DE69706690D1 - Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel - Google Patents

Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel

Info

Publication number: DE69706690D1
Authority: DE; Germany
Prior art keywords: acryloyl; antitumor; production; antiviral agents; distamycin derivatives
Prior art date: 1996-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69706690T

Other languages

English (en)

Other versions

DE69706690T2 (de

Inventor

Paolo Cozzi

Italo Beria

Giovanni Biasoli

Marina Caldarelli

Laura Capolongo

Cristina Franzetti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nerviano Medical Sciences SRL

Original Assignee

Pharmacia and Upjohn SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-10

Publication date

2001-10-18

1997-07-10 Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA

2001-10-18 Publication of DE69706690D1 publication Critical patent/DE69706690D1/de

2002-06-20 Application granted granted Critical

2002-06-20 Publication of DE69706690T2 publication Critical patent/DE69706690T2/de

2017-07-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69706690T 1996-07-25 1997-07-10 Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel Expired - Lifetime DE69706690T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9615692.2A GB9615692D0 (en)	1996-07-25	1996-07-25	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en)	1996-07-25	1997-07-10	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (2)

Publication Number	Publication Date
DE69706690D1 true DE69706690D1 (de)	2001-10-18
DE69706690T2 DE69706690T2 (de)	2002-06-20

Family

ID=10797527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69706690T Expired - Lifetime DE69706690T2 (de)	1996-07-25	1997-07-10	Acryloyl-substituierte distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel

Country Status (27)

Country	Link
US (2)	US6482920B1 (de)
EP (1)	EP0915845B1 (de)
JP (1)	JP4312264B2 (de)
KR (1)	KR100408538B1 (de)
CN (1)	CN1116281C (de)
AR (1)	AR007997A1 (de)
AT (1)	ATE205476T1 (de)
AU (1)	AU724511B2 (de)
BR (1)	BR9710717A (de)
CA (1)	CA2260060C (de)
DE (1)	DE69706690T2 (de)
DK (1)	DK0915845T3 (de)
EA (1)	EA001863B1 (de)
ES (1)	ES2164366T3 (de)
GB (1)	GB9615692D0 (de)
HK (1)	HK1020948A1 (de)
HU (1)	HU224635B1 (de)
IL (1)	IL127689A (de)
MY (1)	MY124103A (de)
NO (1)	NO310817B1 (de)
NZ (1)	NZ334082A (de)
PL (1)	PL199865B1 (de)
PT (1)	PT915845E (de)
TW (1)	TW360652B (de)
UA (1)	UA61922C2 (de)
WO (1)	WO1998004524A1 (de)
ZA (1)	ZA976549B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9806689D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en)	2000-01-28	2003-05-06	California Institute Of Technology	Polyamide-alkylator conjugates and related products and method
PA8515201A1 (es) *	2000-04-14	2002-10-24	Agouron Pharma	Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
GB0017852D0 (en) *	2000-07-20	2000-09-06	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
US6576612B1 (en) *	2000-10-02	2003-06-10	Pharmacia Italia S.P.A.	Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) *	2000-11-28	2001-01-10	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
EP1470119A4 (de) *	2001-06-13	2005-10-19	Genesoft Pharmaceuticals Inc	Benzothiophenverbindungen mit antiinfektiver wirkung
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
EP1461083B1 (de) *	2002-01-02	2006-03-29	Pharmacia Italia S.p.A.	Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren
AU2003219102B2 (en) *	2002-04-02	2008-05-08	Nerviano Medical Sciences S.R.L.	Combined therapy against tumors comprising subtituted acryloyl distamycin derivatives and radiotherapy
MX383577B (es) *	2015-08-06	2025-03-14	Ube Industries	Derivados sustituidos de guanidina.
GB202114032D0 (en) *	2021-09-30	2021-11-17	Univ Strathclyde	Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT387013B (de) *	1985-07-16	1988-11-25	Erba Farmitalia	Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives

1996
- 1996-07-25 GB GBGB9615692.2A patent/GB9615692D0/en active Pending
1997
- 1997-07-10 HU HU9903253A patent/HU224635B1/hu not_active IP Right Cessation
- 1997-07-10 JP JP50842898A patent/JP4312264B2/ja not_active Expired - Fee Related
- 1997-07-10 DK DK97937474T patent/DK0915845T3/da active
- 1997-07-10 BR BR9710717A patent/BR9710717A/pt not_active IP Right Cessation
- 1997-07-10 KR KR10-1999-7000409A patent/KR100408538B1/ko not_active IP Right Cessation
- 1997-07-10 EA EA199900163A patent/EA001863B1/ru not_active IP Right Cessation
- 1997-07-10 DE DE69706690T patent/DE69706690T2/de not_active Expired - Lifetime
- 1997-07-10 AT AT97937474T patent/ATE205476T1/de active
- 1997-07-10 ES ES97937474T patent/ES2164366T3/es not_active Expired - Lifetime
- 1997-07-10 EP EP97937474A patent/EP0915845B1/de not_active Expired - Lifetime
- 1997-07-10 IL IL12768997A patent/IL127689A/xx not_active IP Right Cessation
- 1997-07-10 CA CA002260060A patent/CA2260060C/en not_active Expired - Fee Related
- 1997-07-10 PT PT97937474T patent/PT915845E/pt unknown
- 1997-07-10 PL PL331344A patent/PL199865B1/pl unknown
- 1997-07-10 US US09/147,573 patent/US6482920B1/en not_active Expired - Lifetime
- 1997-07-10 WO PCT/EP1997/003719 patent/WO1998004524A1/en active IP Right Grant
- 1997-07-10 AU AU40098/97A patent/AU724511B2/en not_active Ceased
- 1997-07-10 CN CN97196737A patent/CN1116281C/zh not_active Expired - Fee Related
- 1997-07-10 NZ NZ334082A patent/NZ334082A/xx not_active IP Right Cessation
- 1997-07-18 TW TW086110294A patent/TW360652B/zh not_active IP Right Cessation
- 1997-07-23 ZA ZA9706549A patent/ZA976549B/xx unknown
- 1997-07-25 AR ARP970103377A patent/AR007997A1/es active IP Right Grant
- 1997-07-25 MY MYPI97003389A patent/MY124103A/en unknown
- 1997-10-07 UA UA99021068A patent/UA61922C2/uk unknown
1999
- 1999-01-20 NO NO19990246A patent/NO310817B1/no not_active IP Right Cessation
- 1999-12-22 HK HK99106034A patent/HK1020948A1/xx not_active IP Right Cessation
2002
- 2002-07-17 US US10/196,363 patent/US20030023031A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ZA976549B (en)	1998-02-03
HUP9903253A2 (hu)	2000-02-28
CN1116281C (zh)	2003-07-30
PL199865B1 (pl)	2008-11-28
GB9615692D0 (en)	1996-09-04
CA2260060C (en)	2007-01-30
TW360652B (en)	1999-06-11
KR20000029448A (ko)	2000-05-25
UA61922C2 (uk)	2003-12-15
JP4312264B2 (ja)	2009-08-12
DK0915845T3 (da)	2002-01-07
NO990246D0 (no)	1999-01-20
PL331344A1 (en)	1999-07-05
BR9710717A (pt)	1999-08-17
ATE205476T1 (de)	2001-09-15
IL127689A0 (en)	1999-10-28
HU224635B1 (hu)	2005-12-28
MY124103A (en)	2006-06-30
PT915845E (pt)	2002-03-28
AU724511B2 (en)	2000-09-21
NO310817B1 (no)	2001-09-03
CA2260060A1 (en)	1998-02-05
NZ334082A (en)	1999-08-30
AR007997A1 (es)	1999-11-24
EP0915845A1 (de)	1999-05-19
US20030023031A1 (en)	2003-01-30
WO1998004524A1 (en)	1998-02-05
HUP9903253A3 (en)	2002-01-28
JP2000515164A (ja)	2000-11-14
EA001863B1 (ru)	2001-10-22
DE69706690T2 (de)	2002-06-20
ES2164366T3 (es)	2002-02-16
US6482920B1 (en)	2002-11-19
AU4009897A (en)	1998-02-20
HK1020948A1 (en)	2000-05-26
NO990246L (no)	1999-01-20
EP0915845B1 (de)	2001-09-12
EA199900163A1 (ru)	1999-08-26
KR100408538B1 (ko)	2004-01-13
CN1226232A (zh)	1999-08-18
IL127689A (en)	2003-07-31

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Legal Events

Date	Code	Title	Description
2002-10-10	8364	No opposition during term of opposition
2003-02-13	8327	Change in the person/name/address of the patent owner	Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT
2008-12-04	8327	Change in the person/name/address of the patent owner	Owner name: NERVIANO MEDICAL SCIENCES S.R.L., NERVIANO, MI, IT