JP2002316937A - Anti-allergic agent containing plant extract - Google Patents

Abstract

(57) [Summary] [PROBLEMS] To provide a novel and safe cosmetic composition. [Solution] Orange, olive, artichoke,
The present invention provides an antiallergic agent, a histamine release inhibitor, an arachidonic acid metabolic activity inhibitor, a contact dermatitis inhibitor, and a cosmetic composition containing one or more plant extracts selected from miracle fruits. . [Effect] Antiallergic action, histamine release inhibitory action,
It has arachidonic acid metabolic activity inhibitory activity and contact dermatitis inhibitory activity, and also has skin inflammatory diseases (eg, redness, eczema, edema,
Swelling), atopic dermatitis, rough skin, etc. In addition, it can also be used for cosmetic compositions and other general foods and drinks.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antiallergic agent, a histamine release inhibitor, and an arachidonic acid metabolic activity containing one or more plant extracts selected from spinach, olives, artichokes and miracle fruits. The present invention relates to an application to an inhibitor, a contact dermatitis inhibitor or a cosmetic composition.

[0002]

2. Description of the Related Art Today, environmental conditions are deteriorating, lifestyles are changed, and stress is increased due to the complication of social life. More and more people suffer from allergic diseases, rough skin, dry skin and the like. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, as its increase is screaming not only in children but also in a wide range of ages up to adults.

[0003] In order to eliminate foreign substances (bacteria, pollen, ticks, etc .: antigens), the living body should produce biological components (antibodies, lymphocytes, etc.) to counter the foreign bodies. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into four types.

[0004] The central cells constituting the immune system are a group of two types of lymphocytes called B cells and T cells mainly present in bone marrow, thymus, spleen, lymph nodes, blood and the like.
B cells are involved in humoral immunity (type I-III allergy)
In response to the antigen, the cells differentiate and proliferate into plasma cells (antibody-producing cells), and secrete antibodies outside the cells. Further, T cells are mainly involved in cell-mediated immunity (type IV allergy), and when they react with an antigen, they become activated T cells that differentiate, proliferate, and destroy the antigen.

[0005] Type I allergic reactions are the most frequent type, and involve mainly immunoglobulin E (IgE) antibodies. The onset process is the first step in which IgE antibodies are produced from B cells against exogenous antigens, the IgE antibodies adhere to mast cells and basophils, and sensitization is established. Histamine, serotonin, SRS-A and other chemical mediators are released from the second stage, the released chemical mediators cause smooth muscle contraction, increased vascular permeability, edema, nerve stimulation, etc. It is roughly divided into the third stage of developing allergic symptoms.

[0006] A type II allergic reaction is a disorder reaction that occurs when cells in a tissue are destroyed by IgG or IgM antibodies. When an antibody binds to an antigen cell, the complement system (a serum protein system that is activated by the effector action of the antibody to kill the antigen cell or significantly accelerate the degradation of the antigen by phagocytic cells) is chain-activated. The cells are destroyed because a complex is formed that destroys the cell membrane. When the activated components of the complement system bind to cells, antigen cells are captured by phagocytic cells such as polymorphonuclear leukocytes and macrophages, decomposed, and removed. On the other hand, during the activation of the complement system, a substance called anaphylatoxin, which has an action of significantly promoting the degradation of antigens by phagocytic cells, is generated. It also has the effect of increasing the permeability of capillaries, the effect of contracting smooth muscle, and the effect of releasing histamine from mast cells, so that when it is excessively produced, various allergic symptoms will be manifested.

[0007] Type III allergic reactions are mainly caused by IgG antibodies, but their onset is caused by a complex mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. Antigen-antibody conjugates produced by binding antibodies to antigens are used in blood vessels, kidneys, joints,
It deposits on tissues such as the skin and activates the complement system. When the amount of conjugate is high, the complement system is over-activated to produce anaphylatoxins, which may increase vascular permeability or cause inflammation. Also, when phagocytic cells try to remove antigen-antibody conjugates by the action of anaphylatoxin, lysosomal degranulation reaction occurs, and various types of hydrolases such as proteases in lysosomes are released outside the cells, Tissue and cell damage progresses and type III allergy develops.

[0008] Type I-III allergic reactions are all reactions by humoral immunity, a reaction appears 2-3 minutes after contact with the antigen, and the response is maximized in more than 10 minutes. Type IV allergic reactions appear after a few hours and are called delayed allergies because they take 48-72 hours to reach a maximum. This allergic reaction is a reaction by cell-mediated immunity. A part of T cells reacts with an antigen to become activated T cells, and when this reacts with the antigen again, various inflammatory factors called lymphokines (macrophage chemotactic factor, Release lymphocyte chemotactic factors, macrophage activating factors, vascular permeability factors, etc.). These act to eliminate the antigen, but if this reaction progresses excessively, allergy develops as a disorder reaction.

[0009]

Many of the conventionally used anti-allergic agents have an action point relatively clear.
It is a drug for diseases caused by type allergic reactions. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act in the third stage. Most of them are synthetic pharmaceuticals, and have a problem in side effects.

On the other hand, the most active research on antiallergic agents involved in type I allergic diseases is a drug which suppresses the release of chemical mediators and exhibits an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second step, such as drugs, has not been found to have sufficient efficacy, and specific antiallergic drugs against type II, type III and type IV allergic reactions have also been found. There is no present.

[0011]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have tried to screen substances that are excellent in antiallergic action, have no side effects, and are gentle on the skin from plants that are natural products. As a result, it has been found that one or more plant extracts selected from spinach, olives, artichokes, and miracle fruits have histamine release inhibitory action, arachidonic acid metabolic activity inhibitory action, and contact dermatitis inhibitory action. , Or allergic skin inflammatory diseases containing these (eg,
Redness, edema, eczema, swelling, etc.), atopic dermatitis,
Alternatively, the present invention has been completed by providing a highly safe cosmetic composition which is excellent in prevention and improvement of skin and scalp troubles such as rough skin.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION As used in the present invention, "ouren" refers to the family Ranunculaceae and the genus Copti.
s) plant: Spinach (Coptis japonica Makino), but other species of the same genus, C. japonica Maki
no var.japonica), Seribaouren (C. japonica Makino)
var.dissecta Nakai), Koseribourouren (C. japonica
Makino var major), orchid (C. chinensis), triangular leaf yellow
(C.deltoides), Emeinoren (C.omeiensis), Yunnan Oren (Ct
eetoides), C. quinquesecta, short calyx yellow (C. ch)
inensis var.brevisepala), C.teeta, honey bee
(C. trifolia), Baikaouren (C. quinquefolia Miq.)
Etc. can also be used. Extraction sites include flowers, spikes, pericarp, fruits, stems, leaves, branches, foliage, stems, bark, rhizomes, root bark,
Roots, seeds or whole plants can be mentioned, but rhizomes are preferably used.

"Olives" are defined as Oleacea.
e) Olive (Olea L.) plant: Olive (Olea europ)
aea L.), but other O.chrysophylla L
am., O.europaea var.sylvestris (Mill.) Brotero, O.pan
iculata, O.welwitschii and the like can also be used. Extraction sites include flowers, spikes, pericarp, fruits, stems, leaves, branches, foliage,
Trunks, bark, rhizomes, root bark, roots, seeds, pods, whole plants and the like can be mentioned, but preferably the leaves are used.

"Datura thistle" refers to the Asteraceae family (Compo
sitae), Artichokes (Cynara)
L.) Plant: Artichoke (Artichoke) (Cyna
ra scolymus L.)
(C. cardunculus L.), C. syriaca Boiss., Etc. can also be used. Extraction sites include flowers, spikes, pericarp, fruits, stems,
Examples thereof include leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds, pods, whole plants, and the like. Preferably, a flower (bud) portion is used.

"Miracle fruit" refers to the family Acatetsu (R
utaceae), a plant of the genus Synsepalum: Miracle fruit (Miracle berry) (Synsepalum dulcificum)
D. (= Sideroxylon dulcificum A. DC.)), But other congeners can also be used. Extraction sites include flowers, spikes, pericarp, fruits, stems, leaves, branches, foliage, stems, bark, rhizomes,
Root bark, roots, seeds, pods, whole plants and the like can be mentioned, but preferably a fruit part is used.

The extracts of spinach, olives, artichokes, and miracle fruits used in the present invention refer to various parts (seed, bark, root bark, root, pericarp, etc.) of each plant as they are or after crushing and squeezing. What you did. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more kinds. It can also be used in a state where the extracts are combined.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Various plant extracts of spinach, olives, artichokes and miracle fruits are applied to antiallergic agents, histamine release inhibitors, arachidonic acid metabolic activity inhibitors, contact dermatitis inhibitors and cosmetic composition agents. Drying, concentration, dilution, or the like may be arbitrarily performed depending on the type and form to adjust.

The plant extracts of the present invention, such as spinach, olive, artichoke, and miracle fruit, can be used as antiallergic agents, histamine release inhibitors, arachidonic acid metabolic activity inhibitors, contact dermatitis inhibitors, and cosmetics. Although it can be contained in a cosmetic composition, its content is not particularly limited, and the anti-allergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor, and the form of the cosmetic composition It varies slightly depending on the type, quality and expected degree of action, and is usually 0.0001% by weight or more (hereinafter, expressed as%), preferably 0.001 to 50%.
If the content is less than 0.0001%, the effect cannot be expected sufficiently.

The antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor and cosmetic composition of the present invention may be added to the above-mentioned essential substances, and the effects of the present invention may be added, if necessary. Can be produced by arbitrarily selecting and using the components and additives exemplified below within a range that does not impair the content. The content in the preparation is not particularly limited, but usually 0.0001 to 50%. preferable.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, squalene,
Squalane, pristane, hydrogenated products of these fats and oils (hardened oils, etc.) and the like.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Natural fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, and lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, and 2-ethylhexane Synthetic fatty acids such as acids and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol;
Synthetic alcohols such as hexyldecanol, isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its crosslinked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol, isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other healthy and cosmetic effects, improvement of taste, imparting and stabilizing of color tone, aroma, gloss, etc. It can be used for the purpose of thickening, preserving, etc. Furthermore, in addition to this, we expect various cosmetic and pharmacological effects of each raw material known so far, and aim to increase the intended effect by combining them,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

Specific plants (crude drugs) as raw materials include:
For example, almonds (herring peach), eyes (blue leaves), blue moss
(Seifu Fuji), Aoki (Aoki), Aogiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass root), red pheasant or pheasant (land yellow),
Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Akebi
(Kidori), Asa (Jin Asako), Malva Asagao or Asagao
(Toshiko), hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), asunaro, acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abiu, abiulana, rape and abemaki `` fruit '' ,Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Jade bamboo), Amana (Kojingi), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkok, Sugimorigeito,
Hosoagaitou, Aoagetoi, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Urizusensen), Arcana (Alcanna), Algarrobo (Cave), Altea, Arnica, Alpinia or Katsumadai
(Sorghum), aloe (lux), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokko (benzoic acid), yellow sapote, scutellaria (biliary head), epimedium or primrose (inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubeil), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), kidney beans, oolong tea, fennel (fenka), wheat (chibusanoki), ukiyagara (sanryou), ugiskagura `` fruit '', himeuikyo, turmeric (tsukuji), duckweed (buoying), umebasaishin Or Keirinsaishin or Aushousaishin (spicy), Usvenia oyster, Useniitachioi oyster, Uchoran, Utsubogusa (summer hay), Udo or Shishiudu (Qiang Jing, independent, Tang alone), Unya de Gato (Unkaria, Cats Claw),
Uba tea, plum (crow plum `` seed, pulp ''), vulgar oak, uwaurushi (kusaco peach), unshu mandarin (chen skin), unboku, estragon, elephant grass (Ezo five valley), ezozuri orchid, echinashi (hosobamurasakibarengiku), enoshida, enokida Mushrooms), shrimp and cassia tora (Kyoko), El Campre, Elderberry "fruit",
Elemi, eryngii or pre-lotus eringi, engju (sophora, sophora rice), pea, ogre or kibanaohagi
(Astragalus), Narco Yuri or Kagi Kurumabanaruko Yuri (Yoshisei), Oohisasanoyuki or Sasanoyuki, Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Public engineering incense), Ooturafuji (anti-mystery), Oobako (forehead child, car front grass), Oobaa (Keju Leak, Hakuto Okina), Toucan (Haruko), Toucan cactus, Oobanokera or Okera (white juku), Oobansarusubari (Banaba), Oobayashibashi "fruit", Ooishigusa (cereal grass), Oumiacatetsu, Omihacateshi or Omihasabi Hawthorn (Yamako), coconut palm, barley (barley), oka, okazeri (snake bed), okra `` fruit '', oguruma (turnover), okururihigotai (yushu ashi, indigo sashimi), panax or carrot (carrot) ), St. John's wort or Scutellaria perforatum or St. John's wort (brother cut grass), St. John's wort ( ), Onami fir (blue ears), Onigorumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut (Hihayu), Ominaeshi ), Oyuco,
Dutch mustard (cress), Dutch jelly, Dutch biyu, Dutch honeysuckle, oregano, orange `` fruit, pericarp '', calyxio (ripe yellow), cacao `` fruit, pericarp,
Seeds '', oysters (persimmons `` leaves ''), kagikazura (crop hooks), oysters or kantosori (rensensou), kakiran, gaku hydrangea, cassia, casino, mulberry (fruits `` fruit ''), gajutsu (razatsutsu), kashiwa (Kazuki, Kazaha), Kascarilla, Kascara sagrada, Gypsophila, Kasenso, Kanixa (Kin-sato), Kaniwa, Carnation, Kanokoso (Yoshikone), Hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, capoknoki `` seed '', kahoku sansho (shopper),
Gama (bamboo), chamomile or roman chamomile, chamomile
(Weeds), camu cam (duckling), color, karaksakeman, crow squirrel or cinnamon squirrel (gold melon), crow squirrel (midsummer), oats wheat, guarana `` seed '', karahoo
(Pak), Karaya, Galyu, Karin (Gourd), Garcinia, Kawamidori, Kawara Psycho (Koryo greens, Inverted grass), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Quarter, Quarter), Aoha),
Japanese mugwort (inchinko), kansui (sweet), licorice
(Licorice), cantaraasa, candelilla, cantola, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry,
European strawberry), Kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum,
Oak, oak, oak, oak, oak, oak, oak, pheasant, oak, kid's walnut, kizuta, kidachi aloe, kichichi mint, kina, chinoki, quinoa, quinoa, yellow oak, Pigeonpea, Gymnema sylvesta, Kimmenkaku, cabbage, cabbage `` immature fruit '', caraway, cucumber, gyoryu (Nishikawayanagi, teriyaki), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), Kumquat `` fruit '', Kinkiju, Ginsekai, kimbusen, betel,
Gold Finch (Gianlin), Kinran, Ginran, Kinryohen, Guapeva Vermelha, Guava `` Fruits '', Guayule, Quercus Infectria (Gallery), Kukui Nuts, Kugenumaran, Cucumbers (Gigi, Gycago, Gycago Leaf, Skin Bone), Red-crowned sedge (Tenmen winter), Kuzu
(Kakkon), camphor tree, gooseberry `` fruit '', ginseng, yellowtail, gardenia, gardenia, kunugi, kupuas, kubeba, kumazasa, kumatsuzura (mawhisper), clara ), Cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black crocodile mochi (need rescue), turtle bamboo sprouts or black bamboo sprouts or cypress (extended life grass), cloves
(Cinch, cinch), Gumbai nazuna (Sekimei, Sekimeishi), Kaigai (Ikutake, Ikutakeho), Keito (Rooster corolla, Chicken cop), Gekkavidin, Geckage (laurel), Kenashi Sartoriibara (Tokubukuryo, Yamakiko), Gentian, Gennoshoko (Old Tokusa), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Obenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara
(Tachibana Skin)), Koshinbara (Monthly Flower), Kosui Minka, Kozo (Fruit), Kocha (Tea), Kouhone (Rawbone), Kouhon (Straw Book, Karawara Book), Koulyan, Koryokyo
(Kora Kyo), Cilantro `` fruit '', Kouen (Huanglian),
Koganebana (yellow gon), cowberry (Koshibachi), coconut `` fruit '', goshyu (goshuyu), goshostrawberry (covered bonko), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaf '', kobushi or magnolia ( Koibo), Burdock (burdock, burdock), Kobotoru, Sesame (sesame), Sesame spruce (Ginseng), Gomushi (Gomiko), Sanekazura or Binankazura or Matsubusa, Wheat (wheat), Rice or rice bran `` red bran, white bran '', Rice oil, cola acuminata "seed", cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, kondurango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button or syna button or cinnamon (weird sen), cherry
(Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasabagin , Sage Modaka (Sawaka), Sweet potato, Sugar cane, Sugar beet, Sun jujube (Satsuma jujube), Saffron (Bamboo safflower, West safflower), Sapodilla, Sapotea marillo, Pomelo `` fruit '', Saponsou, Salmon berry `` Fruit '', Sarasin
(Masahima), Saranshito (Sand Ai Sashimi), Salvia (Sage),
Sawagikyo (Yamakona), Sawagurumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (Sanjin ginseng), Sanshuyu (sanshuyu), Sanshoyu (sansho), Sunzucon (Yamato) Root), shea
(Karite), Cyano (fruit), Shiitake (Shiitake), Sion
(Shien), Deer bean, Dikitaris, Shikunshi (Kimiko),
Perilla or Aodiso or Chirimendiso or Catamediso
(Persimmon leaves, persimmon), rosewood, linden, cinnamon,
Chinese forsythia (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiroyishimeji, bunashimeji, honjimesi, shirotamogitake), shimokren (spicy), shimotsukesou, potato, peony (peony), shajin
(Samsin), Jasmine (Matsurika), Jano-Mige (Wheaten winter), Juro-Kusa-shage, Skull gypsophila, Sku-shamitsu (Sandin, condensed sand), Juzudama, Shiro "fruit", Shunlan, Ginger palm, Ginger (Ginger) ,
Jouzan hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku `` Fruits '', Shirakashi `` Seeds '', Silane (Byanchu), Shirogoshi Butterflies `` Seeds '', White clover (Clover), White adzuki bean (Chicken bone grass), White iris (Small iris), White rape (Flower), White pine
Shirominanten (Tamimi Minami), Cinchonasakusylbra, Jingkoge (Mizuka, Mizukahana, Shenchohana), Cinnamon, Cinnammum cassia (cinnamon bark), Watermelon (watermelon), Honeysuckle
(Gold and silver flowers, Shinobi winter), sorrel (acid pattern), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), sugina (question thorn), suberhide
(Horse Tongue, Horse Tongue), Plum "Fruit", Surugaran
(Oran), Pinus sylvestris `` cone '', larch, Scots larch, Scots walnut, Scots blossom, Scots sycamore, Scots dandelion, Scots cypress (malonie), Scots pear `` fruit '', Scots sap, Scots Albino
(Juniper, Juniper), Yarrow (milfoil), Rose of the valley, European cornflower, European mistletoe, Western mint or Western mint, Western horseradish, Japanese horseradish, Sekisho (Iris)
(Sakurasecekku, Kokkisecekku, Obananasecekku, Okinawawasecekku, Honsecekku, Kochosecekku, Shikakusecekku, Kibananosecekku) (Dendrobium, Ishimasu), Cedron (Boshishuboku), Zeniaoi,
Hirohasenega, senega, seri, celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna `` fruits and leaves '', senninsou (large tate),
Assemblage (drug), Sengoku, Soka (grass), Elephant Chestnut, Soshinwabai, Buckwheat `` seed '', Somenimo, Broad bean, Rhubarb (daihuang), Japanese radish, soybean, Daidai (orange peel, Kikomi), Takasagorurigotai (Southeast Ai) Sashimi), Takasaburo (Dried lotus grass), Takatodai (Daigyo), Takawarabi
(Inu spine), Dark sweet cherry "fruit", hollyhock, hollyhock (thyme, momoka), hollyhock
(Hikai), Twill willow, tamarind `` seed '', onion, tamshiba (spicy), taro (fruit, leaf, root bark), tarayou (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia
(Tengui button), Tarui, Tanuki bean, Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Gambakohide) or Shirobana dandelion or Moko dandelion, Dammar, Cherry `` Fruits '', Tigaya `` Fruits, roots, buds '', Chikusetsu carrot (Bamboo ginseng) , Chicory, chancapiedra (Kidachikomikansou), tulip, chocolate nose, Korean daisou (Ohio), Korean lance (Wuyi), Korean sagebrush
(Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukushisakaneran, Tsukuritake (mushroom),
Tsuchiakebi, Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsumukusa (Duckweed grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (What's neck crow), Tsuruna (Kankyo), Tsurujinjin (Four leaf ginseng), Tsurumame, Tsuwabuki, Deiko , Teuchigurumi, duberry `` fruit '', tengusa, tencha (tencha),
Tendai-yaku (crowd drug), Pepper (winter melon), Toukagi Kazura, Pepper (bansho), Touki (Toki), Tokinsenka
(Marigold), touhou locust, tounabena (river cut),
Corn or corn hair (Nanban hair), horned rice mochi (female child), gentian or Korean gentian
(Dragon bile), horsetail (pirate), dog dove (jujube), radish (root), red sea bream or beetle mosquito or stag beetle, eucommia (Tochu `` bark, leaves, roots ''), ash (skin bark), tomato,
Tragant, triacanthus `` seed '', eustoma, tormentilla, dronoki, trolloom, tongue bean, Niseria berry `` fruit '', potato or yam (herbal medicine), nagikadada (butcher bloom), naginata kouju, nazuna, rapeseed, or seaweed Satsume), Natsumikan, Jujube (daijutsu), Naniwaibara (Kanekurako), Navena (intermittent), Nameko, Peanut (peanut),
Nanten (Minami Tenmi), Namban Karamushi (ramie), Smell violet, Nigaki (Maki), Nigamogi (Gum), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabunikei
(Caesar bark) or Keishi (Keishi), Grey-eared plover, Chinese chive (Niriko), Elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (fivefold), leek, nemoki or neb or nebi Or Nemlinoki or Jigokubana (Healing), Thistle
(Ohi), Noibara (real fruit), Nozuka Kazura (Ryoyohana), Nokotome, Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hyindou,
Hauchiwa, Pau Dosé, Hakamauraboshi (Bone Crushing), Hakuka Yumato, Hakusanchidori, Hakusen (ringworm skin), Hakuruberry `` Fruit '', Hakobe (general ripening), Hashibami (Haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (Netherlands jellies), naked mussels, batata, honeysuck or medake (bamboo-boiled), patchouli, mints (lightly-loaded, lightly-leaved leaves), mustard beans, tomatoes ( Yokuinin), Hanasuge (grandmother), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanilla bins, Papaya, Japonica
(Rat malt grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hakimakiran, hamagou or honeysuckle mackerel (vine troglodytes), hamasuge (kosuke), hamabishi (sitriko), hamanas (maikai flower), Hamabofu (Hama Wind), Hamamelis,
Palm, rose (rose), balata, balata rubber tree, agaric (aratake, white-faced agaricus, usukimori nokasa), haran, pariurus (Pleurotus hamanatum), parietaria, harkanran, balsamina (perimeter,
Bitter gourd), harnile (yu bark, yu white bark, yuba), barbasco, harindou, handaikai (beach large sea), breadfruit,
Hiougi (sun dried), lizard ginseng (party), pecan nuts, giganbana (silver, vines), Higulmadaria, Higotai, Hishi (Hisomi), pistachio, beet, Aitsuba (stone reed), Aedes aegypti, daisies (daisy),
Hinata no Kozuchi (cow knees), Hinomi bulbul, Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu (Tama Aoi), Himegama (Kagami), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta `` Fruits '', Byakushi Chickpeas “fruits”, chickpeas, lentils, below-flowers, broadleaf oysters, broadleaf oaks (Hakuto Okina), loquats “fruits, leaves, stems”, betel nuts (large clothing skin, arecarots), puerh tea (pu-cha), houtou kazura (southern rattan) , Butterflies, butterflies (winter flowers, winter leaves), fujibakama (orchid grass), fuji bean
(Tonboshi), Fujimodoki (Chautia japonica, Cinnamon), grape `` fruit, pericarp, seeds, leaves '', beech, Fuyushinatsukutake mushroom (Cordyceps sinensis), Brazilian liquorice, Brazilian carrot,
Brazilian palm, Brazilian elephant palm, black currant `` fruit '', blackberry, blañen, plum `` fruit '', furcellaria, blueberry (Prunus avium), prune, floral blanka, blonde psyllium, bundou (green soybean), hazelnut, loofah ,
Hetkaran, safflower (safflower), Henneken, Belladonna,
Berry "fruit", Persair, Peruvian berg, Pereschia grandifolia, Cryptomeria or duckweed
(Keiten), Boysenberry `` fruits '', Butterflies or Elderweed or Nendowe or Haeukigi Kokia (skin), Hosairan, Balsam's blossom (Fengsen, acute child, osteophyte), Potteria sapota, Potteria lucuma, Spinach, Bohu
(Windbreak), spinach, physalis (Torone), honoki
(Japanese magnolia, Park), Bokeh (Gourd), Hosoba Aburagiku (Gyoku), Hosobaoguruma, Hosovanaokera (Sojutsu), Hosobanokirinsou (Kageten Sanshichi), Hosobabarengiku, Bodaiju (Bodaiju), Button (peony `` flower '') , Leaves, stems, bark ''), buttonpi (peony bark), hops, jojoba, borage (ruriichisha),
Bordeaux, Whiteberry Berries "Fruit", Hong Onik (Niku Ji Ryo, Daigei), Hong Sekkoku (Iron Bark, Sparrow Mountain)
Mizurutennansha (Tennan star), Maitake (Maitake), Ephedra (Maoh), Maca, Macadamia nut, Margaret
(Mokshungiku), Makuri (Seaweed), Magwa (Mulberry white bark `` bark, leaves ''), Magnolia splengeri, Masarampuba, Masaranzuba do Ceara, Masheira
De Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaf,
`` Bark, roots '', Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Bittersweet), Mulberry `` Fruits '', Quince,
Malein (below mou squid), mango, mangosteen, mansagna (andesukamitsure), mansugurumi, mandarin "fruit", mannentake (reishi), pheasant
(Kikumi fruit) Green peppermint, mimosa,
Ginger, myrrh, myrobaran, wheat waragiku, mugwhale
(Moku Geun), Mukunoki, Mukuroji (extended skin), Munya, Purple (purple root), Purple or purple (pearl), Purple maize, Purple purple (Kunming chicken blood wisteria), Megakansa Opuntica, Mehajiki (Masamaki), Mebougi, Melaleuca, Melissa, Melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), ilex, mokko (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry , Moroheiya
(Burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal plate) , Mistletoe (willow parasitism), willow (river willow, twill willow, weeping willow, red willow, cat willow, dog puppy willow, kinuyanagi, koryanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi,
(European willow, fox, willow tree), willow leaf `` leaves, stems '', yabugarashi, yabukouji (purple gold beef),
Japanese tobacco (Tsurusui, Tenmeisei), Japanese pokeweed (land), Japanese alder (Yamaharu), Japanese peach (Yumemei), Japanese sagebrush, Eucalyptus, Yukinoshita (Tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', lily, Artemisia, mugwort (Aiba),
Raigan (Rainmaru), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, fruit '', ratania (clameria), raccoon or shallot (scallop white), lavender, longan (longan meat), agave (Aonour agave, fukurin) Agave), Ryokucha (green tea), Apple `` fruits, seeds, leaves, roots '', gentian, rubus or suabisimus (sweeten), lullama thistle (urajirohigotai, Xinjiang indigo head), litchi (litchi, lichi nucleus), lettuce (Chisha), Red currant `` Fruit '', Red pitaya, Lemon `` Fruit '', Lemongrass, Forsythia or Chinese forsythia (forsythia), Astragalus, Lumbai (wax plum), Waxy palm, Lokon (Yoshi, Azuki), Loganberry `` Fruit '' , Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Cottonweed Remokou
(Chiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usbaaonori, Susiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaaousa (Aosaa), algae [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanoli, Juzumo
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulumimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinori, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himebiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanigusa, Simi, Harigane, Lotus genus:
Lotus lotus, genus genus: squid
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadals, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragon
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Hatakesakinokokihiba, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Phalaenopsis: Himejira, Chaboflavidium, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Materials derived from animal raw materials include cockscomb extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or its degradation product, cow or pig. Extract of brain tissue, collagen water (acid, alkali,
Enzymes, etc.) Decomposed products, collagen derivatives such as water-soluble collagen or acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products or their derivatives, silk proteins and their degradation Products or derivatives thereof, swine or bovine blood cell proteolysates (globin peptides), bovine or swine hemoglobin hydrolysates (hemin, hematin, heme, protohem,
Heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) )
etc.

[0046] Materials derived from plant or animal raw materials include any sites derived from genetically modified products and cell fusions.
Cells, tissues, organs, metabolites and the like can also be used.
Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.

(14) Marine components Seawater such as deep water, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifelfango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Rice fermented extract,
Fermented extract of rice bran (red bran, white bran), euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of leguminous plant, lactic acid bacteria of coconut plant Fermented products, etc.

(16) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazolines Derivatives, pyrimidine derivatives,
Dioxane derivatives, camphor derivatives, furan derivatives,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escalol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening Agents Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, amberjack, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(22) Promoting action of turnover / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Japanese horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley) etc.

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clover, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(27) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, propolis and the like.

(28) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoates, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (Polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactant (odor, etc.) Cetyltrimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitive No. 101, Photosensitive No. 201, Photosensitive No. 401, N-long-chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kudin, propolis, etc. .

(29) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its Salt, sodium lactate, mini-sasanishiki extract, natto metabolite, natto extract, loofah water, birch (birch) or sap of Akamatsu

(30) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, salvia, elderberry, bollige, buttonpi), seaweed extracts and the like.

(31) Hair Agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(32) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(36) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(40) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(41) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(42) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, camphor essential oil, mandarin essential oil, Eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(43) Dyes and Colorants Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye, Turmeric Dye, Endu Dye, Krill Dye, Persimmon Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, cooling agents, stabilizers, emulsifiers,
Vegetable protein and its degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, Foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorants / deodorants, bittering agents, seasonings, etc. are raised. An additive or synergistic improvement of the inventive or other cosmetic effects can be expected.

The dosage forms of the antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor and cosmetic composition of the present invention are arbitrary, and include capsules, powders, granules, solids, It can be used in the form of a liquid, gel, air bubble, emulsion, cream, ointment, sheet or the like.

More specifically, for example, basic preparations such as medicinal preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, etc .; , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth / hair restorations, etc., makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
It can be applied to various products such as deodorant, sanitary cotton, wet tissue, and can be used for general food and drink.

The method of addition to the antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor and cosmetic composition of the present invention is described below.
It may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0081]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and formulation examples, but the present invention is not limited to these examples.

(Production Example 1) 100 g of each dried plant of spinach, olive, artichoke, and miracle fruit was immersed in 1 L of a 20% ethanol solution, extracted at room temperature for 3 days and nights, and then filtered to extract (dried) Solids: Ouren
1.0-3.0%, olives 0.5-2.5%, artichoke 0.
8 ~ 2.4%, Miracle fruit 1.5 ~ 3.2%) about 1.0 ~ 3.0
kg.

(Production Example 2) 100 g of each dried plant of spinach, olive, artichoke, and miracle fruit was mixed at 50 ° C. with 1 L of an equal mixture of 30% propylene glycol solution and 30% 1,3-butylene glycol solution. The mixture was extracted by gently heating for 6 hours, filtered by suction, and the extract (dry solids:
About 1.0-3.0% of orange, 0.5-2.5% of olives, 0.8-2.4% of artichokes, 1.5-3.0% of miracle fruits)
Get 1.0-3.0kg.

(Production Example 3) 100 g of each dried plant of spinach, olive, artichoke, and miracle fruit was immersed in 1 L of purified water (about 80 ° C.), heated and extracted for about 5 hours, and filtered and extracted. Stuff (dry solids: spinach 1.0 ~
3.0%, olives 0.5-2.0%, artichoke 0.8-2.
6%, Miracle Fruit 1.5-3.0%) about 1.0-3.0kg.

(Production Example 4) 100 g of each dried plant of spinach, olive, artichoke and miracle fruit was extracted with 100 g of purified water (normal temperature) for about 5 hours.
Filtration yields about 1.0-3.0 kg of extract (dry solids: 1.0-3.0% of spinach, 0.5-2.0% of olives, 0.8-2.5% of artichokes, 1.5-3.0% of miracle fruits).

(Test 1) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, comp, a histamine release reagent from rat mast cells, was used.
Test method to release histamine at ound48 / 80 (J. Soc. Cos
The extract obtained in Production Example 3 was examined using met.Japan, Vol.25, No.4, P.246 (1992)).

"Test Method and Evaluation Method" a. After evaporating the solvent under reduced pressure, the sample extract was redissolved in purified water to a solid concentration of 0.1% and used for the test. The same concentration of dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a control. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 1), and the results are shown in FIG.

<Equation 1> Histamine release inhibition rate (%) = ｛1- (AC / B-
C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample to mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 1, it was confirmed that the spinach, olive, artichoke and miracle fruit extracts of the present invention had a very excellent histamine release inhibitory action as compared with dipotassium glycyrrhizinate.

(Test 2) Inhibition test of arachidonic acid ear edema In the type I allergic reaction, the reaction between the IgE antibody and the antigen destroys the phospholipids of the cell membrane to release arachidonic acid, which is affected by the action of various enzymes. Prostaglandin, one of the transmitters, is metabolized to SRS-A,
Develops various allergic symptoms. Therefore, the substance having the action of suppressing the metabolic activity of arachidonic acid can be expected to be used as an antiallergic agent. In this test, a hydrophilic ointment containing the extract obtained in Production Example 1 was prescribed, and the method of Shinno et al. (“The effect of 3.4-dihydroxychalcones on mouse arachidonic acid ear edema”: The 113th Annual Meeting of the Pharmaceutical Society of Japan) The study was conducted with reference to FIG.

"Test Method and Evaluation Method" a. The sample extract was concentrated by distilling off the solvent under reduced pressure, and a hydrophilic ointment containing 10.0% in terms of solid content was produced and used by a conventional method. An ointment containing dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a positive control. b. Measurement of edema swelling rate
Three hours before, a mouse (Slc: ICR female mouse, about 6 weeks old) was applied to the right pinna carefully so as to be carefully rubbed. Immediately before arachidonic acid application, wipe off the ointment adhering to the pinna,
20 μL of 5% arachidonic acid (SIGMA) dissolved in acetone
After one hour, the auricle was punch-excised (5.0 mm).
Similarly, the left pinna was resected, and the arachidonic acid ear edema swelling rate was measured from the weight difference between the left and right pinna. For the determination, the ear edema suppression rate was calculated by comparing with the ear edema swelling rate of the control group to which only the base was applied as a blank. In each test system, 8 to 9 mice were used, and the results are shown in Table 1.

[0092]

[Table 1]

(Test Results) As shown in Table 1, the artichoke extract of the present invention had an excellent ear edema inhibitory activity almost equivalent to dipotassium glycyrrhizinate. Also, ours,
The olive and miracle fruit extracts also showed an ear edema inhibitory action, although not as much as the positive control, and were confirmed to have an arachidonic acid metabolic activity inhibitory action.

(Test 3) Contact dermatitis suppression test In the contact dermatitis reaction, T
Lymphocytes, upon contacting the same antigen again, release various lymphokines that activate macrophages and lymphocytes, causing an inflammatory response. Therefore, a substance that suppresses a series of inflammatory reactions that occur against the same antigen can be expected to be used as a delayed (IV) allergic agent. In this test, a hydrophilic petrolatum ointment containing the extract obtained in Production Example 1 was prescribed, and the method of Nakamura (Nihon Pharmacological Journal, 76, 595 (1)
980)), its effect on paraphenylenediamine-induced contact dermatitis reaction was examined.

"Test Method and Evaluation Method" a. The sample extract was concentrated by distilling off the solvent under reduced pressure, and a hydrophilic petrolatum ointment containing 10.0% in terms of solid content was produced and used by a conventional method. An ointment containing dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a positive control. b. Measurement of Edema Swelling Ratio First, 0.1 mL of 2.5% paraphenylenediamine / acetone: olive oil = 4: 1 (hereinafter, PPD) was continuously applied to the shaved abdominal skin of a mouse (BALB / c female mouse: about 8 weeks old) for 3 days. After application, sensitization was performed, and after 5 days, the test drug (20 mg) was applied to the unilateral auricle three times at hourly intervals. One hour after the final application, the test drug was sufficiently wiped off, and 20 μl of PPD was applied to the auricle to raise it. 17 hours after the inoculation, the test drug was applied again to the auricle that had been induced twice at 1 hour intervals, and then, 19 hours after the insult, the test drug was thoroughly wiped out. mm) and weighed. For the determination, the swelling rate was measured from the difference in the weight of the untreated auricle, and the inhibition rate of dermatitis was calculated in comparison with the control group. In the test, 8 to 9 mice were used, and the results are shown in Table 2.

[0096]

[Table 2]

(Test Results) As shown in Table 2, the extract of spinach, olive, artichoke and miracle fruit of the present invention may have an inhibitory effect on contact dermatitis, although it is slightly weaker than the inhibition rate of dipotassium glycyrrhizinate as a positive control. confirmed.

(Test 4) Safety test (1) Skin primary irritation test The extracts obtained in Production Examples 1 to 4 were prepared at a solid content of about 2.0%.
This was applied to the skin of a Hartley-type guinea pig (female, 3 per group, weight: 300 to 350 g) having a shaved back at a rate of 0.03 mL per 2 × 2 cm ² square. Judgment was carried out 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed, and the animals were determined to be negative.

(Test 5) Safety Test (2) Skin Cumulative Irritation Test The extracts obtained in Production Examples 1 to 4 had a solid content of about 2.0%.
It is prepared so that the flank is shaved (2 × 4 cm ² )
Hartley guinea pigs (female, 3 per group, weight 32
0.5 g / animal) was applied to the skin (about 0 g) once a day, 5 times a week. Application was over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and on the day after the last application day, using primary irritancy scoring as an index of erythema and edema. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged to be negative.

(Test 6) Safety test (3) Single dose toxicity test The various plant extract powders obtained in Production Examples 1 to 4 were adjusted with purified water to a concentration of 12.5%. The dose of kg was orally administered to a ddy mouse (male and female, 5 mice per group, 5 weeks old), which had been fasted for 16 hours before the test, and observed over time with the appearance and degree of toxic symptoms. did. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD ₅₀ is 2,00
It was 0 mg / kg or more, and it was judged as a safe substance.

(Prescription Examples) Production of Various Preparations Various cosmetic compositions according to the present invention were produced. The formulation examples are shown below, but the invention is not limited thereto.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: Olive extract of Production Example 2 B: Olive extract of Production Example 2 C: Artichoke extract of Production Example 2 D: Miracle fruit extract of Production Example 2 * Extract of any one of A to D 5.0 10. Preservative (paraoxybenzoate) qs 11. Purified water 100 residue

(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Miracle fruit extract of Production Example 3 1.0 6. Miracle fruit hot water extraction Product 1.0 7. Hot water extract of salvia 1.0 8. Butyl hydroxyanisole 0.1 9. Preservative (benzalkonium chloride) qs 10. Fragrance (fennel water) qs 11. Purified water 100

(Formulation Example 3) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Datura thistle 50% ethanol Extract 2.0 6. Miracle fruit 50% ethanol extract 1.0 7. Moroheya 50% ethanol extract 1.0 8. Antibacterial and preservative (thiamine lauryl sulfate) qs 9. Fragrance (fennel water) qs 10. Purified water 100 Residue

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Miracle fruit 50% 1,3-butylene glycol extract 2.0 5. Olive 50% 1,3-butylene glycol extract 2.0 6. Green tea 50% ethanol extract 1.0 7. Hamamelis 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (thiamine lauryl) Sulfate) Appropriate amount 11. Fragrance (lavender water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 5) Two-layer lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Extraction of spinach in Production Example 2 Product 2.0 6. Artichoke extract of Production Example 2 2.0 7. Spicy 30% ethanol extract 1.0 8. Genoko ginger 30% ethanol extract 1.0 9. Ascorbic acid 0.2 10. Astringent (sodium sulfocarbonate) 0.2 11. Preservative Agent (phenoxyethanol) qs 12. fragrance (bodaiju water) qs 13. purified water 100 balance

(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Olive 50% propylene glycol extract 2.0 8. Grapefruit 50% propylene glycol extract 2.0 9. Peach leaf 50% propylene glycol extract 2.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitizer) No. 201) Appropriate amount 14.Fragrance (Touki water) Appropriate amount 15.Purified water 100 residue

(Formulation Example 7) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethylcellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Spinach extract of Preparation Example 2.0 6. Olive extract of Preparation Example 3 1.0 7. Saxifrage 50% ethanol extract 1.0 8. Soapwort 50% ethanol extract 1.0 9. Preservative (paraoxybenzoate) suitable amount 10. Perfume (sage water) proper amount 11. Purified water 100 residue

(Formulation Example 8) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 Miracle Fruit 50% Ethanol Extract 1.0 9. Seaweed (Hibamata) 50% Ethanol Extract 1.0 10. Preservative (paraoxybenzoate) qs 11. Spice (Touki Water) qs 12. Purified Water 100

(Formulation Example 9) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Olive 50% 1,3-butylene glycol extract 1.0 7 .Natural thistle 20% 1,3-butylene glycol extract 2.0 8. Liquid shea fat 1.0 9. Western plum 50% 1,3-butylene glycol extract 2.0 10. Preservative (acrinol) 0.1 11. Fragrance (sage water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 10) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Miracle fruit 50% 1,3-butylene glycol extract 2.0 10. Eurene 50% 1,3-butylene glycol extract 2.0 11. Melissa 50% 1 , 3-butylene glycol extract 2.0 12. Preservative (paraben) qs 13. flavor (toque water) qs 14. purified water 100

(Formulation Example 11) Face wash cream weight% 1. myristic acid 25.0 2. stearic acid 5.0 3. tallow fatty acid 5.0 4. propylene glycol 10.0 5. potassium hydroxide 6.0 6. coconut oil fatty acid diethanolamide 6.0 7. artichoke 50% 1,3-butylene glycol extract 2.0 8. Shiitake 50% 1,3-butylene glycol extract 2.0 9. Pine 50% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11. Royal jelly extract 0.1 12. Preservative (salicylic acid) 0.1 13. Appropriate amount of fragrance (sage water) 14. Residual to make purified water 100

(Formulation Example 12) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Olive extract of Production Example 4 B: Olive extract of Production Example 4 C: Artichoke extract of Production Example 4 D: Miracle fruit extract of Production Example 4 * A- Extract of any one of D 5.0 10. Glycyrrhetinic acid 1.0 11. Preservative (salicylic acid) 0.1 12. Appropriate amount of fragrance (Touki water) 13. Purified water 100 residue

(Formulation Example 13) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Olive 60% 1,3-butylene glycol extract 0.5 5. Artichoke 60% 1 , 3-butylene glycol extract 0.5 6. Linden 30% 1,3-butylene glycol extract 0.5 7. Tormentilla 30% 1,3-butylene glycol extract 0.5 8. Odorikosou 30% 1,3-butylene glycol extract 0.5 9.Polyethylene powder 0.5 10.Bacillus natto metabolite 0.5 11.Amino acid (glycine, glutamine, etc.) 0.5 12.Appropriate amount of preservative (undecylenic acid, phenol) 13.Appropriate amount of pH adjuster 14.Appropriate amount of perfume (grape water) 15.Purification Water 100 and the rest

(Formulation Example 14) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Olive 30% 1,3- Butylene glycol extract 0.5 14. Birch 50% ethanol extract 0.5 15. Safflower 50% ethanol extract 0.5 16. Preservative (paraben) qs 17. perfume (apple water) qs 18. Purified water 100

(Formulation Example 15) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Artichoke 30% 1, 3-butylene glycol extract 0.5 6. Miracle fruit 30% 1,3-butylene glycol extract 0.5 7. Knapweed 30% 1,3-butylene glycol extract 0.5 8. Astragalus 50% ethanol extract 0.5 9. Antioxidant (Butyl hydroxytoluene) Appropriate amount 10.Perfume (Touki water) Appropriate amount

(Formulation Example 16) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glycerin monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11. Kaolin 3.0 12. Talc 3.0 13. Color pigment 1.0 14. Dry powder of the olive extract of Production Example 1 0.1 15. Production Example 2 Dry powder of Japanese spinach extract 2.0 16. Safflower hot water extract powder 0.5 17. Preservative (paraben) qs 18. Fragrance (lavender water) qs 19. Purified water 100 balance

(Formulation Example 17) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Olive 50% propylene glycol extract 2.0 7. Miracle fruit 50% propylene glycol extract 2.0 8. Rosemary 30% ethanol extract 1.0 9. Collagen hydrolyzate 1.0 10. Antibacterial and preservative (thiamine lauryl sulfate) Appropriate amount 11. pH adjuster Appropriate amount 12. Fragrance (hamamerisu water) Appropriate amount 13. Purified water 100 residue

(Formulation Example 18) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Artemis thistle 30% ethanol extract 1.0 6. Aloe 50% ethanol extract 1.0 7. Hange 50% ethanol extract 1.0 8. Peony 50% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed silk solution 1.0 11. Peony 50% ethanol extract 0.5 12. Antibacterial and preservative (benzalkonium chloride) qs 13. perfume (bodaiju water) qs 14. purified water 100 residue

(Formulation Example 19) Rinse% by weight 1. Stearyl trimethyl ammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Yak 50% ethanol extract 1.0 6. Miracle fruit 50% ethanol extract 1.0 7. 50% ethanol extract in water 1.0 8. Trehalose solution 1.0 9. Hydrolyzed silk solution 1.0 10. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 11. Appropriate amount of fragrance (chamomile water) 12.Remaining with purified water 100

(Formulation Example 20) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yak hot water extract 1.0 6. Koboku 50% hot water extract 1.0 7. Miracle fruit 50% hot water extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 12. Perfume (apple water) Appropriate amount 13. Residual water with purified water of 100

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Olive 50% ethanol extract 1.0 6. Parietaria 50% ethanol extract 1.0 7. Tonin 50% ethanol extract 1.0 8. Seaweed (Hijirimen, Kombu) 50% ethanol extract 1.0 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 11.Fragrance (chamomile water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 22) Hair tonic% by weight 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: The spinach extract of Production Example 1 B: Production Example 1 Olive extract C: Artichoke extract of Production Example 1 D: Miracle fruit extract of Production Example 1 * Any one of extracts A to D 5.0 5. Preservative (paraben) qs 6. Purified water 100 And the rest

(Formulation Example 23) Hair tonic% by weight 1. L-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6. Olive 50% methanol extract 2.0 7 Sodium hyaluronate solution 1.0 8. Carboxymethyl chitin solution 1.0 9. Whey solution 1.0 10. Antibacterial and preservative (paraben) 0.1 11. Appropriate amount of fragrance (rose water) 12. Purified water 100

(Formulation Example 24) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Olive 50% propylene glycol extract 5.0 3. Miracle fruit 50% propylene glycol extract 2.0 4. Bodampi 70% propylene glycol extract 2.0 5. Vitamin E derivative 0.5 6. Pepper tincture 0.5 7. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Beef hematin solution 0.5 11. Birch 50% propylene glycol extract 2.0 12. Amino acids (glycine, glutamine, etc.) 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Perfume (rosemary) appropriate amount 15. Purified water 100 residue

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Artichoke thistle 20% 1,3-butylene glycol extract 5.0 3. Eurene 20% ethanol extract 2.0 4. Koboku 50% 1,3- Butylene glycol extract 5.0 5. Sakura 50% 1,3-butylene glycol extract 5.0 6. Canthari tincture 0.5 7. Pantothenic acid derivative 0.5 8. Resorcin 0.5 9. Glycyrrhizic acid 0.5 10. Salicylic acid 0.5 11. Hydroxyethyl chitosan solution 0.5 12. Elastin hydrolyzate 0.5 13. Astragalus 50% 1,3-butylene glycol extract 2.0 14. Soybean 50% 1,3-butylene glycol extract 2.0 15. Elastin hydrolyzate 0.5 16. Antibacterial and preservative ( Paraben) 0.1 17. Perfume (lavender) Appropriate amount 18. Purified water 100 residue

(Formulation Example 26) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. A: Dry powder of spinach extract of Production Example 3 B: Olive of Production Example 3 Extract dry powder C: Artichoke extract dry powder of Production Example 3 D: Miracle fruit extract dry powder of Production Example 3 * Any one of extracts A to D 10.0 5. Pigment (Gunjo Pink) Appropriate amount

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Artichoke 70% ethanol-extracted powder 1.0 5. Oatwort 70% ethanol-extracted powder 1.0 6 .70% ethanol extracted powder from chamomile 1.0 7. Mulberry bark 70% ethanol extracted powder 1.0 8. Novara 70% ethanol extracted powder 1.0 9. Orange juice powder 1.0 10. Pigment (yellow iron oxide) qs 11. Fragrance (hamamerisu water) Appropriate amount

(Formulation Example 28) Coating protective agent A gauze or liniment cloth is impregnated with a formulation liquid prepared by mixing an appropriate amount of miracle fruit 30% ethanol extract, antibiotics, anti-inflammation, etc., and attached to the wound. Alternatively, a 30% ethanol extract of artichokes may be directly applied locally and covered with gauze or the like.

(Test 7) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. The test used was a panel of 10 people aged 20 to 38 who were suffering from skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis. Was applied to the face for 3 months. Also, for 10 people (20 to 40 years old) who have the same skin disease on the scalp and hairline, after daily hair washing, an appropriate amount of the hair tonic of Formulation Example 22 was applied to the scalp.
Usage tests were performed by applying over a period of months.

Further, the bath preparation of Formulation Example 26 was also applied to 10 20-45 year-olds suffering from skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis, for 1 month for 3 months.
Once a day, they were bathed in bath water in which an appropriate amount of bath agent was dissolved, and a use test was performed. As a control, a liquid prepared by exchanging purified water in the same manner except that the extract of milk, oat, olive, artichoke and miracle fruit of the present invention were removed from milk and hair tonic was used. The bath preparation was prepared in the same manner as in the present invention, except that the dry powder of the extract of spinach, olive, artichoke and miracle fruit of the present invention was replaced with anhydrous sodium sulfate instead of the dry powder. The evaluation was performed according to the following criteria. The results are as shown in Table 3 and the numbers in the table represent the number of persons. No one complained of abnormalities on the skin or scalp during the use period.

[Effect of improving skin (scalp) disease] Effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were improved. Slightly effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were slightly improved. Ineffective: No change from before use.

[0133]

(Test Results) As shown in Table 3, a cosmetic composition (emulsion, hair tonic,
Use of the bath agent) was confirmed to be effective against skin and scalp diseases such as eczema, itch, rough skin and atopic dermatitis.

[0135]

EFFECTS OF THE INVENTION One or more plant extracts selected from spinach, olives, artichokes and miracle fruits according to the present invention have an inhibitory effect on histamine release, an inhibitory effect on arachidonic acid metabolic activity and an inhibitory effect on contact dermatitis. Have
It is safe to use externally for humans or animals. Therefore, it can be used as an antiallergic agent, a histamine release inhibitor, an arachidonic acid metabolic activator, and a contact dermatitis inhibitor, and can be applied to all forms of pharmaceuticals (medicines, quasi-drugs, cosmetics). Further, the cosmetic composition of the present invention can be used for skin and scalp having troubles such as allergic / contact skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), atopic dermatitis, and rough skin. Can be used for the purpose of prevention and improvement thereof, and can also be used for oral compositions and foods and drinks.

[Brief description of the drawings]

FIG. 1 is a diagram showing the histamine release inhibitory effect of an extract of spinach, olive, artichoke and miracle fruit of the present invention.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N Q U 7/021 7/021 7/06 7/06 7/075 7 / 075 7/08 7/08 7/42 7/42 7/50 7/50 A61P 29/00 A61P 29/00 37/00 37/00 43/00 105 43/00 105 113 113 113 // A23L 1/30 A23L 1/30 B 2/38 2/38 C 2/52 2/00 FF term (reference) 4B017 LC03 LG15 4B018 MD61 ME02 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC172 AC182 AC212 AC242 AC252 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC782 AC852 AC862 AC902 AC932 AD022 AD042 AD092 AD112 AD212 AD322 AD332 AD412 AD432 AD452 AD512 AD532 AD552 AD632 CC64CC0651 C07 CC19 CC23 CC25 CC33 CC37 CC38 CC39 DD05 DD23 DD27 DD31 DD33 EE07 EE09 EE10 EE11 EE12 EE13 EE17 EE22 EE28 EE42 FF01 4C088 AB12 AB26 AB32 AB64 AC03 AC04 AC05 AC06 AC11 AC13 BA09 BA10 CA05 CA06 CA07 ZAC13 Z09

Claims (5)

[Claims] 1. An orange, an olive, an artichoke,
An antiallergic agent comprising one or more plant extracts selected from miracle fruits. 2. An orange, an olive, an artichoke,
A histamine release inhibitor comprising one or more plant extracts selected from miracle fruits. 3. An orange, an olive, an artichoke,
An arachidonic acid metabolic activity inhibitor comprising one or more plant extracts selected from miracle fruits. 4. An orange, an olive, an artichoke,
A contact dermatitis inhibitor comprising one or more plant extracts selected from miracle fruits. 5. An antiallergic agent, an inhibitor of histamine release, an inhibitor of arachidonic acid metabolic activity, and an inhibitor of contact dermatitis according to any one of claims 1 to 4. A cosmetic composition characterized by the following.