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HUP9903253A2 - Akriloil-helyettesített disztamicinszármazékok, eljárás előállításukra, valamint tumorellenes és vírusellenes alkalmazásuk - Google Patents

Akriloil-helyettesített disztamicinszármazékok, eljárás előállításukra, valamint tumorellenes és vírusellenes alkalmazásuk

Info

Publication number
HUP9903253A2
HUP9903253A2 HU9903253A HUP9903253A HUP9903253A2 HU P9903253 A2 HUP9903253 A2 HU P9903253A2 HU 9903253 A HU9903253 A HU 9903253A HU P9903253 A HUP9903253 A HU P9903253A HU P9903253 A2 HUP9903253 A2 HU P9903253A2
Authority
HU
Hungary
Prior art keywords
antitumor
preparing
antiviral agents
distamycin derivatives
acryloyl substituted
Prior art date
Application number
HU9903253A
Other languages
English (en)
Inventor
Italo Beria
Giovanni Biasoli
Marina Caldarelli
Laura Capolongo
Paolo Cozzi
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn S.P.A. filed Critical Pharmacia & Upjohn S.P.A.
Publication of HUP9903253A2 publication Critical patent/HUP9903253A2/hu
Publication of HUP9903253A3 publication Critical patent/HUP9903253A3/hu
Publication of HU224635B1 publication Critical patent/HU224635B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány új, (I) általánős képletű disztamicinszármazékőkra -amelyek képletében n 2, 3 vagy 4, R1 és R2 hidrőgén-, halőgénatőm vagy alkilcsőpőrt, R3 hidrőgén- vagy halőgénatőm, B csőpőrt, ahől R4, R5, R6, R7 és R8 hidrőgénatőm vagy alkilcsőpőrt, azzal amegkötéssel, hőgy R4, R5 és R6 legalább egyike alkilcsőpőrt -,gyógyászatilag elfőgadható sóikra, előállítási eljárásűkra, avegyületeket tartalmazó gyógyszerkészítményekre, valamint a vegyületekgyógyászati, különösen tűmőrellenes és vírűsellenes szerekként történőalkalmazására vőnatkőzik. ŕ
HU9903253A 1996-07-25 1997-07-10 Akriloil-helyettesített disztamicinszármazékok, eljárás előállításukra, valamint tumorellenes és vírusellenes alkalmazásuk HU224635B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615692.2A GB9615692D0 (en) 1996-07-25 1996-07-25 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en) 1996-07-25 1997-07-10 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (3)

Publication Number Publication Date
HUP9903253A2 true HUP9903253A2 (hu) 2000-02-28
HUP9903253A3 HUP9903253A3 (en) 2002-01-28
HU224635B1 HU224635B1 (hu) 2005-12-28

Family

ID=10797527

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903253A HU224635B1 (hu) 1996-07-25 1997-07-10 Akriloil-helyettesített disztamicinszármazékok, eljárás előállításukra, valamint tumorellenes és vírusellenes alkalmazásuk

Country Status (27)

Country Link
US (2) US6482920B1 (hu)
EP (1) EP0915845B1 (hu)
JP (1) JP4312264B2 (hu)
KR (1) KR100408538B1 (hu)
CN (1) CN1116281C (hu)
AR (1) AR007997A1 (hu)
AT (1) ATE205476T1 (hu)
AU (1) AU724511B2 (hu)
BR (1) BR9710717A (hu)
CA (1) CA2260060C (hu)
DE (1) DE69706690T2 (hu)
DK (1) DK0915845T3 (hu)
EA (1) EA001863B1 (hu)
ES (1) ES2164366T3 (hu)
GB (1) GB9615692D0 (hu)
HK (1) HK1020948A1 (hu)
HU (1) HU224635B1 (hu)
IL (1) IL127689A (hu)
MY (1) MY124103A (hu)
NO (1) NO310817B1 (hu)
NZ (1) NZ334082A (hu)
PL (1) PL199865B1 (hu)
PT (1) PT915845E (hu)
TW (1) TW360652B (hu)
UA (1) UA61922C2 (hu)
WO (1) WO1998004524A1 (hu)
ZA (1) ZA976549B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
PA8515201A1 (es) * 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
EP1470119A4 (en) * 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
EP1461083B1 (en) * 2002-01-02 2006-03-29 Pharmacia Italia S.p.A. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
AU2003219102B2 (en) * 2002-04-02 2008-05-08 Nerviano Medical Sciences S.R.L. Combined therapy against tumors comprising subtituted acryloyl distamycin derivatives and radiotherapy
MX383577B (es) * 2015-08-06 2025-03-14 Ube Industries Derivados sustituidos de guanidina.
GB202114032D0 (en) * 2021-09-30 2021-11-17 Univ Strathclyde Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives

Also Published As

Publication number Publication date
ZA976549B (en) 1998-02-03
CN1116281C (zh) 2003-07-30
PL199865B1 (pl) 2008-11-28
GB9615692D0 (en) 1996-09-04
CA2260060C (en) 2007-01-30
TW360652B (en) 1999-06-11
KR20000029448A (ko) 2000-05-25
UA61922C2 (uk) 2003-12-15
JP4312264B2 (ja) 2009-08-12
DK0915845T3 (da) 2002-01-07
NO990246D0 (no) 1999-01-20
PL331344A1 (en) 1999-07-05
BR9710717A (pt) 1999-08-17
ATE205476T1 (de) 2001-09-15
IL127689A0 (en) 1999-10-28
HU224635B1 (hu) 2005-12-28
MY124103A (en) 2006-06-30
PT915845E (pt) 2002-03-28
AU724511B2 (en) 2000-09-21
DE69706690D1 (de) 2001-10-18
NO310817B1 (no) 2001-09-03
CA2260060A1 (en) 1998-02-05
NZ334082A (en) 1999-08-30
AR007997A1 (es) 1999-11-24
EP0915845A1 (en) 1999-05-19
US20030023031A1 (en) 2003-01-30
WO1998004524A1 (en) 1998-02-05
HUP9903253A3 (en) 2002-01-28
JP2000515164A (ja) 2000-11-14
EA001863B1 (ru) 2001-10-22
DE69706690T2 (de) 2002-06-20
ES2164366T3 (es) 2002-02-16
US6482920B1 (en) 2002-11-19
AU4009897A (en) 1998-02-20
HK1020948A1 (en) 2000-05-26
NO990246L (no) 1999-01-20
EP0915845B1 (en) 2001-09-12
EA199900163A1 (ru) 1999-08-26
KR100408538B1 (ko) 2004-01-13
CN1226232A (zh) 1999-08-18
IL127689A (en) 2003-07-31

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20051014

GB9A Succession in title

Owner name: NERVIANO MEDICAL SCIENCES S.R.L., IT

Free format text: FORMER OWNER(S): PHARMACIA & UPJOHN S.P.A., IT; PHARMACIA ITALIA S.P.A., IT

MM4A Lapse of definitive patent protection due to non-payment of fees