IT1243358B - Composizioni farmaceutiche per la somministrazione orale di irudina - Google Patents

Composizioni farmaceutiche per la somministrazione orale di irudina

Info

Publication number: IT1243358B
Authority: IT; Italy
Prior art keywords: pharmaceutical compositions; irudina; oral administration; suitable pharmaceutical; oral route
Prior art date: 1990-07-23

Application number

IT02102190A

Other languages

English (en)

Other versions

IT9021021A1 (it

IT9021021A0 (it

Inventor

Riccardo Niada

Adriano Butti

Original Assignee

Iketon Farmaceutici Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1990-07-23

Publication date

1994-06-10

1990-07-23 Application filed by Iketon Farmaceutici Srl filed Critical Iketon Farmaceutici Srl

1990-07-23 Priority to IT02102190A priority Critical patent/IT1243358B/it

1990-07-23 Publication of IT9021021A0 publication Critical patent/IT9021021A0/it

1991-07-15 Priority to EP91111733A priority patent/EP0468327B1/en

1991-07-15 Priority to DE69123190T priority patent/DE69123190D1/de

1991-07-15 Priority to AT91111733T priority patent/ATE145333T1/de

1991-07-22 Priority to JP3204613A priority patent/JPH04270229A/ja

1991-07-22 Priority to PT98406A priority patent/PT98406A/pt

1991-07-22 Priority to IE256691A priority patent/IE912566A1/en

1992-01-23 Publication of IT9021021A1 publication Critical patent/IT9021021A1/it

1994-06-10 Application granted granted Critical

1994-06-10 Publication of IT1243358B publication Critical patent/IT1243358B/it

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Tropical Medicine & Parasitology (AREA)
Diabetes (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT02102190A 1990-07-23 1990-07-23 Composizioni farmaceutiche per la somministrazione orale di irudina IT1243358B (it)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina
EP91111733A EP0468327B1 (en)	1990-07-23	1991-07-15	Oral pharmaceutical compositions containing hirudin
DE69123190T DE69123190D1 (de)	1990-07-23	1991-07-15	Hirudin enthaltende orale Arzneimittel
AT91111733T ATE145333T1 (de)	1990-07-23	1991-07-15	Hirudin enthaltende orale arzneimittel
JP3204613A JPH04270229A (ja)	1990-07-23	1991-07-22	ヒルジンを含む経口用製薬学的組成物
PT98406A PT98406A (pt)	1990-07-23	1991-07-22	Processo para a preparacao de composicoes farmaceuticas orais contendo hirudina
IE256691A IE912566A1 (en)	1990-07-23	1991-07-22	Oral pharmaceutical compositions containing hirudin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina

Publications (3)

Publication Number	Publication Date
IT9021021A0 IT9021021A0 (it)	1990-07-23
IT9021021A1 IT9021021A1 (it)	1992-01-23
IT1243358B true IT1243358B (it)	1994-06-10

Family

ID=11175506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina

Country Status (7)

Country	Link
EP (1)	EP0468327B1 (it)
JP (1)	JPH04270229A (it)
AT (1)	ATE145333T1 (it)
DE (1)	DE69123190D1 (it)
IE (1)	IE912566A1 (it)
IT (1)	IT1243358B (it)
PT (1)	PT98406A (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT63180A (en) *	1990-07-24	1993-07-28	Merrell Dow Pharma	Process for producing anticoagulant peptides
ES2199963T3 (es) *	1993-06-11	2004-03-01	Merrell Pharmaceuticals Inc.	Peptidos trifuncionales antitrombina y antiplaquetarios.
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
GB9401448D0 (en) *	1994-01-26	1994-03-23	Ciba Geigy Ag	Stable dry powders
AU2002342672A1 (en) *	2001-09-11	2003-03-24	Nascacell Gmbh	Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3792M (fr) *	1964-08-21	1965-12-27	Egema	Médicaments nouveaux a base de constituants actifs extraits de sangsues.
NL7900459A (nl) *	1979-01-19	1980-07-22	Hendrik Coenraad Hemker Prof D	Farmaceutisch preparaat en werkwijze ter bereiding daarvan.
US4348384A (en) *	1980-10-17	1982-09-07	Dainippon Pharmaceutical Co., Ltd.	Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
AU3098289A (en) *	1988-03-04	1989-09-07	Biogen, Inc.	Hirudin peptides
JPH04503660A (ja) *	1988-12-05	1992-07-02	バイオジェンインコーポレイテッド	血小板凝集抑制の方法及び組成物

1990
- 1990-07-23 IT IT02102190A patent/IT1243358B/it active IP Right Grant
1991
- 1991-07-15 AT AT91111733T patent/ATE145333T1/de not_active IP Right Cessation
- 1991-07-15 DE DE69123190T patent/DE69123190D1/de not_active Expired - Lifetime
- 1991-07-15 EP EP91111733A patent/EP0468327B1/en not_active Expired - Lifetime
- 1991-07-22 IE IE256691A patent/IE912566A1/en unknown
- 1991-07-22 PT PT98406A patent/PT98406A/pt not_active Application Discontinuation
- 1991-07-22 JP JP3204613A patent/JPH04270229A/ja active Pending

Also Published As

Publication number	Publication date
EP0468327A3 (en)	1992-08-26
IT9021021A1 (it)	1992-01-23
ATE145333T1 (de)	1996-12-15
PT98406A (pt)	1992-05-29
EP0468327B1 (en)	1996-11-20
IE912566A1 (en)	1992-01-29
DE69123190D1 (de)	1997-01-02
JPH04270229A (ja)	1992-09-25
EP0468327A2 (en)	1992-01-29
IT9021021A0 (it)	1990-07-23

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Legal Events

Date	Code	Title	Description
1994-06-10	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19960725