ATE446299T1 - Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin - Google Patents
Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecinInfo
- Publication number
- ATE446299T1 ATE446299T1 AT06708893T AT06708893T ATE446299T1 AT E446299 T1 ATE446299 T1 AT E446299T1 AT 06708893 T AT06708893 T AT 06708893T AT 06708893 T AT06708893 T AT 06708893T AT E446299 T1 ATE446299 T1 AT E446299T1
- Authority
- AT
- Austria
- Prior art keywords
- ethyl
- hydroxycamptothecine
- producing
- temperature
- hydroxycamptothecin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65017505P | 2005-02-07 | 2005-02-07 | |
| PCT/FI2006/000034 WO2006082279A1 (en) | 2005-02-07 | 2006-02-06 | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446299T1 true ATE446299T1 (de) | 2009-11-15 |
Family
ID=36588759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06708893T ATE446299T1 (de) | 2005-02-07 | 2006-02-06 | Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7910737B2 (de) |
| EP (1) | EP1846412B1 (de) |
| JP (1) | JP5133705B2 (de) |
| AT (1) | ATE446299T1 (de) |
| CA (1) | CA2591081C (de) |
| DE (1) | DE602006009901D1 (de) |
| ES (1) | ES2333462T3 (de) |
| PL (1) | PL1846412T3 (de) |
| WO (1) | WO2006082279A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1846412B1 (de) | 2005-02-07 | 2009-10-21 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin |
| ES2430375T3 (es) * | 2005-02-08 | 2013-11-20 | Fermion Oy | Procedimiento para la producción de cloruro de [1,4']bipiperidinil-1'-carbonilo o su clorhidrato |
| EP1928883B1 (de) * | 2005-02-08 | 2013-10-30 | Fermion Oy | Verfahren zur herstellung von irinotecanhydrochlorid |
| TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| EP1951235B1 (de) * | 2005-09-20 | 2010-03-10 | Scinopharm Singapore Pte, Ltd. | Neue kristallformen von irinotecan-hydrochlorid |
| WO2009002489A2 (en) | 2007-06-25 | 2008-12-31 | Scinopharm Taiwan Ltd. | Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin |
| WO2012032531A1 (en) * | 2010-09-06 | 2012-03-15 | Avra Laboratories Pvt. Ltd. | Process for the manufacture of irinotecan hydrochloride by total synthesis |
| KR101327720B1 (ko) * | 2013-02-15 | 2013-11-11 | 제일약품주식회사 | 이리노테칸의 제조방법 |
| CN107428770B (zh) | 2014-10-22 | 2019-10-01 | 维瓦西塔斯肿瘤学公司 | 用于喜树碱类似物合成的方法和体系 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US182990A (en) * | 1876-10-10 | Improvement in corner-finish for rooms | ||
| US103309A (en) * | 1870-05-24 | Improvement in machines for burring wool | ||
| US4473692A (en) | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5053512A (en) | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US4894456A (en) | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| IL117684A (en) * | 1995-04-07 | 2002-02-10 | Pharmacia & Upjohn Inc | Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds |
| CA2340020A1 (fr) | 1998-08-05 | 2000-02-17 | Aventis Pharma S.A. | Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite |
| TWI245768B (en) * | 2001-02-21 | 2005-12-21 | Yakult Honsha Kk | Process for synthesizing camptothecin related compound(s) |
| CN1276923C (zh) | 2002-03-01 | 2006-09-27 | 法玛西雅意大利公司 | 盐酸伊立替康的结晶多晶型物 |
| EP1501799A1 (de) | 2002-04-17 | 2005-02-02 | Pharmacia Corporation | Für die herstellung von camptothecin nützliche verbindungen |
| US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| JP2008509211A (ja) | 2004-08-09 | 2008-03-27 | シルパ・メディケア・リミテッド | 塩酸イリノテカン三水和物の改良された製造方法 |
| EP1846412B1 (de) | 2005-02-07 | 2009-10-21 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin |
-
2006
- 2006-02-06 EP EP06708893A patent/EP1846412B1/de not_active Not-in-force
- 2006-02-06 WO PCT/FI2006/000034 patent/WO2006082279A1/en active Application Filing
- 2006-02-06 PL PL06708893T patent/PL1846412T3/pl unknown
- 2006-02-06 CA CA2591081A patent/CA2591081C/en not_active Expired - Fee Related
- 2006-02-06 AT AT06708893T patent/ATE446299T1/de not_active IP Right Cessation
- 2006-02-06 DE DE602006009901T patent/DE602006009901D1/de active Active
- 2006-02-06 US US11/883,576 patent/US7910737B2/en active Active
- 2006-02-06 ES ES06708893T patent/ES2333462T3/es active Active
- 2006-02-06 JP JP2007553634A patent/JP5133705B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7910737B2 (en) | 2011-03-22 |
| JP2008529993A (ja) | 2008-08-07 |
| WO2006082279A1 (en) | 2006-08-10 |
| CA2591081C (en) | 2014-10-28 |
| US20080103309A1 (en) | 2008-05-01 |
| PL1846412T3 (pl) | 2010-03-31 |
| JP5133705B2 (ja) | 2013-01-30 |
| CA2591081A1 (en) | 2006-08-10 |
| ES2333462T3 (es) | 2010-02-22 |
| EP1846412B1 (de) | 2009-10-21 |
| EP1846412A1 (de) | 2007-10-24 |
| DE602006009901D1 (de) | 2009-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |