AU2002342672A1 - Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes - Google Patents
Method for screening for inhibitors of protein/protein interaction and corresponding ribozymesInfo
- Publication number
- AU2002342672A1 AU2002342672A1 AU2002342672A AU2002342672A AU2002342672A1 AU 2002342672 A1 AU2002342672 A1 AU 2002342672A1 AU 2002342672 A AU2002342672 A AU 2002342672A AU 2002342672 A AU2002342672 A AU 2002342672A AU 2002342672 A1 AU2002342672 A1 AU 2002342672A1
- Authority
- AU
- Australia
- Prior art keywords
- protein
- inhibitors
- screening
- corresponding ribozymes
- interaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000053642 Catalytic RNA Human genes 0.000 title 1
- 108090000994 Catalytic RNA Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000006916 protein interaction Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108091092562 ribozyme Proteins 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144647.0 | 2001-09-11 | ||
| DE10144647A DE10144647A1 (en) | 2001-09-11 | 2001-09-11 | New allosterically regulatable hairpin ribozyme, useful for identifying compounds that bind specific targets, has extra sequence between substrate binding and catalytic domains |
| DE10229393.7 | 2002-06-29 | ||
| DE10229393 | 2002-06-29 | ||
| PCT/EP2002/010140 WO2003022858A2 (en) | 2001-09-11 | 2002-09-10 | Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002342672A1 true AU2002342672A1 (en) | 2003-03-24 |
Family
ID=26010109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002342672A Abandoned AU2002342672A1 (en) | 2001-09-11 | 2002-09-10 | Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2002342672A1 (en) |
| WO (1) | WO2003022858A2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| EP1539941A4 (en) * | 2002-08-27 | 2006-11-29 | Adzymes and uses thereof | |
| JP5006651B2 (en) | 2003-12-05 | 2012-08-22 | ブリストル−マイヤーズ スクウィブ カンパニー | Inhibitor of type 2 vascular endothelial growth factor receptor |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| CN102007145A (en) | 2008-02-14 | 2011-04-06 | 百时美施贵宝公司 | Targeted therapeutics based on engineered proteins that bind egfr |
| AR071874A1 (en) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | ARMAZON DOMAIN PROTEINS BASED ON MULTIVALENT FIBRONECTINE |
| TWI496582B (en) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | Bispecific egfr/igfir binding molecules |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| ES2736127T3 (en) | 2014-03-20 | 2019-12-26 | Bristol Myers Squibb Co | Type III domains of seroalbumin binding fibronectin |
| CN108290941A (en) | 2015-09-23 | 2018-07-17 | 百时美施贵宝公司 | The seralbumin associativity fibronectin type III domain of fast dissociation rate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA88227B (en) * | 1987-01-28 | 1988-06-30 | Warner-Lambert Company | Thrombin preparations |
| US4959212A (en) * | 1988-06-22 | 1990-09-25 | Alexandra Stancesco | Oxidizing-energizing composition and method for the treatment of diabetes |
| IT1243358B (en) * | 1990-07-23 | 1994-06-10 | Iketon Farmaceutici Srl | PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF IRUDINA |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| EP1356105A2 (en) * | 2000-11-22 | 2003-10-29 | NascaCell GmbH | Method for identifying compounds or lead structures against rna target motifs and rna/protein interactions |
-
2002
- 2002-09-10 AU AU2002342672A patent/AU2002342672A1/en not_active Abandoned
- 2002-09-10 WO PCT/EP2002/010140 patent/WO2003022858A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003022858A2 (en) | 2003-03-20 |
| WO2003022858A3 (en) | 2003-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |