JP2001081037A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antiallergic agent excellent in prophylaxis and amelioration of troubles in the skin/scalp such as allergic dermatitis disease and atopic dermatitis or the rough dry skin, and useful for highly safe medicaments, cosmetics, etc., by including a specific plant extract. SOLUTION: This agent comprises at least one kind of extracts from plants selected from the group consisting of (A) cacao, (B) cassia bark and (C.) aurantii nobllis pericarpium. The component A is preferably obtained from cacao seeds, the component B is preferably obtained from the bark, root bark and/or root of Cinnmomum.Cassia and the component C is preferably obtained from the maturation pericarp of Citrus unshiu. The above extract can be utilized as it is as an antiallergic agent and also can be included in a cosmetic composition preferably in a content of usually >=0.001 wt.%, especially 0.2-20 wt.%. The extract is preferably obtained by squeezing various parts of various plant bodies as they are or after being crushed, or by extracting with a solvent various parts of various plant bodies as they are or after being crushed.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cocoa, keihi,
The present invention relates to an application to an antiallergic agent, a histamine release inhibitor, an arachidonic acid metabolic activity inhibitor, a contact dermatitis inhibitor, or a cosmetic composition containing one or more plant extracts selected from thugs.

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agent, depilatory, depilatory, shaving treatment, after-shave lotion, pre-show lotion, shaving cream, etc.),
4) Pharmaceutical or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent liquids, hair dyes, hair styling, hair tonics, hair growth / hair restoration, etc.), 5 ) Bath agent used by throwing it into bath water, 6) Other, axillary deodorant and deodorant, deodorant, sanitary goods, sanitary cotton, wet tissue, mouth freshener (for example,
Brushing, mouthwash, etc.).

[0003]

2. Description of the Related Art In recent years, owing to recent deterioration of environmental conditions, changes in lifestyles, and increased stress due to the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, drug urticity have occurred. The number of people suffering from allergic diseases such as measles, rough skin, and dry skin is increasing. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, as its increase is screaming not only in children but also in a wide range of ages up to adults.

[0004] Originally, in order to eliminate foreign substances (antigens such as bacteria, pollen, mites, etc.) which have entered the body, it is necessary to produce biological components (antibodies, lymphocytes, etc.) to protect the body. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into four types.

[0005] The central cells constituting the immune system are a group of two types of lymphocytes called B cells and T cells mainly present in bone marrow, thymus, spleen, lymph nodes, blood and the like.
B cells are involved in humoral immunity (type I-III allergy)
In response to the antigen, the cells differentiate and proliferate into plasma cells (antibody-producing cells), and secrete the antibody outside the cells. In addition, T cells are mainly involved in cell-mediated immunity (type IV allergy). When they react with an antigen, they become differentiated, proliferate, and become activated T cells that destroy the antigen.

[0006] Type I allergic reactions are the most frequent type, and mainly involve immunoglobulin E (IgE) antibodies. The onset process is the first step in which IgE antibodies are produced from B cells against exogenous antigens, the IgE antibodies adhere to mast cells and basophils, and sensitization is established. Histamine, serotonin, SRS-A and other chemical mediators are released from the second stage, the released chemical mediators cause smooth muscle contraction, increased vascular permeability, edema, nerve stimulation, etc. It is roughly divided into the third stage of developing allergic symptoms.

A type II allergic reaction is a disorder reaction that occurs when cells in a tissue are destroyed by IgG or IgM antibodies. When an antibody binds to an antigen cell, the complement system (a serum protein system that is activated by the effector action of the antibody to kill the antigen cell or significantly accelerate the degradation of the antigen by phagocytic cells) is chain-activated. The cells are destroyed because a complex is formed that destroys the cell membrane. When the activated components of the complement system bind to cells, antigen cells are captured by phagocytic cells such as polymorphonuclear leukocytes and macrophages, decomposed, and removed. On the other hand, during the activation of the complement system, a substance called anaphylatoxin, which has an action of significantly promoting the degradation of antigens by phagocytes, is generated. It also has the effect of increasing the permeability of capillaries, the effect of contracting smooth muscle, and the effect of releasing histamine from mast cells, so that when it is excessively produced, various allergic symptoms will be manifested.

[0008] Type III allergic reactions are mainly caused by IgG antibodies, but their onset is caused by a complex mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. Antigen-antibody conjugates produced by binding antibodies to antigens are used in blood vessels, kidneys, joints,
It deposits on tissues such as the skin and activates the complement system. When the amount of conjugate is high, the complement system is over-activated to produce anaphylatoxins, which may increase vascular permeability or cause inflammation. Also, when phagocytic cells try to remove antigen-antibody conjugates by the action of anaphylatoxin, lysosomal degranulation reaction occurs, and various types of hydrolases such as proteases in lysosomes are released outside the cells, Tissue and cell damage progresses and type III allergy develops.

[0009] Type I-III allergic reactions are all reactions by humoral immunity, a reaction appears 2-3 minutes after contact with the antigen, and the response is highest in more than 10 minutes. Type IV allergic reactions appear after a few hours and are called delayed allergies because they take 48-72 hours to reach a maximum. This allergic reaction is a reaction by cell-mediated immunity. A part of T cells reacts with an antigen to become activated T cells, and when this reacts with the antigen again, various inflammatory factors called lymphokines (macrophage chemotactic factor, Release lymphocyte chemotactic factors, macrophage activating factors, vascular permeability factors, etc.). These act to eliminate the antigen, but if this reaction progresses excessively, allergy develops as a disorder reaction.

[0010]

Many of the conventionally used anti-allergic agents have an action point relatively clear.
It is a drug for diseases caused by type allergic reactions. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act in the third stage. Most of them are synthetic pharmaceuticals, and have a problem in side effects.

On the other hand, the most active research on antiallergic drugs involved in type I allergic diseases at present is a drug which inhibits release of chemical mediators, and exhibits an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second stage, such as drugs, has not been found to have sufficient efficacy, and specific antiallergic drugs against type II, III and IV allergic reactions have also been found. There is no present.

[0012]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have tried to screen substances that are excellent in antiallergic action, have no side effects, and are gentle on the skin from plants that are natural products. As a result, cacao,
In one or more plant extracts selected from cinnamon and cock
Histamine release inhibitory action, metabolic activity inhibitory action of arachidonic acid, found to have contact dermatitis inhibitory action,
It is also excellent for prevention and improvement of skin and scalp troubles such as allergic skin inflammatory diseases (for example, redness, edema, eczema, swelling, etc.), atopic dermatitis, and rough skin, which contain them, and are safe. The present invention has been completed by providing a highly cosmetic composition.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The term “cocoa (cocoa, cocoa tree)” used in the present invention means “Sterculia”.
ceae), a plant of the genus Cacao (Theobroma L.): Cacao (Theobr)
oma cacao L.).

"Keihi: cinnamon bark" means camphoraceae (Laur
aceae), a plant of the genus Camphor (Cinnamomum Schaeff.):
Cinnamomum cassia Blume
The bark, root bark, and roots are used, but other species of the same genus, Nikkei (Cinnamomum sieboldiiMeisn.),
innamomum japonicum Sieb.ex Nakai) can also be used.

"Chimpi: Chen-skin" refers to Rutaceae (Rutacea).
e), plant of Citrus genus: Citrus
s unshiu Marcov.), but other mature plants (Rutaceae) can be used.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The extract of cacao, cinnamon and chimney used in the present invention means that various parts (seed, bark, root bark, root, pericarp, etc.) of each plant are directly or crushed and squeezed. What you did. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more kinds. It can also be used in a state where the extracts are combined.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion-exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The various plant extracts of cacao, calyx and chimpanzee depend on the type and form of the antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor or cosmetic composition to be applied. Drying, concentration, or dilution may be arbitrarily performed and adjusted.

The cocoa, cinnamon and chimpanzee plant extracts of the present invention can be used as anti-allergic agents, histamine release inhibitors, arachidonic acid metabolic activity inhibitors and contact dermatitis inhibitors as they are, and can be used in cosmetic compositions. Although it can be contained, its content is not particularly limited, and anti-allergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor, type, quality, Depending on the expected degree of action,
0.001% by weight or more (hereinafter, represented by weight%)
0.2-20% is good. If the content is less than 0.001%, the effect cannot be expected sufficiently.

The antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor or cosmetic composition of the present invention may be used in addition to the above-mentioned essential substances and, if necessary, the effects of the present invention. Can be produced by arbitrarily selecting and using the components and additives exemplified below as long as the above is not impaired.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguahe (Omiten palm), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Towushi) ), Hydrangea (hydrangea), ashitaba (morning leaf), adzuki (red azuki bean), acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), Amachaworu, Amadokoro (Jade bamboo), Amana (Hikarigi), Amaranthus (Amaranthus), Amaranthus (Hymoptera), Senninkoku, Sugimorigeitou, Hosoaoigaito, Aogetoudo, Haribiyu, Amaranthus hippochondriacus, Amigasayuri or Birnamo Alcanna), Argarrobo (cabbage), Altea, Arnica,
Alpinia or red sea bream (Sou-zuku), aloe (lux),
Aloe vera, angelica, apricot or hon apricot (almond jelly), ansokkou (benzoic), Ikakozolina (bile head), epimedium or potato valerian (inyokaku), rush (light heart grass), knotweed (tiger stick root), yew (first place), Strawberry, fig (fructose `` fruit, leaf ''), strawberry (first time), strawberry (winter aoiko), ichiyakuso (one medicinal herb), ginkgo (ginko `` seed, leaf ''), Itohimehagi (enshi), carob, carob bean ( (Telelexi), Inubiyu (Honagainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwa-hi-chi-chi), iwahiba or iwa-matsu (makikashiwa), oolong tea, fennel-wheat, wheat (Chibusanoki), Ukiyagara (Mitsuryo), Uguisukagura `` fruit '', Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishi Or Keirin Herba Asari or Scots. Recently (Hosokarashi), malva sylvestris, marshmallow, Prunella vulgaris (summer hay), Udo or Angelica (羌活, Udo, Tang Udo), Unyadegato (Uncaria, cat's claw), Uva tea, plum
(Umei `` seed, pulp ''), Vladimir, Owaurushi (Kusaco peach), Estragon, Ezoukogi (Ezo Goka),
Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enoki mushroom), Ebisugusa or Cassia Tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Pre Lotus Elinge, Ende
(Moesa, Sophora rice), oak or Kibana Ogi (Assembly Radix), Ouren (Yellow Ren), Ookarasuri (Karokon), Ooguruma
(Civil engineering incense), Otsu-la-fuji (self-defense), Psyllium (Komazenko,
Forefoot grass), Toucan (Haruko), Oobanokera or Okera (white jitsu), Oobansanasubari (Banaba), Oobayashishabushi "fruit", Ooyama hawthorn or Hawthorn (Yamakoko), Ousei (Nalco lily, Kagikurumabanarukoyuri), Oyusa or Yukiosano Barley (barley), Greater grass (Grass grass), Oka, Okazeri (Snake bed), Ogurma (Wrapping), Okra `` fruit '', Panax ginseng or Panax ginseng (Ginseng), Hypericum or Lycopodium perforatum or St. John's wort (Brother cutting grass)
Odorikosou (intermittent), Onamimomi (blue ears), Onigiri,
Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Onyuri or Sasayuri or Hakatayuri
(Yuri), Ononis, Halibut (Hihayu), Ominaeshi (Loose sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeybee, Olive `` fruit, seed, leaf '',
Oregano, orange "fruit, pericarp,"
(Ripe yellow), persimmon (persimmon `` leaf ''), persimmon (hook), persimmon or perilla (rensensou), cassia, casino
(Kozoumi `` fruits ''), gajutsu (shajutsu), kasiwa (shaki), cascarilla, cascara sagrada, gypsophila, kanikusa (kinsato), kaniwa, kanokoso (valerian grass root), birch or shidare kamba (shirakaba) , Pumpkin, capoknoki "seed", kahoku sansho (shopper), tama (bamboo yellow), chamomile or roman chamomile, chamiyadee (tsukusa), camu cam
(Duck), Karaku salmon, Calla uri or Sinara cucumber (Gourd melon), Callas bishaku (Midsummer), Raspberry, Guarana `` seed '', Karahoo (Popular), Karaya, Karin (Gourd), Garcinia, Kawamidori, Kawara psycho (Koryosai) ,
Japanese white grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaran Ginseng (Aokko), Kawamuragi (Inchinko), Kansui (Kansai), Licorice (Lucifera), Kantarasa, Candelilla, canto, canna, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry,
(European strawberry), Kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum flower), Simakangiku, Daffodilium), Catalpa (Azumino), Rigid japonica (Yotei) Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachimina, Kina, Kinoki (Shincona, Akakinoki), Quinoa (Quinoa), Kihada (Huangbashi),
Gymnema sylvesta, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), kumquat `` fruit '', betel, kinmizukiki (senzaku grass), guava "Fruit", Guayule, Quercus Infectria
(Gallery), Kukui Nuts, Kukui (Gugi, Kikougi, Kikou Leaves, Skeletal Bark), Kusagi Kazura (Tenmen Winter), Kuzu (Kuzukane),
Camphor tree, gooseberry `` fruit '', ginseng, yellow gardenia, gardenia, kunugi, kupuasu,
Kumazasa, Kumamatsuura (horse whip grass), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit /
`` Leaves '', buckthorn, black squirrel (needs rescue), black blossoms, or crab (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Bay laurel, kenashi sartorii rose (Tobukuryo, Yamakiko), gentian, gennoshoko (Old treasured),
Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan
(Koji, Tachibana, Olivenimikan, Fukuromikan,
Sagami Koji, Ponkan, Santara (Tachibana skin)), Koshinbara (Monthly flower), Kouzi mint, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Koryan, Koryokyo ( Kojiro), cilantro (fruit), coconut (kohuangren), koganebana (yellow gon), lingonberry (koshibachi), coconut palm (fruit), goshyu (goshuyu), goshoichigo (covered bonsai), pepper (pepper), kopaiba balsam , Coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame seeds (ginseng), goji (sesame), scallop or binankazura or Matsubusa, wheat (wheat) ),
Rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera “seed”, fenugreek “fruit”,
Colombo, Konzulango, Kombu, Konjac, Comfrey (Shinbari grass), Sisal (Sisal Asa), Sakisima button or Sinata button or Sinensensou (Eisensen), Sakura (Oshimashima cherry, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Someiyoshino, Takanezakura, Kasumizakura, Chojizakura, Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawashari), sweet potato, sugarcane,
Sugar beet, Sun jujube (acid jujube), saffron
(Bamboo safflower, West safflower), Pomelo `` fruit '', Soapwort, Salmonberry `` fruit '', Sarashina-sho (Masahima), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamagomo), Sangre degrad (Croton ), Panax ginseng, Panax ginseng (Sax carrot), Sanshuyu (sanshuyu), Sansho (Sansho), Sandzukon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake mushroom), Zion ( (Shien), Dictalis, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Katamamenjiso (Shiyo-leaf, Shiso), Rosewood, Shinanoki, Shinanohonoki, Chinese Forsythia (Forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshureshimaji) , Honjimeshi, Shimotamogitake), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Ma Rika),
Jano-beard (Bakumon winter), Gypsophila paniculata, Sku-shamitsu (sand sand, sand compaction), Juzudama, Palm `` fruit '', ginger (ginger), jadean hydrangea (Joyama), shobu
(Irises, iris roots), shojiku `` fruits '', shirakashi `` seed '', white walnuts `` seed '', white adzuki bean (chicken bone), white iris (small iris), white napatsuta `` flower '', white nanten (minamitenmi), shinkonasakushi Rubra, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi), Suiba
(Acid model), swim berry `` fruit '', stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (infestation), purslane (horse ken, horse dent), plum berry, pine cone pine cone '', Larch, edible walnuts, walnuts, walnuts, hawthorn, dandelion, horse chestnuts (malonie), pears `` fruits '', plum blossoms, walnuts
(Elder), Atlantic shrew (juniper, juniper), Achillea millefolium (Mirfoil), Atlantic rose, Atlantic anemone butterfly, Atlantic mistletoe, Atlantic mint or Atlantic mint, Horseradish, Sekisho
(Iris), Sekoku (Ishimasu), Cedron (Bowshokuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Sengoku (Kawakyu), Sengshinren (Shinshinren), Sengdan, Sembri (Drug), Senna `` Fruit, Leaf '', Senninsou (great tate), Soka (grass), buckwheat "seed", Somei potato, Rhubarb (daioh), radish, soybean, daidai (orange peel,
Kikomi), Takasaburo (Dried lotus grass), Takatodai (Daikyo),
Takawarabi (Dog), Dark Sweet Cherry "Fruit",
Tachioi, Tachijakoso (thyme, Hyoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), taro tree `` fruit, leaf, root bark '', talwi, tanjin (dansan), dandelion (gakko) Or white dandelion or moko dandelion, dammar, cherry `` fruit '', twigs `` fruit, roots, buds '', ginseng carrots (bamboo ginseng), chicory, chancapiedra (kichichikomikansou), kosendaidai (daihuang), kosensen Ii), Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukutake (Mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose),
Twigweed (duckling grass), vine adzuki (red azuki bean), tsuldokudami
(Hanshu crow), Tsuruna (Ban apricot), Ginseng (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (Tencha), Tendaiyaku (Wakayaku), Touga (Fruit gourd), Toukagizura, Capsicum (Pan pepper), Touki (Toki), Tokinsenka (Marigold), Tounabena (River cut), Corn or corn hair (Nanban hair),
Ligustrum (Female Sadako), Eucalyptus or Korean Rosemary (Ryubin), Tokusa (Pirates), Dokudami (Jyuku), Tokon (root), Toshishi or Mamedaoshi or Porpoise, Eucommia (Tonaka `` bark, leaves, roots '') , Ash (qin peel), tomato, tragacanth, triacanthus `` seed '', tormentilla, dronoki, trolo-mallow, Niseria berry `` fruit '', potato or yam (herbal medicine), nagikadada (butcher bloom), naginata kouji, nazuna, rapeseed, natto bean Or vertical shrimp (swords), jujube, jujube
(Dajutsu), Naniwaibara (Kanekurako), Navena (Continuous), Nameko, Narco lily (Yoshisei), Peanut (peanut), Nanten (Minami Tenmi), Nambangarashi (ramie), Nigaki (Makiki),
Artemisia (bitter mite), nutmeg, leek (niriko), elderberry
(Bone grafted `` fruits, flowers, stems, leaves ''), garlic (garlic), nurde (fivefold), leeks, nemoki or nebu or nebi or nemlinoki or digokubana (healing), thistle (ouji), neubara (real fruit), Yarrow, sawdust (maehu), nobara, peach, palm, pineapple `` fruit '', hibiscus (bussouge, furinbussouge, roselle), hayindou, hakamauraboshi (bone crushing supplement), hakusen (ringworm skin), hakuruberry `` fruit '', Hakobe (revelation), hazel (haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (holland jelly), naked mussels, batata, hachik or madake (bamboo-boiled), patchouli, mint (light-weight, light-weight leaves), pearl barley (yokunin) , Hanasuge (Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shitsuturi), Vanillabins, Papaya, Scotch (Rice koji), Pahalobobo, Hub `` whole plant, stem, leaf '', Paprika, Hamago or Hitsuba Hamago Child), Hamasuge (Kazuke), Hamabishi
(Ritsuko Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamamelis, rose (rose), agaric (aratake,
White agaricus, Usukimori no kasa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigauri), Harunire (Yellow, Yuzhi bark, Yuba), Harlindou, Handaikai (Giantai), Breadfruit, Hiougi Ginseng carrot (party),
Pu'er tea (peo tea), pecan nuts, giganbana (stone and vines), Hishi (hishomi), pistachio, beet, hitsuba (stone reed), hitsuba enishida, hinota nokozuchi
(Cow knee), cypress, hiba, castor, sunflower, pepper,
Himeuzu (Aoi), Himegama (incense crab), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjackyu, Hiyu `` Fruit '', Bilobaoi,
Hiro-Okinagusa (Hakuto Okina), Loquat `` Fruits, Leaves, Stems '', Betel Nuts (Large Cloth, Betel Loaf), Butterbur Kazura (Southern Rattan), Butterbur, Butterfly Poppy (Foliage Flower, Winter Leaves), Fuji Bacama (Rancho), Fuji Bean (Tan Bean) ), Grape "fruit, peel, seeds,
Leaf '', beech, sycamore (caterpillar), licorice brazilian, carrot, black currant `` fruit '', blackberry, plum `` fruit '', flucellaria, blueberry (Prunus avium), prunes,
Blond psyllium, bundou (mung bean), hazelnut, loofah, safflower (safflower), henneken, belladonna,
Berry `` fruit '', Peruvian bergh, beetwort or duckweed (Keiten), Boysenberry `` fruit '', duckweed or elderweed or nendowe or hawkigi kokia (terrestrial), balsam (horizon), acute child, ostrich ,
Bofu (windbreak), spinach, physalis (Torone), honoki (Japanese thick, magnolia), bokeh (wood melon), bonsai (green apricot), bonsai linsou (Sanju Jingtian), bonsai valengus, bodaiju (bodice tree), Button (peony `` flower, leaf, stem,
Bark), buttonpi (peony bark), hops, jojoba, bordeaux, white berries `` fruits '', hon-oniku (meat porcelain, big art), honsekkoku (iron bark stones, sparrow mountain stones), mezul tennanshaw (tennan star) ), Maitake (Maitake), Ephedra
(Mao), maca, macadamia nuts, macri (sea grass), maguwa (mulberry white bark `` bark, leaves ''), magnolia splengeri, masure (tamanousenharen, kukonkinrenka), matatabi (kiten tate), matsukasa , Pine "leaves, bark,
Roots '', Matsuhod (Bukuryo), Matico (Cordon Sillo),
Mayorum (Hanaminka), Malvanojazine (Difficult), Mulberry `` fruit '', Quince, Mango, Mangosteen,
Mansagna (Andesukamitsure), Mansugurumi,
Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima Psycho (Saiko), Mizuobako or Mizuasagao (Ryungoshi), Mizokaku (Hanbe Lotus), Misohagi
(Chikuna), beet willow or elder willow (enrichment), honeywort, honeywort, green peppermint, mimosa, mioga, miracle fruit `` fruit '', myrrh, mirobaran, wheat waragiku, mukuge (wooden), mukunoki, mukuroji (extended life skin), munya , Murasaki (purple root), Murasakisikibu or Omurasakikibu (purple beads), Murasaki maize, Murasaki natsufuji (Kunming chicken blood wisteria), Mehajiki (meadow grass), Mebokugi, Melaleuca, Melissa, melilot, melon `` fruit '', mokoyomigi, mushroom Moje (Keikoboku), Mokko (Kinka), Maple Butterfly, Peach (peach `` leaf, seed,
`` Flowers, fruits ''), sprouts, morello cherries `` fruits '', moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflower (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabashi Fruits, peels, and ears "
(Octagonal gold plate), mistletoe (parasitic willow), willow (river willow,
Twill willow, weeping willow, red eye willow, pussy willow, dog koreanagi, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, coconut palm, yamayanagi, obanyanagi, tyrikkinyanagi, foxeye willow, foxwort, bonsai
(Purple gold beef), yabu tobacco (crane squirrel, Tenna sei), pokeweed (land), yamahanoki (yamaharu), yamamomo (yangmei skin), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu Fruits, Lilies, Yogurusa, Artemisia (Aiba), Lygan (Rainuma), Lime `` Fruit '', Rye, Lacanca `` Fruit '', Raspberry `` Leaf, Fruit '', Latania (Clameria), Rakkyo or Shallot (Scallop), Lavender , Longan (longan meat), agave (Aono agave, fukurin agave),
Ryokucha (green tea), apple "fruits, seeds, leaves, roots", gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant "fruit", lemon "fruit" , Lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, wax palm, lokon
(Yoshi, Azune), Loganberry "fruit", Rosemary
(Mannenrou), Rosehip (Nobara), Wasabi, Waremokou (Jiyu) and the like.

In addition, other seawater, for example, seawater salt, seawater dried product, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific Ocean, sea mud or mud (fango) Species, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Sugiaoonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombubu , Resiliconibu, hosomekombu, mitsuishikomubu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Sujiusbanori, haiusbanori, akaminominori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus Lynch: L., L., L., L .;
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Namiami sp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Examples of the material derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow extract from the stomach, duodenum or intestine or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation product of raw milk or skim milk powder, and trehalose Or a derivative thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, yellowtail, matsuhodo, adlay, hydrangea, hops, hawthorn, eucalyptus, achillea millefolium, althea, mankeishi,
Hamamelis, yamaguwa, life-prolonged grass, bellflower, toshishi, spouse, sun-dried, mako, senkyu, dokkatsu, psycho, bohu, hamabou, ogon, peony, peony,
Gennoshoko, kakkon, licorice, five times child, aloe, ginger, safflower, green tea, black tea, asenyaku).

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Gennoshoko,
Comfrey, sage, elderberry, bollige,
Buttonpi), seaweed extract, etc.

(30) Agent for hair Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate, and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

Further, the dosage form of the antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor or cosmetic composition of the present invention is arbitrary, and capsules, powders, granules, solids, They can be used in the form of liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like.

Specifically, for example, topical pharmaceutical preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, hair removers, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
It can be applied to various products such as deodorant, sanitary cotton, wet tissue, and can be used for general food and drink.

The method of adding the antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor or cosmetic composition of the present invention may be added in advance or prepared. It may be added in the middle, and may be appropriately selected in consideration of workability.

[0079]

The present invention will be described below with reference to Test Examples and Formulation Examples, but the present invention is not limited to these.

(Production Example 1) 100 g of each dried plant of cacao, calyx, and chimpi was immersed in 1 L of a 50% ethanol solution, extracted at room temperature for 3 days and nights, and then filtered to obtain an extract (dry solids: cacao) 0.5-2.5% by weight;

(Production Example 2) 100 g of a dried product of cacao, cinnamon and chimney was added to a 30% propylene glycol solution and a 30% 1,3-
A 1 L mixture of an equal volume of butylene glycol solution is gently heated and extracted at 50 ° C. for 6 hours, filtered by suction, and extracted (dry solids: cacao 0.5-2.5% by weight, caffeine 0.8-2.4% by weight, thimp 1.5- 3.0% by weight).

(Production Example 3) 100 g of each dried plant of cacao, calyx and chimpi was immersed in 1 L of purified water (about 80 ° C.), heated and extracted for about 5 hours, filtered and extracted (dry solid). Min: 0.5-2.0% by weight of cacao, 0.8-2.6% by weight of caffeine, 1.5-3.0% by weight of chimpi) to obtain about 1.0-3.0 kg.

(Production Example 4) 100 g of each dried plant of cacao, cauliflower and chimpi was extracted with 100 g of purified water (normal temperature) for about 5 hours, filtered and extracted (dry solids: cacao 0.5 ~ 2.0% by weight, 0.8 ~ 2.5% by weight, 1.5
~ 3.0% by weight).

(Test 1) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, comp, a histamine release reagent from rat mast cells, was used.
Test method to release histamine at ound48 / 80 (J. Soc. Cos
The extract obtained in Production Example 1 was examined using met.Japan, Vol.25, No.4, P.246 (1992)).

"Test Method and Evaluation Method" a. After evaporating the solvent under reduced pressure, the sample extract was redissolved in purified water so as to have a solid content concentration of 0.5% by weight, and used for the test.
The same concentration of dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a control. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 1), and the results are shown in FIG.

<Equation 1> Histamine release inhibition rate (%) = ｛1- (AC / B−)
C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 1, the cocoa, cinnamon and chimney extracts of the present invention were confirmed to have a very excellent histamine release inhibitory effect as compared with dipotassium glycyrrhizinate, and were used as antiallergic agents. it can.

(Test 2) Inhibition test of arachidonic acid ear edema In the type I allergic reaction, the reaction of the IgE antibody and the antigen destroys the phospholipids of the cell membrane and releases arachidonic acid, which is affected by the action of various enzymes. Prostaglandin, one of the transmitters, is metabolized to SRS-A,
Develops various allergic symptoms. Therefore, the substance having the action of suppressing the metabolic activity of arachidonic acid can be expected to be used as an antiallergic agent. In this test, a hydrophilic ointment containing the extract obtained in Production Example 1 was prescribed, and the method of Shinno et al. (“The effect of 3.4-dihydroxychalcones on mouse arachidonic acid ear edema”: The 113th Annual Meeting of the Pharmaceutical Society of Japan) The study was conducted with reference to FIG.

"Test Method and Evaluation Method" a. The sample extract was concentrated by evaporating the solvent under reduced pressure, and then a hydrophilic ointment containing 10.0% by weight in terms of solid content was produced and used by a conventional method. An ointment containing dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a positive control. b. Measurement of edema swelling rate Apply the above-mentioned ointment in advance with about 3,2,1 of arachidonic acid application.
Three hours before, a mouse (Slc: ICR female mouse, about 6 weeks old) was applied to the right pinna carefully so as to be carefully rubbed. Immediately before arachidonic acid application, wipe off the ointment adhering to the pinna,
5% by weight arachidonic acid dissolved in acetone (SIGMA) 2
0 μL was applied, and after 1 hour, the auricle was punch-excised (5.0 mm). Similarly, the left pinna was resected, and the arachidonic acid ear edema swelling rate was measured from the weight difference between the left and right pinna. For the determination, the ear edema suppression rate was calculated by comparing with the ear edema swelling rate of the control group to which only the base was applied as a blank. In each test system, 8 to 9 mice were used, and the results are shown in Table 1.

[0090]

(Test Results) As shown in Table 1, the cacao and thympi extracts of the present invention have an excellent ear edema-suppressing action almost equivalent to dipotassium glycyrrhizinate. Has an ear edema inhibitory effect,
It was confirmed to have an arachidonic acid metabolic activity inhibitory effect.

(Test 3) Contact dermatitis suppression test In the contact dermatitis reaction, T
Lymphocytes, upon contacting the same antigen again, release various lymphokines that activate macrophages and lymphocytes, causing an inflammatory response. Therefore, a substance that suppresses a series of inflammatory reactions occurring against the same antigen can be expected to be used as a delayed (IV) allergic agent. In this test, a hydrophilic petrolatum ointment containing the extract obtained in Production Example 1 was formulated and the method of Nakamura (Nihon Pharmacological Journal, 76, 595 (1)
980)), its effect on paraphenylenediamine-induced contact dermatitis reaction was examined.

"Test Method and Evaluation Method" a. The sample extract was concentrated under reduced pressure by distilling off the solvent, and a hydrophilic petrolatum ointment containing 10.0 wt% in terms of solid content was produced and used by a conventional method. An ointment containing dipotassium glycyrrhizinate (manufactured by Kishida Chemical) was used as a positive control. b. Measurement of Edema Swelling Ratio First, 0.1 mL of 2.5% paraphenylenediamine / acetone: olive oil = 4: 1 (hereinafter, PPD) was continuously applied to the shaved abdominal skin of a mouse (BALB / c female mouse: about 8 weeks old) for 3 days. After application, sensitization was performed, and after 5 days, the test drug (20 mg) was applied to the unilateral auricle three times at hourly intervals. One hour after the final application, the test drug was sufficiently wiped off, and 20 μl of PPD was applied to the auricle to raise it. 17 hours after the inoculation, the test drug was applied again to the auricle that had been induced twice at 1 hour intervals, and then, 19 hours after the insult, the test drug was thoroughly wiped out. mm) and weighed. For the determination, the swelling rate was measured from the difference in the weight of the untreated auricle, and the inhibition rate of dermatitis was calculated in comparison with the control group. In the test, 8 to 9 mice were used, and the results are shown in Table 2.

[0094]

(Test Results) As shown in Table 2, it was confirmed that the cacao, cinnamon and thimpi extracts of the present invention had an inhibitory effect on contact dermatitis, although it was slightly weaker than that of the positive control dipotassium glycyrrhizinate.

(Test 4) Safety test (1) Primary skin irritation test The extracts obtained in Production Examples 1 to 4 were prepared so that the solid concentration became about 2.0% by weight, and the back was shaved. Hartley guinea pigs (female, 3 per group, weight 300-350g)
0.03 mL was applied per 2 × 2 cm ² square of the skin. Judgment was carried out 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed, and the animals were determined to be negative.

(Test 5) Safety test (2) Cumulative skin irritation test The extracts obtained in Production Examples 1 to 4 were prepared so that the solid content concentration was about 2.0% by weight, and this was applied to the flank. Shearing (2 × 4cm
² ) 0.5 ml / animal was applied to the skin of Hartley-type guinea pigs (female, 3 animals per group, body weight around 320 g) once a day, 5 times a week. Application was over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and on the day after the last application day, using primary irritancy scoring as an index of erythema and edema. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged to be negative.

(Test 6) Safety test (3) Single dose toxicity test Various plant extract powders obtained in Production Examples 1 to 4 were adjusted with purified water to a concentration of 12.5%. The dose of kg was orally administered to a ddy mouse (male and female, 5 animals per group, 5 weeks old), which had been fasted for 16 hours before the test, and observed over time with the appearance and degree of toxic symptoms. did. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 is 2,00
It was 0 mg / kg or more, so it was judged as a safe substance.

(Prescription example) Production of antiallergic agent, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, contact dermatitis inhibitor or cosmetic composition According to the above evaluation results, the formulation examples are shown below. Each formulation example may be one manufactured by a usual method in the manufacture of each product, and only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: Cocoa extract of Production Example 1 B: Caffeine extract of Production Example 1 C: Chimney extract of Production Example 1 * A ~ Extract of any one of C 5.0 10. Preservative (paraoxybenzoate) appropriate amount 11. Purified water 100 residue

(Formulation Example 2) Cosmetic oil wt% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Chimney extract of Production Example 1.0 6. Chimney hot water extract 1.0 7. Hot extract of salvia extract 1.0 8. Butyl hydroxyanisole 0.1 9. Preservative (benzalkonium chloride) proper amount 10. Fragrance (fennel water) proper amount 11. Purified water 100 residue

(Formulation Example 3) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Extraction of 50% ethanol Liquid 2.0 6. Thympi 50% ethanol extract 1.0 7. Morohayer 50% ethanol extract 1.0 8. Appropriate amount of antibacterial and preservative (thiamine lauryl sulphate) 9. Appropriate amount of fragrance (fennel water) 10. Purified water 100

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Timpi 50% 1,3-butylene glycol extract 2.0 5. Cocoa 50% 1 , 3-butylene glycol extract 2.0 6. Green tea 50% ethanol extract 1.0 7. Hamamelis 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (thiamine lauryl sulfate) Salt) Suitable amount 11.Fragrance (lavender water) Suitable amount 12.Purified water 100 residue

(Formulation Example 5) Two-layer lotion (liquid to liquid type) wt% 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Extraction of preparation 2 Liquid 2.0 6. Hot 30% ethanol extract 1.0 7. Genoko 30% ethanol extract 1.0 8. Ascorbic acid 0.2 9. Astringent (sodium sulfocarbonate) 0.2 10. Preservative (phenoxyethanol) qs 11. Perfume (bodaiju water) ) Appropriate amount 12. Residual water to be 100

(Formulation Example 6) Carmine lotion (liquid to solid) weight% 1. glycerin 3.0 2.1,3-butylene glycol 5.0 3. ethanol 15.0 4. iron oxide (bengala) 0.2 5. zinc oxide 0.5 6. kaolin 2.0 7. Cocoa 50% propylene glycol extract 2.0 8. Grapefruit 50% propylene glycol extract 2.0 9. Peach leaf 50% propylene glycol extract 2.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitizer) No. 201) Appropriate amount 14.Fragrance (Touki water) Appropriate amount 15.Purified water 100 residue

(Formulation Example 7) Pack weight% 1. Polyvinyl alcohol 15.0 2. Carboxymethylcellulose sodium 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Cocoa extract 1.0 of Production Example 3 6. Yukinoshita 50% ethanol extract 1.0 7. Sodium soap 50% ethanol extract 1.0 8. Preservative (paraoxybenzoate) suitable amount 9. Perfume (sage water) proper amount 10. Purified water 100 residue

(Formulation Example 8) Peel-off pack wt% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 .Tempe 50% ethanol extract 1.0 9. Seaweed (Hibamata) 50% ethanol extract 1.0 10. Preservative (paraoxybenzoate) qs 11. perfume (toque water) qs 12. Purified water 100

(Formulation Example 9) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Cocoa 50% 1,3-butylene glycol extract 1.0 7 .Chimpi 50% 1,3-butylene glycol extract 2.0 8. Liquid shea fat 1.0 9. Western plum 50% 1,3-butylene glycol extract 2.0 10. Preservative (acrinol) 0.1 11. Flavor (sage water) 12.Remaining with purified water 100

(Formulation Example 10) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Thympi 50% 1,3-butylene glycol extract 2.0 10. Futandanpopo 50% 1,3-butylene glycol extract 2.0 11. Melissa 50% 1, 3-butylene glycol extract 2.0 12. Preservative (paraben) qs 13. flavor (toque water) qs 14. purified water 100

(Formulation Example 11) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Cahi 50 % 1,3-butylene glycol extract 2.0 8. Shiitake 50% 1,3-butylene glycol extract 2.0 9. Pine 50% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11. Royal jelly extract 0.1 12 .Preservative (salicylic acid) 0.1 13.Perfume (sage water) appropriate amount 14.Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. Cocoa, cinnamon or thalass extract of Production Example 1.0 10. Glycyrrhetinic acid 1.0 11. Preservative (salcylic acid) 0.1 12. Perfume (Touki water) Appropriate amount 13. Make purified water 100 Residue

(Formulation Example 13) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Cacao 60% 1,3-butylene glycol extract 0.5 5. Caffeine 60% 1, 3-butylene glycol extract 0.5 6. Shinanoki 30% 1,3-butylene glycol extract 0.5 7. Tormentilla 30% 1,3-butylene glycol extract 0.5 8. Odorikosou 30% 1,3-butylene glycol extract 0.5 9 .Polyethylene powder 0.5 10.Bacillus natto metabolite 0.5 11.Amino acid (glycine, glutamine, etc.) 0.5 12.Appropriate amount of preservative (undecylenic acid, phenol) 13.Appropriate amount of pH adjuster 14.Perfume (grape water) 100 and the rest

(Formulation Example 14) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Cocoa 30% 1,3- Butylene glycol extract 0.5 14. Birch 50% ethanol extract 0.5 15. Safflower 50% ethanol extract 0.5 16. Preservative (paraben) qs 17. Fragrance (apple water) qs 18. Purified water 100

(Formulation Example 15) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. 30% caffeine 1,3 -Butylene glycol extract 0.5 6. Thympi 30% 1,3-butylene glycol extract 0.5 7. Knapweed 30% 1,3-butylene glycol extract 0.5 8. Astragalus 50% ethanol extract 0.5 9. Antioxidant (butyl Hydroxytoluene) Appropriate amount 10.Fragrance (Touki water) Appropriate amount

(Formulation Example 16) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11. Kaolin 3.0 12. Talc 3.0 13. Color pigment 1.0 14. Dry powder of cocoa extract of Production Example 1 0.1 15. Safflower hot water Extracted powder 0.5 16. Preservative (paraben) proper amount 17. Fragrance (lavender water) proper amount 18. Purified water 100 residue

(Formulation Example 17) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Cocoa 50% propylene glycol extract 2.0 7. Chimney 50% propylene glycol extract 2.0 8. Rosemary 30% ethanol extract 1.0 9. Collagen hydrolyzate 1.0 10. Antibacterial and preservative (thiamine lauryl sulfate) 11. Appropriate amount of pH adjuster 12. Appropriate amount of fragrance (hamamelis water) 13. Residual to make purified water 100

(Formulation Example 18) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. 50% ethanol extract 1.0% 6. Aloe 50 % Ethanol extract 1.0 7. Hange 50% ethanol extract 1.0 8. Peony 50% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed silk solution 1.0 11. Peony skin 50% ethanol extract 0.5 12. Antibacterial・ Preservative (benzalkonium chloride) proper amount 13.Perfume (bodaiju water) proper amount 14.Purified water 100 residue

(Formulation Example 19) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Yak 50% ethanol extract 1.0 6. Cahi 50 % Ethanol extract 1.0 7. Peony 50% ethanol extract 1.0 8. Trehalose solution 1.0 9. Hydrolyzed silk solution 1.0 10. Antibacterial and preservative (benzalkonium chloride) qs 11. Spice (chamomile water) qs 12 .Remaining amount of purified water 100

(Formulation Example 20) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yak hot water extract 1.0 6. Koboku 50% hot water extract 1.0 7. Timpi 50% hot water extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalkonium chloride) qs 12. (Apple water) Appropriate amount 13. Residual water with 100 purified water

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Cocoa 50% ethanol extract 1.0 6. Parietaria 50% ethanol extract 1.0 7. Tonin 50% ethanol extract 1.0 8. Seaweed (Hijirimen, Kombu) 50% ethanol extract 1.0 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 11.Fragrance (chamois water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 22) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Cocoa extract of Production Example 1 B: Production Example 1 Extract of C. bean extract C: Chimney extract of Production Example 1 * Extract of any one of A to C 5.0 5. Preservative (paraben) qs 6. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. cacao 50% methanol extract 2.0 7 Sodium hyaluronate solution 1.0 8. Carboxymethyl chitin solution 1.0 9. Whey solution 1.0 10. Antibacterial and preservative (paraben) 0.1 11. Appropriate amount of fragrance (rose water) 12. Purified water 100

(Formulation Example 24) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Cocoa 50% propylene glycol extract 5.0 3. Chimney 50% propylene glycol extract 2.0 4. Bodampi 70% propylene glycol extract 2.0 5. Vitamin E derivative 0.5 6. Pepper tincture 0.5 7. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Beef hematin solution 0.5 11. Thympi 50% propylene glycol extract 2.0 12. Birch 50% propylene glycol extract 2.0 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary) qs 16. Purified water 100

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Timpi 50% 1,3-butylene glycol extract 5.0 3. Koboku 50% 1,3-butylene glycol extract 5.0 4. Sakura 50% 1,3-butylene glycol extract 5.0 5.cantaris tincture 0.5 6.pantothenic acid derivative 0.5 7.resorcin 0.5 0.5 glycyrrhizic acid 0.5 9.salicylic acid 0.5 10.hydroxyethyl chitosan solution 0.5 11.elastin hydrolyzate 0.5 12. Astragalus 50% 1,3-butylene glycol extract 2.0 13. Soybean 50% 1,3-butylene glycol extract 2.0 14. Elastin hydrolyzate 0.5 15. Antibacterial and preservative (paraben) 0.1 16. Perfume (lavender) 17.Purified water = 100

(Formulation Example 26) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. A: Dry powder of cocoa extract of Production Example 1 B: Cahied of Production Example 1 Extract dry powder C: Dried extract extract powder of Production Example 1 * Extract of any one of A to C 10.0 5. Dye (Gunjo pink) Appropriate amount

(Formulation Example 27) Granule bath agent wt% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Caffeine 70% ethanol extracted powder 1.0 5. Olekosou 70% ethanol extracted powder 1.0 6. Chamomile 70% ethanol extracted powder 1.0 7. Mulberry bark 70% ethanol extracted powder 1.0 8. Novara 70% ethanol extracted powder 1.0 9. Orange juice powder 1.0 10. Dye (yellow iron oxide) qs 11. Fragrance (hamamellis water qs)

(Formulation Example 28) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution prepared by mixing an appropriate amount of thympi 30% ethanol extract, antibiotics, anti-inflammation, etc., and attached to the wound. Alternatively, a thympi 30% ethanol extract may be directly applied locally and covered with gauze or the like.

(Test 7) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. Use test is 2-30 which is troubled by skin diseases such as eczema, skin kayumi, rough skin and atopic dermatitis
The test was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face for three months, twice daily in the morning and evening, after washing the face twice a year. Also, for 10 people (2 to 10 years old) who have the same skin disease on the scalp or hairline, apply the appropriate amount of the hair tonic of Formulation Example 22 to the scalp for 3 months after daily hair washing. A use test was conducted by

Further, the bath preparation of Prescription Example 26 was also used for 20 persons aged 0 to 45 years old who suffered from skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis for 3 months, always for 1 day. One time, the subject was bathed in bath water in which an appropriate amount of bath agent was dissolved, and a use test was performed. A control prepared by the same method except that the cacao, calyx and chimney extracts of the present invention were removed from the emulsion and the hair tonic and replaced with purified water was used as a control. As the bath agent, a cacao, cinnamon and thimpi extract of the present invention was prepared in the same manner as described above, instead of the dry powder, corrected with anhydrous sodium sulfate. The evaluation was performed according to the following criteria. The results are as shown in Table 3 and the numerical values in the table represent the number of persons. No one complained of abnormalities in the skin or scalp during the use period.

"Skin (scalp) disease improving effect" Effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were improved. Slightly effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were slightly improved. Ineffective: No change from before use.

<Table 3>

(Test Results) As shown in Table 3, the use of the cosmetic compositions (emulsions, hair tonics, bath preparations) containing the cacao, calyx, and chimney extracts of the present invention was evaluated for eczema, itching, rough skin and atopic property. Good effects were confirmed for skin and scalp diseases such as dermatitis.

[0133]

EFFECT OF THE INVENTION One or more plant extracts of the present invention selected from cocoa, cinnamon and chimpanzee have histamine release inhibitory activity, arachidonic acid metabolic activity inhibitory activity and contact dermatitis inhibitory activity, and are useful for humans or animals. It is safe for external use. Therefore, it can be used as an antiallergic agent, a histamine release inhibitor, an arachidonic acid metabolic activator, and a contact dermatitis inhibitor, and can be applied to all forms of pharmaceuticals (medicines, quasi-drugs, cosmetics). Further, the cosmetic composition of the present invention can be used for skin and scalp having troubles such as allergic / contact skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), atopic dermatitis, and rough skin. Can be used for the purpose of prevention and improvement thereof, and can also be used for oral compositions and foods.

[Brief description of the drawings]

FIG. 1 is a graph showing the histamine release inhibitory effect of the cacao, cinnamon and thrush extract of the present invention.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 17/00 A61P 17/00 // A61K 7/06 A61K 7/06 7/075 7/075 7/08 7/08 7/42 7/42 7/50 7/50 F term (reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AB032 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC082 AC092 AC102 AC122 AC132 AC172 AC182 AC242 AC252 AC402 AC402 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC782 AC792 AC812 AC852 AC862 AC902 AD022 AD092 AD112 AD202 AD272 AD322 AD332 AD412 AD432 AD442 AD452 AD512 AD532 AD552 AD662 CC03 CC04 CC05 CC06 CC07 CC12 CC22 CC23 CC25 CC32 DD37 CC38 DD DD32 DD33 EE13 EE21 EE22 EE41 4C088 AB12 AB33 AB62 AC04 AC06 AC11 BA08 BA09 BA10 MA07 MA63 NA15 ZA89 ZB11 ZB13 ZC13 ZC21

Claims (5)

[Claims] 1. An anti-allergic agent comprising at least one plant extract selected from cacao, calyx and chimpanzee. 2. A histamine release inhibitor comprising at least one plant extract selected from cocoa, cauliflower, and chimney. 3. An arachidonic acid metabolic activity inhibitor comprising one or more plant extracts selected from cacao, calyx, and chimney. 4. A contact dermatitis inhibitor comprising one or more plant extracts selected from cacao, calyx and chimpanzee. 5. An antiallergic agent, a histamine release inhibitor, an arachidonic acid metabolic activity inhibitor, and a contact dermatitis inhibitor according to any one of claims 1 to 4, comprising at least one of them. A cosmetic composition characterized by the following: