IL127689A - Acryloyl substituted distamycin derivatives, process for preparing them and their use for the manufacture of antitumor and antiviral agents - Google Patents

Acryloyl substituted distamycin derivatives, process for preparing them and their use for the manufacture of antitumor and antiviral agents

Info

Publication number: IL127689A
Authority: IL; Israel
Prior art keywords: antitumor; preparing; manufacture; antiviral agents; distamycin derivatives
Prior art date: 1996-07-25

Application number

IL12768997A

Other languages

English (en)

Other versions

IL127689A0 (en

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-10

Publication date

2003-07-31

1997-07-10 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1999-10-28 Publication of IL127689A0 publication Critical patent/IL127689A0/xx

2003-07-31 Publication of IL127689A publication Critical patent/IL127689A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL12768997A 1996-07-25 1997-07-10 Acryloyl substituted distamycin derivatives, process for preparing them and their use for the manufacture of antitumor and antiviral agents IL127689A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9615692.2A GB9615692D0 (en)	1996-07-25	1996-07-25	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en)	1996-07-25	1997-07-10	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (2)

Publication Number	Publication Date
IL127689A0 IL127689A0 (en)	1999-10-28
IL127689A true IL127689A (en)	2003-07-31

Family

ID=10797527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12768997A IL127689A (en)	1996-07-25	1997-07-10	Acryloyl substituted distamycin derivatives, process for preparing them and their use for the manufacture of antitumor and antiviral agents

Country Status (26)

Country	Link
US (2)	US6482920B1 (de)
EP (1)	EP0915845B1 (de)
JP (1)	JP4312264B2 (de)
KR (1)	KR100408538B1 (de)
CN (1)	CN1116281C (de)
AR (1)	AR007997A1 (de)
AT (1)	ATE205476T1 (de)
AU (1)	AU724511B2 (de)
BR (1)	BR9710717A (de)
CA (1)	CA2260060C (de)
DE (1)	DE69706690T2 (de)
DK (1)	DK0915845T3 (de)
EA (1)	EA001863B1 (de)
ES (1)	ES2164366T3 (de)
GB (1)	GB9615692D0 (de)
HU (1)	HU224635B1 (de)
IL (1)	IL127689A (de)
MY (1)	MY124103A (de)
NO (1)	NO310817B1 (de)
NZ (1)	NZ334082A (de)
PL (1)	PL199865B1 (de)
PT (1)	PT915845E (de)
TW (1)	TW360652B (de)
UA (1)	UA61922C2 (de)
WO (1)	WO1998004524A1 (de)
ZA (1)	ZA976549B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9806689D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en)	2000-01-28	2003-05-06	California Institute Of Technology	Polyamide-alkylator conjugates and related products and method
PE20011277A1 (es) *	2000-04-14	2002-01-07	Agouron Pharma	Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
GB0017852D0 (en) *	2000-07-20	2000-09-06	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
US6576612B1 (en) *	2000-10-02	2003-06-10	Pharmacia Italia S.P.A.	Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) *	2000-11-28	2001-01-10	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
JP2005505508A (ja) *	2001-06-13	2005-02-24	ジーンソフトファーマシューティカルズインコーポレイテッド	抗感染活性を有するベンゾチオフェン化合物
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
SI1461083T1 (sl) *	2002-01-02	2006-08-31	Nerviano Medical Sciences Srl	Kombinirana terapija proti tumorjem na osnovi substituiranih akriloil distamicinskih derivatov in inhibitorjev protein-kinaze (serin/treonin-kinaze)
BR0308976A (pt) *	2002-04-02	2005-01-11	Pharmacia Italia Spa	Terapia combinada contra tumores compreendendo derivados de acriloil distamicina substituìda e radioterapia
MX383577B (es)	2015-08-06	2025-03-14	Ube Industries	Derivados sustituidos de guanidina.
GB202114032D0 (en) *	2021-09-30	2021-11-17	Univ Strathclyde	Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT387013B (de) *	1985-07-16	1988-11-25	Erba Farmitalia	Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives

1996
- 1996-07-25 GB GBGB9615692.2A patent/GB9615692D0/en active Pending
1997
- 1997-07-10 DK DK97937474T patent/DK0915845T3/da active
- 1997-07-10 EA EA199900163A patent/EA001863B1/ru not_active IP Right Cessation
- 1997-07-10 AU AU40098/97A patent/AU724511B2/en not_active Ceased
- 1997-07-10 WO PCT/EP1997/003719 patent/WO1998004524A1/en active IP Right Grant
- 1997-07-10 CN CN97196737A patent/CN1116281C/zh not_active Expired - Fee Related
- 1997-07-10 NZ NZ334082A patent/NZ334082A/xx not_active IP Right Cessation
- 1997-07-10 BR BR9710717A patent/BR9710717A/pt not_active IP Right Cessation
- 1997-07-10 IL IL12768997A patent/IL127689A/xx not_active IP Right Cessation
- 1997-07-10 JP JP50842898A patent/JP4312264B2/ja not_active Expired - Fee Related
- 1997-07-10 DE DE69706690T patent/DE69706690T2/de not_active Expired - Lifetime
- 1997-07-10 US US09/147,573 patent/US6482920B1/en not_active Expired - Lifetime
- 1997-07-10 KR KR10-1999-7000409A patent/KR100408538B1/ko not_active Expired - Fee Related
- 1997-07-10 PT PT97937474T patent/PT915845E/pt unknown
- 1997-07-10 EP EP97937474A patent/EP0915845B1/de not_active Expired - Lifetime
- 1997-07-10 PL PL331344A patent/PL199865B1/pl unknown
- 1997-07-10 AT AT97937474T patent/ATE205476T1/de active
- 1997-07-10 CA CA002260060A patent/CA2260060C/en not_active Expired - Fee Related
- 1997-07-10 HU HU9903253A patent/HU224635B1/hu not_active IP Right Cessation
- 1997-07-10 ES ES97937474T patent/ES2164366T3/es not_active Expired - Lifetime
- 1997-07-18 TW TW086110294A patent/TW360652B/zh not_active IP Right Cessation
- 1997-07-23 ZA ZA9706549A patent/ZA976549B/xx unknown
- 1997-07-25 AR ARP970103377A patent/AR007997A1/es active IP Right Grant
- 1997-07-25 MY MYPI97003389A patent/MY124103A/en unknown
- 1997-10-07 UA UA99021068A patent/UA61922C2/uk unknown
1999
- 1999-01-20 NO NO19990246A patent/NO310817B1/no not_active IP Right Cessation
2002
- 2002-07-17 US US10/196,363 patent/US20030023031A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1226232A (zh)	1999-08-18
US6482920B1 (en)	2002-11-19
DE69706690D1 (de)	2001-10-18
EP0915845B1 (de)	2001-09-12
NZ334082A (en)	1999-08-30
GB9615692D0 (en)	1996-09-04
NO310817B1 (no)	2001-09-03
PL199865B1 (pl)	2008-11-28
EA199900163A1 (ru)	1999-08-26
AU4009897A (en)	1998-02-20
HK1020948A1 (en)	2000-05-26
AU724511B2 (en)	2000-09-21
KR100408538B1 (ko)	2004-01-13
EA001863B1 (ru)	2001-10-22
DK0915845T3 (da)	2002-01-07
JP2000515164A (ja)	2000-11-14
MY124103A (en)	2006-06-30
IL127689A0 (en)	1999-10-28
HUP9903253A2 (hu)	2000-02-28
CA2260060C (en)	2007-01-30
DE69706690T2 (de)	2002-06-20
HUP9903253A3 (en)	2002-01-28
ZA976549B (en)	1998-02-03
BR9710717A (pt)	1999-08-17
CN1116281C (zh)	2003-07-30
TW360652B (en)	1999-06-11
WO1998004524A1 (en)	1998-02-05
UA61922C2 (uk)	2003-12-15
PT915845E (pt)	2002-03-28
AR007997A1 (es)	1999-11-24
ES2164366T3 (es)	2002-02-16
JP4312264B2 (ja)	2009-08-12
PL331344A1 (en)	1999-07-05
NO990246D0 (no)	1999-01-20
HU224635B1 (hu)	2005-12-28
EP0915845A1 (de)	1999-05-19
NO990246L (no)	1999-01-20
KR20000029448A (ko)	2000-05-25
US20030023031A1 (en)	2003-01-30
CA2260060A1 (en)	1998-02-05
ATE205476T1 (de)	2001-09-15

Publication	Publication Date	Title
GB9623522D0 (en)	1997-01-08	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9823873D0 (en)	1998-12-30	2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
IL147923A0 (en)	2002-08-14	3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
IL147925A0 (en)	2002-08-14	3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents
IL127689A (en)	2003-07-31	Acryloyl substituted distamycin derivatives, process for preparing them and their use for the manufacture of antitumor and antiviral agents
AU1596097A (en)	1997-08-22	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
HUP9901387A3 (en)	2002-10-28	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
ZA969220B (en)	1997-06-02	Nucleoside derivatives and process for preparing the same
GB9806689D0 (en)	1998-05-27	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
AU6629496A (en)	1997-02-26	Antiviral agent and process for preparing the same
AU4172693A (en)	1994-01-06	Novel thienothiazine derivatives, process for their preparation and their use
HUP9902883A3 (en)	2001-01-29	Bis/acridinecarboxamide/ and bis/phenazinecarboxamide/ derivatives as antitumour agents, preparation and use thereof
AU8132094A (en)	1995-11-29	Khellactone derivatives and related compounds, process for their preparation and their use as antiviral and immunostimulating agents
GR3035834T3 (en)	2001-08-31	Benzoxazindione derivatives, process for their preparation and their use
GB9613987D0 (en)	1996-09-04	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9602163D0 (en)	1996-04-03	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
AU8303291A (en)	1992-03-17	Novel adenosine derivatives, their production and use
HUP9700542A3 (en)	1998-01-28	Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them
HUP9700502A2 (en)	1997-12-29	Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them
HU9700543D0 (en)	1997-04-28	Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them
ZA936840B (en)	1994-04-14	Novel thiomarinol derivatives, and processes for their preparation

Legal Events

Date	Code	Title
2004-01-04	FF	Patent granted
2004-02-08	KB	Patent renewed
2004-02-19	HP	Change in proprietorship
2007-08-19	KB	Patent renewed
2011-07-31	KB	Patent renewed
2015-07-30	KB	Patent renewed
2018-02-28	EXP	Patent expired