components of the dialysate exceeds the appropriate range, And a notification means 11 for performing notification by display, notification by sound output, and the like.

  The supply flow path H is composed of a pipe for circulating dialysate (including cleaning liquid and disinfectant) from the dialysate supply means 2 to each blood purification means 1 and is connected to a drain valve V at the end. The drainage valve V is opened so that the water remaining in the supply channel H2 is pushed out and drained at the start of the dialysate feeding, and the inside of the supply channel H2 is quickly replaced with the dialysate. Alternatively, at the time of washing and disinfecting after completion of dialysis, the dialysate or disinfectant remaining in the supply flow path H2 is quickly pushed out and discharged. In addition, the blood purification means 1 may be arranged in each of the branched supply flow paths H by branching the supply flow path H in the middle.

  Further, the supply flow path H according to the present embodiment can discharge the dialysate from the end, but as shown in FIG. 7, it is formed endlessly via the circulation heating unit Y, It may be supplied to each blood purification means 1 while circulating the liquid. The circulation warming unit Y is for circulating the circulating dialysate while heating, and in this embodiment, a discharge pipe Hd for discharging the circulating dialysate to the outside is extended. .

  Here, in the supply channel H according to the present embodiment, a concentration measurement capable of measuring the concentration (composition concentration) of individual components contained in the dialysate flowing through the supply channel H over time during blood purification treatment. Means (M1 to M3) are connected. The concentration measuring means M1 is connected further upstream (between the dialysate supply means 2 and the blood purification means 1 located at the uppermost stream) than the blood purification means 1 disposed on the most upstream side in the supply flow path H. At the same time, the concentration measuring means M2 and M3 are connected to the supply channel H at a position sandwiching the injection means 12.

  More specifically, as shown in FIG. 3, the concentration measuring unit M1 (same as the concentration measuring units M2 and M3) includes a drawing channel h1 that can draw dialysate flowing through the supply channel H, and the drawing A concentration measuring unit N that can measure the concentration of individual components while accommodating the dialysate drawn in the flow path h1, and an infusion pump Pa that is arranged in the drawing flow path h1 and feeds the dialysate into the concentration measuring unit N. And a discharge channel h2 for discharging the dialysate after the concentration of the individual components is measured by the concentration measuring unit N to the outside.

The concentration of the individual component measured by the concentration measuring unit N is the concentration of the individual component contained in the dialysate. For example, sodium (Na) ion, potassium (K) ion, calcium (Ca) ion, bicarbonate ( The concentration of CO ₃ ) ion, glucose (C ₆ H ₁₂ O ₆ ) and the like can be mentioned. Further, the concentration measuring means M1 may measure the osmotic pressure, pH, and conductivity of the dialysate in addition to the concentration of individual components contained in the dialysate flowing through the supply flow path H. In addition to the suitability of the concentration of the dialysate flowing through the supply channel H, the suitability of the osmotic pressure, pH, and conductivity can also be determined.

  Further, the concentration measuring means (M1 to M3) may be configured to measure the concentrations of the same individual components, or may measure the concentrations of different individual components. Furthermore, in the present embodiment, an infusion pump Pa is provided in the drawing flow path h1 to send the dialysate to the concentration measuring unit N. Instead of the infusion pump Pa, FIG. As shown in FIG. 4, a shutoff valve Va may be provided. Further, in the present embodiment, the discharge flow path h2 for discharging the dialysate after the concentration of the individual component is measured by the concentration measuring unit N is extended, but instead of the discharge flow path h2, the discharge flow path h2 is extended. The dialysate after the concentration of the individual component is measured by the concentration measuring unit N may be a flow path that returns the supply flow path H again.

  Thus, during blood purification treatment (during dialysis treatment), when the infusion pump Pa is driven (the shut-off valve Va may be opened), a part of the dialysate flowing through the supply flow path H is drawn into the suction flow path h1. The concentration reaches the concentration measurement unit N, and the concentration of the individual components is measured while being stored in the state where the flow is stopped at the concentration measurement unit N, and the dialysate after the measurement flows through the discharge channel h2 and is discharged Will be. By repeating this operation continuously or intermittently during the blood purification treatment, the concentration of the individual components contained in the dialysate flowing through the supply channel H can be measured over time. Information on the concentration of the individual component measured here is transmitted to the determination unit 10 of the dialysate supply unit 2, and it is determined whether or not the concentration of the individual component is appropriate. Note that the determination means 10 is not necessarily provided in the dialysate supply means 2, and may be provided, for example, in each of the concentration measurement means (M1 to M3) or independently. Also good.

  Furthermore, in the present embodiment, a cleaning liquid or a disinfecting liquid can be supplied from the dialysate supply means 2 to each blood purification means 1 before or after the blood purification treatment, and the concentration measuring means (M1 to M3). Is preferably configured to measure the concentration of individual components (for example, chlorine (Cl), etc.) contained in the cleaning liquid or the disinfecting liquid. In this case, whether or not the concentration of the cleaning solution or the disinfecting solution supplied from the dialysate supplying unit 2 to the blood purification unit 1 during cleaning or disinfection can be determined with high accuracy.

Furthermore, in this embodiment, the concentration measuring means (M1 to M3) can measure the concentration of the carbonic acid component (CO ₂ ) contained in the dialysate flowing through the supply flow path H, and the measured value. An injection means 12 that can inject the carbonic acid component into the supply channel H based on the concentration of the carbonic acid component is provided. The injection unit 12 includes a storage unit D that stores a stock solution of the B agent that is a carbonic acid component, an injection channel L that can inject the stock solution of the B agent in the storage unit D into the supply channel H, and an injection channel. And an infusion pump P for feeding the stock solution of the B agent in the storage means D to the supply flow path H.

  Thus, when the concentration of the carbonic acid component measured by the concentration measuring means M2 or the concentration measuring means M3 is lower than the concentration of the carbonic acid component (concentration of the individual component) measured by the concentration measuring means M1, the dialysis fluid distribution process Thus, it can be determined that the carbonic acid component has decreased, and the injection pump P can be driven to inject and supplement the reduced carbonic acid component. The injection means 12 may inject the stock solution (carbonic acid component) of the B agent in the storage means D by its own weight. In that case, it is preferable to connect a shutoff valve instead of the injection pump P.

Next, an example of the control content (determination of proper concentration of individual components) in the blood purification system according to the present embodiment will be described based on the flowchart of FIG.
When blood purification treatment (dialysis treatment) is started, dialysate is circulated from the dialysate supply means 2 through the supply flow path H and supplied to each blood purification means 1 (S1), and the concentration measurement means (M1 to M3). ), The concentration of the individual components of the dialysate flowing through the supply flow path H is measured (S2). Thereafter, the measured values of the concentration measuring means (M1 to M3) are transmitted to the determining means 10, and it is determined whether or not the concentration of the individual components of the dialysate is appropriate (S3). When it is determined in S3 that the concentration of the individual components of the dialysate is appropriate (within an appropriate range), the dialysate supply means 2 continues to supply the dialysate (S4) and dialysis is performed in S3. If it is determined that the concentration of the individual components of the liquid is not appropriate (out of the appropriate range), it is determined whether only one of the concentration measuring means (M1 to M3) has been measured for an inappropriate concentration (S5). ).

  If it is determined in S5 that only one of the concentration measurement means (M1 to M3) is not appropriate in concentration (the concentration measured by the other concentration measurement means (M1 to M3) is appropriate), After proceeding to S6 and notifying by the notification means 11, the supply of the dialysate by the dialysate supply means 2 is continued (S4) or waiting for the operator's input (S7), and the operator supplies the dialysate. When there is an input to continue, the dialysate supply means 2 continues to supply the dialysate (S4). On the other hand, if it is determined in S5 that the concentrations measured by all the concentration measuring means (M1 to M3) or the two concentration measuring means are not appropriate, the process proceeds to S8 and the dialysate supply means 2 supplies the dialysate. Then, the dialysate supply means 2 prepares the dialysate again (re-preparation) (S9), returns to S1, and performs the subsequent control again.

Next, an example of the control content (determination of carbonic acid component decrease) in the blood purification system according to the embodiment will be described based on the flowchart of FIG.
When blood purification treatment (dialysis treatment) is started, dialysate is circulated from the dialysate supply means 2 through the supply flow path H and supplied to each blood purification means 1 (S1), and the concentration measurement means (M1 to M3). ), The concentration of the carbonic acid component which is one of the individual components of the dialysate flowing through the supply channel H is measured (S2). Thereafter, the measurement values of the concentration measuring means (M1 to M3) are transmitted to the determining means 10, and it is determined whether or not the concentration of the carbonic acid component contained in the dialysate is appropriate (S3). When it is determined in S3 that the concentration of the carbonic acid component of the dialysate is appropriate (within an appropriate range), the dialysate supply means 2 continues to supply the dialysate (S4) and dialysis is performed in S3. If it is determined that the concentration of the carbonic acid component of the liquid is not appropriate (outside the proper range), the process proceeds to S5, where the injection pump P in the injection means 12 is controlled to inject the changed (decreased) carbonic acid component. After driving so that the concentration of the carbonic acid component of the dialysate becomes an appropriate value, the process returns to S2 and the subsequent control is performed again. In order to find a failure in the concentration measuring means (M1 to M3), it is determined whether or not the measured value of the concentration measuring means M1 ≧ the measured value of the concentration measuring means M2 ≧ the measured value of the concentration detecting means M3. Alternatively, two sensors may be provided in each concentration measuring means (M1 to M3) to compare the two.

  According to the above embodiment, since blood concentration treatment means (M1 to M3) capable of measuring the concentration of individual components contained in the dialysate flowing through the supply channel H over time during blood purification treatment, blood is provided. During the purification treatment, the concentration of the dialysate supplied from the dialysate supply means 2 to the blood purification means 1 can be accurately and automatically measured, and the suitability of the dialysate concentration can be determined more accurately.

  Further, the concentration measuring means (M1 to M3) according to the present embodiment accommodates the drawing channel h1 that can draw the dialysate flowing through the supply channel H and the dialysate drawn by the drawing channel h1. Since it has a concentration measuring unit N that can measure the concentration of individual components, and an infusion pump Pa or a shut-off valve Va that is disposed in the drawing channel h and sends the dialysate to the concentration measuring unit N, blood purification treatment is in progress Thus, the concentration of the dialysate supplied from the dialysate supply means 2 to the blood purification means 1 can be measured more accurately and smoothly.

  Furthermore, the concentration measuring means (M1 to M3) according to the present embodiment can measure the concentration of the carbonic acid component contained in the dialysate flowing through the supply flow path H, and the measured concentration of the carbonic acid component can be measured. Since the injection means 12 capable of injecting the carbonic acid component into the supply channel is provided, the injection means 12 can replenish even if the carbonic acid component decreases in the process of dialysis fluid flowing through the supply channel H. The concentration of the carbonic acid component can always be kept constant.

  Although the blood purification system according to the present embodiment has been described above, the present invention is not limited to this. For example, the concentration measuring means is a supply flow path in the blood purification means 1 (pipe L1 or dialysate in FIG. 2). It may be connected to the introduction line L4 or the like, and the concentration of individual components different from the above may be measured over time during the blood purification treatment. Further, the arrangement position and the number of the density measuring means (M1 to M3) may be in other forms. In addition, in this embodiment, although it is set as the system which performs a hemodialysis treatment, you may make it apply to the blood purification system which performs another blood purification treatment.

  A blood purification system equipped with a concentration measuring means capable of measuring the concentration of individual components contained in the dialysate flowing through the supply flow channel over time during blood purification treatment is provided with other functions. The present invention can also be applied.

DESCRIPTION OF SYMBOLS 1 Blood purification means 2 Dialysate supply apparatus 3 Dialyzer (blood purifier)
4 Blood circuit 5 Conductivity sensor 6 Fluid pressure detection sensor 7 Control means 10 Determination means 11 Notification means 12 Injection means H Supply flow path M1 to M3 Concentration measurement means

Claims (5)

A plurality of blood purification means to which a blood purifier for performing blood purification treatment on a patient is attached;
Dialysate supply means capable of supplying dialysate to each of the blood purification means;
A supply channel for circulating and supplying the dialysate from the dialysate supply means to each blood purification means;
In the blood purification system comprising
A blood purification system comprising a concentration measuring means capable of measuring the concentration of individual components contained in the dialysate flowing through the supply channel over time during blood purification treatment.   The concentration measuring means is a drawing channel that can draw dialysate flowing through the supply channel, a concentration measuring unit that can measure the concentration of individual components while containing the dialysate drawn in the drawing channel, The blood purification system according to claim 1, further comprising an infusion pump or a shut-off valve disposed in the drawing-in channel and configured to send dialysate into the concentration measuring unit.   The said concentration measurement means can measure the osmotic pressure, pH, and electric conductivity of the dialysate in addition to the density | concentration of the individual component contained in the dialysate which distribute | circulates the said supply flow path. The blood purification system according to claim 2.   The dialysate supply means can supply a cleaning liquid or a disinfecting liquid to each blood purification means, and the concentration measuring means can measure the concentration of individual components contained in the cleaning liquid or the disinfecting liquid. The blood purification system according to any one of claims 1 to 3.   The concentration measuring means can measure the concentration of the carbonate component contained in the dialysate flowing through the supply channel, and injects the carbonate component into the supply channel based on the measured concentration of the carbonate component. The blood purification system according to any one of claims 1 to 4, further comprising an injecting unit that can perform the operation.

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