IT1230166B - Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. - Google Patents

Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Info

Publication number: IT1230166B
Authority: IT; Italy
Prior art keywords: phyphate; mythomycin; derivatives; cancer activity; reduced toxicity
Prior art date: 1988-06-29

Application number

IT8921023A

Other languages

English (en)

Other versions

IT8921023A0 (it

Inventor

Peter D Senter

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-29

Filing date

1989-06-28

Publication date

1991-10-14

1989-06-28 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1989-06-28 Publication of IT8921023A0 publication Critical patent/IT8921023A0/it

1991-10-14 Application granted granted Critical

1991-10-14 Publication of IT1230166B publication Critical patent/IT1230166B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IT8921023A 1988-06-29 1989-06-28 Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. IT1230166B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/213,201 US4874779A (en)	1988-06-29	1988-06-29	Mitomycin phosphate derivatives

Publications (2)

Publication Number	Publication Date
IT8921023A0 IT8921023A0 (it)	1989-06-28
IT1230166B true IT1230166B (it)	1991-10-14

Family

ID=22794125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8921023A IT1230166B (it)	1988-06-29	1989-06-28	Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Country Status (31)

Country	Link
US (1)	US4874779A (it)
JP (1)	JP2742568B2 (it)
KR (1)	KR0145088B1 (it)
AT (1)	AT398203B (it)
AU (1)	AU606288B2 (it)
BE (1)	BE1002655A3 (it)
CA (1)	CA1334671C (it)
CH (1)	CH678728A5 (it)
CY (1)	CY1815A (it)
DD (1)	DD284017A5 (it)
DE (1)	DE3921022B4 (it)
DK (1)	DK168293B1 (it)
ES (1)	ES2016032A6 (it)
FI (1)	FI90982C (it)
FR (1)	FR2633625B1 (it)
GB (1)	GB2220205B (it)
GR (1)	GR1000955B (it)
HK (1)	HK39695A (it)
HU (1)	HU202245B (it)
IE (1)	IE62363B1 (it)
IL (1)	IL90751A (it)
IT (1)	IT1230166B (it)
LU (1)	LU87543A1 (it)
MY (1)	MY104044A (it)
NL (1)	NL194916C (it)
NO (1)	NO176103C (it)
NZ (1)	NZ229650A (it)
PT (1)	PT91004B (it)
SE (1)	SE468770B (it)
YU (1)	YU132689A (it)
ZA (1)	ZA894875B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5552154A (en) *	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5091523A (en) *	1990-04-25	1992-02-25	Georgetown University	Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6098229A (en) *	1998-09-17	2000-08-08	Ward; William Kevin	Grill cleaning apparatus
EP1368054B1 (en) *	2001-03-08	2007-10-03	Nymox Pharmaceutical Corporation	Using neural thread proteins to treat tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1090707A (en) *	1965-11-05	1967-11-15	Kyowa Hakko Kogyo Kk	Mitomycin c derivatives
FR2397425A1 (fr) *	1977-07-11	1979-02-09	Rhone Poulenc Ind	Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
US4642352A (en) *	1983-12-23	1987-02-10	Bristol-Myers Company	Acylamino mitosanes
JPS6354380A (ja) *	1986-08-26	1988-03-08	Kyowa Hakko Kogyo Co Ltd	マイトマイシン誘導体

1988
- 1988-06-29 US US07/213,201 patent/US4874779A/en not_active Expired - Lifetime
1989
- 1989-06-16 FR FR898908011A patent/FR2633625B1/fr not_active Expired - Fee Related
- 1989-06-21 NZ NZ229650A patent/NZ229650A/xx unknown
- 1989-06-26 AT AT0155589A patent/AT398203B/de not_active IP Right Cessation
- 1989-06-26 IL IL9075189A patent/IL90751A/en not_active IP Right Cessation
- 1989-06-26 FI FI893115A patent/FI90982C/fi active IP Right Grant
- 1989-06-27 DD DD89330008A patent/DD284017A5/de unknown
- 1989-06-27 NL NL8901623A patent/NL194916C/nl not_active IP Right Cessation
- 1989-06-27 ZA ZA894875A patent/ZA894875B/xx unknown
- 1989-06-27 CA CA000604093A patent/CA1334671C/en not_active Expired - Fee Related
- 1989-06-27 DK DK318789A patent/DK168293B1/da not_active IP Right Cessation
- 1989-06-27 KR KR1019890008899A patent/KR0145088B1/ko not_active IP Right Cessation
- 1989-06-27 DE DE3921022A patent/DE3921022B4/de not_active Expired - Fee Related
- 1989-06-28 YU YU01326/89A patent/YU132689A/xx unknown
- 1989-06-28 SE SE8902340A patent/SE468770B/sv not_active IP Right Cessation
- 1989-06-28 PT PT91004A patent/PT91004B/pt not_active IP Right Cessation
- 1989-06-28 LU LU87543A patent/LU87543A1/fr unknown
- 1989-06-28 GB GB8914848A patent/GB2220205B/en not_active Expired - Lifetime
- 1989-06-28 JP JP1164084A patent/JP2742568B2/ja not_active Expired - Fee Related
- 1989-06-28 MY MYPI89000872A patent/MY104044A/en unknown
- 1989-06-28 CH CH2398/89A patent/CH678728A5/de not_active IP Right Cessation
- 1989-06-28 IE IE210489A patent/IE62363B1/en not_active IP Right Cessation
- 1989-06-28 BE BE8900708A patent/BE1002655A3/fr not_active IP Right Cessation
- 1989-06-28 NO NO892688A patent/NO176103C/no not_active IP Right Cessation
- 1989-06-28 IT IT8921023A patent/IT1230166B/it active
- 1989-06-28 ES ES8902273A patent/ES2016032A6/es not_active Expired - Fee Related
- 1989-06-29 GR GR890100421A patent/GR1000955B/el not_active IP Right Cessation
- 1989-06-29 HU HU893320A patent/HU202245B/hu not_active IP Right Cessation
- 1989-06-29 AU AU37217/89A patent/AU606288B2/en not_active Ceased
1995
- 1995-03-23 HK HK39695A patent/HK39695A/xx not_active IP Right Cessation
- 1995-10-20 CY CY181595A patent/CY1815A/xx unknown

Also Published As

Publication number	Publication date
FI893115A (fi)	1989-12-30
FR2633625B1 (fr)	1991-11-15
ES2016032A6 (es)	1990-10-01
PT91004B (pt)	1994-11-30
HU202245B (en)	1991-02-28
DK318789A (da)	1989-12-30
ATA155589A (de)	1994-02-15
DE3921022A1 (de)	1990-03-15
BE1002655A3 (fr)	1991-04-23
GB8914848D0 (en)	1989-08-16
US4874779A (en)	1989-10-17
ZA894875B (en)	1990-05-30
NL8901623A (nl)	1990-01-16
DD284017A5 (de)	1990-10-31
HUT51638A (en)	1990-05-28
NZ229650A (en)	1991-10-25
GB2220205A (en)	1990-01-04
PT91004A (pt)	1989-12-29
YU132689A (en)	1991-04-30
NO176103B (no)	1994-10-24
GB2220205B (en)	1991-10-16
SE8902340D0 (sv)	1989-06-28
AU606288B2 (en)	1991-01-31
AU3721789A (en)	1990-01-04
IL90751A (en)	1994-01-25
FR2633625A1 (fr)	1990-01-05
NO892688D0 (no)	1989-06-28
NL194916B (nl)	2003-03-03
KR910000738A (ko)	1991-01-30
FI90982C (fi)	1994-04-25
SE468770B (sv)	1993-03-15
CH678728A5 (it)	1991-10-31
IE62363B1 (en)	1995-01-25
AT398203B (de)	1994-10-25
JP2742568B2 (ja)	1998-04-22
KR0145088B1 (ko)	1998-07-15
GR890100421A (en)	1991-11-15
FI90982B (fi)	1994-01-14
DK168293B1 (da)	1994-03-07
CA1334671C (en)	1995-03-07
NO176103C (no)	1995-02-01
NL194916C (nl)	2003-07-04
JPH0248588A (ja)	1990-02-19
HK39695A (en)	1995-03-31
FI893115A0 (fi)	1989-06-26
DE3921022B4 (de)	2004-02-26
GR1000955B (el)	1993-03-16
IE892104L (en)	1989-12-29
CY1815A (en)	1995-10-20
SE8902340L (sv)	1989-12-30
IL90751A0 (en)	1990-01-18
IT8921023A0 (it)	1989-06-28
LU87543A1 (fr)	1990-02-28
MY104044A (en)	1993-10-30
NO892688L (no)	1990-01-02
DK318789D0 (da)	1989-06-27

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DK19689D0 (da)	1989-01-17	Vitamin d derivater
IT8848619A0 (it)	1988-12-02	Derivati di lisosfingolipidi
IT1231481B (it)	1991-12-07	Derivati di furano
IT1230884B (it)	1991-11-08	Derivati della benzazepina e della benzotiazepina ad attivita' vasodilatatoria.
DE68925161D1 (de)	1996-02-01	Alkylavermectin-Derivate
DK130389D0 (da)	1989-03-17	Catecholderivater og farmaceutiske praeparater omfatende samme
TR24895A (tr)	1992-07-01	PIRIMIDIN TüREVLERI,BUNLARIN ISTIHSAL EDILMESI VE KULLANILMASI
IT1230166B (it)	1991-10-14	Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.
IT8848618A0 (it)	1988-12-02	Derivati di lisogangliosidi
IT8622453A0 (it)	1986-11-25	Impiego fungicida di derivati della tetraidrobenzotienilurea.
DK368789A (da)	1990-01-27	Glycosphingolipid-derivater
ITPD910110A1 (it)	1992-12-14	Derivati della cumarina.
IT8521236A0 (it)	1985-06-21	Amminoacil derivati di 4(5)-imidazolidinoni ad attivita
FI892281A (fi)	1989-11-13	3-pyrrolidinyltio-1-azabicyklo/3.2.0/ hept-2-en-2-karboxylsyraderivat och deras framstaellning.
FR2640378B1 (fr)	1991-02-22	Osmometre statique
DE68908838D1 (de)	1993-10-07	Pharmazeutisch wirksame Dithioketen-Derivaten.
IT8819959A0 (it)	1988-03-25	Derivati alcossibenzimidazolici farmacologicamente attivi eprocedimento di preparazione.
IT8720996A0 (it)	1987-06-23	Derivati lipidici della l-acetilcarnitina dotati di attivita'antilipemica, antiarteriosclerotica ed antiischemica.
IT1232692B (it)	1992-03-04	Derivati ergolinici con attivita' dopaminergica
DK619589A (da)	1990-06-10	Sphingenin og derivater heraf
IT8821862A0 (it)	1988-09-08	Derivati imidazolinici di diidronaftalene e tetraidronaftalene.
DK179288A (da)	1988-10-02	Dioxolan- og dioxanderivater
IT1243774B (it)	1994-06-28	Derivati della prourochinasi
ITMI921423A1 (it)	1993-12-10	Derivati benzossazinonici e benzotiazinonici ad attivita' cardiovascolare
ITMI921005A1 (it)	1993-10-28	Derivati otticamente attivi della n-imminoalchil-n'-((2-idrossi2-fen

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970628