IL93609A - A polypeptide containing a yeast and amino acid processing site with a negative charge adjacent to it for yeast expression and a process to form a polypeptide or protein using the above polypeptide - Google Patents

A polypeptide containing a yeast and amino acid processing site with a negative charge adjacent to it for yeast expression and a process to form a polypeptide or protein using the above polypeptide

Info

Publication number: IL93609A
Authority: IL; Israel
Prior art keywords: glu; leu; asp; ala; polypeptide
Prior art date: 1989-03-03

Application number

IL9360990A

Other languages

English (en)

Hebrew (he)

Other versions

IL93609A0 (en

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-03

Filing date

1990-03-02

Publication date

2001-11-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26065137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL93609(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-06 Priority claimed from DK494189A external-priority patent/DK494189D0/da

1990-03-02 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1990-12-23 Publication of IL93609A0 publication Critical patent/IL93609A0/xx

2001-11-25 Publication of IL93609A publication Critical patent/IL93609A/en

Links

150000001413 amino acids Chemical class 0.000 title claims abstract description 111
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108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 107
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 103
229920001184 polypeptide Polymers 0.000 title claims abstract description 99
102000004169 proteins and genes Human genes 0.000 title claims abstract description 94
240000004808 Saccharomyces cerevisiae Species 0.000 title claims abstract description 92
238000012545 processing Methods 0.000 title claims abstract description 46
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VSMYBNPOHYAXSD-GUBZILKMSA-N Asp-Lys-Glu Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O VSMYBNPOHYAXSD-GUBZILKMSA-N 0.000 claims abstract 2
NLOAIFSWUUFQFR-CIUDSAMLSA-N Ser-Leu-Asp Chemical group [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O NLOAIFSWUUFQFR-CIUDSAMLSA-N 0.000 claims abstract 2
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Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL9360990A 1989-03-03 1990-03-02 A polypeptide containing a yeast and amino acid processing site with a negative charge adjacent to it for yeast expression and a process to form a polypeptide or protein using the above polypeptide IL93609A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK105489A DK105489D0 (da)	1989-03-03	1989-03-03	Polypeptid
DK494189A DK494189D0 (da)	1989-10-06	1989-10-06	Polypeptid

Publications (2)

Publication Number	Publication Date
IL93609A0 IL93609A0 (en)	1990-12-23
IL93609A true IL93609A (en)	2001-11-25

Family

ID=26065137

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9360990A IL93609A (en)	1989-03-03	1990-03-02	A polypeptide containing a yeast and amino acid processing site with a negative charge adjacent to it for yeast expression and a process to form a polypeptide or protein using the above polypeptide

Country Status (23)

Country	Link
US (3)	US5395922A (de)
EP (1)	EP0461165B2 (de)
JP (1)	JP2609367B2 (de)
KR (1)	KR970005928B1 (de)
AT (1)	ATE110414T1 (de)
AU (1)	AU624694B2 (de)
CA (1)	CA2050336C (de)
CZ (1)	CZ285239B6 (de)
DD (1)	DD296965A5 (de)
DE (1)	DE69011853T3 (de)
DK (2)	DK105489D0 (de)
ES (1)	ES2062514T5 (de)
FI (1)	FI104985B (de)
HU (2)	HU215538B (de)
IE (1)	IE66469B1 (de)
IL (1)	IL93609A (de)
NO (2)	NO304236B1 (de)
NZ (1)	NZ232742A (de)
PL (1)	PL163532B1 (de)
RU (1)	RU2194758C2 (de)
UA (1)	UA27706C2 (de)
WO (1)	WO1990010075A1 (de)
ZA (1)	ZA901476B (de)

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JPH04507341A (ja) *	1989-05-19	1992-12-24	バイオテクノロジー　リサーチ　アンド　ディヴェロプメント　コーポレーション	ｉｎ　ｖｉｖｏ翻訳後修飾部位を有する融合タンパク質及び製造及び精製方法
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GB9106185D0 (en) *	1991-03-22	1991-05-08	Wellcome Found	Biological control agents
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FI92601C (fi) *	1992-03-11	1994-12-12	Marja Makarow	Menetelmä hyötyproteiinien erittämiseksi hiivoista
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IL114160A (en) *	1994-06-17	2006-12-31	Novo Nordisk As	Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US5861267A (en) *	1995-05-01	1999-01-19	Vertex Pharmaceuticals Incorporated	Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
ZA9610456B (en) *	1995-12-20	1997-06-20	Novo Nordisk As	N-terminally extended proteins expressed in yeast
US5851800A (en) *	1996-05-14	1998-12-22	Pharmacia & Upjohn Ab	Process for producing a protein
DE19629982A1 (de)	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
EP0948538B1 (de)	1996-12-13	2008-06-11	Novartis Vaccines and Diagnostics, Inc.	Analyse und separation von pdgf-proteinen
WO1998028429A1 (en) *	1996-12-20	1998-07-02	Novo Nordisk A/S	N-terminally extended proteins expressed in yeast
WO1998032867A1 (en) *	1997-01-24	1998-07-30	Novo Nordisk A/S	Synthetic leader peptide sequences
US6046000A (en) *	1997-11-07	2000-04-04	Millennium Biotherapeutics, Inc.	Method for identifying genes encoding signal sequences
AU2149899A (en)	1998-01-23	1999-08-09	Novo Nordisk A/S	Process for making desired polypeptides in yeast
BR0016860A (pt)	1999-12-29	2002-10-01	Novo Nordisk As	Precursor da insulina ou análogo de precursor de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor da insulina ou análogo de precursor de insulina, e, insulina ou um análogo de insulina
CA2747325A1 (en) *	2000-04-12	2001-10-25	Human Genome Sciences, Inc.	Albumin fusion proteins
US20050100991A1 (en) *	2001-04-12	2005-05-12	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en) *	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
US20050054051A1 (en) *	2001-04-12	2005-03-10	Human Genome Sciences, Inc.	Albumin fusion proteins
US7595172B2 (en)	2001-07-24	2009-09-29	Novo Nordisk A/S	Method for making acylated polypeptides
CA2484556A1 (en) *	2001-12-21	2003-07-24	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2471363C (en)	2001-12-21	2014-02-11	Human Genome Sciences, Inc.	Albumin fusion proteins
DE60335497D1 (de)	2002-09-13	2011-02-03	Cornell Res Foundation Inc	Ergillus-phytasen
EP1594530A4 (de)	2003-01-22	2006-10-11	Human Genome Sciences Inc	Albuminfusionsproteine
WO2005047508A1 (en)	2003-11-14	2005-05-26	Novo Nordisk A/S	Processes for making acylated insulin
ATE517119T1 (de)	2003-12-03	2011-08-15	Novo Nordisk As	Einzelketteninsulin
JP5366546B2 (ja)	2005-08-16	2013-12-11	ノボ・ノルデイスク・エー／エス	成熟インスリンポリペプチドの作製方法
WO2007096431A1 (en)	2006-02-27	2007-08-30	Novo Nordisk A/S	Insulin derivatives
US20080026376A1 (en) *	2006-07-11	2008-01-31	Huaming Wang	KEX2 cleavage regions of recombinant fusion proteins
US8198046B2 (en)	2006-07-11	2012-06-12	Danisco Us Inc.	KEX2 cleavage regions of recombinant fusion proteins
ES2601839T3 (es)	2006-09-22	2017-02-16	Novo Nordisk A/S	Análogos de insulina resistentes a proteasas
EP2069502B1 (de)	2006-09-27	2014-02-26	Novo Nordisk A/S	Verfahren zur herstellung gereifter insulinpolypeptide
US8153395B2 (en)	2006-11-22	2012-04-10	Novo Nordisk A/S	Method of making activated carboxypeptidases
EP2170945A1 (de)	2007-07-16	2010-04-07	Novo Nordisk A/S	Proteasestabilisierte pegylierte insulinanaloga
WO2009021955A1 (en)	2007-08-13	2009-02-19	Novo Nordisk A/S	Rapid acting insulin analogues
JP5721432B2 (ja)	2007-08-15	2015-05-20	ノボ・ノルデイスク・エー／エス	アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン
ES2548304T3 (es)	2007-08-15	2015-10-15	Novo Nordisk A/S	Análogos de la insulina que contienen una fracción acilo y alquilenglicol
US8501449B2 (en)	2007-12-04	2013-08-06	Proteon Therapeutics, Inc.	Recombinant elastase proteins and methods of manufacturing and use thereof
ES2609288T3 (es)	2008-03-18	2017-04-19	Novo Nordisk A/S	Análogos de insulina acilada, estabilizados frente a proteasas
JP5818681B2 (ja)	2008-04-01	2015-11-18	ノボ・ノルデイスク・エー／エス	インスリンアルブミンコンジュゲート
WO2011089170A2 (en)	2010-01-22	2011-07-28	Novo Nordisk A/S	Process for preparing fgf-21 with low degree of o-glycosylation
SG174313A1 (en) *	2009-03-12	2011-10-28	Bigtec Private Ltd	A polynucleotide and polypeptide sequence and methods thereof
WO2010149772A1 (en)	2009-06-26	2010-12-29	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and an amino acid
ES2550761T3 (es)	2009-11-25	2015-11-12	Novo Nordisk A/S	Método para producción de polipéptidos
JP5931857B2 (ja)	2010-06-23	2016-06-08	ノヴォノルディスクアー／エス	追加のジスルフィド結合を含有するインスリン誘導体
US8815798B2 (en)	2010-06-23	2014-08-26	Novo Nordisk A/S	Insulin analogues containing additional disulfide bonds
WO2011161083A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Human insulin containing additional disulfide bonds
JP2013545782A (ja)	2010-12-14	2013-12-26	ノヴォノルディスクアー／エス	長時間作用型インスリンと組み合わせた速効型インスリン
MX2013006174A (es)	2010-12-14	2013-07-15	Novo Nordisk As	Preparacion que comprende insulina, nicotinamida y un aminoacido.
US9260503B2 (en)	2011-06-15	2016-02-16	Novo Nordisk A/S	Multi-substituted insulins
RU2460795C1 (ru) *	2011-07-06	2012-09-10	Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика")	Способ микробиологического синтеза секретируемого соматотропина человека и штамм дрожжей saccharomyces cerevisiae - продуцент секретируемого соматотропина человека
WO2013186138A1 (en)	2012-06-14	2013-12-19	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and arginine
WO2014088836A1 (en)	2012-12-03	2014-06-12	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
CN103254277B (zh) *	2013-05-03	2017-02-08	南京工业大学	强分泌性信号肽增强小肽模序及其应用
CN105308067B (zh)	2013-06-07	2020-07-24	诺和诺德股份有限公司	制备成熟胰岛素多肽的方法
PL233560B1 (pl)	2014-12-05	2019-10-31	Mabion Spolka Akcyjna	Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
EP3268384B1 (de)	2015-03-10	2021-11-03	Merck Sharp & Dohme Corp.	Verfahren zur herstellung von rekombinantem insulin unter verwendung von mikrofiltration
JP6983075B2 (ja)	2015-06-02	2021-12-17	ノヴォノルディスクアー／エス	極性の組換え延長部を有するインスリン
JP2018531901A (ja)	2015-08-25	2018-11-01	ノヴォノルディスクアー／エス	新規インスリン誘導体及びその医学的使用
WO2017032798A1 (en)	2015-08-25	2017-03-02	Novo Nordisk A/S	Novel insulin derivatives and the medical uses hereof
US20180244743A1 (en)	2015-08-25	2018-08-30	Novo Nordisk A/S	Novel Insulin Derivatives and the Medical Uses Hereof
KR102043067B1 (ko) *	2017-08-08	2019-11-11	엘지전자 주식회사	차량용 사이드 미러 및 차량
CN111032685A (zh)	2017-08-17	2020-04-17	诺沃挪第克公司	新型酰化胰岛素类似物及其用途
LT4073097T (lt)	2019-12-11	2024-09-10	Novo Nordisk A/S	Nauji insulino analogai ir jų naudojimas
WO2023144240A1 (en)	2022-01-26	2023-08-03	Novo Nordisk Research Centre Oxford Limited	Glucose sensitive insulin derivatives and uses thereof
DE202024104234U1 (de)	2024-07-26	2024-12-18	Australian Geekkit Health Pty Ltd	Peptid-Struktur-Partikel mit Signalübertragung

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AU5712580A (en) *	1979-04-05	1980-10-09	James Joseph Connell	Engine charging and scavenging
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
WO1984004330A1 (en) *	1983-04-22	1984-11-08	Amgen	Secretion of exogenous polypeptides from yeast
US4588684A (en) *	1983-04-26	1986-05-13	Chiron Corporation	a-Factor and its processing signals
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
EP0195680A3 (de) *	1985-03-21	1987-06-10	Immunex Corporation	Proteinsynthese mit einem Identifizierungspeptid
JPS6236183A (ja) *	1985-06-20	1987-02-17	ザ・サルク・インステイチユ−ト・バイオテクノロジ−／インダストリアル・アソシエイツ・インコ−ポレ−テツド	サツカロミセス・セレビシエからのポリペプチドの発現および分泌
MC1834A1 (fr) *	1986-07-10	1988-06-03	Transgene Sa	Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
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WO1988010299A1 (en) *	1987-06-24	1988-12-29	Novo-Nordisk A/S	A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DK463887D0 (da) *	1987-09-07	1987-09-07	Novo Industri As	Gaerleader
JPH01240191A (ja) *	1988-02-16	1989-09-25	Green Cross Corp:The	酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
DK336188D0 (da) *	1988-06-20	1988-06-20	Nordisk Gentofte	Propeptider
WO1990001063A1 (en) *	1988-07-23	1990-02-08	Delta Biotechnology Limited	New secretory leader sequences
DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid

1989
- 1989-03-03 DK DK105489A patent/DK105489D0/da not_active Application Discontinuation
1990
- 1990-02-27 ZA ZA901476A patent/ZA901476B/xx unknown
- 1990-03-01 AT AT90904258T patent/ATE110414T1/de not_active IP Right Cessation
- 1990-03-01 ES ES90904258T patent/ES2062514T5/es not_active Expired - Lifetime
- 1990-03-01 AU AU52612/90A patent/AU624694B2/en not_active Ceased
- 1990-03-01 KR KR1019910701029A patent/KR970005928B1/ko not_active IP Right Cessation
- 1990-03-01 DE DE69011853T patent/DE69011853T3/de not_active Expired - Lifetime
- 1990-03-01 NZ NZ232742A patent/NZ232742A/xx unknown
- 1990-03-01 UA UA5010019A patent/UA27706C2/uk unknown
- 1990-03-01 WO PCT/DK1990/000058 patent/WO1990010075A1/en active IP Right Grant
- 1990-03-01 CA CA002050336A patent/CA2050336C/en not_active Expired - Fee Related
- 1990-03-01 RU SU5010019/13A patent/RU2194758C2/ru not_active IP Right Cessation
- 1990-03-01 DK DK90904258.2T patent/DK0461165T3/da active
- 1990-03-01 EP EP90904258A patent/EP0461165B2/de not_active Expired - Lifetime
- 1990-03-01 JP JP2504527A patent/JP2609367B2/ja not_active Expired - Lifetime
- 1990-03-01 HU HU902376A patent/HU215538B/hu not_active IP Right Cessation
- 1990-03-02 IE IE74990A patent/IE66469B1/en not_active IP Right Cessation
- 1990-03-02 CZ CS901039A patent/CZ285239B6/cs not_active IP Right Cessation
- 1990-03-02 DD DD90338353A patent/DD296965A5/de unknown
- 1990-03-02 PL PL90284146A patent/PL163532B1/pl not_active IP Right Cessation
- 1990-03-02 IL IL9360990A patent/IL93609A/en not_active IP Right Cessation
1991
- 1991-09-02 FI FI914125A patent/FI104985B/fi not_active IP Right Cessation
- 1991-09-02 NO NO913427A patent/NO304236B1/no unknown
1994
- 1994-02-15 US US08/196,887 patent/US5395922A/en not_active Expired - Lifetime
1995
- 1995-03-02 US US08/397,595 patent/US5510249A/en not_active Expired - Lifetime
- 1995-03-02 US US08/397,597 patent/US5514585A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00592P patent/HU211600A9/hu unknown
1997
- 1997-10-23 NO NO974899A patent/NO974899D0/no unknown

Also Published As

Publication number	Publication date
ES2062514T3 (es)	1994-12-16
WO1990010075A1 (en)	1990-09-07
IE66469B1 (en)	1995-12-27
AU5261290A (en)	1990-09-26
EP0461165B1 (de)	1994-08-24
ZA901476B (en)	1990-11-28
US5510249A (en)	1996-04-23
HU211600A9 (en)	1995-12-28
FI104985B (fi)	2000-05-15
DE69011853T2 (de)	1994-12-15
JPH04504846A (ja)	1992-08-27
US5395922A (en)	1995-03-07
DE69011853D1 (de)	1994-09-29
DE69011853T3 (de)	1998-06-25
FI914125A0 (fi)	1991-09-02
RU2194758C2 (ru)	2002-12-20
HUT58370A (en)	1992-02-28
PL163532B1 (pl)	1994-04-29
EP0461165B2 (de)	1998-03-25
US5514585A (en)	1996-05-07
KR970005928B1 (ko)	1997-04-22
JP2609367B2 (ja)	1997-05-14
CA2050336C (en)	2000-01-18
NO913427L (no)	1991-11-01
NO913427D0 (no)	1991-09-02
KR920701452A (ko)	1992-08-11
CA2050336A1 (en)	1990-09-04
EP0461165A1 (de)	1991-12-18
IE900749L (en)	1990-09-03
DK0461165T3 (da)	1994-11-21
DD296965A5 (de)	1991-12-19
ES2062514T5 (es)	1998-06-01
AU624694B2 (en)	1992-06-18
UA27706C2 (uk)	2000-10-16
NO974899L (no)	1997-10-23
HU215538B (hu)	1999-01-28
IL93609A0 (en)	1990-12-23
NZ232742A (en)	1991-10-25
HU902376D0 (en)	1991-11-28
CZ103990A3 (cs)	1999-03-17
CZ285239B6 (cs)	1999-06-16
DK105489D0 (da)	1989-03-03
ATE110414T1 (de)	1994-09-15
NO304236B1 (no)	1998-11-16
NO974899D0 (no)	1997-10-23

Publication	Publication Date	Title
US5395922A (en)	1995-03-07	Yeast processing system
US5316923A (en)	1994-05-31	Synthetic yeast leader peptides
JP3085973B2 (ja)	2000-09-11	組換え酵母による成熟タンパク質の分泌に関するシグナルペプチドについてコードする配列として新規ｄｎａ断片の適用、発現カセット、形質転換酵母及びそれに対応するタンパク質の製造方法
JP3730255B2 (ja)	2005-12-21	イーストにおいて発現されたｎ末端に伸長した蛋白質
US5795746A (en)	1998-08-18	Synthetic leader peptide sequences
AU633020B2 (en)	1993-01-21	New secretory leader sequences
JP2001527387A (ja)	2001-12-25	合成リーダーペプチド配列
EP0946735B1 (de)	2006-02-08	N-terminal verlängerte proteine exprimiert in hefe
EP0375718B1 (de)	1994-11-09	Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe
EP0868523B1 (de)	2005-05-18	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
US20020192753A1 (en)	2002-12-19	Method of making proteins in transformed yeast cells
EP1097228B1 (de)	2006-03-01	Verfahren zur herstellung von proteinen in transformierten hefezellen
MXPA01000516A (en)	2001-09-07	Method of making proteins in transformed yeast cells

Legal Events

Date	Code	Title
2002-05-23	KB	Patent renewed
2004-05-12	KB	Patent renewed
2009-02-11	MM9K	Patent not in force due to non-payment of renewal fees
2010-04-14	MM9K	Patent not in force due to non-payment of renewal fees