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FR2782009B1 - Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite - Google Patents

Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite

Info

Publication number
FR2782009B1
FR2782009B1 FR9810043A FR9810043A FR2782009B1 FR 2782009 B1 FR2782009 B1 FR 2782009B1 FR 9810043 A FR9810043 A FR 9810043A FR 9810043 A FR9810043 A FR 9810043A FR 2782009 B1 FR2782009 B1 FR 2782009B1
Authority
FR
France
Prior art keywords
comptothecin
derivatives
gastrointestinal toxicity
reduced gastrointestinal
reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9810043A
Other languages
English (en)
Other versions
FR2782009A1 (fr
Inventor
Herve Toutain
Magali Guffroy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to FR9810043A priority Critical patent/FR2782009B1/fr
Priority to UA2001020806A priority patent/UA72468C2/uk
Priority to CZ2001382A priority patent/CZ295775B6/cs
Priority to KR1020017001471A priority patent/KR20010072228A/ko
Priority to US09/762,092 priority patent/US6476043B1/en
Priority to NZ509859A priority patent/NZ509859A/en
Priority to TR2001/00331T priority patent/TR200100331T2/xx
Priority to EA200100214A priority patent/EA002917B1/ru
Priority to HU0103314A priority patent/HUP0103314A3/hu
Priority to SI9930036T priority patent/SI1102594T1/xx
Priority to DK99936674T priority patent/DK1102594T3/da
Priority to EP99936674A priority patent/EP1102594B1/fr
Priority to EEP200100066A priority patent/EE04264B1/xx
Priority to CNB998088366A priority patent/CN1144592C/zh
Priority to AU51687/99A priority patent/AU771195B2/en
Priority to CA002340020A priority patent/CA2340020A1/fr
Priority to YU5301A priority patent/YU5301A/sh
Priority to IL14123299A priority patent/IL141232A0/xx
Priority to BR9912765-2A priority patent/BR9912765A/pt
Priority to PCT/FR1999/001916 priority patent/WO2000007605A1/fr
Priority to PL99345826A priority patent/PL345826A1/xx
Priority to JP2000563290A priority patent/JP2002522392A/ja
Priority to PT99936674T priority patent/PT1102594E/pt
Priority to AT99936674T priority patent/ATE217531T1/de
Priority to SK173-2001A priority patent/SK1732001A3/sk
Priority to GEAP19995779A priority patent/GEP20043254B/en
Priority to DE69901506T priority patent/DE69901506T2/de
Priority to IDW20010273A priority patent/ID27253A/id
Priority to ES99936674T priority patent/ES2176009T3/es
Publication of FR2782009A1 publication Critical patent/FR2782009A1/fr
Application granted granted Critical
Publication of FR2782009B1 publication Critical patent/FR2782009B1/fr
Priority to NO20010454A priority patent/NO20010454L/no
Priority to BG105216A priority patent/BG64641B1/bg
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9810043A 1998-08-05 1998-08-05 Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite Expired - Fee Related FR2782009B1 (fr)

Priority Applications (31)

Application Number Priority Date Filing Date Title
FR9810043A FR2782009B1 (fr) 1998-08-05 1998-08-05 Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite
UA2001020806A UA72468C2 (en) 1998-08-05 1999-03-08 Use of sodium chloride for preventing gastrointestinal side effects upon administration of camptothecin derivatives
BR9912765-2A BR9912765A (pt) 1998-08-05 1999-08-03 Utilização de cloreto de sódio
US09/762,092 US6476043B1 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
NZ509859A NZ509859A (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
TR2001/00331T TR200100331T2 (tr) 1998-08-05 1999-08-03 Kamptotesin türevlerinin az bir gastrointestinal toksisite ile kullanımı
EA200100214A EA002917B1 (ru) 1998-08-05 1999-08-03 Применение хлорида натрия для уменьшения вторичных желудочно-кишечных эффектов, обусловленных применением производных камптотецина
HU0103314A HUP0103314A3 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
SI9930036T SI1102594T1 (en) 1998-08-05 1999-08-03 Use of sodium chloride to reduce the gastrointestinal toxicity of camptothecin derivatives
DK99936674T DK1102594T3 (da) 1998-08-05 1999-08-03 Anvendelse af natriumchlorid til nedsættelse af den gastrointestinale toxicitet af derivater af camptothecin
EP99936674A EP1102594B1 (fr) 1998-08-05 1999-08-03 Utilisation de chlorure de sodium pour reduire la toxicite gastro-intestinale des derives de la camptothecine
PL99345826A PL345826A1 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
CNB998088366A CN1144592C (zh) 1998-08-05 1999-08-03 低胃肠毒性喜树碱衍生物的应用
AU51687/99A AU771195B2 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
CA002340020A CA2340020A1 (fr) 1998-08-05 1999-08-03 Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite
YU5301A YU5301A (sh) 1998-08-05 1999-08-03 Primena derivata kamptotecina sa smanjenom gastro-intestinalnom toksičnošću
CZ2001382A CZ295775B6 (cs) 1998-08-05 1999-08-03 Perorálně podatelné činidlo pro omezení nebo potlačení sekundárních gastrointestinálních účinků způsobených podáním derivátů kamptothecinu
PCT/FR1999/001916 WO2000007605A1 (fr) 1998-08-05 1999-08-03 Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite
KR1020017001471A KR20010072228A (ko) 1998-08-05 1999-08-03 위장 독성이 감소된 캠프토테신 유도체의 용도
EEP200100066A EE04264B1 (et) 1998-08-05 1999-08-03 Naatriumkloriidi kasutamine aine valmistamiseks kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsete kõrvaltoimete vähendamiseks
JP2000563290A JP2002522392A (ja) 1998-08-05 1999-08-03 低下された消化管毒性を有するカンプトテシン誘導体の使用
PT99936674T PT1102594E (pt) 1998-08-05 1999-08-03 Utilizacao de cloreto de sodio para reduzir a toxicidade gastrointestinal de derivados de camptotecina
AT99936674T ATE217531T1 (de) 1998-08-05 1999-08-03 Verwendung von natriumchlorid zur verminderung der gastrointestinalen toxizität von camptotecinderivaten.
SK173-2001A SK1732001A3 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
GEAP19995779A GEP20043254B (en) 1998-08-05 1999-08-03 Use of Camptothecin Derivatives with Reduced Gastrointestinal Toxicity
DE69901506T DE69901506T2 (de) 1998-08-05 1999-08-03 Verwendung von natriumchlorid zur verminderung der gastrointestinalen toxizität von camptotecinderivaten.
IDW20010273A ID27253A (id) 1998-08-05 1999-08-03 Penggunaan turunan-turunan kampotesin dengan toksisitas gastrointestinal yang tereduksi
ES99936674T ES2176009T3 (es) 1998-08-05 1999-08-03 Utilizacion de cloruro de sodio para reducir la toxicidad gastrointestinal de los derivados de la competencia.
IL14123299A IL141232A0 (en) 1998-08-05 1999-08-03 Use of camptothecin derivatives, with reduced gastrointestinal toxicity
NO20010454A NO20010454L (no) 1998-08-05 2001-01-26 Anvendelse av derivater av camptotécin med en redusert gastrointestinal toksisitet
BG105216A BG64641B1 (bg) 1998-08-05 2001-02-05 Използване на производни на каптотецин с намалена стомашно-чревна токсичност

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9810043A FR2782009B1 (fr) 1998-08-05 1998-08-05 Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite

Publications (2)

Publication Number Publication Date
FR2782009A1 FR2782009A1 (fr) 2000-02-11
FR2782009B1 true FR2782009B1 (fr) 2000-09-15

Family

ID=9529409

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9810043A Expired - Fee Related FR2782009B1 (fr) 1998-08-05 1998-08-05 Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite

Country Status (6)

Country Link
CN (1) CN1144592C (fr)
BR (1) BR9912765A (fr)
FR (1) FR2782009B1 (fr)
PL (1) PL345826A1 (fr)
UA (1) UA72468C2 (fr)
YU (1) YU5301A (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
WO1996011005A2 (fr) * 1994-10-06 1996-04-18 Atlas Leon T Utilisation de camptothecine ou de derives de camptothecine dans la fabrication d'un medicament destine au traitement de maladies virales

Also Published As

Publication number Publication date
PL345826A1 (en) 2002-01-14
CN1354667A (zh) 2002-06-19
UA72468C2 (en) 2005-03-15
BR9912765A (pt) 2001-05-15
CN1144592C (zh) 2004-04-07
FR2782009A1 (fr) 2000-02-11
YU5301A (sh) 2005-06-10

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Legal Events

Date Code Title Description
CD Change of name or company name
ST Notification of lapse

Effective date: 20080430