IL141232A0 - Use of camptothecin derivatives, with reduced gastrointestinal toxicity - Google Patents

Use of camptothecin derivatives, with reduced gastrointestinal toxicity

Info

Publication number: IL141232A0
Authority: IL; Israel
Prior art keywords: camptothecin derivatives; gastrointestinal toxicity; reduced gastrointestinal; sodium chloride; reduced
Prior art date: 1998-08-05

Application number

IL14123299A

Other languages

English (en)

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-05

Filing date

1999-08-03

Publication date

2002-03-10

1998-08-05 Priority claimed from FR9810043A external-priority patent/FR2782009B1/fr

1999-08-03 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-03-10 Publication of IL141232A0 publication Critical patent/IL141232A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

IL14123299A 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity IL141232A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9810043A FR2782009B1 (fr)	1998-08-05	1998-08-05	Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite
US9631898P	1998-08-12	1998-08-12
PCT/FR1999/001916 WO2000007605A1 (fr)	1998-08-05	1999-08-03	Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite

Publications (1)

Publication Number	Publication Date
IL141232A0 true IL141232A0 (en)	2002-03-10

Family

ID=26234482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14123299A IL141232A0 (en)	1998-08-05	1999-08-03	Use of camptothecin derivatives, with reduced gastrointestinal toxicity

Country Status (24)

Country	Link
US (1)	US6476043B1 (et)
EP (1)	EP1102594B1 (et)
JP (1)	JP2002522392A (et)
KR (1)	KR20010072228A (et)
AT (1)	ATE217531T1 (et)
AU (1)	AU771195B2 (et)
BG (1)	BG64641B1 (et)
CA (1)	CA2340020A1 (et)
CZ (1)	CZ295775B6 (et)
DE (1)	DE69901506T2 (et)
DK (1)	DK1102594T3 (et)
EA (1)	EA002917B1 (et)
EE (1)	EE04264B1 (et)
ES (1)	ES2176009T3 (et)
GE (1)	GEP20043254B (et)
HU (1)	HUP0103314A3 (et)
ID (1)	ID27253A (et)
IL (1)	IL141232A0 (et)
NO (1)	NO20010454L (et)
NZ (1)	NZ509859A (et)
PT (1)	PT1102594E (et)
SK (1)	SK1732001A3 (et)
TR (1)	TR200100331T2 (et)
WO (1)	WO2000007605A1 (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1189637E (pt)	1999-05-17	2007-01-31	Cancer Res Ventures Ltd	Composições para melhorar a biodisponibilidade de fármacos administrados oralmente
CA2295429A1 (en) *	2000-01-06	2001-07-06	Michael Michael	Treatment or prevention of diarrhea
ATE489094T1 (de) *	2004-02-13	2010-12-15	Yakult Honsha Kk	Wässrige lösung mit einem camptothecin
US20050197355A1 (en) *	2004-03-02	2005-09-08	Henegar Kevin E.	Compounds useful in preparing camptothecin derivatives
CA2562904C (en)	2004-04-27	2013-07-02	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
JP2006151950A (ja) *	2004-11-05	2006-06-15	Oto Corporation:Kk	納豆菌培養エキス含有製剤及び納豆菌培養エキスの保存方法
ATE446299T1 (de) *	2005-02-07	2009-11-15	Fermion Oy	Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
WO2006084940A1 (en) *	2005-02-08	2006-08-17	Fermion Oy	Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
US7767813B2 (en) *	2005-02-08	2010-08-03	Fermion Oy	Preparation method
US7994186B2 (en) *	2005-04-18	2011-08-09	Kabushiki Kaisha Yakult Honsha	Pharmaceutical compositions containing camptothecins
US7767200B2 (en)	2005-07-14	2010-08-03	Wellstat Biologics Corporation	Cancer treatment using viruses, fluoropyrimidines and camptothecins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4284579A (en) *	1979-07-17	1981-08-18	The United States Of America As Represented By The Of The Department Of Health & Human Services	(N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt
US4399276A (en) *	1981-01-09	1983-08-16	Kabushiki Kaisha Yakult Honsha	7-Substituted camptothecin derivatives
JPS58154582A (ja) *	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法
JPS6019790A (ja) *	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
CH663353A5 (de) *	1984-03-28	1987-12-15	Joaquin Amat Larraz	Mittel gegen krebs.
CA1332413C (en) *	1987-06-25	1994-10-11	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5225404A (en) *	1989-11-06	1993-07-06	New York University	Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
IT1247937B (it) *	1991-05-16	1995-01-05	Ist Naz Ric Sul Cancro	Associazione farmaceutica ad attivita' antineoplastica
JP3359955B2 (ja) *	1992-07-16	2002-12-24	第一製薬株式会社	抗腫瘍剤
WO1996011005A2 (en)	1994-10-06	1996-04-18	Atlas Leon T	Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases

1999
- 1999-08-03 US US09/762,092 patent/US6476043B1/en not_active Expired - Fee Related
- 1999-08-03 CZ CZ2001382A patent/CZ295775B6/cs not_active IP Right Cessation
- 1999-08-03 ES ES99936674T patent/ES2176009T3/es not_active Expired - Lifetime
- 1999-08-03 CA CA002340020A patent/CA2340020A1/fr not_active Abandoned
- 1999-08-03 TR TR2001/00331T patent/TR200100331T2/xx unknown
- 1999-08-03 HU HU0103314A patent/HUP0103314A3/hu unknown
- 1999-08-03 AT AT99936674T patent/ATE217531T1/de not_active IP Right Cessation
- 1999-08-03 JP JP2000563290A patent/JP2002522392A/ja active Pending
- 1999-08-03 EP EP99936674A patent/EP1102594B1/fr not_active Expired - Lifetime
- 1999-08-03 AU AU51687/99A patent/AU771195B2/en not_active Ceased
- 1999-08-03 NZ NZ509859A patent/NZ509859A/en unknown
- 1999-08-03 DK DK99936674T patent/DK1102594T3/da active
- 1999-08-03 IL IL14123299A patent/IL141232A0/xx unknown
- 1999-08-03 KR KR1020017001471A patent/KR20010072228A/ko not_active Application Discontinuation
- 1999-08-03 PT PT99936674T patent/PT1102594E/pt unknown
- 1999-08-03 SK SK173-2001A patent/SK1732001A3/sk unknown
- 1999-08-03 GE GEAP19995779A patent/GEP20043254B/en unknown
- 1999-08-03 EE EEP200100066A patent/EE04264B1/et not_active IP Right Cessation
- 1999-08-03 WO PCT/FR1999/001916 patent/WO2000007605A1/fr not_active Application Discontinuation
- 1999-08-03 EA EA200100214A patent/EA002917B1/ru unknown
- 1999-08-03 ID IDW20010273A patent/ID27253A/id unknown
- 1999-08-03 DE DE69901506T patent/DE69901506T2/de not_active Expired - Fee Related
2001
- 2001-01-26 NO NO20010454A patent/NO20010454L/no not_active Application Discontinuation
- 2001-02-05 BG BG105216A patent/BG64641B1/bg unknown

Also Published As

Publication number	Publication date
TR200100331T2 (tr)	2001-07-23
ATE217531T1 (de)	2002-06-15
CZ2001382A3 (en)	2001-05-16
BG105216A (en)	2001-10-31
BG64641B1 (bg)	2005-10-31
AU771195B2 (en)	2004-03-18
DE69901506T2 (de)	2002-11-28
KR20010072228A (ko)	2001-07-31
NO20010454D0 (no)	2001-01-26
EA002917B1 (ru)	2002-10-31
WO2000007605A1 (fr)	2000-02-17
GEP20043254B (en)	2004-06-25
EE200100066A (et)	2002-06-17
ES2176009T3 (es)	2002-11-16
HUP0103314A2 (hu)	2002-01-28
DE69901506D1 (de)	2002-06-20
EP1102594B1 (fr)	2002-05-15
EE04264B1 (et)	2004-04-15
PT1102594E (pt)	2002-10-31
DK1102594T3 (da)	2002-08-26
ID27253A (id)	2001-03-22
US6476043B1 (en)	2002-11-05
NO20010454L (no)	2001-01-26
CA2340020A1 (fr)	2000-02-17
JP2002522392A (ja)	2002-07-23
SK1732001A3 (en)	2001-06-11
CZ295775B6 (cs)	2005-11-16
AU5168799A (en)	2000-02-28
EP1102594A1 (fr)	2001-05-30
HUP0103314A3 (en)	2002-07-29
NZ509859A (en)	2003-09-26
EA200100214A1 (ru)	2001-08-27

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PL325825A1 (en)	1998-08-03	Microemulsion for use as a carrier for administering active compounds
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EP1017675A4 (en)	2001-08-22	HIGHLY LIPOPHILIC CAMPTOTHECIN DERIVATIVES
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