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IT1193190B - 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito - Google Patents

2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito

Info

Publication number
IT1193190B
IT1193190B IT24165/79A IT2416579A IT1193190B IT 1193190 B IT1193190 B IT 1193190B IT 24165/79 A IT24165/79 A IT 24165/79A IT 2416579 A IT2416579 A IT 2416579A IT 1193190 B IT1193190 B IT 1193190B
Authority
IT
Italy
Prior art keywords
tetraidro
benzazepine
mercapto
replaced
benzazepine mercapto
Prior art date
Application number
IT24165/79A
Other languages
English (en)
Other versions
IT7924165A0 (it
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IT7924165A0 publication Critical patent/IT7924165A0/it
Application granted granted Critical
Publication of IT1193190B publication Critical patent/IT1193190B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IT24165/79A 1978-07-07 1979-07-06 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito IT1193190B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07

Publications (2)

Publication Number Publication Date
IT7924165A0 IT7924165A0 (it) 1979-07-06
IT1193190B true IT1193190B (it) 1988-06-02

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24165/79A IT1193190B (it) 1978-07-07 1979-07-06 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito

Country Status (24)

Country Link
EP (2) EP0007070B1 (it)
JP (1) JPS5511584A (it)
AR (1) AR222828A1 (it)
AU (1) AU525789B2 (it)
CA (1) CA1115271A (it)
CS (1) CS213381B2 (it)
DD (1) DD147355A5 (it)
DE (1) DE2964530D1 (it)
DK (1) DK156001C (it)
ES (3) ES482282A1 (it)
FI (1) FI67215C (it)
GR (1) GR69675B (it)
HU (1) HU179315B (it)
IE (1) IE48654B1 (it)
IL (1) IL57532A (it)
IT (1) IT1193190B (it)
JO (1) JO1273B1 (it)
NO (1) NO152213C (it)
NZ (1) NZ190745A (it)
PH (1) PH15754A (it)
PL (1) PL216908A1 (it)
PT (1) PT69855A (it)
SU (1) SU1029827A3 (it)
ZA (1) ZA792785B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
DE69929704T2 (de) * 1998-10-08 2006-07-20 Smithkline Beecham Plc, Brentford Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2004031181A1 (en) * 2002-10-07 2004-04-15 Glaxo Group Limited Sulfonamide derivatives as antipsychotic agents
EP2332919A3 (en) 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
WO2005003096A1 (en) 2003-06-17 2005-01-13 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
KR100848411B1 (ko) * 2004-02-25 2008-07-28 일라이 릴리 앤드 캄파니 5-ｈｔ2ｃ 수용체 아고니스트로서 6-치환된2,3,4,5-테트라히드로-1ｈ-벤조[ｄ]아제핀
ES2332009T3 (es) 2004-12-21 2010-01-22 Arena Pharmaceuticals, Inc. Formas cristalinas de hidrocloruro de (r)-8-cloro-1-metil-2,3,4,5-tetrahidro-1h-3-benzazepina.
EA015012B1 (ru) 2004-12-23 2011-04-29 Арена Фармасьютикалз, Инк. Композиция, содержащая фентермин и избирательный агонист рецептора 5ht, и ее применение
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
EA201390335A1 (ru) 2010-09-01 2013-09-30 Арена Фармасьютикалз, Инк. Введение лоркасерина индивидуумам с почечной недостаточностью
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
AU2011296014A1 (en) 2010-09-01 2013-04-04 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
JPS5511584A (en) 1980-01-26
NO152213C (no) 1985-08-28
ES482281A1 (es) 1980-04-01
DK278379A (da) 1980-01-08
IE791276L (en) 1980-01-07
NO792267L (no) 1980-01-08
FI792125A7 (fi) 1980-01-08
EP0080012A1 (en) 1983-06-01
PT69855A (en) 1979-08-01
FI67215B (fi) 1984-10-31
ES482276A1 (es) 1980-04-01
SU1029827A3 (ru) 1983-07-15
JPH0153271B2 (it) 1989-11-13
EP0007070B1 (en) 1983-01-19
AU525789B2 (en) 1982-12-02
CS213381B2 (en) 1982-04-09
DK156001B (da) 1989-06-12
NZ190745A (en) 1981-01-23
EP0007070A1 (en) 1980-01-23
DD147355A5 (de) 1981-04-01
GR69675B (it) 1982-07-07
IT7924165A0 (it) 1979-07-06
HU179315B (en) 1982-09-28
PH15754A (en) 1983-03-18
NO152213B (no) 1985-05-13
CA1115271A (en) 1981-12-29
ES482282A1 (es) 1980-04-01
PL216908A1 (it) 1980-08-11
JO1273B1 (en) 1986-11-30
IL57532A (en) 1982-08-31
IE48654B1 (en) 1985-04-03
AR222828A1 (es) 1981-06-30
IL57532A0 (en) 1979-10-31
AU4861379A (en) 1980-02-07
DE2964530D1 (en) 1983-02-24
DK156001C (da) 1989-11-06
EP0080012B1 (en) 1986-04-09
ZA792785B (en) 1980-08-27
FI67215C (fi) 1985-02-11

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