[go: up one dir, main page]

JP2008534627A5 - - Google Patents

Download PDF

Info

Publication number
JP2008534627A5
JP2008534627A5 JP2008504532A JP2008504532A JP2008534627A5 JP 2008534627 A5 JP2008534627 A5 JP 2008534627A5 JP 2008504532 A JP2008504532 A JP 2008504532A JP 2008504532 A JP2008504532 A JP 2008504532A JP 2008534627 A5 JP2008534627 A5 JP 2008534627A5
Authority
JP
Japan
Prior art keywords
amylin
seq
disorder
disease
agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008504532A
Other languages
English (en)
Other versions
JP2008534627A (ja
JP5114381B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/012601 external-priority patent/WO2006105527A2/en
Publication of JP2008534627A publication Critical patent/JP2008534627A/ja
Publication of JP2008534627A5 publication Critical patent/JP2008534627A5/ja
Application granted granted Critical
Publication of JP5114381B2 publication Critical patent/JP5114381B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Claims (24)

  1. 気分障害、不安障害または精神分裂病である精神の疾患または障害を治療するための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体であって、
    医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではない該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  2. 該疾患または障害が不安障害である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  3. 該不安障害が強迫障害である、請求項2記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  4. 疾患または障害が鬱病である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  5. 疾患または障害が精神分裂病である、請求項1記載の精神の疾患または障害の治療のためのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  6. 該化合物が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項1〜5のいずれか1記載のアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体。
  7. 請求項1〜5のいずれかのアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体を含む医薬上許容される組成物。
  8. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項6記載の医薬上許容される組成物。
  9. 気分障害、不安障害または精神分裂病である精神の疾患または障害を治療するための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体を含む医薬組成物であって、
    医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではない該医薬組成物。
  10. 該疾患または障害が不安障害である請求項9記載の医薬組成物。
  11. 該不安障害が強迫障害である請求項10記載の医薬組成物。
  12. 疾患または障害が鬱病である請求項9記載の医薬組成物。
  13. 疾患または障害が精神分裂病である請求項9記載の医薬組成物。
  14. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択される請求項9記載の医薬組成物。
  15. 気分障害、不安障害または精神分裂病である精神の疾患または障害の治療用医薬の製造のための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体の使用であって、
    医薬が該疾患または障害を治療するために有効な量で投与され、アミリンアゴニストがカルシトニンではないことを特徴とする該使用。
  16. 疾患または障害が不安障害であることを特徴とする請求項15記載の使用。
  17. 不安障害が強迫障害であることを特徴とする請求項16記載の使用。
  18. 疾患または障害が鬱病であることを特徴とする請求項15記載の使用。
  19. 疾患または障害が精神分裂病であることを特徴とする請求項15記載の使用。
  20. 少なくとも1つの他の精神医薬が対象に投与されることを特徴とする請求項15記載の使用。
  21. 精神障害を治療用医薬の製造のための配列番号:3、配列番号:33、配列番号:35、配列番号:67、配列番号:80、配列番号:81、配列番号:82および配列番号:83に記載の化合物よりなる群から選択されるアミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体の使用であって、
    医薬が該障害を治療するために有効な量で投与され、物質関連障害が、物質依存、物質嗜癖、物質誘導不安障害および物質誘導気分障害よりなる群から選択される該使用。
  22. 物質関連障害が、物質嗜癖、物質誘導不安障害または物質誘導気分障害であることを特徴とする請求項21記載の使用。
  23. 少なくとも1つの他の精神医薬が対象に投与されることを特徴とする請求項22記載の使用。
  24. 該アミリン、アミリンアゴニスト、アミリンアナログまたはアミリン誘導体が、配列番号:4-31、36-66および86-253よりなる群から選択されることを特徴とする請求項15〜23のいずれか1記載の使用。
JP2008504532A 2005-03-31 2006-03-31 精神疾患および障害治療用アミリンおよびアミリンアゴニスト Expired - Fee Related JP5114381B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US66668105P 2005-03-31 2005-03-31
US66733505P 2005-03-31 2005-03-31
US60/666,681 2005-03-31
US60/667,335 2005-03-31
US67544105P 2005-04-28 2005-04-28
US60/675,441 2005-04-28
US76058306P 2006-01-20 2006-01-20
US60/760,583 2006-01-20
PCT/US2006/012601 WO2006105527A2 (en) 2005-03-31 2006-03-31 Amylin and amylin agonists for treating psychiatric diseases and disorders

Publications (3)

Publication Number Publication Date
JP2008534627A JP2008534627A (ja) 2008-08-28
JP2008534627A5 true JP2008534627A5 (ja) 2009-05-21
JP5114381B2 JP5114381B2 (ja) 2013-01-09

Family

ID=37054153

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008504532A Expired - Fee Related JP5114381B2 (ja) 2005-03-31 2006-03-31 精神疾患および障害治療用アミリンおよびアミリンアゴニスト
JP2008504396A Expired - Fee Related JP5415067B2 (ja) 2005-03-31 2006-03-31 肥満および摂食障害の制御、防止および治療のための組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008504396A Expired - Fee Related JP5415067B2 (ja) 2005-03-31 2006-03-31 肥満および摂食障害の制御、防止および治療のための組成物および方法

Country Status (17)

Country Link
US (7) US7879794B2 (ja)
EP (5) EP2135617A3 (ja)
JP (2) JP5114381B2 (ja)
KR (3) KR20130122983A (ja)
CN (3) CN101189021B (ja)
AT (2) ATE480255T1 (ja)
AU (2) AU2006230420B2 (ja)
BR (2) BRPI0609595A8 (ja)
CA (2) CA2602261A1 (ja)
DE (2) DE602006016760D1 (ja)
DK (1) DK1888094T3 (ja)
EA (1) EA013121B1 (ja)
ES (1) ES2330671T3 (ja)
IL (1) IL186200A (ja)
MX (2) MX2007012237A (ja)
NZ (3) NZ561936A (ja)
WO (2) WO2006105527A2 (ja)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CA2556226A1 (en) * 2004-02-11 2006-08-10 Amylin Pharmaceuticals, Inc. Amylin family peptides and methods for making and using them
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
MX2007012237A (es) 2005-03-31 2007-12-07 Amylin Pharmaceuticals Inc Amilina y agonistas de amilina para tratar enfermedades y trastornos siquiatricos.
WO2007014051A2 (en) * 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
WO2007104789A2 (en) 2006-03-15 2007-09-20 Novo Nordisk A/S Amylin derivatives
US20090181890A1 (en) * 2006-03-31 2009-07-16 Amylin Pharmaceuticals , Inc. Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders
KR20080106950A (ko) * 2006-03-31 2008-12-09 아밀린 파마슈티칼스, 인크. 정신의학적 질환 및 장애를 치료하기 위한 아밀린 및 아밀린 효능제
DK2020990T3 (da) 2006-05-30 2010-12-13 Intarcia Therapeutics Inc Strømningsmodulator med en indre kanal til et todelt osmotisk fremføringssystem
KR101200728B1 (ko) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 삼투성 전달 시스템 및 피스톤 조립체
ES2389747T3 (es) 2007-02-05 2012-10-31 Amylin Pharmaceuticals, Inc. Péptidos FN-38 para su uso en el tratamiento de desórdenes psicóticos y de ansiedad
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US20110152183A1 (en) * 2008-06-25 2011-06-23 Novo Nordisk A/S Derivatised hybrid peptides of amylin and salmon calcitonin
JP5703226B2 (ja) * 2008-10-21 2015-04-15 ノヴォ ノルディスク アー/エス アミリン誘導体
DK2373681T3 (en) 2008-12-10 2017-04-24 Glaxosmithkline Llc PHARMACEUTICAL COMPOSITIONS OF ALBIGLUTID
WO2010085700A2 (en) * 2009-01-22 2010-07-29 Unigene Laboratories Inc. Treatment for obesity
EP2416797A4 (en) * 2009-04-10 2013-04-24 Amylin Pharmaceuticals Llc AMYLINAGONIST COMPOUNDS FOR OXYGEN ANIMAL MICE
US8828953B2 (en) * 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
WO2010123930A2 (en) 2009-04-20 2010-10-28 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
RU2753280C2 (ru) 2009-09-28 2021-08-12 Интарсия Терапьютикс, Инк. Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US8691763B2 (en) 2010-05-04 2014-04-08 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
US20110317346A1 (en) 2010-06-28 2011-12-29 Zte Corporation Totally-enclosed integrative access system and power consumption reduction method thereof
CA2815024A1 (en) 2010-10-19 2012-04-26 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
CA2823397C (en) 2011-01-07 2020-03-10 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CA3080189C (en) * 2011-06-17 2023-01-17 Hanmi Science Co., Ltd. A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof
KR20230095124A (ko) 2012-01-06 2023-06-28 앤지 파마 유에스 엘엘씨 바이구아나이드 조성물 및 대사 장애를 치료하는 방법
AU2013211929B2 (en) * 2012-01-26 2016-05-26 Christopher J. Soares Peptide antagonists of the calcitonin CGRP family of peptide hormones and their use
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
BR102013017626A2 (pt) * 2013-06-14 2015-02-10 Univ Rio De Janeiro Bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, uso de bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, composições farmacêuticas de baixa toxicidade, adjuvante para a prevenção ou tratamento das doenças, medicamento, método de tratamento ou prevenção de doenças.
EP3027644B1 (en) * 2013-07-30 2019-08-21 Christopher J. Soares Cgrp agonist peptides
AR097701A1 (es) * 2013-09-19 2016-04-13 Zealand Pharma As Análogos de amilina
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
KR102650751B1 (ko) 2015-06-03 2024-03-22 인타르시아 세라퓨틱스 인코포레이티드 임플란트 배치 및 제거 시스템들
TWI814219B (zh) 2016-05-16 2023-09-01 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
IL265099B2 (en) 2016-09-02 2024-09-01 Christopher J Soares Pharmaceutical compositions comprising an effective amount of calcitonin gene-related peptide (cgrp) receptor antagonist or pharmaceutically acceptable salt thereof, for treating glaucoma
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
EP3568411B1 (en) * 2017-01-13 2024-03-06 Pietro P. Sanna Methods and compositions for treating hpa hyperactivity
EP3628233B1 (en) * 2018-09-28 2021-06-02 Siemens Healthcare GmbH Method and system for providing a dose reference value for a patient
US11443843B2 (en) 2019-01-04 2022-09-13 International Business Machines Corporation Personal customized guidance for treating patients
CN111700904A (zh) * 2020-07-31 2020-09-25 江南大学 一种利用酰化淀粉定点释放短链脂肪酸的抗抑郁的方法
WO2025120001A1 (en) * 2023-12-04 2025-06-12 Zealand Pharma A/S Amylin analogues for reducing consumption of high-fat food
WO2025120002A1 (en) * 2023-12-04 2025-06-12 Zealand Pharma A/S Petrelintide for reducing weight whilst preserving lean mass

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024807B1 (en) 1979-07-28 1983-11-02 Beecham Group Plc Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them
US4401593A (en) 1982-02-12 1983-08-30 Armour Pharmaceutical Company Glycine - 8 calcitonin
US4397780A (en) 1982-02-12 1983-08-09 Armour Pharmaceutical Company Leucine22 -calcitonin
US4414149A (en) 1983-03-04 1983-11-08 Armour Pharmaceutical Company Glycine8 -D-arginine24 calcitonin
US4497731A (en) 1983-04-04 1985-02-05 Armour Pharmaceutical Company Glycine 8-des-tyrosine 22 calcitonin
US4495097A (en) 1983-04-04 1985-01-22 Armour Pharmaceutical Company Des-serine2 -glycine8 calcitonin
US4572208A (en) 1983-06-29 1986-02-25 Utah Medical Products, Inc. Metabolic gas monitoring apparatus and method
US4597900A (en) 1983-08-22 1986-07-01 Armour Pharmaceutical Co. Des2 -glycine8 -des22 -calcitonin
US4537716A (en) 1983-12-05 1985-08-27 Armour Pharmaceutical Co. Des-serine2 or des-glycine2 -leucine22 calcitonin
FI78231C (fi) 1984-11-21 1989-07-10 Instrumentarium Oy Maetanordning foer metaboliska storheter anslutbar till en respirator.
US4604238A (en) 1984-12-10 1986-08-05 Armour Pharmaceutical Company Analogs of calcitonin
US4606856A (en) 1985-03-18 1986-08-19 Seyler Jay K [Des-1-amino, 8-glycine]calcitonin
US4652627A (en) 1985-08-16 1987-03-24 Kempe Tomas G Calcitonin analogs with C-terminal D-amino acid substituents
US4687839A (en) 1985-12-23 1987-08-18 Kempe Tomas G Calcitonin gene related peptide analogs with C-terminal D-amino acid substituents
US4697002A (en) 1985-12-23 1987-09-29 Kempe Tomas G Calcitonin gene related peptide analogs with amino acid subdstituents at the penultimate position 36
GB8709871D0 (en) 1987-04-27 1987-06-03 Turner R C Peptides
US5175145A (en) 1988-08-26 1992-12-29 Amylin Pharmaceuticals, Inc. Treatment of diabetes mellitus with amylin agonists
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US5405831A (en) * 1989-07-08 1995-04-11 Amylin Pharmaceuticals, Inc. Treatment of bone disorders
US5264372A (en) 1991-03-15 1993-11-23 Amylin Pharmaceuticals, Inc. Receptor-based screening methods for amylin agonists and antagonists
US5234906A (en) 1991-01-10 1993-08-10 Amylin Pharmaceuticals, Inc. Hyperglycemic compositions
HU222249B1 (hu) 1991-03-08 2003-05-28 Amylin Pharmaceuticals Inc. Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
ATE205854T1 (de) * 1991-11-19 2001-10-15 Amylin Pharmaceuticals Inc Peptide als amylin-agonisten und ihre verwendung
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US6001364A (en) 1993-05-05 1999-12-14 Gryphon Sciences Hetero-polyoxime compounds and their preparation by parallel assembly
US6174530B1 (en) 1993-05-05 2001-01-16 Gryphon Sciences Homogeneous polyoxime compositions and their preparation by parallel assembly
US5589356A (en) 1993-06-21 1996-12-31 Vanderbilt University Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement
KR100429966B1 (ko) 1993-09-07 2004-05-04 아밀린 파마슈티칼스, 인크. 위장 운동성 조절을 위한 제약 조성물
US5766627A (en) 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6184344B1 (en) 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
US6013009A (en) 1996-03-12 2000-01-11 Karkanen; Kip Michael Walking/running heart rate monitoring system
US5677279A (en) * 1996-12-16 1997-10-14 Amylin Pharmaceuticals, Inc. Methods and compositions for treating pain with amylin or agonists thereof
US6307018B1 (en) 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
DE69831673C5 (de) 1997-01-07 2015-01-22 Amylin Pharmaceuticals, Llc Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme
US6410511B2 (en) 1997-01-08 2002-06-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US7312196B2 (en) 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6309360B1 (en) 1997-03-17 2001-10-30 James R. Mault Respiratory calorimeter
US7101853B2 (en) 1997-05-06 2006-09-05 Amylin Pharmaceuticals, Inc. Method for treating or preventing gastritis using amylin or amylin agonists
US20040022807A1 (en) * 1998-06-05 2004-02-05 Duft Bradford J Methods for treating obesity
ATE354584T1 (de) 1997-06-13 2007-03-15 Gryphon Therapeutics Inc Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen
DE69942453D1 (de) 1998-05-29 2010-07-15 Jgc Catalysts & Chemicals Ltd Verfahren zur herstellung photoelektrischer zellen
US6087334A (en) 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
EP1107979B1 (en) 1998-08-31 2006-07-05 Gryphon Therapeutics, Inc. Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
TW514510B (en) 1999-06-11 2002-12-21 Tanita Seisakusho Kk Method and apparatus for measuring distribution of body fat
US6468222B1 (en) 1999-08-02 2002-10-22 Healthetech, Inc. Metabolic calorimeter employing respiratory gas analysis
US6530886B1 (en) 1999-10-08 2003-03-11 Tanita Corporation Method and apparatus for measuring subcutaneous fat using ultrasonic wave
US6264987B1 (en) 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
TW515705B (en) 2000-05-31 2003-01-01 Yamato Scale Co Ltd Visceral fat meter
US6296842B1 (en) 2000-08-10 2001-10-02 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
AU2001273385B2 (en) 2000-09-08 2005-04-07 Gryphon Therapeutics, Inc. Polymer-modified synthetic proteins
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US6475158B1 (en) 2000-10-24 2002-11-05 Korr Medical Technologies, Inc. Calorimetry systems and methods
GB0113657D0 (en) 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
FR2827599A1 (fr) 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
US20040138412A1 (en) 2001-09-07 2004-07-15 Paolo Botti Extended native chemical ligation
US7884182B2 (en) 2001-11-14 2011-02-08 Amylin Pharmaceuticals, Inc. Chemical peptide ligation with three or more components
NZ534557A (en) * 2002-01-08 2007-10-26 Amylin Pharmaceuticals Inc Use of amylin or amylin agonists in the manufacture of a medicament for use in the treatment of dyslipidemia, wherein the medicament reduces post-prandial triglyceride levels
AR040126A1 (es) * 2002-05-29 2005-03-16 Glaxo Group Ltd Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento
EP1511760B1 (en) 2002-06-10 2006-01-18 Geneprot, Inc. Carboxy protection strategies for acidic c-terminal amino acids in chemical ligation of oligopeptides
AU2003298739A1 (en) 2002-11-26 2004-06-18 The Board Of Trustees Of The Leland Stanford Junior University Intermedin and its uses
US20060275768A1 (en) 2002-12-30 2006-12-07 Kochendoerfer Gerd G Multiplex polymer ligation
US20040197287A1 (en) * 2003-04-04 2004-10-07 The Procter & Gamble Company Personal care composition containing an antidandruff component and a nonionic surfactant
WO2004105685A2 (en) 2003-05-22 2004-12-09 Gryphon Therapeutics, Inc. Displaceable linker solid phase chemical ligation
CA2556226A1 (en) 2004-02-11 2006-08-10 Amylin Pharmaceuticals, Inc. Amylin family peptides and methods for making and using them
US7399744B2 (en) * 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
CN101035806A (zh) 2004-10-08 2007-09-12 安米林药品公司 新的糊精家族多肽-6(afp-6)类似物和制备和使用它们的方法
MX2007012237A (es) 2005-03-31 2007-12-07 Amylin Pharmaceuticals Inc Amilina y agonistas de amilina para tratar enfermedades y trastornos siquiatricos.

Similar Documents

Publication Publication Date Title
JP2008534627A5 (ja)
JP2019031502A5 (ja)
Bourne et al. Sleep disruption in critically ill patients–pharmacological considerations
Kruk-Slomka et al. Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: mechanism of action and possible interactions with cholinergic system
JP2010535252A5 (ja)
JP2014517050A5 (ja)
JP2008538582A (ja) 精神病性障害の治療または予防のための新規の治療的組み合わせ
JP2010529118A5 (ja)
JP2007523168A5 (ja)
WO2007002516A3 (en) Improved dosage forms for movement disorder treatment
JP2005506370A5 (ja)
JP2008540356A (ja) 薬物乱用の治療方法
EP2283843A3 (en) Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)
NO20092231L (no) Arylvinylazasykloalkan-forbindelser og fremgangsmater for deres fremstilling og anvendelse derav
ATE451368T1 (de) Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems
JP2007516193A5 (ja)
JP2011507861A5 (ja)
JP2014506933A5 (ja)
MX2010009643A (es) Derivados de 2-aminoquinolina como antagonistas del receptor 5-hidroxitriptamina (5a).
JP2022180531A5 (ja)
JP2007509960A5 (ja)
JP2008533079A5 (ja)
JP2011524898A5 (ja)
JP2011500589A5 (ja)
JP2011500819A5 (ja)